THE IMPACT OF OBSTRUCTIVE SLEEP APNEA/HYPOPNEA SYNDROME ON THE LEVELS OF TISSUE INHIBITOR OF MATRIX METALLOPROTEINASE-1 AND HYPOXIA-INDUCIBLE FACTOR-1Α IN ATRIAL FIBRILLATION PATIENTS

Background/Aim. It is necessary to find eligible oxidative stress markers for predicting the severity of obstructive sleep apnea hypopnea syndrome (OSAHS), a sleep disorder-related respiratory disease. We aimed to explore the correlation between oxidative stress and cognitive impairment in OSAHS patients. Methods. A total of 220 eligible patients were divided into snoring, mild to moderate OSAHS and severe OSAHS groups according to polysomnography (PSG). Apnea-hypopnea index (AHI), oxygen desaturation index (ODI) and baseline data were monitored. Oxidative stress indices were measured by colorimetry in early morning. They were divided into normal cognitive and cognitive impairment groups based on Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Independent risk factors for cognitive impairment were analyzed by multivariate logistic regression. Correlation between oxidative stress and cognitive impairment was analyzed by Pearson?s method. Receiver operating characteristic (ROC) curves were plotted to analyze the efficiency of oxidative stress combined with detection for assessing the cognitive impairment in OSAHS patients. Results. Snoring, mild to moderate OSAHS and severe OSAHS groups had significantly different snoring loudness, BMI, AHI, ODI, MoCA and MMSE scores, and levels of malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) (P<0.05). Cognitive impairment and normal cognitive groups had different BMI, GSH-Px, MDA and SOD levels, neuroglobin, hypoxia-inducible factor, AHI and lowest nocturnal oxygen saturation (P<0.05 or P<0.01). BMI, GSH-Px, MDA, SOD, neuroglobin, hypoxia-inducible factor, AHI and lowest nocturnal oxygen saturation were independent risk factors for cognitive impairment. The MoCA and MMSE scores of cognitive impairment had positive correlations with GSH-Px and SOD, but negative correlations with MDA (P<0.05). AUCs of GSH-Px, MDA, SOD and their combination for prediction were 0.670, 0.702, 0.705 and 0.836, respectively. Conclusion. Oxidative stress may be the biochemical basis of cognitive impairment in OSAHS patients.

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Homocysteine level in patients with obstructive sleep apnea/hypopnea syndrome and the impact of continuous positive airway pressure treatment

Advances in Clinical and Experimental Medicine ◽

10.17219/acem/74178 ◽

2018 ◽

Vol 27 (11) ◽

pp. 1549-1554 ◽

Cited By ~ 1

Author(s):

Jie LI ◽

Li-qiang YU ◽

Min JIANG ◽

Ling WANG ◽

Qi FANG

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Continuous Positive Airway Pressure ◽

Airway Pressure ◽

Positive Airway Pressure ◽

Homocysteine Level ◽

Pressure Treatment ◽

Obstructive Sleep ◽

Hypopnea Syndrome ◽

The Impact

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The Role of Obstructive Sleep Apnea/Hypopnea Syndrome in Stratification of the Cardiovascular Risk in Patients with Non-Valvular Atrial Fibrillation Associated with Ishemic Heart Disease and/or Arterial Hypertension

Health and Ecology Issues ◽

10.51523/2708-6011.2018-15-4-6 ◽

2018 ◽

pp. 30-36

Author(s):

T. I. Balabanovich ◽

V. I. Shyshko

Keyword(s):

Atrial Fibrillation ◽

Obstructive Sleep Apnea ◽

Heart Disease ◽

Cardiovascular Risk ◽

Sleep Apnea ◽

Arterial Hypertension ◽

Obstructive Sleep ◽

Hypopnea Syndrome

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CIRCULATING SERUM LEVELS OF GROWTH DIFFERENTIATION FACTOR-15 IN NON-VALVULAR ATRIAL FIBRILLATION PATIENTS WITH CONCOMITANT OBSTRUCTIVE SLEEP APNEA/HYPOPNEA SYNDROME

Biological Markers in Fundamental and Clinical Medicine (collection of abstracts) ◽

10.29256/v.02.02.2018.escbm27 ◽

2018 ◽

Vol 2 (2) ◽

pp. 35-36

Author(s):

T.I. Balabanovich ◽

V.I. Shyshko ◽

V.R. Shulika

Keyword(s):

Atrial Fibrillation ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Serum Levels ◽

Growth Differentiation Factor 15 ◽

Differentiation Factor ◽

Obstructive Sleep ◽

Hypopnea Syndrome

CIRCULATING SERUM LEVELS OF GROWTH DIFFERENTIATION FACTOR-15 IN NON-VALVULAR ATRIAL FIBRILLATION PATIENTS WITH CONCOMITANT OBSTRUCTIVE SLEEP APNEA/HYPOPNEA SYNDROME

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Uncovering Synergistic Mechanism of Chinese Herbal Medicine in the Treatment of Atrial Fibrillation with Obstructive Sleep Apnea Hypopnea Syndrome by Network Pharmacology

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2019/8691608 ◽

2019 ◽

Vol 2019 ◽

pp. 1-13 ◽

Cited By ~ 2

Author(s):

Ting Mao ◽

Jingchun Zhang ◽

Yu Qiao ◽

Bei Liu ◽

Shan Zhang

Keyword(s):

Atrial Fibrillation ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Signaling Pathway ◽

Therapeutic Targets ◽

Network Pharmacology ◽

Pathway Enrichment Analysis ◽

Obstructive Sleep ◽

Target Network ◽

Hypopnea Syndrome

Paroxysmal atrial fibrillation (AF) combined with obstructive sleep apnea hypopnea syndrome (OSAHS) is very common in clinical practice. Traditional Chinese medicine (TCM) rule of regulating the liver based on psycho-cardiology shows satisfactory effectiveness in the treatment of paroxysmal AF combined with OSAHS. However, its underlying pharmacological mechanism has not yet been elucidated. This study applied network pharmacology to identify 94 active components in the six TCM liver-regulating herbs and 182 corresponding targets from several databases and comprehensive literature studies, as well as retrieved AF combined with OSAHS-related targets. Cytoscape software was adopted to construct the component-component target network and component-putative target-AF combined with OSAHS target network. Then, we obtained 38 putative therapeutic targets against AF combined with OSAHS. After the production of a putative therapeutic target interaction network, topological analysis was adopted to determine the core targets of TCM liver-regulating herbs in the treatment of paroxysmal AF combined with OSAHS. For all putative therapeutic targets, biological process analysis and pathway enrichment analysis were utilized to investigate the possible mechanism of TCM liver-regulating herbs in the treatment of paroxysmal AF combined with OSAHS. Mechanistically, it included positive regulation of nitric oxide biosynthetic process, aging, response to hypoxia, TNF signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, neuroactive ligand-receptor interaction, and calcium signaling pathway. Especially, six core targets of TCM liver-regulating herbs, namely, TNF, STAT3, AKT1, IL-6, TP53, and INS, were significant in the regulation of the above biological processes and pathways. This study demonstrates the multicomponent, multitarget, and multipathway feature of TCM liver-regulating herbs, provides an extensional foundation for further research, and facilitates the reasonable application of TCM liver-regulating herbs in treating paroxysmal AF combined with OSAHS.

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