CLINICAL FACTORS AFFECTING THE EFFECTIVENESS OF THE THERAPY OF PEMPHIGUS VULGARIS - A RETROSPECTIVE STUDY

AbstractThe presence of postoperative complications may have a significant impact on the outcome of the breast reconstruction. The aim of this study was to investigate early postoperative complications and the risk factors for their occurrence. A prospective analysis was carried out to evaluate surgical outcomes after breast reconstructive surgeries performed over a 2-year period. Procedures included expander/implant (TE/IMP), pedicle transverse rectus abdominis musculocutaneous (pTRAM), and latissimus dorsi (LD) techniques. All adverse events which occurred within 6 weeks of surgery were ranked according to severity based on the contracted Accordion grading system. Outcomes were assessed for their association with surgical, demographic, and clinical variables. Sixty-one consecutive breast reconstruction procedures were analyzed. The overall complication rate was 60.7% (n = 37), and 8 patients (13.1%) required reoperation. The lowest complication rate was observed in implant-based reconstructions (TE/IMP, 18.8%; pTRAM, 72.7%; LD, 78.3%; p = 0.008). Mild complications occurred significantly more often after LD reconstructions (LD, 60.9%; pTRAM, 22.7%; TE/IMP, 12.5%; p = 0.031), while severe complications were significantly more frequent after the pTRAM procedures (pTRAM, 27.3%; TE/IMP, 6.2%; LD, 8.7%; p = 0.047). Severe complications were associated with higher rehospitalization rate (p = 0.010) and longer hospital stay. Study revealed a significant impact of the operative method on the incidence and severity of early complications after breast reconstruction procedures with little effect from other demographic and clinical factors.

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What Are the Factors Affecting Total Sleep Time During Video Polysomnography in Infants?

American Journal of Perinatology ◽

10.1055/s-0040-1718948 ◽

2020 ◽

Author(s):

Grace R. Paul ◽

Don Hayes ◽

Dmitry Tumin ◽

Ish Gulati ◽

Sudarshan Jadcherla ◽

...

Keyword(s):

Total Sleep Time ◽

Sleep Time ◽

Time Of Day ◽

Apnea Hypopnea Index ◽

Clinical Factors ◽

Initial Management ◽

Factors Affecting ◽

Modifiable Factors ◽

Key Points ◽

Medical Complexity

Objective The aim of the study is to investigate factors affecting total sleep time (TST) during infant polysomnography (PSG) and assess if <4 hours of TST is sufficient for accurate interpretation. Study Design Overall, 242 PSGs performed in 194 infants <6 months of chronological age between March 2013 and December 2015 were reviewed to identify factors that affect TST, including age of infant, location and timing of study, presence of medical complexity, and presence of nasal tubes. A continuum of apnea-hypopnea index (AHI) in relation to TST was reviewed. Data were examined in infants who had TST <4 hours and low AHI. Results Greater TST (p < 0.001) was noted among infants during nocturnal PSGs, at older chronological and post-menstrual ages, and without medical complexity. The presence of nasogastric/impedance probes reduced TST (p = 0.002). Elevated AHIs were identified even in PSGs with TST <4 hours. Short TST may have affected interpretation and delayed initial management in one infant without any inadvertent complications. Conclusion Clinical factors such as PMA and medical complexity, and potentially modifiable factors such as time of day and location of study appeared to affect TST during infant PSGs. TST < 4 hours can be sufficient to identify high AHI allowing physician interpretation. Key Points

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Factors affecting pregnancy rate following nonsurgical embryo transfer in buffalo (Bubalus bubalis) : A retrospective study

Theriogenology ◽

10.1016/s0093-691x(99)00105-3 ◽

1999 ◽

Vol 52 (1) ◽

pp. 1-10 ◽

Cited By ~ 7

Author(s):

A.K. Misra ◽

M. Mutha Rao ◽

R. Kasiraj ◽

N.S. Ranga Reddy ◽

H.C. Pant

Keyword(s):

Retrospective Study ◽

Pregnancy Rate ◽

Embryo Transfer ◽

Bubalus Bubalis ◽

Factors Affecting

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A multicenter retrospective study of heterogeneous tissue aggregates obstructing ventricular catheters explanted from patients with hydrocephalus

Fluids and Barriers of the CNS ◽

10.1186/s12987-021-00262-3 ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Prashant Hariharan ◽

Jeffrey Sondheimer ◽

Alexandra Petroj ◽

Jacob Gluski ◽

Andrew Jea ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

Retrospective Study ◽

Foreign Body ◽

Foreign Body Giant Cell ◽

Clinical Factors ◽

Histological Features ◽

Ventricular Catheters ◽

Heterogeneous Tissue ◽

Histology And Immunohistochemistry ◽

Macroscopic Analysis

Abstract Background Implantation of ventricular catheters (VCs) to drain cerebrospinal fluid (CSF) is a standard approach to treat hydrocephalus. VCs fail frequently due to tissue obstructing the lumen via the drainage holes. Mechanisms driving obstruction are poorly understood. This study aimed to characterize the histological features of VC obstructions and identify links to clinical factors. Methods 343 VCs with relevant clinical data were collected from five centers. Each hole on the VCs was classified by degree of tissue obstruction after macroscopic analysis. A subgroup of 54 samples was analyzed using immunofluorescent labelling, histology and immunohistochemistry. Results 61.5% of the 343 VCs analyzed had tissue aggregates occluding at least one hole (n = 211) however the vast majority of the holes (70%) showed no tissue aggregates. Mean age at which patients with occluded VCs had their first surgeries (3.25 yrs) was lower than in patients with non-occluded VCs (5.29 yrs, p < 0.02). Mean length of time of implantation of occluded VCs, 33.22 months was greater than for non-occluded VCs, 23.8 months (p = 0.02). Patients with myelomeningocele had a greater probability of having an occluded VC (p = 0.0426). VCs with occlusions had greater numbers of macrophages and astrocytes in comparison to non-occluded VCs (p < 0.01). Microglia comprised only 2–6% of the VC-obstructing tissue aggregates. Histologic analysis showed choroid plexus occlusion in 24%, vascularized glial tissue occlusion in 24%, prevalent lymphocytic inflammation in 29%, and foreign body giant cell reactions in 5% and no ependyma. Conclusion Our data show that age of the first surgery and length of time a VC is implanted are factors that influence the degree of VC obstruction. The tissue aggregates obstructing VCs are composed predominantly of astrocytes and macrophages; microglia have a relatively small presence.

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