scholarly journals A Computational and Literature-Based Evaluation for a Combination of Chiral Anti-CoV Drugs to Block and Eliminate SARS-CoV-2 Safely

2020 ◽  
Author(s):  
Mohd. Suhail
Keyword(s):  
Side Effects ◽  
Mechanism Of Action ◽  
Jc Virus ◽  
Computational Study ◽  
The Body ◽  
Biologically Active ◽  
Positive Test ◽  
Chiral Drugs ◽  
Racemic Form ◽  
Main Protease

<div>It has been a great challenge for the scientists to develop an anti-covid drug/vaccine with fewer side effects, since the coronavirus began. Besides, the mechanism of action and the reason of causing side effects, has also become a great challenge for the scientists in the case of chiral drugs. The main reason behind it, is the prescription of chiral drugs in the racemic form. Another hurdle in front of the world, is the positive test of the patient recovered from coronavirus. This</div><div>positive test of recovered person, shows the demand of such drugs whose mechanism is understandable, and which can block and eliminate SARS-CoV-2 or its material from the body completely, with fewer side effects. The presented computational study explains (i) the mechanism of action of drugs (chloroquine and hydroxychloroquine) that block SARS-CoV-2 (ii) the strength of mefloquine that may eliminate SARS-CoV-2. First, the binding affinities of main protease (Mpro) of JC virus for which mefloquine has already shown its strength to remove, were calculated. After that, same method was applied for SARS-CoV-2, and both the results were compared to know the strength of mefloquine against SARS-CoV-2. Till now, the experimental data found in the literature survey, was neither used in the interpretation nor evaluated computationally, in such a way, as I did for the first time to fight against the pandemic</div><div>situation. Hence, the current study includes the docking results and literature data for the prescription of a combination of only biologically active enantiomers to the patient fighting with coronavirus, with less side effect. Two enantiomers that could do it, are S-(+)hydroxychloroquine</div><div>and (+) mefloquine. Of course, one of these two drugs, will block the coronavirus, while another one will eliminate it.</div>

scholarly journals A Computational and Literature-Based Evaluation for a Combination of Chiral Anti-CoV Drugs to Block and Eliminate SARS-CoV-2 Safely

2020 ◽  
Author(s):  
Mohd. Suhail
Keyword(s):  
Side Effects ◽  
Mechanism Of Action ◽  
Jc Virus ◽  
Computational Study ◽  
The Body ◽  
Biologically Active ◽  
Positive Test ◽  
Chiral Drugs ◽  
Racemic Form ◽  
Main Protease

<div>It has been a great challenge for the scientists to develop an anti-covid drug/vaccine with fewer side effects, since the coronavirus began. Besides, the mechanism of action and the reason of causing side effects, has also become a great challenge for the scientists in the case of chiral drugs. The main reason behind it, is the prescription of chiral drugs in the racemic form. Another hurdle in front of the world, is the positive test of the patient recovered from coronavirus. This</div><div>positive test of recovered person, shows the demand of such drugs whose mechanism is understandable, and which can block and eliminate SARS-CoV-2 or its material from the body completely, with fewer side effects. The presented computational study explains (i) the mechanism of action of drugs (chloroquine and hydroxychloroquine) that block SARS-CoV-2 (ii) the strength of mefloquine that may eliminate SARS-CoV-2. First, the binding affinities of main protease (Mpro) of JC virus for which mefloquine has already shown its strength to remove, were calculated. After that, same method was applied for SARS-CoV-2, and both the results were compared to know the strength of mefloquine against SARS-CoV-2. Till now, the experimental data found in the literature survey, was neither used in the interpretation nor evaluated computationally, in such a way, as I did for the first time to fight against the pandemic</div><div>situation. Hence, the current study includes the docking results and literature data for the prescription of a combination of only biologically active enantiomers to the patient fighting with coronavirus, with less side effect. Two enantiomers that could do it, are S-(+)hydroxychloroquine</div><div>and (+) mefloquine. Of course, one of these two drugs, will block the coronavirus, while another one will eliminate it.</div>

scholarly journals A Computational and Literature-Based Evaluation for a Combination of Chiral Anti-CoV Drugs to Block and Eliminate SARS-CoV-2 Safely

2020 ◽  
Author(s):  
Mohd. Suhail
Keyword(s):  
Side Effects ◽  
Mechanism Of Action ◽  
Jc Virus ◽  
Computational Study ◽  
The Body ◽  
Biologically Active ◽  
Positive Test ◽  
Chiral Drugs ◽  
Racemic Form ◽  
Main Protease

<div>It has been a great challenge for the scientists to develop an anti-covid drug/vaccine with fewer side effects, since the coronavirus began. Besides, the mechanism of action and the reason of causing side effects, has also become a great challenge for the scientists in the case of chiral drugs. The main reason behind it, is the prescription of chiral drugs in the racemic form. Another hurdle in front of the world, is the positive test of the patient recovered from coronavirus. This</div><div>positive test of recovered person, shows the demand of such drugs whose mechanism is understandable, and which can block and eliminate SARS-CoV-2 or its material from the body completely, with fewer side effects. The presented computational study explains (i) the mechanism of action of drugs (chloroquine and hydroxychloroquine) that block SARS-CoV-2 (ii) the strength of mefloquine that may eliminate SARS-CoV-2. First, the binding affinities of main protease (Mpro) of JC virus for which mefloquine has already shown its strength to remove, were calculated. After that, same method was applied for SARS-CoV-2, and both the results were compared to know the strength of mefloquine against SARS-CoV-2. Till now, the experimental data found in the literature survey, was neither used in the interpretation nor evaluated computationally, in such a way, as I did for the first time to fight against the pandemic</div><div>situation. Hence, the current study includes the docking results and literature data for the prescription of a combination of only biologically active enantiomers to the patient fighting with coronavirus, with less side effect. Two enantiomers that could do it, are S-(+)hydroxychloroquine</div><div>and (+) mefloquine. Of course, one of these two drugs, will block the coronavirus, while another one will eliminate it.</div>

scholarly journals A Computational and Literature-Based Evaluation for a Combination of Chiral Anti-CoV Drugs to Block and Eliminate SARS-CoV-2 Safely

2021 ◽  
Author(s):  
Mohd. Suhail
Keyword(s):  
Side Effects ◽  
Jc Virus ◽  
Computational Study ◽  
Human Cells ◽  
The Body ◽  
Binding Affinities ◽  
Chiral Drugs ◽  
Main Protease ◽  
The World ◽  
Second Wave

<p><a>It has been a great challenge for scientists to develop an anti-covid drug/vaccine with fewer side effects, since the coronavirus began. Of course, the prescription of chiral drugs (chloroquine or hydroxychloroquine) has been proved wrong because these chiral drugs neither kill the virus nor eliminate it from the body, but block SARS-CoV-2 from binding to human cells. Another hurdle in front of the world, is not only the positive test of the patient recovered from coronavirus but also the second wave of Covid 19. Hence, the word demands such a drug or drug combination which not only prevents the entry of SARS-CoV-2 in the human cell but also eliminates it or its material from the body completely. The presented computational study explains (i) why the prescription of chiral drugs was not satisfactory (ii) what types of modification can make their prescription satisfactory (iii) the mechanism of action of chiral drugs (chloroquine and hydroxychloroquine) to block SARS-CoV-2 from binding to human cells, and (iv) the strength of mefloquine to eliminate SARS-CoV-2. As the main protease (M<b><sup>pro</sup></b>) of microbes is considered as an effective target for drug design and development, the binding affinities of mefloquine with the main proteases (M<sup>pros</sup>) of JC virus and SARS-CoV-2, were calculated, and then compared to know the eliminating strength of mefloquine against SARS-CoV-2. The main protease (M<sup>pro</sup>) of JC virus was taken because mefloquine has already shown a tremendous result of eliminating it from the body. The current study includes the docking results and literature data in support of the prescription of a combination of S-(+)-hydroxychloroquine and (+) mefloquine. Besides, the presented study also confirms that the prescription of only hydroxychloroquine would not be so effective as in combined form with mefloquine.</a></p>

scholarly journals A Computational and Literature-Based Evaluation for a Combination of Chiral Anti-CoV Drugs to Block and Eliminate SARS-CoV-2 Safely

2021 ◽  
Author(s):  
Mohd. Suhail
Keyword(s):  
Side Effects ◽  
Jc Virus ◽  
Computational Study ◽  
Human Cells ◽  
The Body ◽  
Binding Affinities ◽  
Chiral Drugs ◽  
Main Protease ◽  
The World ◽  
Second Wave

<p><a>It has been a great challenge for scientists to develop an anti-covid drug/vaccine with fewer side effects, since the coronavirus began. Of course, the prescription of chiral drugs (chloroquine or hydroxychloroquine) has been proved wrong because these chiral drugs neither kill the virus nor eliminate it from the body, but block SARS-CoV-2 from binding to human cells. Another hurdle in front of the world, is not only the positive test of the patient recovered from coronavirus but also the second wave of Covid 19. Hence, the word demands such a drug or drug combination which not only prevents the entry of SARS-CoV-2 in the human cell but also eliminates it or its material from the body completely. The presented computational study explains (i) why the prescription of chiral drugs was not satisfactory (ii) what types of modification can make their prescription satisfactory (iii) the mechanism of action of chiral drugs (chloroquine and hydroxychloroquine) to block SARS-CoV-2 from binding to human cells, and (iv) the strength of mefloquine to eliminate SARS-CoV-2. As the main protease (M<b><sup>pro</sup></b>) of microbes is considered as an effective target for drug design and development, the binding affinities of mefloquine with the main proteases (M<sup>pros</sup>) of JC virus and SARS-CoV-2, were calculated, and then compared to know the eliminating strength of mefloquine against SARS-CoV-2. The main protease (M<sup>pro</sup>) of JC virus was taken because mefloquine has already shown a tremendous result of eliminating it from the body. The current study includes the docking results and literature data in support of the prescription of a combination of S-(+)-hydroxychloroquine and (+) mefloquine. Besides, the presented study also confirms that the prescription of only hydroxychloroquine would not be so effective as in combined form with mefloquine.</a></p>

A Computational and Literature-Based Evaluation for a Combination of Chiral Anti-CoV Drugs to Block and Eliminate SARS-CoV-2 Safely

2021 ◽  
Vol 20 (04) ◽  
pp. 417-432
Author(s):  
Mohd. Suhail
Keyword(s):  
Drug Design ◽  
Jc Virus ◽  
Computational Study ◽  
Human Cells ◽  
The Body ◽  
Chiral Drugs ◽  
Structure Based Drug Design ◽  
Drug Candidates ◽  
Main Protease ◽  
The World

It has been a great challenge for scientists to develop an anti-Covid drug/vaccine with fewer side effects, since the coronavirus pandemic began. Of course, the prescription of chiral drugs (chloroquine or hydroxychloroquine) has been proved wrong because these chiral drugs neither kill the virus nor eliminate it from the body, but block SARS-CoV-2 from binding to human cells. Another hurdle facing the world is not only the positive test of the patient recovered from coronavirus, but also the second wave of Covid-19. Hence, the world demands such a drug or drug combination which not only prevents the entry of SARS-CoV-2 in the human cell but also ejects it or its material from the body completely. The current computational study not only utilizes a structure-based drug design approach to find possible drug candidates but also explains (i) why the prescription of chiral drugs was not satisfactory, (ii) what types of modification can make their prescription satisfactory, (iii) the mechanism of action of chiral drugs (chloroquine and hydroxychloroquine) to block SARS-CoV-2 from binding to human cells, and (iv) the strength of mefloquine to eliminate SARS-CoV-2. As the main protease (M[Formula: see text]) of microbes is considered as an effective target for drug design and development, the binding affinities of mefloquine with the M[Formula: see text] of JC virus and SARS-CoV-2 were calculated, and then compared to know the eliminating strength of mefloquine against SARS-CoV-2. The M[Formula: see text] of JC virus was taken because mefloquine has already shown a tremendous result of eliminating it from the body. The prescription of a combination of S-[Formula: see text]-hydroxychloroquine and [Formula: see text]-mefloquine is considered as a boon by the predicted study.

The Target Determination and the Mechanism of Action of Chiral-Antimalarial Drugs: A Docking Approach

2021 ◽  
pp. 1-16
Author(s):  
Mohd. Suhail
Keyword(s):  
Side Effects ◽  
Mechanism Of Action ◽  
Antimalarial Activity ◽  
Docking Study ◽  
Biologically Active ◽  
Binding Affinities ◽  
Racemic Form ◽  
Docking Approach ◽  
Target Determination ◽  
First Time

Due to an undecided target and the prescription of chiral-aminoquinolines (chloroquine, primaquine and quinacrine) in the racemic form, the mechanism of action as well as the reason of causing side effects become unclear. Based on computationally evaluated literature data, the things determined theoretically were (i) the target of aminoquinolines during antimalarial activity, (ii) the mechanism of action of chiral-aminoquinolines and (iii) biologically active enantiomers of aminoquinolines. For the presented study, the enantiomeric binding affinities of aminoquinolines with all the targets claimed by other scientists were calculated, and then used in interpretation with the help of many investigations done/observed by others. The results were very interesting based on which, a new and acceptable mechanism of action of chiral-aminoquinolines during malaria curing step, is given for the first time. The current docking study not only resolves the questionable point about a definite target of aminoquinolines but also makes the mechanism of action understandable.

scholarly journals The Role of Phlebotomy (Fasd) and Wet Cupping (Hijamat) to Manage Dizziness and Vertigo From the Viewpoint of Persian Medicine

2016 ◽  
Vol 22 (3) ◽  
pp. 369-373 ◽  
Author(s):  
Gholamreza Kordafshari ◽  
Mohammad Reza Shams Ardakani ◽  
Mansoor Keshavarz ◽  
Mohammad Mehdi Esfahani ◽  
Esmaeil Nazem ◽  
...  
Keyword(s):  
Side Effects ◽  
Health System ◽  
Mechanism Of Action ◽  
Economic Burden ◽  
Modern Medicine ◽  
Pharmacological Therapy ◽  
The Body ◽  
Full Control ◽  
Persian Medicine

Dizziness and vertigo are the most common complaints of patients that has a high economic burden on the health system. In modern medicine, treatment for dizziness and vertigo consists of chemical pharmacological therapy. Although these drugs are useful in controlling the disease, their side effects and inefficiency in full control of the disease require the use of complementary medicine in this field. Persian medicine consists of valuable experiences of Persian medicine scholars based on the theory of humors and temperaments. In Persian medicine, 2 types of disease are presented: dizziness ( sadar) and vertigo ( dovar). Persian medicine physicians expressed a different mechanism of action than modern medicine for these diseases. They believed that accumulation of abnormal humors, reeh (normal bloating) or causative pathologic substances, is the basic cause of sadar and dovar and that the most important treatment is cleansing the body, particularly the head from accumulated substances by bloodletting methods.

An Advanced Computational Evaluation for the Most Biologically Active Enantiomers of Chiral Anti-Cancer Agents

2020 ◽  
Vol 21 ◽  
Author(s):  
Mohd. Suhail ◽  
Imran Ali
Keyword(s):  
Side Effects ◽  
Data Bank ◽  
Docking Study ◽  
Biologically Active ◽  
Adrenocortical Cancer ◽  
Chiral Drugs ◽  
Computational Evaluation ◽  
Anti Cancer ◽  
Work Done ◽  
First Time

Background:: Cancer is a very dangerous disease, whose treatment can be improved by removing the factors that cause side effects, if the drugs prescribed for cancer, are chiral in nature. Objectives:: A computational evaluation for the most biologically active enantiomeric form of chiral drugs attacking on DNA of the cell, was done for the first time, and compared with the experimental work done by others previously. Methods:: All the enantiomeric structures of the drugs taken in the present study, were obtained using Marvin sketch, and the structure of DNA to be docked with enantiomers, was obtained from the protein data bank. After that, all the enantiomers of the chiral drugs were docked with DNA one by one for the evaluation of the most biologically active enantiomeric form. Results:: The docking study showed that the different enantiomers interacted with DNA differently because of having different arrangements of atoms/groups. The binding affinity of one of the two enantiomeric forms was higher than that of another. Conclusion:: R-methotrexate for breast cancer; R-mitotane for adrenocortical cancer; R-duvelisib for blood cancer, and S-irinotecan for colon cancer, would be a suitable drug with less toxicity as well as other side effects.

scholarly journals Awareness of Medicinal Applications of Piper nigrum among Dental Students

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 927-930
Author(s):  
Nithyanandham Masilamani ◽  
Dhanraj Ganapathy
Keyword(s):  
Side Effects ◽  
Mechanism Of Action ◽  
Black Pepper ◽  
Dental Students ◽  
Biologically Active ◽  
Piper Nigrum ◽  
Medical Applications ◽  
Therapeutic Effects ◽  
White Pepper ◽  
Anti Inflammatory

Black pepper includes the many commonly used ingredients upon this planet, remarkable for some of its potent component piperine. White pepper is made with closely related species, while black pepper is prepared by fast processing and wind drying of underripe natural products, white pepper is made from dried, regular and ready-mixed seeds. Piperine has been the conventional biologically active conjugate of Piper nigrum and Piper longum, having been taken into consideration for therapeutic effects. The purpose of this survey was for assessing the awareness of medicinal applications of Piper nigrum amongst dental students. A cross-sectional survey was done with a self-administered questionnaire with 10 questions circulated among 100 dental students. The questionnaire assessed the awareness about Piper nigrumtherapy in medical applications, their immunomodulatory properties, antipyretic properties, antispasmodic activity, anti-inflammatory activity, and its mechanism of action and side effects. The responses were recorded and analysed. 16% of the respondents were aware of the medical applications of Piper nigrum therapy.11 % were aware of the anti immunomodulatory activity of Piper nigrum therapy .9 % were aware of antipyretic properties of Piper nigrum therapy .13 % were aware of antispasmodic properties of Piper nigrum therapy .10 % were aware of anti-inflammatory properties of Piper nigrum therapy . 6 % were an aware mechanism of action and side effects of Piper nigrum therapy. The awareness about the use of Piper nigrum therapy in medicinal applications is low among dental students. Increased awareness programs and sensitization and continuing dental education programs along with greater importance to the curricular modifications, can further enhance knowledge and awareness about Piper nigrum therapy.

scholarly journals Details of the release of antistress properties of a biologically active iodine in a chicken embryos

2019 ◽  
pp. 58-63
Author(s):  
E. N. Indyuhova ◽  
T. O. Azarnova ◽  
V. I. Maksimov
Keyword(s):  
Mechanism Of Action ◽  
Health Workers ◽  
Medical Science ◽  
Antioxidant Properties ◽  
The Body ◽  
Biologically Active ◽  
Model Systems ◽  
Control Group ◽  
Diene Conjugates ◽  
Drug Mechanism

The physiological and biochemical effects of transovarial treatment by using biologically active iodine were examined with and without impact of extreme irritant on chicken and hen embryos which are the most popular model systems for investigations of the drug mechanism of action in the veterinary science and the medical science. The increasing functional activity of thyroid of chickens from an experienced team in the first days of life was investigated and analysed. The level of iodothyronines is higher in chickens under the action of heat stress factor: T3 total – 1.3 times, T3 free – of 20.9%, and T4 total”– of 23.2%, T4 free – 1.3 times compared with the control. There was an activation of the antioxidant defense system of the body in day-old chickens from the 2nd experimental group against the background of optimization of thyroid status, which resulted in a significant increase in the antioxidant activity of the blood serum compared to that in the control group 1.3 times, indicated a decrease in the level of: lipids, containing isolated double bonds – of 8.8%, diene conjugates – 1.4 times, triene conjugates - of 16.3%, oxodienic conjugates – 1.5 times and Schiff bases – 1.4 times. The central aspects of the iodothyronine mechanism of action at high intensity of free radical reactions and, consequently lipid peroxidation are presented in framework form. The results of the study will make possible the use of the drug products based on this chemical element for veterinarians and health workers. The more stressors affect the bird's body, the higher efficacy of the release of antioxidant properties is in thyroid hormones.

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