scholarly journals Seroprevalence of Fasciola infection among Iranian patients hospitalized during the initial wave of COVID-19

2021 ◽  
Author(s):  
Fatemeh Balazadeh ◽  
Mohammad Zibaei ◽  
Aliehsan Heidari ◽  
Hadis Rastad ◽  
Farzaneh Firoozeh
Keyword(s):  
Initial Wave ◽  
Iranian Patients

Assessment of Risk Factors for Severe Coronavirus Disease 2019 among Iranian Patients

2020 ◽  
Keyword(s):  
Risk Factors ◽  
Immune System ◽  
Medical Records ◽  
Critical Role ◽  
Diabetic Patients ◽  
Medication History ◽  
Epidemiological Features ◽  
Hookah Smoking ◽  
And Behavior ◽  
Iranian Patients

Background: The outbreak of Coronavirus Disease 2019 (COVID-19) has led to a major concern for those who are more vulnerable to infections. Objectives: This study aimed to evaluate the most important risk factors for severe COVID-19 pneumonia. Methods: This retrospective study included information on clinical and epidemiological features of 105 patients with severe COVID-19 pneumonia hospitalized in Tajrish Hospital, Tehran, Iran. Initially, the medical records of the patients were investigated, and an interview was conducted based on a pre-prepared checklist to seek information about symptoms, past medical history, medication history, and behavior before hospitalization. Results: Out of 105 participants, 76 (72.5%) cases were male, and 54 (51.4%) patients were older than 54 years old. The majority of the patients (n=18; 17.1%) had both hypertension and diabetes (n=12; 11.4%). Metformin (n=36; 34.3%) was the most used medication amongst the studied patient. In addition, 24 (22.9%) patients were recreational hookah smokers, and the majority (75%) of them were under the age of 46 years old. Eventually, 19 patients were excluded from the study, of whom 11 individuals had diabetes, and 10 cases were using metformin. Conclusion: Apparently, hookah smoking played a critical role in the spread of COVID-19 in Iran and has made younger people more susceptible. In addition to older age, the immunosuppressive effects of Metformin seem to make diabetic patients with an impaired immune system more vulnerable to severe COVID-19 pneumonia. More studies on the immune system of vulnerable individuals by identifying their differences can help to protect them.

scholarly journals Neurological manifestations of COVID-19: with emphasis on Iranian patients

2021 ◽  
Author(s):  
Cynthia Aslan ◽  
Sepideh Nikfarjam ◽  
Mohammad Asadzadeh ◽  
Reza Jafari
Keyword(s):  
Neurological Manifestations ◽  
Iranian Patients

scholarly journals Association between colorectal cancer and Fusobacterium nucleatum and Bacteroides fragilis bacteria in Iranian patients: a preliminary study

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Aref Shariati ◽  
Shabnam Razavi ◽  
Ehsanollah Ghaznavi-Rad ◽  
Behnaz Jahanbin ◽  
Abolfazl Akbari ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Relative Abundance ◽  
Normal Tissue ◽  
Bacteroides Fragilis ◽  
Fusobacterium Nucleatum ◽  
Normal Mucosa ◽  
Clinicopathologic Characteristics ◽  
Tissue Samples ◽  
Adjacent Normal Mucosa ◽  
Iranian Patients

Abstract Background and aim Recent studies have proposed that commensal bacteria might be involved in the development and progression of gastrointestinal disorders such as colorectal cancer (CRC). Therefore, in this study, the relative abundance of Fusobacterium nucleatum, Bacteroides fragilis, Streptococcus bovis/gallolyticus, and Enteropathogenic Escherichia coli (EPEC) in CRC tissues, and their association with clinicopathologic characteristics of CRC was investigated in Iranian patients. Moreover, the role of these bacteria in the CRC-associated mutations including PIK3CA, KRAS, and BRAF was studied. Method To these ends, the noted bacteria were quantified in paired tumors and normal tissue specimens of 30 CRC patients, by TaqMan quantitative Real-Time Polymerase Chain Reaction (qPCR). Next, possible correlations between clinicopathologic factors and mutations in PIK3CA, KRAS, and BRAF genes were analyzed. Results In studied samples, B. fragilis was the most abundant bacteria that was detected in 66 and 60% of paired tumor and normal samples, respectively. Furthermore, 15% of the B. fragilis-positive patients were infected with Enterotoxigenic B. fragilis (ETBF) in both adenocarcinoma and matched adjacent normal samples. F. nucleatum was also identified in 23% of tumors and 13% of adjacent normal tissue samples. Moreover, the relative abundance of these bacteria determined by 2-ΔCT was significantly higher in CRC samples than in adjacent normal mucosa (p < 0.05). On the other hand, our findings indicated that S. gallolyticus and EPEC, compared to adjacent normal mucosa, were not prevalent in CRC tissues. Finally, our results revealed a correlation between F. nucleatum-positive patients and the KRAS mutation (p = 0.02), while analyses did not show any association between bacteria and mutation in PIK3CA and BRAF genes. Conclusion The present study is the first report on the analysis of different bacteria in CRC tissue samples of Iranian patients. Our findings revealed that F. nucleatum and B. fragilis might be linked to CRC. However, any link between gut microbiome dysbiosis and CRC remains unknown.

Psychometric evaluation of the Persian version of the spiritual well-being scale (SWBS) in Iranian patients with cancer

2021 ◽  
pp. 1-9
Author(s):  
Hamid Sharif Nia ◽  
Mobin Mohammadinezhad ◽  
Kelly A. Allen ◽  
Christopher Boyle ◽  
Saeed Pahlevan Sharif ◽  
...  
Keyword(s):  
Discriminant Validity ◽  
Psychometric Evaluation ◽  
Well Being ◽  
Validity And Reliability ◽  
Cross Sectional ◽  
Patients With Cancer ◽  
Persian Version ◽  
Convergent And Discriminant Validity ◽  
Spiritual Well Being ◽  
Iranian Patients

Abstract Objective The spiritual well-being scale (SWBS) is a widely used clinical scale which should be evaluated for Iranian patients with cancer. The aim of this study is to evaluate the psychometric properties of the Persian version of the SWBS in Iranian patients with cancer. Method This cross-sectional, methodological study was conducted among Iranian patients with cancer (n = 400). The participants were recruited using convenience sampling. The content, construct, convergent and discriminant validity, and reliability of the Persian version of the SWBS were evaluated. Results A two-factor structure for the scale was indicated with the factors being: connecting with God and meaningless life that explained 54.18% of the total variance of the concept of spiritual well-being. The results demonstrated the model had a good fit. Cronbach's alpha, McDonald's omega, and the inter-item correlation values of the factors indicated good internal consistency of the scale. Significance of results These results suggest that the Persian version of the SWBS is a reliable and valid measure to assess the spiritual well-being of patients with cancer through 16 items related to connecting with God and meaningless life.

scholarly journals Influence of Tsunami Aspect Ratio on Near and Far-Field Tsunami Amplitude

Geosciences ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 178
Author(s):  
Natalia K. Sannikova ◽  
Harvey Segur ◽  
Diego Arcas
Keyword(s):  
Aspect Ratio ◽  
Near Field ◽  
Decay Rates ◽  
Far Field ◽  
Present Evidence ◽  
Positive Wave ◽  
Initial Wave ◽  
N Wave ◽  
Tsunami Amplitude ◽  
Wave Shapes

This study presents a numerical investigation of the source aspect ratio (AR) influence on tsunami decay characteristics with an emphasis in near and far-field differences for two initial wave shapes Pure Positive Wave and N-wave. It is shown that, when initial total energy for both tsunami types is kept the same, short-rupture tsunami with more concentrated energy are likely to be more destructive in the near-field, whereas long rupture tsunami are more dangerous in the far-field. The more elongated the source is, the stronger the directivity and the slower the amplitude decays in the intermediate- and far-fields. We present evidence of this behavior by comparing amplitude decay rates from idealized sources and showing their correlation with that observed in recent historical events of similar AR.

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