scholarly journals A comprehensive review of pathogenesis of mucormycosis with implications of COVID-19: Indian perspective

2021 ◽  
Vol 4 ◽  
pp. 116-122
Author(s):  
Sanpreet Singh Sachdev ◽  
Tabita Joy Chettiankandy ◽  
Manisha Ahire Sardar ◽  
Easwaran Ramaswamy ◽  
Aakruti Mahendra Shah ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Fungal Infection ◽  
Fungal Infections ◽  
Global Burden ◽  
Comprehensive Review ◽  
The World ◽  
Indian Perspective

Mucormycosis is a deadly fungal infection that targets immunocompromised individuals. India being the “diabetes” capital of the world contributes to about 40% of global burden of the infectious disease. With the addition of COVID-19 pandemic to the equation, there has been an alarming increase in the number of reported cases of mucormycosis. The disease itself along with corticosteroid and certain other strategies used in its treatment predispose the patients to develop secondary bacterial and fungal infections. Therefore, it is imperative for clinicians to understand the pathogenesis of mucormycosis at present so that they can develop combative counter strategies. We provide a comprehensive review of the pathogenetic process of mucormycosis while also elucidating implications of COVID-19 pandemic in the epidemiology and pathogenesis of the infectious malice in an Indian background.

scholarly journals COVID-19 and Fungal Infection

2020 ◽  
pp. 47-50
Author(s):  
Ji Hyun Lee ◽  
Hwa Jung Yook
Keyword(s):  
Fungal Infection ◽  
Multiple Organ Failure ◽  
World Health Organization ◽  
Organ Failure ◽  
Fungal Infections ◽  
Severe Disease ◽  
Multiple Organ ◽  
World Health ◽  
The World ◽  
Health Organization

In November 2019, the coronavirus disease-2019 (COVID-19) outbreak was first reported. The infection of COVID-19 has rapidly spread worldwide. Some have unapparent or mild symptoms, but some patients have fatal forms including respiratory or multiple organ failure. In March 2020, the World Health Organization announced COVID-19 as pandemic disease. The COVID-19 pandemic is a sudden, difficult-to-control, and severe disease that can also appear to patients in dermatology. However, understanding disease and experience with it is still insufficient. Therefore, we would like to review patients with fungal infections in the COVID-19 pandemic era.

scholarly journals The Zebrafish as a Model Host for Invasive Fungal Infections

2018 ◽  
Vol 4 (4) ◽  
pp. 136 ◽  
Author(s):  
Emily Rosowski ◽  
Benjamin Knox ◽  
Linda Archambault ◽  
Anna Huttenlocher ◽  
Nancy Keller ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Fungal Infection ◽  
Small Molecule ◽  
In Vivo Imaging ◽  
Fungal Infections ◽  
Invasive Fungal Infections ◽  
Small Molecule Screening

The zebrafish has become a widely accepted model host for studies of infectious disease, including fungal infections. The species is genetically tractable, and the larvae are transparent and amenable to prolonged in vivo imaging and small molecule screening. The aim of this review is to provide a thorough introduction into the published studies of fungal infection in the zebrafish and the specific ways in which this model has benefited the field. In doing so, we hope to provide potential new zebrafish researchers with a snapshot of the current toolbox and prior results, while illustrating how the model has been used well and where the unfulfilled potential of this model can be found.

scholarly journals Magnitude and Associated Factors of Superficial Fungal Infections on HIV/AIDS Patients Who Attends in Debretabor General Hospital ART Clinic, Debretabor, North West Ethiopia, 2015/16

2016 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Fungal Infection ◽  
General Hospital ◽  
Associated Factors ◽  
Opportunistic Infections ◽  
Fungal Infections ◽  
Aids Patients ◽  
Work Condition ◽  
Income Source ◽  
The World ◽  
Hiv Aids

Introduction: HIV/AIDS has been occurring in the world as the major pandemic disease that affects all parts of the world, but sub-Saharan Africa it is high in prevalence which reduces the effectiveness of the immune system and makes individuals susceptible to opportunistic infections and tumors. This often leads the patients to a variety of opportunistic infections including fungal infections and the like. Superficial fungal infections are common in HIV patients that can have an atypical clinical severity and variability of presentation and may be extensive, recurrent, and difficult to treat. Objectives: This study aims to determine the magnitude and associated factors of superficial fungal infections on HIV/ AIDS patients who have follow up at ART clinic in Debretabore General Hospital. Methods: Institutional based cross sectional study design was used via systematic random method with kth value of 3rd on 299 study population from December/2015-Feburaray/2016. Result: Prevalence of superficial fungal infection in this study was 59.2% with 99.7% response rate. Female {AOR(95% CI); 2.6 (3.06, 7.901)}, age ranges less than 15 [AOR(95% CI); 4.03 (0.002, 0.994)], and ages between 16-30 years [AOR(95% CI);2.1 (1.93, 7.16)], uneducated subjects [AOR (95% CI); 3.4 (0.00, 0.150)], presence of pets in the home 5.3 [(0.001, 0.183)], income source being a farmer [AOR (95% CI); 4.3 (0.031,0.72)], CD4 level less than 200cells/ mm3 [AOR (95% CI); 8 (0.00, 0.007)] and work condition associated to water [AOR (95% CI); 6.3 (7.31, 13.800)] were statistically significant to the presence of superficial fungal infection in Debretabor General hospital at ART clinic. Concussion: The overall prevalence of superficial fungal infection in the study area was relatively high (59.2%) with 78% of the cases were neglected as nothing would do on patients life having a statistical significant association with age, sex, income source (farmer), educational status, presence of pets in the home, CD4 level, work condition associated with water body. Thus, a continuous health education about the disease, factors with education on preventive methods and treating the cases accordingly of fungal infections should be sought.

scholarly journals Philogenetic Analysis of S. Scabiei Var. Hominis, Var. Cuniculi, and Var. Marmoota

2021 ◽  
Vol 5 (3) ◽  
pp. 838-842
Author(s):  
Gita Dwi Prasasty ◽  
Miftahurrizqiyah ◽  
Dalilah ◽  
Dwi Handayani ◽  
Tia Sabrina ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Phylogenetic Analysis ◽  
Genetic Variation ◽  
Mortality Rate ◽  
Genetic Information ◽  
Distinct Species ◽  
Global Burden ◽  
Its Sequencing ◽  
The World ◽  
Very High

Introduction: Based on data from the 2017 Global Burden of Disease, it is known that Indonesia is the country with the highest number of scabies incidences out of 195 countries in the world. In addition to humans, scabies is also an infectious disease in mammals with a prevalence of 300 million infestations every year, even in animals the mortality rate from scabies is very high. Until now, it is still unclear whether there is a cross-infestation between human and animal scabies. Morphologically, S. scabiei between variants cannot be distinguished, while research on genetic variation is still not much done. Therefore, it is necessary to conduct studies to enrich genetic information and phylogenetic analysis. Methods: The samples tested were positive PCR results for ITS 2 and CO 1 genes, each on five amplicons, namely three S. scabiei var. hominis, one var. cuniculi, and one var. marmoota. Phylogenetics were arranged based on the closeness of the base arrangement in variants and geographically available in NCBI. Results: Of the five sample isolates studied, the ITS 2 gene amplicon is located in the 417bp band and the phylogenetic analysis of its sequencing has two branches that are unable to distinguish var. hominis and var. animalia. The CO1 gene has electrophoretic results at 317 bp as well as phylogenetic analysis results that specifically divide branches between var. hominis and var. animalia. Conclusion: S. scabiei var. hominis and var. marmoota, and var. cuniculi are distinct species and are host monospecific.

scholarly journals Philogenetic Analysis of S. Scabiei Var. Hominis, Var. Cuniculi, and Var. Marmoota

2021 ◽  
Vol 5 (10) ◽  
pp. 911-915
Author(s):  
Gita Dwi Prasasty ◽  
Miftahurrizqiyah ◽  
Dalilah ◽  
Dwi Handayani ◽  
Tia Sabrina ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Phylogenetic Analysis ◽  
Genetic Variation ◽  
Mortality Rate ◽  
Genetic Information ◽  
Distinct Species ◽  
Global Burden ◽  
Its Sequencing ◽  
The World ◽  
Very High

Introduction: Based on data from the 2017 Global Burden of Disease, it is known that Indonesia is the country with the highest number of scabies incidences out of 195 countries in the world. In addition to humans, scabies is also an infectious disease in mammals with a prevalence of 300 million infestations every year, even in animals the mortality rate from scabies is very high. Until now, it is still unclear whether there is a cross-infestation between human and animal scabies. Morphologically, S. scabiei between variants cannot be distinguished, while research on genetic variation is still not much done. Therefore, it is necessary to conduct studies to enrich genetic information and phylogenetic analysis. Methods: The samples tested were positive PCR results for ITS 2 and CO 1 genes, each on five amplicons, namely three S. scabiei var. hominis, one var. cuniculi, and one var. marmoota. Phylogenetics were arranged based on the closeness of the base arrangement in variants and geographically available in NCBI. Results: Of the five sample isolates studied, the ITS 2 gene amplicon is located in the 417bp band and the phylogenetic analysis of its sequencing has two branches that are unable to distinguish var. hominis and var. animalia. The CO1 gene has electrophoretic results at 317 bp as well as phylogenetic analysis results that specifically divide branches between var. hominis and var. animalia. Conclusion: S. scabiei var. hominis and var. marmoota, and var. cuniculi are distinct species and are host monospecific.

Islam and the West: Coexistence or Clash?

2012 ◽  
Vol 8 ◽  
pp. 363-374
Author(s):  
Noor Mohammad Osmani ◽  
Tawfique Al-Mubarak
Keyword(s):  
Cold War ◽  
Critical Evaluation ◽  
Western Civilization ◽  
Peaceful Coexistence ◽  
The West ◽  
Comprehensive Review ◽  
The World ◽  
Islamic Civilization ◽  
The Cold War

Samuel Huntington (1927-2008) claimed that there would be seven eight civilizations ruling over the world in the coming centuries, thus resulting a possible clash among them. The West faces the greatest challenge from the Islamic civilization, as he claimed. Beginning from the Cold-War, the Western civilization became dominant in reality over other cultures creating an invisible division between the West and the rest. The main purpose of this research is to examine the perceived clash between the Western and Islamic Civilization and the criteria that lead a civilization to precede others. The research would conduct a comprehensive review of available literatures from both Islamic and Western perspectives, analyze historical facts and data and provide a critical evaluation. This paper argues that there is no such a strong reason that should lead to any clash between the West and Islam; rather, there are many good reasons that may lead to a peaceful coexistence and cultural tolerance among civilizations

Designing an Outer Membrane Protein (Omp-W) Based Vaccine for Immunization against Vibrio and Salmonella: An in silico Approach

2020 ◽  
Vol 14 (4) ◽  
pp. 312-324
Author(s):  
Sadra S. Tehrani ◽  
Abolfazl Jahangiri ◽  
Mortaza Taheri-Anganeh ◽  
Hossein Maghsoudi ◽  
Saeed Khalili ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Vibrio Cholerae ◽  
Gram Negative Bacteria ◽  
B Cell Epitopes ◽  
E Coli ◽  
Beta Barrel ◽  
The World ◽  
Cd4 Cell ◽  
Stimulating Factor ◽  
Topology Prediction

Background: Cholera triggered by Vibrio cholerae remains the main reason for morbidity and mortality all over the world. In addition, salmonellosis is regarded as an infectious disease that makes it essential for the identification and detection of Salmonella. With a beta-barrel structure consisting of eight non-parallel beta strands, OmpW family is widely distributed among gram-negative bacteria. Moreover, OmpW isolated from S. typhimurium and Vibrio cholerae can be used in vaccine design. Methods: Topology prediction was determined. T-cell and B-cell epitopes were selected from exposed areas, and sequence conservancy was evaluated. The remaining loops and inaccessible residues were removed to prepare OmpW-1. High antigenicity peptides were detected to replace inappropriate residues to obtain OmpW-2. Physicochemical properties were assessed, and antigenicity, hydrophobicity, flexibility, and accessibility were compared to the native Omp-W structure. Low score areas were removed from the designed structure for preparing the OmpW-3. To construct OmpW-4, TTFrC was used as T-CD4+ cell-stimulating factor and CTB as adjuvant to the end of the C-terminal of this sequence, which can increase the antigenicity and sequence density. The sequences were re-analyzed to delete the unfavorable residues. Besides, the solubility of the mature OmpW and the designed structure were predicted while overexpressed in E. coli. Results: The designed vaccine is a stable protein which has immune cells recognizing epitopes and is considered as an antigen. The construct can be overexpressed in a E. coli. Conclusion: The multi-epitope vaccine is a suitable stimulator for immune system and would be a candidate for experimental research. Recent patents describing numerous inventions related to the clinical facets of vaccine peptide against human infectious disease.

scholarly journals Infectious disease outbreaks in the African region: overview of events reported to the World Health Organization in 2018

2019 ◽  
Vol 147 ◽  
Author(s):  
F. Mboussou ◽  
P. Ndumbi ◽  
R. Ngom ◽  
Z. Kassamali ◽  
O. Ogundiran ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Disease Onset ◽  
Disease Outbreaks ◽  
Case Fatality ◽  
World Health ◽  
African Region ◽  
Regional Office ◽  
Member States ◽  
Infectious Disease Outbreaks ◽  
The World

Abstract The WHO African region is characterised by the largest infectious disease burden in the world. We conducted a retrospective descriptive analysis using records of all infectious disease outbreaks formally reported to the WHO in 2018 by Member States of the African region. We analysed the spatio-temporal distribution, the notification delay as well as the morbidity and mortality associated with these outbreaks. In 2018, 96 new disease outbreaks were reported across 36 of the 47 Member States. The most commonly reported disease outbreak was cholera which accounted for 20.8% (n = 20) of all events, followed by measles (n = 11, 11.5%) and Yellow fever (n = 7, 7.3%). About a quarter of the outbreaks (n = 23) were reported following signals detected through media monitoring conducted at the WHO regional office for Africa. The median delay between the disease onset and WHO notification was 16 days (range: 0–184). A total of 107 167 people were directly affected including 1221 deaths (mean case fatality ratio (CFR): 1.14% (95% confidence interval (CI) 1.07%–1.20%)). The highest CFR was observed for diseases targeted for eradication or elimination: 3.45% (95% CI 0.89%–10.45%). The African region remains prone to outbreaks of infectious diseases. It is therefore critical that Member States improve their capacities to rapidly detect, report and respond to public health events.

scholarly journals The Prediction and Prognosis of Fungal Infection in Lung Transplant Recipients—A Retrospective Cohort Study in South Korea

2021 ◽  
Vol 7 (8) ◽  
pp. 639
Author(s):  
Yae-Jee Baek ◽  
Yun-Suk Cho ◽  
Moo-Hyun Kim ◽  
Jong-Hoon Hyun ◽  
Yu-Jin Sohn ◽  
...  
Keyword(s):  
Cohort Study ◽  
South Korea ◽  
Fungal Infection ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Lung Transplant ◽  
Fungal Infections ◽  
Transplant Recipients ◽  
Tertiary Center ◽  
Lung Transplant Recipients

(1) Background: Lung transplant recipients (LTRs) are at substantial risk of invasive fungal disease (IFD), although no consensus has been reached on the use of antifungal agents (AFAs) after lung transplantation (LTx). This study aimed to assess the risk factors and prognosis of fungal infection after LTx in a single tertiary center in South Korea. (2) Methods: The study population included all patients who underwent LTx between January 2012 and July 2019 at a tertiary hospital. It was a retrospective cohort study. Culture, bronchoscopy, and laboratory findings were reviewed during episodes of infection. (3) Results: Fungus-positive respiratory samples were predominant in the first 90 days and the overall cumulative incidence of Candida spp. was approximately three times higher than that of Aspergillus spp. In the setting of itraconazole administration for 6 months post-LTx, C. glabrata accounted for 36.5% of all Candida-positive respiratory samples. Underlying connective tissue disease-associated interstitial lung disease, use of AFAs before LTx, a longer length of hospital stay after LTx, and old age were associated with developing a fungal infection after LTx. IFD and fungal infection treatment failure significantly increased overall mortality. Host factors, antifungal drug resistance, and misdiagnosis of non-Aspergillus molds could attribute to the breakthrough fungal infections. (4) Conclusions: Careful bronchoscopy, prompt fungus culture, and appropriate use of antifungal therapies are recommended during the first year after LTx.

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