scholarly journals Meta-Analysis of Zinc Deficiency and Its Influence Factors in Children Under 14-year-old in China

2021 ◽  
Vol 8 (5) ◽  
Author(s):  
Cai-Jin Y ◽  
◽  
Jing-Ying S ◽  
Gang-Xi L ◽  
◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Influencing Factors ◽  
Zinc Deficiency ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Influence Factors ◽  
Mainland China ◽  
School Age ◽  
Age Group ◽  
Significant Difference

Background: In recent years, zinc deficiency in children has attracted global attention. There are some differences in zinc deficiency in different countries and regions. However, there are few multi-center and large-sample studies on zinc deficiency in children in mainland China. Objective: To evaluate the status of zinc deficiency and its influence factors in children under 14-year-old in mainland China, and to provide evidence-based evidence for the strategy of prevention and treatment of zinc deficiency in children. Methods: PubMed, Embase, CNKI and other databases were searched about the cross-sectional survey literature on zinc deficiency and its influencing factors of under 14-year-old children in mainland China from 2005 to 2021. Stata 14.0 statistical software was used for Meta-analysis. Two independent reviewers identified eligible studies. Results: We identified 55 studies with 292,877 healthy children and adolescents in the Meta-analysis. The overall zinc deficiency rate was 27.0% (95% CI 22.8%-31.3%). From coastal areas of China showed that the zinc deficiency rate was 21.7% (95% CI 16.2%-27.1%) as 29.6% (95% CI 24.9%- 34.4%) from inland area of China. The zinc deficiency rate in the male group was greater than in the female group, and the difference was statistically significant [OR=1.052, 95% CI (1.019, 1.087), p=0.002]. The zinc deficiency rate in infant group was higher than that in toddler group [OR=1.38, 95% CI (1.16, 1.64), p=0.000], preschool group [OR=1.475, 95% CI (1.163, 1.870), p=0.001], and school-age group [OR=1.746, 95% CI (1.257, 2.425), p=0.001], with statistical significance. There was no significant difference in zinc deficiency rate between the toddler group and the preschool group [OR=1.059, 95% CI (0.918, 1.222), p=0.429], the toddler group and the school-age group [OR=1.136, 95% CI (0.848, 1.523), p=0.394], and the preschool group and the school-age group [OR=0.986, 95% CI (0.754, 1.291), p=0.919]. There was no statistically significant difference in zinc deficiency rate between the groups of well-educated and the poor-educated dietary provider. (OR=1.095, 95% CI (0.867, 1.383), p=0.446), and no statistical significance in zinc deficiency rate between urban group and rural group [OR=1.152, 95% CI (0.810, 1.637), p=0.432]. Conclusions: At present, zinc deficiency in children and adolescents in mainland China is still serious, especially in infants. The zinc deficiency rate in male children was more serious than that of female children. The zinc deficiency rate of children in inland areas was higher than that in coastal areas. Factors such as different educational level of food providers and different areas from urban or rural were not the major influencing factors of zinc deficiency.

scholarly journals The Prevalence of Sleep Disorders Among Children in Mainland China: A Meta-analysis and Systemic-analysis

2020 ◽  
Author(s):  
Xianrui Chen ◽  
Xiaoxia Lin ◽  
Zhong ling Ke ◽  
Yanhui Chen
Keyword(s):  
Sleep Disorders ◽  
Prevalence Rate ◽  
Meta Analysis ◽  
Mainland China ◽  
School Age Children ◽  
Reliable Estimate ◽  
School Age ◽  
Age Group ◽  
West China ◽  
Epidemiological Characteristics

Abstract Background: We conducted a meta-analysis and systematic review to identify a reliable estimate of sleep disorders prevalence among children in mainland China and to describe its epidemiological characteristics.Methods: Relevant studies were searched thoroughly via electronic databases included China National Knowledge Infrastructure, Wanfang,Weipu,PubMed,Web of Science and Medline databases from inception until December 2020.Prevalence estimates were calculated by random-effects models. The sources of heterogeneity were explored using subgroup analyses and Meta-regression analysis, and publication bias was estimated by funnel plots and Egger’s Test. Results: Overall, 66 studies were included in this meta-analysis, which revealed that the pooled prevalence of sleep disorders was 37.6% (95%CI: 34.3-40.9%)with high heterogeneity (I2=99.6%,P=0.000).The prevalence rate of sleep disorders among males was higher than females (OR:1.01,95%CI:1.05-1.13).In all age groups, the prevalence rates of sleep disorders increased with age, including infancy or early childhood group(33.3%),pre-school group(38.9%), school-age group(43.7%). The prevalence rate in South China (30.4%, 95%CI: 23.9–36.8%) was the lowest, and the highest prevalence rate was in West China (47.4 %,95%CI:35.9–58.9%), which than any other region in China. The point estimate for sleep disorders prevalence obtained using the CSHQ criterion was higher than other criteria.Meta-regression indicated that age group could influence prevalence estimation (P = 0.011).Conclusions: Over the past two decades, the prevalence rate of sleep disorders among children in mainland China has increased, significantly affecting two-fifth of the school-age children. The prevalence rate of sleep disorders in west China was significantly higher than in any other area. There is still a lack of guidelines on children's sleep disorders in mainland China, so future research should pay special attention to the sleep disorders of school-age children and children in economically backward areas.

Effectiveness and Safety Studies of Omalizumab in Children and Adolescents With Moderate-To-Severe Asthma

2021 ◽  
pp. 089719002110382
Author(s):  
Lu Cheng ◽  
Tianrui Yang ◽  
Xiang Ma ◽  
Yuling Han ◽  
Yongtai Wang
Keyword(s):  
Children And Adolescents ◽  
Allergic Asthma ◽  
Severe Asthma ◽  
Fixed Effects ◽  
Vital Capacity ◽  
Immunoglobulin E ◽  
Meta Analysis ◽  
Fixed Effects Model ◽  
Significant Difference ◽  
Severe Allergic Asthma

Background Omalizumab is currently approved for the treatment of moderate-to-severe allergic asthma in patients 6 years and older. Objective To assess the effectiveness and safety of subcutaneous omalizumab as an add-on therapy option for moderate–severe allergic asthma in patients aged 6—20 years old. Methods The studies published from July, 1970 to May, 2021 were searched from the electronic databases which followed keywords: (“anti-IgE” OR “anti-immunoglobulin E” OR “anti-IgE antibody” OR “omalizumab” OR “rhuMAb-E25” OR “Xolair”) AND “asthma” AND (“child” OR “children” OR “adolescents” OR “youth” OR “teenager” OR “kids” OR “pediatric”). Thirteen studies were pooled to determine the effectiveness and safety of omalizumab. Efficacy endpoints were evaluated using a fixed-effects model or a random-effects model depending on heterogeneity. Safety endpoints were evaluated by odds ratio. Results Thirteen studies were included. In this meta-analysis, our results showed that fractional exhaled nitric oxide and asthma control test scores were significantly improved with omalizumab treatment. Serum immunoglobulin E was also decreased in children with moderate-to-severe asthma after treatment with omalizumab. The analysis found that there was no significant difference between pre-and post-treatment in forced expiratory volume in one second/ forced vital capacity ratio, forced expiratory flow between 25 and 75% of vital capacity, or FEV1. Overall, more adverse events occurred with omalizumab compared to placebo. However, the degree was mild to moderate. Conclusion This meta-analysis indicates that omalizumab is safe and effective to treat children and adolescents with moderate-to-severe asthma.

scholarly journals Rates of post-traumatic stress disorder in trauma-exposed children and adolescents: meta-analysis

2014 ◽  
Vol 204 (5) ◽  
pp. 335-340 ◽  
Author(s):  
Eva Alisic ◽  
Alyson K. Zalta ◽  
Floryt van Wesel ◽  
Sadie E. Larsen ◽  
Gertrud S. Hafstad ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Mental Health Treatment ◽  
Stress Disorder ◽  
Meta Analysis ◽  
Interpersonal Trauma ◽  
Post Traumatic Stress ◽  
Significant Difference ◽  
Post Traumatic

BackgroundIt is unclear how many children and adolescents develop post-traumatic stress disorder (PTSD) after trauma.AimsTo determine the incidence of PTSD in trauma-exposed children and adolescents as assessed with well-established diagnostic interviews and to examine potential moderators of the estimate.MethodA systematic literature search identified 72 peer-reviewed articles on 43 independent samples (n = 3563). Samples consisting only of participants seeking or receiving mental health treatment were excluded. Main analyses involved pooled incidence estimates and meta-analyses of variance.ResultsThe overall rate of PTSD was 15.9% (95% CI 11.5–21.5), which varied according to the type of trauma and gender. Least at risk were boys exposed to non-interpersonal trauma (8.4%, 95% CI 4.7–14.5), whereas girls exposed to interpersonal trauma showed the highest rate (32.9%, 95% CI 19.8–49.3). No significant difference was found for the choice of assessment interview or the informant of the assessment.ConclusionsResearch conducted with the best available assessment instruments shows that a significant minority of children and adolescents develop PTSD after trauma exposure, with those exposed to interpersonal trauma and girls at particular risk. The estimates provide a benchmark for DSM-5 and ICD-11.

scholarly journals Influence of Therapeutic Play on the anxiety of hospitalized school-age children: Clinical trial

2017 ◽  
Vol 70 (6) ◽  
pp. 1244-1249 ◽  
Author(s):  
Sabrina Gisele Tobias da Silva ◽  
Maiara Aurichio Santos ◽  
Claudia Maria de Freitas Floriano ◽  
Elaine Buchhorn Cintra Damião ◽  
Fernanda Vieira de Campos ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Statistical Significance ◽  
School Age Children ◽  
Control Group ◽  
School Age ◽  
Chi Square ◽  
Number Of Children ◽  
Significant Difference ◽  
Therapeutic Play ◽  
And Control

ABSTRACT Objective: To evaluate the effects of Dramatic Therapeutic Play (DTP) technique on the degree of anxiety in hospitalized school-age children. Method: Randomized clinical trial performed in two hospitals ofSão Paulo, between May and October 2015. The intervention consisted of the application of DTP and the outcome was evaluated through the Child Drawing: Hospital (CD: H) instrument. The Wilcoxon-Mann Whitney, Corrected t, Fisher’s exact and Chi-square tests were used in the analysis. Statistical significance was set at 5%. Results: In all, 28 children participated in the study. The majority of children (75%) had a low anxiety score, with a mean CD: H score of 73.9 and 69.4 in the intervention and control groups respectively, and with no significant difference. Conclusion: Children submitted to DTP had the same degree of anxiety as those in the control group. However, it is suggested that new studies be performed with a larger number of children in different hospitalization scenarios.

scholarly journals Baclofen Use in Alcohol Withdrawal Patients in Inpatient Settings: A Systematic Review

2020 ◽  
Author(s):  
Mona Petal
Keyword(s):  
Systematic Review ◽  
Alcohol Withdrawal ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Signs And Symptoms ◽  
Withdrawal Symptoms ◽  
Significant Difference ◽  
Health Decision ◽  
Inpatient Settings ◽  
Ebsco Host

Aim: To carry out a systematic review of the available evidence from health decision makers, patients, and therapists regarding the ability of Baclofen use in decreasing alcohol withdrawal symptoms to patients in inpatient settings. acute care setting. Methodology: Systematic searches were carried out on the following databases: Academic Search Premier, CINAHL, Cochrane and PsycINFO via EBSCO Host, Embase, MEDLINE via PubMed, and Web of Science. The last search date was May 28, 2019. The search was limited to the last 10 years, i.e., from January 1st, 2010. Findings: Four studies were included in the final review. The total population was 258 patients. The studies did not report any statistically significant difference between Baclofen to placebo during the end of the treatment when it comes to decreasing alcohol withdrawal symptoms and reduction of alcohol intake. There was also not a considerable difference between baclofen and standard care dropout, adverse events, and anxiety. Baclofen also increased the frequency of vertigo, dry mouth, and sleepiness. Conclusions: It was uncertain whether Baclofen improves withdrawal signs and symptoms and reduces side effects in comparison to placebo or other medicines as the studies reviewed did not point to any statistical significance. It is recommended that future reviews assume the meta-analysis approach that can help in measuring the level of heterogeneity in such studies to effectively examine the extent to which baclofen can be effective.

scholarly journals Efficacy and Safety of Vacuum-Assisted Excision for Benign Breast Mass Lesion: A Meta-Analysis

Medicina ◽  
2021 ◽  
Vol 57 (11) ◽  
pp. 1260
Author(s):  
Hee-Seon Yoo ◽  
Wu-Seong Kang ◽  
Jung-Soo Pyo ◽  
Junghan Yoon
Keyword(s):  
Meta Analysis ◽  
Statistical Significance ◽  
Complete Resection ◽  
Breast Mass ◽  
Breast Lesions ◽  
Significant Difference ◽  
Regression Test ◽  
Benign Breast Lesions ◽  
Meta Regression ◽  
Mass Lesions

Background and Objective: Breast mass lesions are common; however, determining the malignant potential of the lesion can be ambiguous. Recently, to evaluate breast mass lesions, vacuum-assisted excision (VAE) biopsy has been widely used for both diagnostic and therapeutic purposes. This study aimed to investigate the therapeutic role of VAE. Materials and Methods: Relevant articles were obtained by searching PubMed and EMBASE on September 3, 2021. Meta-analyses were performed using odds ratios and proportions. To assess heterogeneity, we conducted a subgroup analysis and meta-regression tests. Results: Finally, 26 studies comprising 18,170 patients were included. All of these were observational studies. The meta-analysis showed that the complete resection rate of VAE was 0.930. In the meta-regression test, there was no significant difference. The meta-analysis showed a recurrence rate of 0.039 in the VAE group. The meta-regression test showed no statistical significance. Postoperative hematoma, pain, and ecchymosis after VAE were 0.092, 0.082, and 0.075, respectively. Conclusion: VAE for benign breast lesions showed favorable outcomes with respect to complete resection and complications. This meta-analysis suggested that VAE for low-risk benign breast lesions is a reasonable option for both diagnostic and therapeutic purposes.

scholarly journals Nasopharyngeal Meningococcal Carriage among Children and Adolescents in Turkey in 2018: An Unexpected High Serogroup X Carriage

Children ◽  
2021 ◽  
Vol 8 (10) ◽  
pp. 871
Author(s):  
Mahmut Can Kizil ◽  
Omer Kilic ◽  
Mehmet Ceyhan ◽  
Merve Iseri Nepesov ◽  
Adem Karbuz ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Control Strategies ◽  
Age Groups ◽  
Antibiotic Use ◽  
Age Group ◽  
Upper Respiratory Tract ◽  
Carriage Rate ◽  
Significant Difference ◽  
Tract Infections ◽  
The Impact

Meningococcal carriage studies and transmission modeling can predict IMD epidemiology and used to define invasive meningococcal disease (IMD) control strategies. In this multicenter study, we aimed to evaluate the prevalence of nasopharyngeal Neisseria meningitidis (Nm) carriage, serogroup distribution, and related risk factors in Turkey. Nasopharyngeal samples were collected from a total of 1267 children and adolescents and were tested with rt-PCR. Nm carriage was detected in 96 participants (7.5%, 95% CI 6.1–9.0), with the peak age at 13 years (12.5%). Regarding age groups, Nm carriage rate was 7% in the 0–5 age group, was 6.9%in the 6–10 age group, was 7.9% in the 11–14 age group, and was 9.3% in the 15–18 age group. There was no statistically significant difference between the groups (p > 0.05). The serogroup distribution was as follows: 25% MenX, 9.4% MenA, 9.4% MenB, 2.1% MenC, 3.1% MenW, 2.1% for MenY, and 48.9% for non-groupable. The Nm carriage rate was higher in children with previous upper respiratory tract infections and with a high number of household members, whereas it was lower in children with antibiotic use in the last month (p < 0.05 for all). In this study, MenX is the predominant carriage strain. The geographical distribution of Nm strains varies, but serogroup distribution in the same country might change in a matter of years. Adequate surveillance and/or a proper carriage study is paramount for accurate/dynamic serogroup distribution and the impact of the proposed vaccination.

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