scholarly journals A Computational and Literature-Based Evaluation for a Combination of Chiral Anti-CoV Drugs to Block and Eliminate SARS-CoV-2 Safely

2021 ◽  
Author(s):  
Mohd. Suhail
Keyword(s):  
Side Effects ◽  
Jc Virus ◽  
Computational Study ◽  
Human Cells ◽  
The Body ◽  
Binding Affinities ◽  
Chiral Drugs ◽  
Main Protease ◽  
The World ◽  
Second Wave

<p><a>It has been a great challenge for scientists to develop an anti-covid drug/vaccine with fewer side effects, since the coronavirus began. Of course, the prescription of chiral drugs (chloroquine or hydroxychloroquine) has been proved wrong because these chiral drugs neither kill the virus nor eliminate it from the body, but block SARS-CoV-2 from binding to human cells. Another hurdle in front of the world, is not only the positive test of the patient recovered from coronavirus but also the second wave of Covid 19. Hence, the word demands such a drug or drug combination which not only prevents the entry of SARS-CoV-2 in the human cell but also eliminates it or its material from the body completely. The presented computational study explains (i) why the prescription of chiral drugs was not satisfactory (ii) what types of modification can make their prescription satisfactory (iii) the mechanism of action of chiral drugs (chloroquine and hydroxychloroquine) to block SARS-CoV-2 from binding to human cells, and (iv) the strength of mefloquine to eliminate SARS-CoV-2. As the main protease (M<b><sup>pro</sup></b>) of microbes is considered as an effective target for drug design and development, the binding affinities of mefloquine with the main proteases (M<sup>pros</sup>) of JC virus and SARS-CoV-2, were calculated, and then compared to know the eliminating strength of mefloquine against SARS-CoV-2. The main protease (M<sup>pro</sup>) of JC virus was taken because mefloquine has already shown a tremendous result of eliminating it from the body. The current study includes the docking results and literature data in support of the prescription of a combination of S-(+)-hydroxychloroquine and (+) mefloquine. Besides, the presented study also confirms that the prescription of only hydroxychloroquine would not be so effective as in combined form with mefloquine.</a></p>

scholarly journals A Computational and Literature-Based Evaluation for a Combination of Chiral Anti-CoV Drugs to Block and Eliminate SARS-CoV-2 Safely

2021 ◽  
Author(s):  
Mohd. Suhail
Keyword(s):  
Side Effects ◽  
Jc Virus ◽  
Computational Study ◽  
Human Cells ◽  
The Body ◽  
Binding Affinities ◽  
Chiral Drugs ◽  
Main Protease ◽  
The World ◽  
Second Wave

<p><a>It has been a great challenge for scientists to develop an anti-covid drug/vaccine with fewer side effects, since the coronavirus began. Of course, the prescription of chiral drugs (chloroquine or hydroxychloroquine) has been proved wrong because these chiral drugs neither kill the virus nor eliminate it from the body, but block SARS-CoV-2 from binding to human cells. Another hurdle in front of the world, is not only the positive test of the patient recovered from coronavirus but also the second wave of Covid 19. Hence, the word demands such a drug or drug combination which not only prevents the entry of SARS-CoV-2 in the human cell but also eliminates it or its material from the body completely. The presented computational study explains (i) why the prescription of chiral drugs was not satisfactory (ii) what types of modification can make their prescription satisfactory (iii) the mechanism of action of chiral drugs (chloroquine and hydroxychloroquine) to block SARS-CoV-2 from binding to human cells, and (iv) the strength of mefloquine to eliminate SARS-CoV-2. As the main protease (M<b><sup>pro</sup></b>) of microbes is considered as an effective target for drug design and development, the binding affinities of mefloquine with the main proteases (M<sup>pros</sup>) of JC virus and SARS-CoV-2, were calculated, and then compared to know the eliminating strength of mefloquine against SARS-CoV-2. The main protease (M<sup>pro</sup>) of JC virus was taken because mefloquine has already shown a tremendous result of eliminating it from the body. The current study includes the docking results and literature data in support of the prescription of a combination of S-(+)-hydroxychloroquine and (+) mefloquine. Besides, the presented study also confirms that the prescription of only hydroxychloroquine would not be so effective as in combined form with mefloquine.</a></p>

A Computational and Literature-Based Evaluation for a Combination of Chiral Anti-CoV Drugs to Block and Eliminate SARS-CoV-2 Safely

2021 ◽  
Vol 20 (04) ◽  
pp. 417-432
Author(s):  
Mohd. Suhail
Keyword(s):  
Drug Design ◽  
Jc Virus ◽  
Computational Study ◽  
Human Cells ◽  
The Body ◽  
Chiral Drugs ◽  
Structure Based Drug Design ◽  
Drug Candidates ◽  
Main Protease ◽  
The World

It has been a great challenge for scientists to develop an anti-Covid drug/vaccine with fewer side effects, since the coronavirus pandemic began. Of course, the prescription of chiral drugs (chloroquine or hydroxychloroquine) has been proved wrong because these chiral drugs neither kill the virus nor eliminate it from the body, but block SARS-CoV-2 from binding to human cells. Another hurdle facing the world is not only the positive test of the patient recovered from coronavirus, but also the second wave of Covid-19. Hence, the world demands such a drug or drug combination which not only prevents the entry of SARS-CoV-2 in the human cell but also ejects it or its material from the body completely. The current computational study not only utilizes a structure-based drug design approach to find possible drug candidates but also explains (i) why the prescription of chiral drugs was not satisfactory, (ii) what types of modification can make their prescription satisfactory, (iii) the mechanism of action of chiral drugs (chloroquine and hydroxychloroquine) to block SARS-CoV-2 from binding to human cells, and (iv) the strength of mefloquine to eliminate SARS-CoV-2. As the main protease (M[Formula: see text]) of microbes is considered as an effective target for drug design and development, the binding affinities of mefloquine with the M[Formula: see text] of JC virus and SARS-CoV-2 were calculated, and then compared to know the eliminating strength of mefloquine against SARS-CoV-2. The M[Formula: see text] of JC virus was taken because mefloquine has already shown a tremendous result of eliminating it from the body. The prescription of a combination of S-[Formula: see text]-hydroxychloroquine and [Formula: see text]-mefloquine is considered as a boon by the predicted study.

scholarly journals A Computational and Literature-Based Evaluation for a Combination of Chiral Anti-CoV Drugs to Block and Eliminate SARS-CoV-2 Safely

2020 ◽  
Author(s):  
Mohd. Suhail
Keyword(s):  
Side Effects ◽  
Mechanism Of Action ◽  
Jc Virus ◽  
Computational Study ◽  
The Body ◽  
Biologically Active ◽  
Positive Test ◽  
Chiral Drugs ◽  
Racemic Form ◽  
Main Protease

<div>It has been a great challenge for the scientists to develop an anti-covid drug/vaccine with fewer side effects, since the coronavirus began. Besides, the mechanism of action and the reason of causing side effects, has also become a great challenge for the scientists in the case of chiral drugs. The main reason behind it, is the prescription of chiral drugs in the racemic form. Another hurdle in front of the world, is the positive test of the patient recovered from coronavirus. This</div><div>positive test of recovered person, shows the demand of such drugs whose mechanism is understandable, and which can block and eliminate SARS-CoV-2 or its material from the body completely, with fewer side effects. The presented computational study explains (i) the mechanism of action of drugs (chloroquine and hydroxychloroquine) that block SARS-CoV-2 (ii) the strength of mefloquine that may eliminate SARS-CoV-2. First, the binding affinities of main protease (Mpro) of JC virus for which mefloquine has already shown its strength to remove, were calculated. After that, same method was applied for SARS-CoV-2, and both the results were compared to know the strength of mefloquine against SARS-CoV-2. Till now, the experimental data found in the literature survey, was neither used in the interpretation nor evaluated computationally, in such a way, as I did for the first time to fight against the pandemic</div><div>situation. Hence, the current study includes the docking results and literature data for the prescription of a combination of only biologically active enantiomers to the patient fighting with coronavirus, with less side effect. Two enantiomers that could do it, are S-(+)hydroxychloroquine</div><div>and (+) mefloquine. Of course, one of these two drugs, will block the coronavirus, while another one will eliminate it.</div>

scholarly journals A Computational and Literature-Based Evaluation for a Combination of Chiral Anti-CoV Drugs to Block and Eliminate SARS-CoV-2 Safely

2020 ◽  
Author(s):  
Mohd. Suhail
Keyword(s):  
Side Effects ◽  
Mechanism Of Action ◽  
Jc Virus ◽  
Computational Study ◽  
The Body ◽  
Biologically Active ◽  
Positive Test ◽  
Chiral Drugs ◽  
Racemic Form ◽  
Main Protease

<div>It has been a great challenge for the scientists to develop an anti-covid drug/vaccine with fewer side effects, since the coronavirus began. Besides, the mechanism of action and the reason of causing side effects, has also become a great challenge for the scientists in the case of chiral drugs. The main reason behind it, is the prescription of chiral drugs in the racemic form. Another hurdle in front of the world, is the positive test of the patient recovered from coronavirus. This</div><div>positive test of recovered person, shows the demand of such drugs whose mechanism is understandable, and which can block and eliminate SARS-CoV-2 or its material from the body completely, with fewer side effects. The presented computational study explains (i) the mechanism of action of drugs (chloroquine and hydroxychloroquine) that block SARS-CoV-2 (ii) the strength of mefloquine that may eliminate SARS-CoV-2. First, the binding affinities of main protease (Mpro) of JC virus for which mefloquine has already shown its strength to remove, were calculated. After that, same method was applied for SARS-CoV-2, and both the results were compared to know the strength of mefloquine against SARS-CoV-2. Till now, the experimental data found in the literature survey, was neither used in the interpretation nor evaluated computationally, in such a way, as I did for the first time to fight against the pandemic</div><div>situation. Hence, the current study includes the docking results and literature data for the prescription of a combination of only biologically active enantiomers to the patient fighting with coronavirus, with less side effect. Two enantiomers that could do it, are S-(+)hydroxychloroquine</div><div>and (+) mefloquine. Of course, one of these two drugs, will block the coronavirus, while another one will eliminate it.</div>

scholarly journals A Computational and Literature-Based Evaluation for a Combination of Chiral Anti-CoV Drugs to Block and Eliminate SARS-CoV-2 Safely

2020 ◽  
Author(s):  
Mohd. Suhail
Keyword(s):  
Side Effects ◽  
Mechanism Of Action ◽  
Jc Virus ◽  
Computational Study ◽  
The Body ◽  
Biologically Active ◽  
Positive Test ◽  
Chiral Drugs ◽  
Racemic Form ◽  
Main Protease

<div>It has been a great challenge for the scientists to develop an anti-covid drug/vaccine with fewer side effects, since the coronavirus began. Besides, the mechanism of action and the reason of causing side effects, has also become a great challenge for the scientists in the case of chiral drugs. The main reason behind it, is the prescription of chiral drugs in the racemic form. Another hurdle in front of the world, is the positive test of the patient recovered from coronavirus. This</div><div>positive test of recovered person, shows the demand of such drugs whose mechanism is understandable, and which can block and eliminate SARS-CoV-2 or its material from the body completely, with fewer side effects. The presented computational study explains (i) the mechanism of action of drugs (chloroquine and hydroxychloroquine) that block SARS-CoV-2 (ii) the strength of mefloquine that may eliminate SARS-CoV-2. First, the binding affinities of main protease (Mpro) of JC virus for which mefloquine has already shown its strength to remove, were calculated. After that, same method was applied for SARS-CoV-2, and both the results were compared to know the strength of mefloquine against SARS-CoV-2. Till now, the experimental data found in the literature survey, was neither used in the interpretation nor evaluated computationally, in such a way, as I did for the first time to fight against the pandemic</div><div>situation. Hence, the current study includes the docking results and literature data for the prescription of a combination of only biologically active enantiomers to the patient fighting with coronavirus, with less side effect. Two enantiomers that could do it, are S-(+)hydroxychloroquine</div><div>and (+) mefloquine. Of course, one of these two drugs, will block the coronavirus, while another one will eliminate it.</div>

scholarly journals PENETAPAN KADAR KAFEIN PADA BUBUK TEH HITAM YANG BEREDAR DI PASAR DELI TUA MENGGUNAKAN SPEKTROFOTOMETRI UV

2020 ◽  
Vol 3 (1) ◽  
pp. 21-28
Author(s):  
DIAN IKA PERBINA MELIALA
Keyword(s):  
Side Effects ◽  
Sampling Method ◽  
Negative Impact ◽  
Black Tea ◽  
The Body ◽  
Test Results ◽  
Ultraviolet Spectrophotometry ◽  
The Public ◽  
Validation Test ◽  
The World

Tea is a drink that is very familiar in the world and is very common in everyday life. Tea is also the most consumed and favored beverage by the public after water. Besides being beneficial, tea also contains compounds that have a negative impact on the body, namely caffeine compounds. Caffeine is an alkaloid of the methylxanthine group which plays a role in increasing the work of psychomotor in the body, and side effects that can be caused are anxiety, irregular heartbeat, difficulty sleeping, tremors, diuresis and others. The purpose of this study was to determine the caffeine content in black tea powder circulating in the Old Deli market. This type of research is descriptive with a purposive sampling method. The analytical method used is qualitative with murexide and quantitative ultraviolet spectrophotometry with a wavelength of 267nm. The results of a qualitative analysis of all positive samples contained caffeine. The average quantitative yield of caffeine in brand A black tea powder was (4,82 ±0,0356)%, B brand black tea powder (4,89 ± 0,0173)% and C brand black tea powder (4,93 ± 0,0531)%. The validation test results obtained linearity r = 0,9984, LOD and LOQ is 0,8074 mcg/ml and 2,6914 mcg/ml ,% recovery = 100,07%, RSD = 0,33%. Based on the results of research conducted, it can be concluded that ultraviolet spectrophotometry can be used to determine caffeine levels in black tea powder.

scholarly journals THE ROLE OF MUSIC IN STRESS MANAGEMENT

2015 ◽  
Vol 3 (1SE) ◽  
pp. 1-39
Author(s):  
Anuradha Awasthi
Keyword(s):  
Side Effects ◽  
Stress Management ◽  
Human Mind ◽  
The Body ◽  
Negative Effects ◽  
Physiological Mechanisms ◽  
Happy Life ◽  
The World ◽  
Unique Power

Stress management refers to the development of certain psychological and physiological mechanisms that can be learned to reduce the side effects of human body and mind. According to Richard Lazarus and Susan Folk Men, when a person has few resources to reach a goal and the work to be done is too much, then he gets stressed. Research by Walter Cannon and Hans Salleay found that stress has negative effects on the body and mind. It is necessary for every human being to learn the techniques of stress management in order to live a satisfying, balanced and happy life. One of these techniques is the use of music. According to Jain Collingwood, music has such unique power that it reduces stress by affecting us emotionally. The melody of music makes the human mind happy, the lyrics of the song inspire the person and the heart likes the rhythm. Music affects all humans. The tradition of singing and dancing with different instruments in different languages ​​and dialects has been found in all the societies of the world, that is, music provides universal joy. तनाव प्रबंधन का अर्थ कुछ ऐसी मनेावैज्ञानिक और शारीरिक क्रियाआंे की प्रणाली विकसित करने से है जिन्हें सीख कर मनुष्य के शरीर और मन पर पडने वाले दुष्प्रभावोें को कम किया जा सकता है। रिचर्ड लज़ारस तथा सुसैन फोक मेन के अनुसार जब मनुष्य के पास किसी लक्ष्य तक पहुंचने के लिए संसाधन कम होते है और पूरे किये जाने वाले काम बहुत अधिक होते है तो उसे तनाव होता है। वाॅल्टर कैनन तथा हैन्स सेल्ये ने मनुष्यों तथा प्राणियों पर किये गये शोध मे पाया कि तनाव शरीर और मन पर नकारात्मक प्रभाव डालता है। प्रत्येक मनुष्य के लिए यह आवश्यक है कि वह संतोषप्रद, संतुलित और सुखी जीवन जीने के लिये तनाव प्रबंधन की तकनीके सीखे। इन्हीं तकनीको मे से एक है संगीत का उपयोग। जैन कालिंगवुड के अनुसार संगीत मे एैसी अनोखी शक्ति होती है जो कि हमें भावनात्मक रूप से प्रभावित कर तनाव को कम करती है। संगीत की स्वर लहरियाँ मनुष्य के मन को आनंदित करती हैं गीत के बोल व्यक्ति को प्रेरित करते हैं तथा लय मन को अच्छी लगती है। सभी मनुष्यों को संगीत प्रभावित करता है। विश्व के सभी समाजों मंे भिन्न - भिन्न भाषाओं और बोलियों में विभिन्न वाद्यों के साथ गाने तथा नृत्य करने की परंपरा पाई गई है अर्थात् संगीत सार्वभौमिक रूप से आनन्द प्रदान करता है।

scholarly journals Evaluation of Phytochemicals of Cassia occidentalis L. for their Binding Affinities to SARS-CoV-2 3C-Like Protease: An in Silico Approach

2020 ◽  
pp. 8-14
Author(s):  
Tohmina Afroze Bondhon ◽  
Md. Aynal Haque Rana ◽  
Anamul Hasan ◽  
Rownak Jahan ◽  
Khoshnur Jannat ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Virtual Screening ◽  
In Silico ◽  
Binding Affinities ◽  
Autodock Vina ◽  
Cassia Occidentalis ◽  
Main Protease ◽  
In Silico Studies ◽  
The World ◽  
Docking Approach

Aims: Corona virus SARS-CoV-2, otherwise known as COVID-19 has created a pandemic resulting in social and financial crisis throughout the world. The virus has no known drugs or vaccines for preventive or therapeutic purposes. The objective of the present study was to screen phytochemicals from Cassia occidentalis L. in virtual screening (in silico) studies to evaluate their potential of binding to the main 3C-like protease of the virus and so stop its replication. Study Design: Molecular docking approach was used for virtual screening studies. Place and Duration of Study: University of Development Alternative between April and July 2020. Methodology: Molecular docking (blind) were done with the help of Autodock Vina. We have used the pdb file (6LU7) of the main protease of SARS-CoV-2 3C-like protease or SARS-CoV-2 3CLpro (monomeric form) to study binding of the phytochemicals. Results: Of the nine phytochemicals studied, the C-glycosidic flavonoids, cassiaoccidentalins A-C demonstrated excellent binding affinities to the protease. The compounds bound to the active site of the protease with binding energy values of -8.2 to-8.4 kcal/mol. Conclusion: The in silico studies suggest that the compounds merit actual COVID-19 inhibitory tests and have potential for anti-COVID-19 use.

scholarly journals Preparation and investigation of the ayurvedic churna formulation for diabetes

2018 ◽  
Vol 8 (2) ◽  
pp. 9-12
Author(s):  
Chaitanya Kumar K ◽  
Mothilal K ◽  
Mahender K ◽  
Ravi D
Keyword(s):  
Side Effects ◽  
The Body ◽  
The Other ◽  
Antidiabetic Activity ◽  
200Mg Dose ◽  
100Mg Dose ◽  
Physiological Conditions ◽  
Synthetic Drugs ◽  
The World ◽  
Synthetic Drug

Out of most of the dreadful diseases in the world Diabetes, shortly known as DM, is the most dreadful. The primary cause of diabetes is the lack of insulin due to the insufficient secretion of insulin by the pancreas or the insensitivity of the body to reuptake the insulin. This results in the accumulation of the sugar or glucose in the blood, only thereby disturbing all the other physiological conditions in the body. Herbs, as we know, are devoid of or have very fewer side effects when compared to the antidiabetic synthetic drugs. There is evidence to show that the herbs are safer and the chemical leads that are isolated from the medicinal plants are potent in controlling diabetes. The antidiabetic activity of herbs was proven, and the mechanism of action of the drugs was also established in many pieces of research. The polyherbal churna was prepared using various herbs like Tinospora, Glycerrihiza etc. that are already proven for the antidiabetic activity. This formulation was investigated for the antidiabetic activity at two doses and was compared with a marketed formulation and also a standard synthetic drug in STZ induced DM method. The prepared churna formulation showed a better activity compared with the standard and the marketed churna. The prepared churna at 200mg dose showed better activity than the 100mg dose.

scholarly journals USE OF SIBUTRAMIN IN PHARMACEUTICAL DRUGS AND ANOREXIC DIETARY SUPPLEMENTS (REVIEW)

2019 ◽  
Vol 8 (1) ◽  
pp. 97-101
Author(s):  
A. M. Sukhanova ◽  
I. B. Perova ◽  
G. M. Rodionova ◽  
K. I. Eller ◽  
V. I. Gegechkori
Keyword(s):  
Side Effects ◽  
Dietary Supplements ◽  
Dietary Supplement ◽  
Diastolic Pressure ◽  
Pharmaceutical Market ◽  
The Body ◽  
Excess Body Weight ◽  
Array Detectors ◽  
Wide Range ◽  
The World

Background. The most effective anorexic drugs on the pharmaceutical market are sibutramine. According to the standard scheme, sibutramine is similar to amphetamine. The active metabolites of sibutramine, formed in the process of its metabolism, have high pharmacological activity compared with the original substances, so the drug may be toxic to the body. Sibutramine is used in the complex treatment of obesity, when adjusting excess body weight in type II diabetes, and also used in polycystic ovary syndrome. The drug has many serious undesirable side effects, such as an increase in systolic and / or diastolic pressure and heart rate; headaches, insomnia, disorders of the gastrointestinal tract and can cause death. In many countries of the world a wide range of serious side effects has been banned. Text. A description of the drug sibutramine, its status on the pharmaceutical market of the Russian Federation and other countries of the world, an overview of possible methods for determining sibutramine in food supplements. Conclusion. Recently, information about the undeclared addition of sibutramine to the anorexigenic dietary supplement (dietary supplement) to increase their effectiveness has increasingly appeared. Therefore, it is necessary to develop methods for determining sibutramine in anorexic dietary supplements. In this regard, an analysis of the methods used for the quantitative determination of sibutramine. As a rule, spectral methods are used to determine the authenticity of a sibutramine substance. The most common and effective method for determining authenticity and quantitative analysis of sibutramine is the HPLC (high performance liquid chromatography) method using mass spectrometric and diode array detectors (DAD). At the moment, a method for determining sibutramine in the composition of multicomponent drugs and dietary supplements to food of anorexigenic action is being developed, which will contribute to the development of pharmacy.

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