Relationship of the ovarian reserve with autoimmune thyroid diseases in the reproductive period

Aim. To compare ovarian reserve in healthy women of reproductive age - carriers of antithyroid antibodies (ATA) and in healthy women of reproductive age negative for ATA. Materials and methods. 70 healthy women of young reproductive age in the state of euthyroidism (from 18 to 38 years old) were examined. Participants were divided into equal groups (n=35) depending on the status of the presence of antithyroid antibodies (AT-TPO, AT-TG). On the 2nd-4th days of the menstrual cycle, the following markers of the ovarian reserve were determined: serum levels of anti-Müllerian hormone (AMG), inhibin B, FSH, LH, estradiol, testosterone and progesterone, as well as ultrasound parameters - the number of antral follicles and the volume of the ovaries. In addition, to determine the predisposition to premature ovarian failure, an analysis was performed to the number of CGG repeats in the FMR1 gene. Results and discussion. Statistically significantly differs such parameters as the level of estradiol and testosterone, while the differences were not clinically significant. All the parameters evaluated were within the normal range, the main predictors of the ovarian reserve (levels of AMG and inhibin B, the number of antral follicles) remained in the normal range. An increase in the number of repeats of CGG in the FMR1 gene was not detected in any of the participants in the study. Conclusion. In healthy young reproductive age women, the status of ATA does not have a direct effect on the ovarian reserve.

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Features of the ovarian reserve of women of reproductive age suffering from autoimmune diseases

GYNECOLOGY ◽

10.26442/20795696.2020.5.200416 ◽

2020 ◽

Vol 22 (5) ◽

pp. 27-30

Author(s):

Elena N. Andreeva ◽

Olga R. Grigoryan ◽

Yulia S. Absatarova ◽

Irina S. Yarovaya ◽

Robert K. Mikheev

Keyword(s):

Type 1 Diabetes ◽

Thyroid Gland ◽

Autoimmune Diseases ◽

Ovarian Reserve ◽

Reproductive Potential ◽

Reproductive Age ◽

Control Group ◽

Antithyroid Antibodies ◽

Healthy Women

The reproductive potential of a woman depends on indicators of the ovarian reserve, such as the anti-Muller hormone (AMH) and the number of antral follicles (NAF). Autoimmune diseases have a significant effect on fertility and contribute to the development of premature ovarian failure. Aim.To evaluate the parameters of the ovarian reserve in patients with type 1 diabetes mellitus, carriers of antibodies to the thyroid gland in a state of euthyroidism and compare them with similar parameters in healthy women. Materials and methods.In the first block of the study, the level of AMH, follicle-stimulating hormone, luteinizing hormone, NAF was studied among 224 women with diabetes and 230 healthy women in the control group. In block II, the level of the above hormonal indices was studied in 35 carriers of antithyroid antibodies in the state of euthyroidism and 35 healthy women. Results.In patients with type 1 diabetes, the level of AMH, NAF was statistically significantly lower when compared with the control group. Among carriers of antithyroid antibodies and healthy women, no difference in AMH and NAF was found. Conclusion.The autoimmune processes accompanying diabetes are more influenced by the ovarian reserve indices than autoimmune aggression to the tissues of the thyroid gland.

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ESTIMATION TO EFFICIENCY OF THE MULTIFUNCTION METHOD ОF ENDOMETRIOSIS OVARIЕS TREATMENT

Wiadomości Lekarskie ◽

10.36740/wlek202005106 ◽

2020 ◽

Vol 73 (5) ◽

pp. 868-872

Author(s):

Iryna M. Nikitina ◽

Volodymyr I. Boiko ◽

Svitlana A. Smiian ◽

Tetiana V. Babar ◽

Natalia V. Kalashnyk ◽

...

Keyword(s):

Gonadotropin Releasing Hormone ◽

Inhibin B ◽

Reproductive Age ◽

Sexual Life ◽

Control Group ◽

Women Of Reproductive Age ◽

Releasing Hormone ◽

Antral Follicles ◽

Group I ◽

Laparoscopic Removal

The aim: The aim of the study was to improve the results of treatment of patients with endometriosis by using a combination method of therapy. Materials and methods: For two years, 136 women of reproductive age who underwent laparoscopic surgeries for ovarian endometriosis were monitored: Group I (n = 24) did not receive any hormonal treatment in the perioperative period; Group II (n = 32) – received gonadotropin-releasing hormone agonists within 3 months after surgery; Group III (n = 80) prior to laparoscopic removal of the ovarian cyst used gonadotropin-releasing hormone agonists – Triptorelin 3.75 mg intramuscularly for 2 months, as well as three months after surgery. The control group consisted of 30 healthy women of reproductive age with regular menstrual periods. All patients underwent transvaginal ultrasound, counting the number of antral follicles before and after treatment. Serum hormone levels (FSH, prolactin, thyrotropic hormone, anti-Mullerian hormone, inhibin B) were determined by enzyme-linked immunosorbent assay on Cobas e-411 analyzer (Roche Diagnostics, Switzerland) on day 2-3 of the menstrual cycle and on day 2–3 of the first menstrual period after the end of treatment. Laparoscopic removal of the cyst was performed with exfoliation of the cyst, hemostasis on the wound surface of the bed of the cyst was performed with a bipolar electrocoagulator. Bipolar coagulation and resection of the ovarian tissue with no potential was used during surgical treatment of the ovaries, which made it possible to preserve the intact portion of the ovary as much as possible. Results: Analysis of ovarian reserve indices, namely number of antral foliculs, number of antral follicles, AMG, and inhibin B levels in all examined patients with ovarian endometriomas were significantly lower than those of the control group before the start of treatment: in the ovarian endometrial group group 1.26 times (p <0.01), inhibin B – 1.5 times (p <0.01), the number of antral follicles – 1.2 times (p <0.01), due to the development dystrophic changes of the follicular apparatus due to prolonged compression, hypoxia, fibrosis in the ovaries. Patients who planned pregnancy were advised to have an active sexual life before menstruation was restored. In 23 (46.9%) of 49 patients who had reproductive plans, pregnancy occurred without first menstruation after a course of gonadotropin-releasing hormone agonists, 12 (24.5%) women became pregnant during the first three menstrual cycles. Extracorporeal fertilization was recommended for women who did not have pregnancy within 6 months of surgery. For two years in women who did not plan pregnancy, recurrence of endometriosis was not observed. Conclusions: The combination of laparoscopic treatment with gonadotropin-releasing hormone agonists in patients with endometriosis with infertility allowed to restore reproductive function in 71.4% of women, which indicates the effectiveness of the treatment method used. In addition, it helps to achieve lasting remission and addresses the socio-social problems of women’s health and maternity.

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The status and comparison of ovarian reserve between fertile and infertile healthy Chinese women of reproductive age

Medicine ◽

10.1097/md.0000000000025361 ◽

2021 ◽

Vol 100 (17) ◽

pp. e25361

Author(s):

Shan-Jie Zhou ◽

Tie-Cheng Sun ◽

Ling-Li Song ◽

Ming Yang ◽

Xin-Ping Sun ◽

...

Keyword(s):

Ovarian Reserve ◽

Chinese Women ◽

Reproductive Age ◽

Women Of Reproductive Age ◽

The Status ◽

Healthy Chinese

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Ovarian aromatase activity in endometriosis

Journal of obstetrics and women s diseases ◽

10.17816/jowd62217-22 ◽

2013 ◽

Vol 62 (2) ◽

pp. 17-22 ◽

Cited By ~ 2

Author(s):

Valentina Mikhaylovna Denisova ◽

Vladimir Vsevolodovich Potin ◽

Mariya Igorevna Yarmolinskaya ◽

Yekaterina Mikhaylovna Timofeyeva

Keyword(s):

Antral Follicle ◽

Reproductive Age ◽

Control Group ◽

Aromatase Activity ◽

Women Of Reproductive Age ◽

Antral Follicles ◽

Gonadotropin Releasing Hormone Agonist ◽

Healthy Women ◽

Key Enzyme

Aromatase is the key enzyme, which converts androgens into estrogens. To study the role of aromatase in pathogenesis of endometriosis 57 patients and 15 healthy women of reproductive age were examined. Aromatase activity was detected by reaction of estrogens on aromatase inhibitor letrozol intake. Ovarian source of detected aromatase activity was proved by suppression of reaction on letrozole intake during therapy with gonadotropin- releasing hormone agonist. Aromatase activity in recalculation on antral follicle in endometriosis patients withII–IV stages was higher than in healthy women, though total ovarian aromatase activity was not differed from control group because of low number of antral follicles in endometriosis patients. The disturbance of folliculogenesis in endometriosis is connected probably with hyperestronaemia, which has ovarian and extragonandal origin.

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Relantionship between antimullerian hormone (AMH) levels and the antral follicles count (AFC) by ultrasonography as a predictor of ovarian reserve in a cohort of women of reproductive age

Clinica Chimica Acta ◽

10.1016/j.cca.2019.03.695 ◽

2019 ◽

Vol 493 ◽

pp. S320

Author(s):

P. Maidana ◽

J. Bonomo ◽

M.I. Torres ◽

N. Pasqualini ◽

L. Singh ◽

...

Keyword(s):

Ovarian Reserve ◽

Reproductive Age ◽

Women Of Reproductive Age ◽

Antral Follicles ◽

Antimullerian Hormone ◽

Antimüllerian Hormone

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THE SPECIFICITY OF THE OVARIAN RESERVE OF WOMEN WITH CHRONIC SALPINGOOPHORITIS

Kuban Scientific Medical Bulletin ◽

10.25207/1608-6228-2018-25-6-119-126 ◽

2018 ◽

Vol 25 (6) ◽

pp. 119-126

Author(s):

V. A. Novikova ◽

F. R. Autleva ◽

A. A. Sorochenko ◽

D. I. Fayzullina ◽

E. V. Nurgalieva

Keyword(s):

Ovarian Reserve ◽

Reproductive Period ◽

Main Group ◽

Reproductive Age ◽

Control Group ◽

Regression Equations ◽

Women Of Reproductive Age ◽

Antral Follicles ◽

Preconception Consultation ◽

The Impact

Aim. The research was conducted for the assessment of the impact of chronic salpingoophoritis on the ovarian reserve of women in various phases of reproductive age.Materials and methods. A prospective, controlled and open cohort study was performed in 2013-2018 (n=202). The main group consisted of women with chronic salpingoophoritis (ChrSO) who applied for preconception consultation (n=138). In accordance with the reproductive age phase, the main group was divided into subgroups: the early reproductive age period (ERP, n=44), the peak reproductive age period (PRP, n=56), the late reproductive period (LRP, n=38). The control group consisted of conditionally healthy women of reproductive age (n=64). The ovarian reserve (OR) was estimated on the basis of the serum level of antimullerian hormone (AMH), inhibin B, estradiol, follicle stimulating hormone (FSH), an ultrasoundbased assessment of the number of antral follicles (AF), and the ovarian volume. Results. The age of women ranged from 18 to 40 years. Based on the discriminant analysis, it was found that the main indicators determining the specificity of the OR in ChrSO, depending on the phase of reproductive age, are the number of antral follicles, estradiol level and AMH (Wilks’ lambda = 0.35503, p<0.0001). The specificity of the OR of women with ChrSO (difference from the control group), regardless of the phase of reproductive age, initially and when evaluated after 6 months, is determined by the number of AF and the level of estradiol and AMH; the number of AF and AMH is determined with a similar estimate after 12 months. The specificity of the OR in ChrSO, which is dependent on the reproductive age phase, has been proved through the analysis with the neural networks training(the proportion of correct answers is more than 80%). The linear relationships were established between the values of each OR parameter in women with ChrSO. Initially, when estimating after 6 and 12 months, linear regression equations were calculated, allowing the values of individual OR parameters to be calculated over 6 and 12 months.Conclusion. Chronic salpingoophoritis (ChrSO) is associated with a decrease in ovarian reserve in women of reproductive age. The effect of ChrSO on some parameters of the ovarian reserve depends on the age phase of the reproductive period, which increases with time (after 6, 12 months). The presence of ChrSO in women planning future pregnancies requires preventive and therapeutic measures aimed at preserving the ovarian reserve and the preferred implementation of fertility in early reproductive age before the ovarian reserve starts to decline.

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Plasma Volume, Hydration and Nutritional Biomarker Concentrations Across the Menstrual Cycle (P24-052-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz044.p24-052-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Sixtus Aguree ◽

Hilary Bethancourt ◽

Leigh Taylor ◽

Asher Yoel Rosinger ◽

Lacy M Alexander ◽

...

Keyword(s):

Menstrual Cycle ◽

Plasma Volume ◽

Plasma Osmolality ◽

Reproductive Age ◽

Magnesium Concentration ◽

Women Of Reproductive Age ◽

Blood Draw ◽

Healthy Women ◽

Markers Of Inflammation ◽

Concentration Changes

Abstract Objectives To examine changes in plasma volume, hydration, and micronutrient concentrations across the menstrual cycle among healthy women of reproductive age. Methods Healthy women aged 18 to 44 years were studied longitudinally across a single menstrual cycle (n = 35). Women made three visits (v1, v2, and v3) to the study center around cycle days 2, 12 and 21 (adjusted for individual cycle length) representing early follicular, late follicular and midluteal phases, respectively. At each visit, blood samples were collected before and after injection of indocyanine green (ICG). ICG in plasma was measured with a spectrophotometer within 2 hours of blood draw, to estimate plasma volume. Urine specific gravity (USG) was measured with a hand-held refractometer; urine and plasma osmolality were measured using freezing point depression osmometry. Serum ferritin was measured by ELISA; serum concentrations for 5 minerals were measured by inductively coupled plasma mass spectrometry. A mixed-effects model was used to examine changes in plasma volume and biomarker concentrations across the menstrual cycle; plasma volume and biomarker associations were tested with Spearman's correlation. Results Participants had a mean (SD) BMI of 21.6 (1.9) kg/m2. Plasma volume showed a non-significant decrease of 122 mL from v1 to v2 (P = 0.165; Table 1) and remained stable from v2 to v3 (P = 0.900). However, plasma osmolality decreased throughout the cycle from v1 to v3 (P < 0.001). Urine osmolality fell slightly from v1 to v2 (P = 0.214) followed by a significant rise from v2 to v3 (P = 0.026) but USG was constant across the cycle. From v1 to v3, serum magnesium concentration declined by 4.5% (P = 0.001); zinc had a similar decline that did not reach statistical significance (P = 0.057). Mean copper, calcium, manganese, ferritin, and hemoglobin concentrations did not change across the cycle (all P > 0.05). Adjusting for markers of inflammation (α1-acid glycoprotein and C-reactive protein) and plasma volume did not affect biomarker concentration changes. Plasma volume was not correlated with nutritional biomarkers at any timepoint (all P > 0.05, Table 2). Conclusions Concentrations of micronutrients were not related to plasma volume. Some hydration and micronutrient biomarkers changed across the menstrual cycle, which could have implications for the timing of measurements in women of reproductive age. Funding Sources The Pennsylvania State University. Supporting Tables, Images and/or Graphs

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