Redesigned Silk: A New Macroporous Biomaterial Platform for Antimicrobial Dermal Patches with Unique Exudate Wicking Ability

2020 ◽  
Author(s):  
Kankan Qin ◽  
Rui F.P. Pereira ◽  
Thibaud Coradin ◽  
Verónica de Zea Bermudez ◽  
Francisco Fernandes
Keyword(s):  
Controlled Drug Delivery ◽  
Wound Treatment ◽  
Lateral Deformation ◽  
New Materials ◽  
Silk Fibers ◽  
The Core ◽  
History Of ◽  
Drug Eluting ◽  
Improved Performance ◽  
First Time

Silk is one of the most important materials in the history of medical practice. Owing to its excellent strength, biocompatibility and degradability, silk from Bombyx mori – which is structured as a concentric assembly of silk fibroin (SF) coated by a sheath of sericin (SS) – has long been used for wound treatment. Here, we recapitulate for the first time the topology of native silk fibers using a radically new materials design-oriented approach to achieve unprecedented porous dermal patches suitable for controlled drug delivery. The method implies four steps: (1) removing SS; (2) creating anisotropic macroporosity in SF via ice templating; (3) stabilizing the SF foam with a methanolic solution of Rifamycin (Rif) antibiotic; and (4) coating Rif-loaded redesigned SF foams with a SS sheath. The core-shell SS@SF foams exhibit water wicking properties accommodate up to ~20% lateral deformation. Moreover, monitoring of antibacterial activity against Staphylococcus aureus revealed that the SS@SF foams’ Rif release extended up to 9 days. We anticipate that reverse-engineering of silk foams opens exciting new avenues towards the fabrication of advanced drug eluting silk-based biomaterial platforms with improved performance. The present approach can be generalizable to re-build multicomponent biological materials with tunable porosity.<br>

Redesigned Silk: A New Macroporous Biomaterial Platform for Antimicrobial Dermal Patches with Unique Exudate Wicking Ability

2020 ◽  
Author(s):  
Kankan Qin ◽  
Rui F.P. Pereira ◽  
Thibaud Coradin ◽  
Verónica de Zea Bermudez ◽  
Francisco Fernandes
Keyword(s):  
Controlled Drug Delivery ◽  
Wound Treatment ◽  
Lateral Deformation ◽  
New Materials ◽  
Silk Fibers ◽  
The Core ◽  
History Of ◽  
Drug Eluting ◽  
Improved Performance ◽  
First Time

Silk is one of the most important materials in the history of medical practice. Owing to its excellent strength, biocompatibility and degradability, silk from Bombyx mori – which is structured as a concentric assembly of silk fibroin (SF) coated by a sheath of sericin (SS) – has long been used for wound treatment. Here, we recapitulate for the first time the topology of native silk fibers using a radically new materials design-oriented approach to achieve unprecedented porous dermal patches suitable for controlled drug delivery. The method implies four steps: (1) removing SS; (2) creating anisotropic macroporosity in SF via ice templating; (3) stabilizing the SF foam with a methanolic solution of Rifamycin (Rif) antibiotic; and (4) coating Rif-loaded redesigned SF foams with a SS sheath. The core-shell SS@SF foams exhibit water wicking properties accommodate up to ~20% lateral deformation. Moreover, monitoring of antibacterial activity against Staphylococcus aureus revealed that the SS@SF foams’ Rif release extended up to 9 days. We anticipate that reverse-engineering of silk foams opens exciting new avenues towards the fabrication of advanced drug eluting silk-based biomaterial platforms with improved performance. The present approach can be generalizable to re-build multicomponent biological materials with tunable porosity.<br>

Vasily Sapelnikov vs Imperial Russian Musical Society (1903): New Materials

10.34690/120 ◽  
2020 ◽  
pp. 172-183
Author(s):  
Елена Марковна Шабшаевич
Keyword(s):  
Detailed Analysis ◽  
National Museum ◽  
New Materials ◽  
History Of ◽  
First Time ◽  
Concert Life

В статье рассматривается история конфликта выдающегося пианиста Василия Львовича Сапельникова с руководством Императорского Русского музыкального общества (в лице глав Петербургской и Московской дирекций - Цезаря Антоновича Кюи и Василия Ильича Сафонова) в 1903 году. Инцидент был вызван нарушением договоренности о неучастии Сапельникова в концертах Московского филармонического общества в случае заключения контракта с ИРМО. Посредником в переговорах стало немецкое концертное агентство Вольфа, которое устраивало данный ангажемент. Подробный анализ сложившейся ситуации стал возможен благодаря привлечению новых архивных источников из фондов Российского национального музея музыки - переписки непосредственных участников инцидента, которая впервые вводится в научный оборот. Ее анализ в комплексе с сопутствующими уже опубликованными материалами не только проясняет конкретные обстоятельства дела, но и позволяет воссоздать контекст концертной жизни русских столиц начала XX века - в частности, особенности менеджмента в условиях конкуренции филармонических организаций, институциональное положение артиста, степень юридического оформления его прав и обязанностей. The article deals with the history of the conflict between the outstanding pianist Vasily L. Sapelnikov and the Directorate of the Imperial Russian Musical Society (represented by the Heads of St. Petersburg and Moscow Divisions-Cesar A. Cui and Vasily I. Safonov) in 1903. The incident was caused by Sapelnikov's breach of condition of his non-participation in concerts of Moscow Philharmonic Society in case of signing a contract with Imperial Russian Musical Society. Wolff's Concert Agency, which arranged this engagement, became the mediator in the negotiations. A detailed analysis of the case was made possible by attracting new archival sources from the collections of the Russian National Museum of Music, i. e. the correspondence of participants of the incident, which is being introduced into scientific circulation for the first time. Its study and analysis, together with the accompanying published materials, not only clarify the specific circumstances of the case, but also allow us to reconstruct the context of the concert life of Russian capitals in the early 20 century-in particular, the features of management in the conditions of competing Philharmonic organizations, the institutional position of the artist, the degree of legal registration of his rights and duties.

scholarly journals Sejarah Gerakan Politik Pemuda di Jakarta Sekitar Proklamasi

2021 ◽  
Vol 1 (2) ◽  
pp. 94-109
Author(s):  
Satriono Priyo Utomo
Keyword(s):  
Young People ◽  
Youth Activism ◽  
National Politics ◽  
Political Movement ◽  
Historical Events ◽  
Political Activities ◽  
The Core ◽  
History Of ◽  
First Time ◽  
Political Actions

The history of the Indonesian youth political movement in 1928 not only inherited national politics with the ties of "imagine of Indonesia" as a homeland, nation and language, namely Indonesia. But it also gave birth to the view that youth is the core of change. This view became the belief of Indonesian youth in the 1940s to be involved in the revolutionary wave of "imagine of Indonesia" in a more critical and progressive manner in political actions. This paper aims to explain youth activism in Jakarta around a more advanced proclamation, accelerating from national politics to populist politics. There were two strongest youth node organizations in Jakarta at that time, Asrama Menteng Raya 31 and Prapatan 10. Both of them brought together young people from different ethnic and national backgrounds. But the youth political movement in the 1940s had a more populist political tone with its political activities carrying out political education work in order to mobilize people's awareness of the struggle for independence. Then the youth in Jakarta formed an organizational node called the Angkatan Pemuda Indonesia (API), which contributed to the historical events of the grand meeting at Ikada Square on September 19, 1945. Where Sukarno spoke as President of Indonesia for the first time in front of a mass mobilized by youth after the reading of the proclamation on August 17, 1945.

scholarly journals Contamination tracer testing with seabed drills: IODP Expedition 357

2017 ◽  
Vol 23 ◽  
pp. 39-46 ◽  
Author(s):  
Beth N. Orcutt ◽  
Markus Bergenthal ◽  
Tim Freudenthal ◽  
David Smith ◽  
Marvin D. Lilley ◽  
...  
Keyword(s):  
Delivery System ◽  
Deep Biosphere ◽  
Ocean Drilling Program ◽  
Ocean Drilling ◽  
The Core ◽  
Tracer Testing ◽  
Atlantis Massif ◽  
History Of ◽  
First Time

Abstract. IODP Expedition 357 utilized seabed drills for the first time in the history of the ocean drilling program, with the aim of collecting intact sequences of shallow mantle core from the Atlantis Massif to examine serpentinization processes and the deep biosphere. This novel drilling approach required the development of a new remote seafloor system for delivering synthetic tracers during drilling to assess for possible sample contamination. Here, we describe this new tracer delivery system, assess the performance of the system during the expedition, provide an overview of the quality of the core samples collected for deep biosphere investigations based on tracer concentrations, and make recommendations for future applications of the system.

scholarly journals La representación teatral de Vida, pasión y muerte de Lorenzo Mombo

2019 ◽  
pp. 93-105
Author(s):  
Wilfredo Kapsoli Escudero
Keyword(s):  
National History ◽  
The Core ◽  
History Of ◽  
First Time ◽  
The Revolution

ResumenEn 1975 la Universidad Ricardo Palma publicó el libro Sublevaciones de Esclavos en el Perú, s. XVIII. Por primera vez en la historia nacional se revelaban sucesos ocultos e ignorados durante siglos. Tras 41 años, la suerte nos deparó un hallazgo extraordinario: el programa y el libreto de la representación coreográfica basada en dicho libro y realizada bajo la dirección de Rolando Campos y del poeta César Calvo. Precisamente, este documento es el núcleo delas anotaciones y comentarios para demostrar la historia del primer grito de la libertad e independencia protagonizado por los esclavos antes de la Revolución de Túpac Amaru II. La recreación artístico-musical, así como las reflexiones históricas que aporta este encuentro forman parte del Bicentenario en el Aula. Palabras claves: esclavitud, libertad, Perú Negro, independencia, Lorenzo Mombo, César Calvo. AbstractIn 1975, the Ricardo Palma University published my book Sublevaciones de Esclavos en el Perú s. XVIII. For the first time in national history, events that had been hidden and ignored for centuries were revealed. After 41 years, luck brought us an extraordinary discovery: the program and the booklet of the choreographic representation based on this book and made under the direction of Rolando Campos and the poet César Calvo. Precisely this document is the core of the annotations and comments to demonstrate the history of the first cry of Freedom and Independence starring the slaves before the Revolution ofTúpac Amaru II. The artistic - musical recreation, as well as the historical reflections that this meeting brings are part of the Bicentennial. Keywords: Slavery, freedom, Black Peru, independence, Lorenzo Mombo, César Calvo.

What is a Function?

2011 ◽  
pp. 91-139
Author(s):  
Brian Hyer
Keyword(s):  
Harmonic Function ◽  
Critical Appraisal ◽  
The Core ◽  
Term Function ◽  
Tonal Function ◽  
History Of ◽  
First Time

This article discusses Hugo Riemann's notion of a tonal or harmonic function, which he first introduced into musical-theoretical discourse, Vereinfachte Harmonielehre in 1893. Riemann's notion of a tonal function refers to either the chords or properties of chords, classified as: tonic, dominant, and subdominant. In this article, the focus is on the equation of “function” with “meaning”, because it is in this connection that the term “function” occurs for the first time, and because the equation forms the core of the later references to the idea. What follows is a critical appraisal rather than history of the concept. The aim in this article is to consider within broad but specific historical boundaries, the discursive potential of the term in Riemann's theoretical writings.

The McDonaldization of Fencing. The Tauberbischofsheim Coaching Method as a Turning Point in the History of Fencing

STADION ◽  
2019 ◽  
Vol 43 (1) ◽  
pp. 99-114
Author(s):  
Udi Carmi
Keyword(s):  
Traditional Instruction ◽  
Turning Point ◽  
Formal System ◽  
Training Model ◽  
The Core ◽  
The World ◽  
History Of ◽  
First Time ◽  
The Way ◽  
The Revolution

In the early 1970s, the German fencing coach Emil Beck invented a new training model that deviated from the traditional French and Italian schools. Beck's model, named for the fencing club he established, Tauberbischofsheim, revolutionized the way fencing was taught. It was a rational, formal system based on McDonaldization - the economic consumption paradigm developed by sociologist George Ritzer. This article studies the Tauberbischofsheim training model as a turning point in the history of fencing. It analyzes the core principles of the system and the revolution it brought about. The McDonaldization paradigm applied to fencing undermined the basic tenets of fencing instruction, introducing a rational coaching plan and individualized lessons chosen from a pre-set menu. The coach became more of a guide than a trainer. For the first time, it was possible to teach fencing without being a consummate professional or an expert in the traditional instruction methods. The success of Beck's students has been unprecedented in the world of fencing.

scholarly journals BLACKSMITH LOCKS OF DAGESTAN (FORGOTTEN PAGES OF DARGIN ETHNOCULTURE)

2017 ◽  
Vol 13 (1) ◽  
pp. 120-133
Author(s):  
A Dzh Magomedov ◽  
Kh A Yusupov
Keyword(s):  
Cultural History ◽  
Middle Ages ◽  
Metal Working ◽  
New Materials ◽  
Iron Metal ◽  
Locking Mechanism ◽  
History Of ◽  
The Republic ◽  
Spring Mechanism ◽  
First Time

Article is devoted to it to the phenomenon of the Dagestan ethnographic culture «forgotten» by scientists as superimposed forge locks. They aren't also in the state museums of the republic. Dagestanis had still such locks in which the locking mechanism widely known in the Middle Ages was used, as in Russia until recently, and in the east and the West. At the same time, the type of the lock (delivery note), a form of a design, its variation, an original forge pattern, names testify to the original ethnocultural phenomenon which sources aren't up to the end clear. Superimposed forge locks for the first time were revealed by us at Dargins of Dakhadayevsky district. Still in due time the famous caucasiologist E. M. Shilling paid attention that the ethnoculture of Dargins contains the interesting materials of archaic type which didn't remain at other mountain people of Dagestan. Field material demonstrates that such locks were generally manufactured by masters of villages Amuzgi and Harbuk. The description of a design of locks, in particular their spring mechanism is given. Some data on names of locks are provided in article and the attempt to explain their origin becomes. Material shows that all versions of names of forge locks of a local origin. In the Dargwa language the word "meg" means "iron", "metal". The same word, as a rule, designates also the lock. Forge superimposed locks of Dargins - the unique phenomenon of cultural history of Dagestan bearing on itself a seal of early traditions of metal working. It is obvious that it is necessary to continue searches of new materials and studying of this phenomenon of culture.

scholarly journals “How the Fourteenth Division Got to Heaven” by Demyan Bedny: from a Poem to a Play

2019 ◽  
pp. 111-121
Author(s):  
Максим Фёдоров ◽  
Maksim Fedorov
Keyword(s):  
Performing Arts ◽  
World Literature ◽  
Russian Science ◽  
The Core ◽  
History Of ◽  
Music Hall ◽  
First Time

For the first time in the Russian science, the research focuses on the drama of Demyan Bedny. It dwells upon the works of the poet, which were staged. Using the archived materials of the manuscript department of the Institute of World Literature, the author shows the history of the play by Demyan Bedny “How the Fourteenth Division Got to Heaven” and explores one of the core dramatic principles of the poet: a poem is first written, and later staged. The performance of the Moscow Music Hall “How the Fourteenth Division Got to Heaven” (1932), having entered the history of the Soviet theatre as one of its highlights, played a key role in shaping the special phenomenon of performing arts — the theatre of satire and variety entertainment.

scholarly journals XVII.—Conclusion of New Materials for a Life of Sir Walter Raleigh. In a Letter addressed to Lord Viscount Mahon, President, from J. Payne Collier, Esq. Vice-President of the Society of Antiquaries

Archaeologia ◽  
1853 ◽  
Vol 35 (1) ◽  
pp. 213-222
Author(s):  
J. Payne Collier
Keyword(s):  
Vice President ◽  
New Materials ◽  
Public And Private ◽  
Great Learning ◽  
History Of ◽  
Sir Walter Raleigh ◽  
First Time

With the permission of your Lordship I am about to address to you a short and concluding continuation of some Papers which were read in the season of 1850-1, containing hitherto unnoticed materials for a Memoir of Sir Walter Raleigh. Those materials were derived from various sources, public and private, and brought the history of one of the founders of our Society—a man of great learning, multifarious talents, and energetic and enterprising spirit—down to the year 1598; when I showed, I believe for the first time, that he was employed against the rebels in Ireland, and had offered a price for the head of Tyrone.

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