scholarly journals Transmembrane Transport of copper(I) by Imidazole-Functionalised Calix[4]arenes

2020 ◽  
Author(s):  
Nathan Renier ◽  
Olivia Reinaud ◽  
Ivan Jabin ◽  
Hennie Valkenier
Keyword(s):  
Biomedical Applications ◽  
Selective Extraction ◽  
Transmembrane Transport ◽  
Further Development ◽  
Linear Coordination ◽  
The Way

Synthetic carriers for various cations and anions have been reported, but here we present the first synthetic Cu<sup>+</sup> transporters. A series of calix[4]arenes with two imidazole groups has been developed and their bidentate linear coordination motif allows the selective extraction of Cu<sup>+</sup> into chloroform. Transmembrane transport of Cu<sup>+</sup> into liposomes was investigated with a newly developed assay and opens the way to the further development of Cu<sup>+</sup> ionophores for biomedical applications.

scholarly journals Transmembrane Transport of copper(I) by Imidazole-Functionalised Calix[4]arenes

2020 ◽  
Author(s):  
Nathan Renier ◽  
Olivia Reinaud ◽  
Ivan Jabin ◽  
Hennie Valkenier
Keyword(s):  
Biomedical Applications ◽  
Selective Extraction ◽  
Transmembrane Transport ◽  
Further Development ◽  
Linear Coordination ◽  
The Way

Synthetic carriers for various cations and anions have been reported, but here we present the first synthetic Cu<sup>+</sup> transporters. A series of calix[4]arenes with two imidazole groups has been developed and their bidentate linear coordination motif allows the selective extraction of Cu<sup>+</sup> into chloroform. Transmembrane transport of Cu<sup>+</sup> into liposomes was investigated with a newly developed assay and opens the way to the further development of Cu<sup>+</sup> ionophores for biomedical applications.

scholarly journals Transmembrane Transport of copper(I) by Imidazole-Functionalised Calix[4]arenes

2020 ◽  
Author(s):  
Nathan Renier ◽  
Olivia Reinaud ◽  
Ivan Jabin ◽  
Hennie Valkenier
Keyword(s):  
Biomedical Applications ◽  
Selective Extraction ◽  
Transmembrane Transport ◽  
Further Development ◽  
Linear Coordination ◽  
The Way

Synthetic carriers for various cations and anions have been reported, but here we present the first synthetic Cu<sup>+</sup> transporters. A series of calix[4]arenes with two imidazole groups has been developed and their bidentate linear coordination motif allows the selective extraction of Cu<sup>+</sup> into chloroform. Transmembrane transport of Cu<sup>+</sup> into liposomes was investigated with a newly developed assay and opens the way to the further development of Cu<sup>+</sup> ionophores for biomedical applications.

scholarly journals Transmembrane Transport of copper(I) by Imidazole-Functionalised Calix[4]arenes

2020 ◽  
Author(s):  
Nathan Renier ◽  
Olivia Reinaud ◽  
Ivan Jabin ◽  
Hennie Valkenier
Keyword(s):  
Biomedical Applications ◽  
Selective Extraction ◽  
Transmembrane Transport ◽  
Further Development ◽  
Linear Coordination ◽  
The Way

Synthetic carriers for various cations and anions have been reported, but here we present the first synthetic Cu<sup>+</sup> transporters. A series of calix[4]arenes with two imidazole groups has been developed and their bidentate linear coordination motif allows the selective extraction of Cu<sup>+</sup> into chloroform. Transmembrane transport of Cu<sup>+</sup> into liposomes was investigated with a newly developed assay and opens the way to the further development of Cu<sup>+</sup> ionophores for biomedical applications.

scholarly journals Interrogating the Founding Gestures of the New Materialism

2016 ◽  
Vol 22 (2) ◽  
Author(s):  
Dennis Bruining
Keyword(s):  
New Materialism ◽  
The Past ◽  
The World ◽  
Further Development ◽  
Selection Of ◽  
The Way

In this article, I aim to further thinking in the broadly ‘new materialist’ field by insisting it attends to some ubiquitous assumptions. More specifically, I critically interrogate what Sara Ahmed has termed ‘the founding gestures of the “new materialism”’. These founding rhetorical gestures revolve around a perceived neglect of the matter of materiality in ‘postmodernism’ and ‘poststructuralism’ and are meant to pave the way for new materialism’s own conception of matter-in/of-the-world. I argue in this article that an engagement with the postmodern critique of language as constitutive, as well as the poststructuralist critique of pure self-presence, does not warrant these founding gestures to be so uncritically rehearsed. Moreover, I demonstrate that texts which rely on these gestures, or at least the ones I discuss in this article, are not only founded on a misrepresentation of postmodern and poststructuralist thought, but are also guilty of repeating the perceived mistakes of which they are critical, such as upholding the language/matter dichotomy. I discuss a small selection of texts that make use of those popular rhetorical gestures to juxtapose the past that is invoked with a more nuanced reading of that past. My contention is that if ‘the founding gestures of the “new materialism”’ are not addressed, the complexity of the postmodern and poststructuralist positions continues to be obscured, with damaging consequences for the further development of the emerging field of new materialism, as well as our understanding of cultural theory’s past.

scholarly journals Young GI Societies in Europe: 2019 update

2020 ◽  
Vol 8 (2) ◽  
pp. 227-232 ◽  
Author(s):  
Henriette Heinrich ◽  
Iago Rodríguez-Lago ◽  
Radislav Nakov ◽  
Vita Skuja ◽  
Pilar Acedo ◽  
...  
Keyword(s):  
Quality Of Care ◽  
Health Inequalities ◽  
The State ◽  
Future Research ◽  
Web Based ◽  
Research Education ◽  
Excellent Quality ◽  
Further Development ◽  
The Way

Background One of the aims of the Young Talent Group (YTG) is to make United European Gastroenterology (UEG) more attractive to young fellows interested in gastroenterology (GI), and to actively involve them in UEG activities and the activities of their respective national societies. In 2017, we conducted a survey among the Friends of the UEG YTG with the aim of identifying the state of organization and needs of Young GI Sections (YGISs) throughout Europe, highlighting areas for further development and improvement. Aims The aim of the current web-based survey was to assess the progress of YGISs over 1 year, and persisting hurdles in forming and running a YGIS. Results Overall, 38 of 42 Friends answered the survey (91%). The number of YGISs has increased significantly from 12 in 2017 to 25 in 2019. Young gastroenterologists remained supported, but not influenced, by national societies. Results of the survey suggest that a lack of dedicated and motivated fellows has replaced a lack of funding as the most prevalent hurdle in forming these types of sections. Conclusion Our survey shows that the development of YGISs has improved markedly within the last 2 years. However, several limitations, like underrepresentation in subcommittees of national societies, remain and need to be addressed in order to involve young gastroenterologists in their respective national societies and within UEG, to pave the way for future research, education and excellent quality of care, and reduce health inequalities across Europe.

scholarly journals Spreading lesson study in pre-service teacher instruction

2018 ◽  
Vol 7 (1) ◽  
pp. 23-36 ◽  
Author(s):  
Maria Laura Angelini ◽  
Neus Álvarez
Keyword(s):  
Classroom Management ◽  
Lesson Study ◽  
Structured Interview ◽  
Teacher Instruction ◽  
Content Type ◽  
Written Responses ◽  
School Based ◽  
Further Development ◽  
Pre Service Teacher ◽  
The Way

Purpose The purpose of this paper is to examine the perceptions of pre-service teachers (PSTs) who used lesson study on a five-week school-based teaching placement. The paper analyses 12 undergraduate PSTs’ perceptions of the way lesson study affected classroom-based teaching of English as a foreign language to pre-school and primary school. Design/methodology/approach A qualitative study is carried out from the responses to a semi-structured interview to the PSTs, and written responses to the open-ended question: What are your perceptions of lesson study? Findings This paper provides empirical insights about the way lesson study reinforced the PSTs’ classroom management and lesson planning skills. The case-pupils’ responses to the PSTs’ questions post-treatment indicated that games and active techniques in the classroom led to high retention of the taught content. Nevertheless, PSTs’ evaluations of pupils’ learning outcomes require further development. These evaluations often resulted in vague perceptions of overall lesson performance. Research limitations/implications This study provides hints of how case-pupils better learned and how PSTs did the observations and performed. However, the results cannot be generalized. Originality/value The researchers sustain that the teaching degrees should encourage critical thinking in PSTs’ self-evaluations to reduce the focus on standards and expectations. It is believed that if the pressure of designing perfect lessons is removed from the equation, and instead, sensible and realistic lessons are planned, PSTs will be more inclined to learn and respond resourcefully, creatively, and resolutely to classroom situations.

Nanosystems: the use of nanoalloys, metallic, bimetallic, and magnetic nanoparticles in biomedical applications

2015 ◽  
Vol 17 (42) ◽  
pp. 27981-27995 ◽  
Author(s):  
Karrina McNamara ◽  
Syed A. M. Tofail
Keyword(s):  
Magnetic Nanoparticles ◽  
Material Properties ◽  
Biomedical Applications ◽  
The Way

There is a growing interest in the use of nanosystems in biomedical applications. In this perspective, we survey current applications and advances in magnetic nanoparticles used in biomedical applications, so as to understand the material properties that can pave the way for the use of nanoalloys.

Bias, innateness and domain specificity

2004 ◽  
Vol 31 (4) ◽  
pp. 927-930
Author(s):  
SIMON KIRBY
Keyword(s):  
Natural Language ◽  
Domain Specificity ◽  
Further Development ◽  
The Way

For over 35 years, beliefs about the learnability of natural language have acted as roadblocks in the way of further development in linguistics. Rigorous and useful formal work has led to the unwarranted adoption of extreme positions which in turn have tended to stifle collaboration and polarize debate. In his article, MacWhinney suggests a way around such roadblocks – or rather many ways around. He demonstrates that we should look for multiple mechanisms to help understand how it is that children learn language from the evidence to which they are exposed.

scholarly journals The Origins and Development of the Definite Article in Egyptian-Coptic

2014 ◽  
Vol 18 ◽  
pp. 223-237
Author(s):  
Maxim Kupreyev
Keyword(s):  
A Priori ◽  
Weak Form ◽  
Definite Article ◽  
Middle Kingdom ◽  
Grammatical Category ◽  
Indefinite Article ◽  
Definite Articles ◽  
Further Development ◽  
The Way ◽  
Good Deeds

The first appearance of the emphatic demonstratives pA/tA/nA in northern Egyptian letters of the 6th Dynasty and their absence from southern Egyptian sources indicates the growing difference between the language variants spoken in these broadly defined regions. Originating from the Old Egyptian pronominal stems p-/t-/n-, the use of these new demonstratives expands rapidly during the Middle Kingdom. In their weak form as definite articles, they indicate that a noun is knownin discourse and thus signal a hitherto hidden grammatical category – definiteness. Once the definite article is grammaticalised and starts to be used with a priori definite nouns such as pA nTr wa ‘the sole god’ or pA HqA ‘the ruler’ (18th Dynasty), the indefinite article appears. The further development in Demotic and Coptic shows that the article was on the way to becoming a noun marker. When attached to a relative phrase, it created a new noun, which could be further determined (xenpetnanouf ‘some good deeds’, ppetouaab ‘the saint’). The following article traces the regional origins of the definite article as well as the main principles governing their development.

scholarly journals Red-Emitting SBBF (Single-Benzene-Based Fluorophore)-Silica Hybrid Material: One-Pot Synthesis, Characterization, and Biomedical Applications

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2036
Author(s):  
Jaehoon Kim ◽  
Jong Min An ◽  
Yuna Jung ◽  
Na Hee Kim ◽  
Youngwoong Kim ◽  
...  
Keyword(s):  
Hybrid Materials ◽  
Hybrid Material ◽  
Biomedical Applications ◽  
Antibacterial Effect ◽  
One Pot ◽  
Bio Imaging ◽  
High Scalability ◽  
Robust Formulation ◽  
First Time ◽  
Further Development

We report, for the first time, a new red-emitting hybrid material based on a single-benzene-based fluorophore (SBBF) and silica. This robust formulation shows several features, including bright emissions at a red wavelength (>600 nm), high scalability (>gram-scale), facile synthesis (one-pot reaction; SBBF formation, hydrolytic condensation, propagation), high stability (under different humidity, pH, light), bio-imaging applicability with low cellular toxicity, and an antibacterial effect within Gram-negative/Gram-positive strains. Based on our findings, we believe that these hybrid materials can pave the way for the further development of dye-hybrid materials and applications in various fields.

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