SYSTEMIC FACTORS ASSOCITED WITH STROKE DOOR TO NEEDLE TIME: A COUNTRY WIDE ANALYSIS

2018 ◽  
Author(s):  
Ferghal McVerry
Keyword(s):  
Systemic Factors

The role of personality in shaping pandemic response: Systemic sociopolitical factors drive country differences

2020 ◽  
Author(s):  
Meghan Siritzky ◽  
David M Condon ◽  
Sara J Weston
Keyword(s):  
Individual Differences ◽  
Big Five ◽  
Public Health Research ◽  
Cross Cultural ◽  
Economic Factors ◽  
State Fragility ◽  
Systemic Factors ◽  
Pandemic Response ◽  
The Relationship

The current study utilizes the current COVID-19 pandemic to highlight the importance of accounting for the influence of external political and economic factors in personality public-health research. We investigated the extent to which systemic factors modify the relationship between personality and pandemic response. Results shed doubt on the cross-cultural generalizability of common big-five factor models. Individual differences only predicted government compliance in autocratic countries and in countries with income inequality. Personality was only predictive of mental health outcomes under conditions of state fragility and autocracy. Finally, there was little evidence that the big five traits were associated with preventive behaviors. Our ability to use individual differences to understand policy-relevant outcomes changes based on environmental factors and must be assessed on a trait-by-trait basis, thus supporting the inclusion of systemic political and economic factors in individual differences models.

scholarly journals Targeting obesity-related dysfunction in hormonally driven cancers

2021 ◽  
Author(s):  
Maria M. Rubinstein ◽  
Kristy A. Brown ◽  
Neil M. Iyengar
Keyword(s):  
Cell Signalling ◽  
Treatment Resistance ◽  
Tumour Microenvironment ◽  
Subsequent Increase ◽  
Treatment And Prevention ◽  
Cancer Pathogenesis ◽  
Diet And Exercise ◽  
Systemic Factors ◽  
Tumour Vascularity ◽  
Obesity And Cancer

AbstractObesity is a risk factor for at least 13 different types of cancer, many of which are hormonally driven, and is associated with increased cancer incidence and morbidity. Adult obesity rates are steadily increasing and a subsequent increase in cancer burden is anticipated. Obesity-related dysfunction can contribute to cancer pathogenesis and treatment resistance through various mechanisms, including those mediated by insulin, leptin, adipokine, and aromatase signalling pathways, particularly in women. Furthermore, adiposity-related changes can influence tumour vascularity and inflammation in the tumour microenvironment, which can support tumour development and growth. Trials investigating non-pharmacological approaches to target the mechanisms driving obesity-mediated cancer pathogenesis are emerging and are necessary to better appreciate the interplay between malignancy, adiposity, diet and exercise. Diet, exercise and bariatric surgery are potential strategies to reverse the cancer-promoting effects of obesity; trials of these interventions should be conducted in a scientifically rigorous manner with dose escalation and appropriate selection of tumour phenotypes and have cancer-related clinical and mechanistic endpoints. We are only beginning to understand the mechanisms by which obesity effects cell signalling and systemic factors that contribute to oncogenesis. As the rates of obesity and cancer increase, we must promote the development of non-pharmacological lifestyle trials for the treatment and prevention of malignancy.

scholarly journals Microglia in Neurodegenerative Events—An Initiator or a Significant Other?

2021 ◽  
Vol 22 (11) ◽  
pp. 5818
Author(s):  
Gaylia Jean Harry
Keyword(s):  
Neurovascular Unit ◽  
Cell Types ◽  
In Vitro Assays ◽  
Significant Other ◽  
Neurodegenerative Process ◽  
Target Sites ◽  
Systemic Factors ◽  
Injury And Repair ◽  
The Brain

A change in microglia structure, signaling, or function is commonly associated with neurodegeneration. This is evident in the patient population, animal models, and targeted in vitro assays. While there is a clear association, it is not evident that microglia serve as an initiator of neurodegeneration. Rather, the dynamics imply a close interaction between the various cell types and structures in the brain that orchestrate the injury and repair responses. Communication between microglia and neurons contributes to the physiological phenotype of microglia maintaining cells in a surveillance state and allows the cells to respond to events occurring in their environment. Interactions between microglia and astrocytes is not as well characterized, nor are interactions with other members of the neurovascular unit; however, given the influence of systemic factors on neuroinflammation and disease progression, such interactions likely represent significant contributes to any neurodegenerative process. In addition, they offer multiple target sites/processes by which environmental exposures could contribute to neurodegenerative disease. Thus, microglia at least play a role as a significant other with an equal partnership; however, claiming a role as an initiator of neurodegeneration remains somewhat controversial.

scholarly journals Service-user efforts to maintain their wellbeing during and after successful withdrawal from antipsychotic medication

2021 ◽  
Vol 11 ◽  
pp. 204512532198913
Author(s):  
Miriam Larsen-Barr ◽  
Fred Seymour
Keyword(s):  
Antipsychotic Medication ◽  
Online Survey ◽  
Structured Interviews ◽  
Obsessive Compulsive ◽  
Convenience Sample ◽  
Internal Resources ◽  
Compulsive Disorder ◽  
What Works ◽  
Systemic Factors ◽  
The Impact

Background: It is well-known that attempting antipsychotic withdrawal can be a fraught process, with a high risk of relapse that often leads people to resume the medication. Nonetheless, there is a group of people who appear to be able to discontinue successfully. Relatively little is known about how people do this. Methods: A convenience sample of adults who had stopped taking antipsychotic medication for more than a year were recruited to participate in semi-structured interviews through an anonymous online survey that investigated antipsychotic medication experiences in New Zealand. Thematic analysis explored participant descriptions of their efforts to maintain their wellbeing during and after the withdrawal process. Results: Of the seven women who volunteered to participate, six reported bipolar disorder diagnoses and one reported diagnoses of obsessive compulsive disorder and depression. The women reported successfully discontinuing antipsychotics for 1.25–25 years; six followed a gradual withdrawal method and had support to prepare for and manage this. Participants defined wellbeing in terms of their ability to manage the impact of any difficulties faced rather than their ability to prevent them entirely, and saw this as something that evolved over time. They described managing the process and maintaining their wellbeing afterwards by ‘understanding myself and my needs’, ‘finding what works for me’ and ‘connecting with support’. Sub-themes expand on the way in which they did this. For example, ‘finding what works for me’ included using a tool-box of strategies to flexibly meet their needs, practicing acceptance, drawing on persistence and curiosity and creating positive life experiences. Conclusion: This is a small, qualitative study and results should be interpreted with caution. This sample shows it is possible for people who experience mania and psychosis to successfully discontinue antipsychotics and safely manage the impact of any symptoms that emerge as a result of the withdrawal process or other life stressors that arise afterwards. Findings suggest internal resources and systemic factors play a role in the outcomes observed among people who attempt to stop taking antipsychotics and a preoccupation with avoiding relapse may be counterproductive to these efforts. Professionals can play a valuable role in facilitating change.

Revolution, Personalist Dictatorships, and International Conflict

2014 ◽  
Vol 69 (1) ◽  
pp. 163-194 ◽  
Author(s):  
Jeff D. Colgan ◽  
Jessica L.P. Weeks
Keyword(s):  
High Risk ◽  
International Conflict ◽  
Risk Tolerance ◽  
Military Conflicts ◽  
Systemic Factors ◽  
Political Structures

AbstractA consensus exists that countries that have recently undergone domestic political revolutions are particularly likely to become involved in military conflicts with other states. However, scholars seek to understand when and why revolutions increase the likelihood of international violence. In contrast to existing work focusing on international systemic factors, we argue that revolution fosters conflict in part by affecting states’ domestic political structures. Previous research has shown that revolution tends to bring particularly aggressive leaders to power. We demonstrate that revolutions also frequently result in personalist dictatorships, or regimes that lack powerful institutions to constrain and punish leaders. By empowering and ensconcing leaders with revisionist preferences and high risk tolerance, revolutions that result in personalist dictatorships are significantly more likely to lead to international conflict than revolutions that culminate in other forms of government. Our arguments and evidence help explain not only why revolution so commonly leads to conflict, but also why some revolutions lead to conflict whereas others do not.

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