The concomitant estrogen-dependent diseases and the ovarian reserve condition for patients with severe peritoneal endometriosis, included in the vitro fertilization programmes

GYNECOLOGY ◽  
2021 ◽  
Vol 23 (5) ◽  
pp. 386-391
Author(s):  
Irina Yu. Ershova ◽  
Ksenia V. Krasnopolskaya ◽  
Mekan R. Orazov ◽  
Elena V. Lagutina
Keyword(s):  
Ovarian Reserve ◽  
Clinical Status ◽  
Diagnostic Procedures ◽  
Reproductive Age ◽  
Vitro Fertilization ◽  
Infertile Women ◽  
Peritoneal Endometriosis ◽  
Immunoenzyme Method ◽  
Status Assessment ◽  
Low Efficiency

Aim. Is specification of the nature and frequency of concomitant forms of genital endometriosis and other estrogen-dependent diseases (EDD) for the infertile women with severe peritoneal endometriosis (PE), as well as the assessment of the ovarian reserve condition for the patients of different ages. Materials and methods. The total 142 infertile women with severe peritoneal endometriosis (IIIIV stage of the external genital endometriosis according to the American Fertility Society classification) were examined at the age of 32.33.2 years (minmax = 2340 years). The clinical status assessment was conducted, using a standard set of diagnostic procedures, prescribed for the inclusion of patients in the IVF program. The ovarian reserve was estimated by the level of the anti-Mullerian Hormone level determined by the immunoenzyme method. Results. The concomitant 2-sided endometriotic ovarian cysts (96%), myoma (19.7%) and the adenomyosis (16.9%) were most common for the patients with severe peritoneal endometriosis. The severely reduced the anti-Mullerian Hormone rates (0.4 ng/ml) were much higher among patients 35 years old (24.6% compared to 10.6% for younger patients; p=0.028). Conclusion. The infertility for severe peritoneal endometriosis is supported by concomitant estrogen-dependent diseases, of which 2-sided endometriomas, adenomyosis and uterine myoma are of the most pathological. The low efficiency of IVF in the treatment of patients with severe peritoneal endometriosis and concomitant estrogen-dependent diseases is explained by the aggravation of the embryonic and endometrial factors for the infertility. The other reason that worsens the results of IVF for such patients is late reproductive age (35 years) that increases the observed reduction of the ovarian reserve.

scholarly journals ADA activity in the follicular fluid of infertile women with diminished ovarian reserve can act as a predictor of ovarian reserve

2021 ◽  
Vol 10 (2) ◽  
pp. 452
Author(s):  
Gülşah İlhan ◽  
Besim H. Bacanakgil ◽  
Ayşe Köse ◽  
Ayben Atıcı ◽  
Şener Yalçınkaya ◽  
...  
Keyword(s):  
Follicular Fluid ◽  
Ovarian Reserve ◽  
Reproductive Tract ◽  
Vitro Fertilization ◽  
Infertile Women ◽  
Significant Difference ◽  
Human Reproductive ◽  
Ovarian Reserve Markers ◽  
Work Up

Background: Adenosine deaminase (ADA) catalyses the deamination of adenosine to inosine. In the human reproductive tract, the importance of enzymes that affect metabolism of adenosine, particularly ADA, has been emphasized. It is aimed to evaluate the plasma and follicular fluid (FF) activities of total ADA (ADAT) in infertile women and to determine its relation with ovarian reserve markers and in vitro fertilization (IVF) outcomes.Methods: Plasma and FF activities of ADAT were measured in 106 infertile women. Its relation with ovarian reserve markers and IVF outcomes were determined.Results: There was a significant difference in the ADAT activities between plasma and FF of infertile women (p<0.01). The activity of plasma ADAT was higher than FF ADAT in infertile women (p<0.01). The activity of FF ADAT in DOR group was higher than that of the others (p<0.01). In DOR group; the activity of FF ADAT activity had a negative correlation with BMI and a positive correlation with FSH and no relation with IVF outcomes.Conclusions: Increased ADAT activity can lead to reduced adenosine levels, which might be resulted in disturbed fertility process. The activity of FF ADAT activity might be important for fertility work-up. Further studies are needed.

scholarly journals Surgical Management of Endometrial Polyps in Infertile Women: A Comprehensive Review

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Nigel Pereira ◽  
Allison C. Petrini ◽  
Jovana P. Lekovich ◽  
Rony T. Elias ◽  
Steven D. Spandorfer
Keyword(s):  
Observational Studies ◽  
Detrimental Effect ◽  
Expectant Management ◽  
Reproductive Age ◽  
Endometrial Polyps ◽  
Vitro Fertilization ◽  
Infertile Women ◽  
The Cost ◽  
Infertile Patients

Endometrial polyps are benign localized lesions of the endometrium, which are commonly seen in women of reproductive age. Observational studies have suggested a detrimental effect of endometrial polyps on fertility. The natural course of endometrial polyps remains unclear. Expectant management of small and asymptomatic polyps is reasonable in many cases. However, surgical resection of endometrial polyps is recommended in infertile patients prior to treatment in order to increase natural conception or assisted reproductive pregnancy rates. There is mixed evidence regarding the resection of newly diagnosed endometrial polyps during ovarian stimulation to improve the outcomes of fresh in vitro fertilization cycles. Hysteroscopy polypectomy remains the gold standard for surgical treatment. Evidence regarding the cost and efficacy of different methods for hysteroscopic resection of endometrial polyps in the office and outpatient surgical settings has begun to emerge.

scholarly journals The Impact of Endometriosis on Controlled Ovarian Stimulation Outcome

2021 ◽  
Author(s):  
Dragoș Albu ◽  
Alice Albu
Keyword(s):  
In Vitro Fertilization ◽  
Ovarian Reserve ◽  
Ovarian Stimulation ◽  
Predictive Value ◽  
Reproductive Age ◽  
Important Predictor ◽  
Controlled Ovarian Stimulation ◽  
Vitro Fertilization ◽  
The Impact

Endometriosis, a frequent condition in reproductive age women, is also associated with infertility by mechanisms incompletely clarified. The effectiveness of endometriosis treatment for infertility is debated, being possible that in vitro fertilization (IVF) offers a better alternative. The response to controlled ovarian stimulation (COS) is an important predictor of live birth, but it might be affected in endometriosis possibly through a decrease of ovarian reserve. Moreover, the predictive value of anti-mullerian hormone (AMH) for the response to COS could be altered by factors disrupting the AMH production in endometriosis. Therefore, we aim to review the literature regarding the response to COS and the AMH production and their predictive value for COS response in patients with endometriosis.

scholarly journals Body Mass Index (BMI) dependent effect of thyroid stimulating hormone (TSH) and gonadotropins on ovarian reserve markers in the secondary infertile women at fertile age.

2021 ◽  
Author(s):  
Haroon Latif Khan ◽  
Komal Fatima ◽  
Shahzad Bhatti ◽  
Sammar Nathanial ◽  
Hooria Younus
Keyword(s):  
Ovarian Reserve ◽  
Medical Condition ◽  
Tertiary Care ◽  
Thyroid Stimulating Hormone ◽  
Reproductive Age ◽  
P Value ◽  
Cross Sectional ◽  
Infertile Women ◽  
Ovarian Reserve Markers ◽  
Tsh Levels

Abstract Background: Infertility is a medical condition when a couple fails to conceive after having regular unprotected intercourse without the use of any contraceptive, it a complex global health issue that can be primary with no previous conception or secondary with one or more previous conceptions. A number of anomalies in the reproductive track govern the state of infertility in female of reproductive age.Materials and Methods: The study was conducted on 100 secondary infertile women based on BMI groups {Normal 18-23.9 kg/m2 (N=35) and Overweight 24-27 kg/m2 (N=65)}, attending tertiary care infertility center: Lahore Institute of Fertility and Endocrinology, Hameed Latif Hospital. The present analytical cross sectional study was conducted to assess the BMI based combinatorial effect of gonadotropins with thyrotropin and ovarian reserve markers in secondary infertile women. Serum hormonal levels of TSH, LH, FSH and AMH were measured by using Roche electrochemiluminescence immunoassay (ECLIA) and AFC was recorded by transvaginal ultrasonography. The results were statistically analyzed by Spearman correlation test using XLSTAT, considered significant at p-value <0.05. Results: A total of 18% of secondary infertile women with normal BMI were found to have a lower serum TSH levels (<0.27µIU/ml) which can be characterized as hyperthyroidism as compared to overweight population. A strong significant positive correlation was found in the TSH, age and BMI, however, these factors were found to be negatively correlated with AMH and AFC. Gonadotropins level was increased with increase in TSH levels among participants with normal BMI but decreased with TSH escalation values among overweight population. Conclusion: TSH was found to be one of the most important diagnostic factors of infertility must be monitored in relation with other parameters (AMH, AFC, FSH, and LH) in order to spot instigation point, as it directly acts upon ovulation surge by controlling gonadotropins related actions on ovarian reserve. Weight should also be assessed regularly with age to minimize the infertility issues.

Ovarian reserve in infertile women of reproductive age with non-operated ovarian endometriomas

2016 ◽  
pp. 165-168
Author(s):  
V.G. Dubinina ◽  
◽  
О.М. Nosenko ◽  
O.I. Chuzhyk ◽  
G.S. Grytsenko ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Reproductive Age ◽  
Control Group ◽  
Reproductive Disorders ◽  
Pathological Study ◽  
Women Of Reproductive Age ◽  
Tubal Infertility ◽  
Ovarian Endometriosis ◽  
Infertile Women ◽  
Ovarian Endometriomas

The objective: of the study was to investigate the indicators of ovarian reserve in infertile women of reproductive age with non-operated ovarian endometriomas more than 3 cm in diameter. Patients and methods. It were examined 63 patients of reproductive age with ovarian endometriosis, including 33 with unilateral ones and 30 with bilateral. The control group consisted of 30 conditionally somatically healthy women of reproductive age with secondary tubal infertility, with regular ovulatory menstrual cycle. All the women were operated on. Prior to the surgery it were studied biochemical and sonographic markers of ovarian reserve, and after pathological study of operational materials – histological markers. Results. It was registered decrease in biochemical, ultrasonographic and histological indicators of ovarian reserve compared to control. Conclusion. The authors conclude that endometriosis directly affects ovarian reserve and ovarian reserve should be assessed not only after it, but before surgery in women with endometriomas and reproductive disorders. It is important to determine the tactics of their management. Key words: endometrioma, ovary, ovarian reserve, operation, Anti-Mьllerian hormone, inhibin B, FSH, estradiol, the number of antral follicles.

scholarly journals Correlation Analysis Between Ovarian Reserve and Thyroid Hormone Levels in Infertile Women of Reproductive Age

2021 ◽  
Vol 12 ◽  
Author(s):  
Jie Wu ◽  
Ying-jie Zhao ◽  
Min Wang ◽  
Ming-qiang Tang ◽  
Yao-fang Liu
Keyword(s):  
Thyroid Function ◽  
Ovarian Reserve ◽  
Statistical Significance ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Reproductive Age ◽  
Thyroid Peroxidase ◽  
Infertile Women ◽  
Positive Rate ◽  
Infertility Patients

ObjectiveTo analyze the correlation between ovarian reserve and thyroid function in women with infertility.MethodsRetrospective analysis of the data of 496 infertility patients who visited the clinic between January 2019 and December 2020. According to the TSH level, it is grouped into &lt;2.5 mIU/L, 2.5~4.0mIU/L and ≥4.0 mIU/L or according to the positive/negative thyroid autoimmune antibody. The relationship was assessed through the ovarian reserve, thyroid function, and anti-Müllerian hormone (AMH) levels in infertile patients. On the other hand, the patients are divided into groups according to age (≤29 years old, 30-34 years old and ≥35 years old), basic FSH (&lt;10 IU/L and ≥10 IU/L), and AMH levels. The ovarian reserve was evaluated through the AMH and the antral follicle count (AFC).ResultsThe average age of the patients was 30.31 ± 4.50 years old, and the average AMH level was 5.13 ± 4.30 ng/mL. 3.63% (18/496) of patients had abnormal TSH levels (normal: 0.35-5.5 mIU/L), the positive rate of thyroid peroxidase antibody (TPOAb) was 14.52% (72/496), the positive rate of anti-thyroglobulin antibody (TgAb) was 16.94% (84/496), and the positive rate of TPOAb and TgAb was 10.48% (52/496). After grouping according to TSH level or thyroid autoimmune antibody positive/negative grouping, the analysis found that there was no statistical significance in age, AMH level and basic FSH level among the groups (P&gt;0.05). There were no significant differences in the levels of TSH, FT3, and FT4 among different ages, AMH, and FSH levels (P&gt;0.05).ConclusionThere is no significant correlation between ovarian reserve and thyroid function in infertile women.

scholarly journals Effect of Tuberculosis on Ovarian Reserve of Patients undergoing in vitro Fertilization

2015 ◽  
Vol 6 (2) ◽  
pp. 73-83 ◽  
Author(s):  
Prabhjot Singh Hans ◽  
Mohan Lal Swarankar ◽  
Swati Garg ◽  
Manisha Chowdhary ◽  
Karnika Tiwari
Keyword(s):  
Ovarian Reserve ◽  
Past History ◽  
Transvaginal Ultrasound ◽  
Serum Levels ◽  
Control Group ◽  
Genital Tuberculosis ◽  
Chi Square ◽  
Vitro Fertilization ◽  
Infertile Women

ABSTRACT Aim To assess ovarian reserve, in infertile women with genital tuberculosis, planning to undergo in vitro fertilization (IVF) and to compare it with infertile women without genital tuberculosis, planning to undergo IVF. Materials and methods The study group consisted of 100 women with genital tuberculosis and the control group of 100 women who had no present or past history of tuberculosis. A diagnosis of genital tuberculosis was made based either on the results of tests performed from an endometrial aspiration sample or on histopathologic, hysterosalpingography, hysteroscopy, or laparoscopy findings. Basal ovarian reserve studies included measuring serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and E2 on day 3 of a natural cycle. On the same day, the participants underwent a transvaginal ultrasound examination by means of a two-dimensional 5.0 MHz probe fitted to a Toshiba Famio 5. Ovarian volume and number of antral follicles were estimated for each ovary on the same day of hormonal assessment. Control participants underwent the same tests on day 2 or 3 of their menstrual cycle. Unpaired or independent t-test and Chi-square test were used for statistical analysis. Results The present study highlights that women with genital tuberculosis have poor ovarian reserve in comparison to women of similar age without tuberculosis. Conclusion It can be concluded that there is no single absolute method of assessing ovarian reserve, but a combination of methods can closely predict the outcome of IVF cycles in women with genital tuberculosis. How to cite this article Hans PS, Swarankar ML, Garg S, Chowdhary M, Tiwari K. Effect of Tuberculosis on Ovarian Reserve of Patients undergoing IVF. Int J Infertil Fetal Med 2015;6(2):73-83.

Features of the ovarian reserve of women of reproductive age suffering from autoimmune diseases

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (5) ◽  
pp. 27-30
Author(s):  
Elena N. Andreeva ◽  
Olga R. Grigoryan ◽  
Yulia S. Absatarova ◽  
Irina S. Yarovaya ◽  
Robert K. Mikheev
Keyword(s):  
Type 1 Diabetes ◽  
Thyroid Gland ◽  
Autoimmune Diseases ◽  
Ovarian Reserve ◽  
Reproductive Potential ◽  
Reproductive Age ◽  
Control Group ◽  
Antithyroid Antibodies ◽  
Healthy Women

The reproductive potential of a woman depends on indicators of the ovarian reserve, such as the anti-Muller hormone (AMH) and the number of antral follicles (NAF). Autoimmune diseases have a significant effect on fertility and contribute to the development of premature ovarian failure. Aim.To evaluate the parameters of the ovarian reserve in patients with type 1 diabetes mellitus, carriers of antibodies to the thyroid gland in a state of euthyroidism and compare them with similar parameters in healthy women. Materials and methods.In the first block of the study, the level of AMH, follicle-stimulating hormone, luteinizing hormone, NAF was studied among 224 women with diabetes and 230 healthy women in the control group. In block II, the level of the above hormonal indices was studied in 35 carriers of antithyroid antibodies in the state of euthyroidism and 35 healthy women. Results.In patients with type 1 diabetes, the level of AMH, NAF was statistically significantly lower when compared with the control group. Among carriers of antithyroid antibodies and healthy women, no difference in AMH and NAF was found. Conclusion.The autoimmune processes accompanying diabetes are more influenced by the ovarian reserve indices than autoimmune aggression to the tissues of the thyroid gland.

Sign in / Sign up

Export Citation Format

Share Document