scholarly journals Clinicopathological study of renal tumours in surgically excised specimens

2020 ◽  
Vol 11 (4) ◽  
pp. 5335-5343
Author(s):  
Pranita Warhate ◽  
Jagtap S V ◽  
Sujata Kanetkar
Keyword(s):  
Renal Cell ◽  
Clinical Results ◽  
Flank Pain ◽  
Malignant Tumours ◽  
Medical Sciences ◽  
Female Ratio ◽  
Renal Tumours ◽  
Clinicopathological Study ◽  
Male Female Ratio ◽  
Male Preponderance

A study on Clinicopathological Study Of Renal Tumours In Surgically Excised Specimens was conducted for two years from June 2016 to May 2018. The study was on twenty-eight surgically excised specimens of renal tumours in the Department of Pathology of Krishna Institute of Medical Sciences at Karad District in Satara, Maharastra, India. The observed results stood as 75% of Radical Nephrectomy, 17.85% of renal biopsies and partial Nephrectomy in 7.14% cases. The reading revealed 28.5% of cases, that is, a maximum number were found in their 6th decade of life. The rest of the cases, 21.42% were either septuagenarian or quadragenarian. The male preponderance was noted with Male: Female ratio 2.5:1. Out of 28 cases of renal tumours, 50% of cases had flank pain, 28.57% cases with flank pain associated with hematuria in A maximum number of instances had issues that were involving the left-sided kidney. The most common site for tumour involvement was upper pole comprising of 35.71% followed by the lower pole in 28.57% of cases. In a maximum number of instances, grossly the size of tumour ranged from 0-4 cm. Out of all malignant tumours, Renal Cell Carcinoma-RCC was the most common tumour comprising (75%). The majority (42.10%) of renal cell carcinomas were of Fuhrman nuclear grade II. Majority of cases (56.5%) were at TNM stage I. A detailed histopathology examination and routine H and E staining help - to diagnose accurately and to determine the various histological type, subtype. It also helps to evaluate other histopathological determinants. The clinical results shifts as per the histologic subtypes.

scholarly journals Anastomosing hemangioma of the kidney: radiologic and pathologic distinctions of a kidney cancer mimic

2018 ◽  
Vol 25 (3) ◽  
pp. 220 ◽  
Author(s):  
P.M. Cheon ◽  
R. Rebello ◽  
A. Naqvi ◽  
S. Popovic ◽  
M. Bonert ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Lymph Node ◽  
Renal Cell ◽  
Vascular Tumour ◽  
Node Dissection ◽  
Malignant Tumours ◽  
Genitourinary System ◽  
Biopsy Specimens ◽  
Renal Tumours ◽  
Anastomosing Hemangioma

Anastomosing hemangioma (ah) is a rare subtype of primary vascular tumour that can, clinically and radiologically, present similarly to malignant renal tumours such as renal cell carcinoma (rcc) and angiosarcoma. Rarely seen in the genitourinary system, the ah we report here occurred in a 40-year-old male patient diagnosed initially with rcc based on imaging and successfully treated by laparoscopic left radical nephrectomy, with adrenal sparing and perihilar lymph node dissection. The pathologic diagnosis of ah can be challenging on small biopsy specimens; we therefore opine that it is appropriate to excise these lesions to facilitate diagnosis and definitively exclude common renal cancers. However, in this review, we describe some radiologic and pathologic distinctions between ah and malignant tumours.

Age at Onset and Sex Ratio in Cluster Headache: Observations Over Three Decades

Cephalalgia ◽  
2002 ◽  
Vol 22 (2) ◽  
pp. 94-100 ◽  
Author(s):  
K Ekbom ◽  
DA Svensson ◽  
H Träff ◽  
E Waldenlind
Keyword(s):  
Cluster Headache ◽  
Age At Onset ◽  
Chronic Cluster Headache ◽  
Hormone Regulation ◽  
Female Ratio ◽  
Age Related ◽  
Episodic Cluster Headache ◽  
Headache Onset ◽  
Male Female Ratio ◽  
Male Preponderance

Five hundred and fifty-four patients with episodic cluster headache (ECH) and chronic cluster headache (CCH) were examined between 1963 and 1997. Mean age at onset was significantly higher in women with CCH compared with women with ECH and in men with ECH or CCH. In women with CCH age at onset was evenly distributed from 10 to 69 years, whereas in men with CCH and in both sexes with ECH, there was a peak when they were in their 20s. In women with ECH a second peak of onset occurred in their 50s. Although not statistically significant, primary CCH started later in women (mean 50.8 years) than secondary CCH (mean 35.5 years). There was a significant variation in the male : female ratio with respect to age at onset, being largest between 30 and 49 years of age (ECH 7.2 : 1; CCH 11.0 : 1) and lowest after 50 (ECH 2.3 : 1; CCH 0.6 : 1). During the observation period of more than 30 years there was a trend towards a decreasing male preponderance; the male: female ratio was significantly higher among patients with onset before rather than after 1970. The proportion of episodic vs. chronic CH did not change during the study period. The nature of the sex- and age-related pattern of cluster headache onset remains to be elucidated but mechanisms associated with sex hormone regulation, perhaps of hypothalamic origin, may be involved, as well as environmental factors related to lifestyle.

scholarly journals Study of glottic lesions in patients undergoing microlaryngeal surgery

2020 ◽  
Vol 6 (2) ◽  
pp. 277
Author(s):  
Vikrant Mittal ◽  
Manish Munjal ◽  
Rohit Verma ◽  
Parth Chopra ◽  
Hemant Chopra
Keyword(s):  
Clinical Diagnosis ◽  
Histopathological Examination ◽  
Detailed Examination ◽  
Histopathological Diagnosis ◽  
Female Ratio ◽  
Histopathological Correlation ◽  
Male Female Ratio ◽  
Male Preponderance ◽  
Vocal Nodules ◽  
Microlaryngeal Surgery

<p class="abstract"><strong>Background:</strong> Vocal cords are the most common site of laryngeal pathologies. Hoarseness is the sentinel symptom for lesions affecting the glottis. The aim of this study was to categorize various types of lesions affecting the glottis in patients undergoing microlaryngeal surgery. Patients’ demographic profile, gender, occupational factors were studied. Clinical, microlaryngeal and histopathological correlation of the lesions was done.</p><p class="abstract"><strong>Methods:</strong> 50 patients with glottic pathologies undergoing microlaryngeal surgery were included. Patients underwent detailed examination including indirect laryngoscopy, flexible fibreoptic laryngoscopy, followed by microscopic laryngeal examination under general anaesthesia. The lesions were excised using standard microlaryngeal instruments and the specimens were subjected to histopathological examination. The data was analysed.  </p><p class="abstract"><strong>Results:</strong> There was male preponderance (male: female ratio of 1.27:1). Housewives formed the largest group (28%). Commonest pathologies were vocal nodules (34%), vocal polyps (22%) and carcinoma (22%). Microlaryngoscopy was found to be the best means of visualizing the lesions and reaching a clinical diagnosis. In 10 (20%) patients, the final histopathological diagnosis was different from clinical diagnosis.</p><p class="abstract"><strong>Conclusions:</strong> In this study, vocal nodules were the commonest lesions to affect the glottis. Microlaryngoscopy proved to be the best method for examination. Also, there was discrepancy in the clinical and histopathological diagnosis in 20% cases.</p>

scholarly journals Clinical- pathological features and surgical outcome of renal cell carcinoma: Experience from a zonal referral hospital-northern of Tanzania

2021 ◽  
Vol 12 (2) ◽  
pp. 434-440
Author(s):  
Vitus Kajerero ◽  
Frank Bright ◽  
Orgeness J. Mbwambo ◽  
Alfred K. Mteta ◽  
Patrick Amsi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Advanced Disease ◽  
Abdominal Mass ◽  
Significant Proportion ◽  
Flank Pain ◽  
Pathological Feature ◽  
Female Ratio

Background: Renal cell carcinoma (RCC) is the most common primary malignant tumour of kidney in adults. Recent studies from developed countries have shown that most renal tumour are currently diagnosed incidentally during screening for other disease which leads to better prognosis while few studies done in Africa still shows significant proportion of patients present with classic triad ( >10%) which is a sign of advanced disease. Objectives: This study aimed at determining clinical pathological feature and outcome of RCC in Northern zone of Tanzania. Patients and Methods: This was a hospital based descriptive retrospective cohort study conducted at Kilimanjaro Christian Medical (KCMC) from January 2002 to December 2017. Data were analysed using statistical package for social science (SPSS) version 16. 0 and summarized in tables and figures. Results: Forty three patients (43) underwent radical nephrectomy for RCC during the study period. Male to female ratio was1. 7: 1 with mean age of 53+/- 12 years. Flank pain (84%), abdominal mass (76%) and hematuria (44%) were the most common clinical presentation while classical triad was found in 40%. The most common clinical tumor stage was T3(72. 1%) whilst clear cell carcinoma was the commonest histological pattern. Five years survival length for T1, T2, T3 and T4 were 100%, 62. 5%, 32. 3% and 0% respectively. Conclusion: The most common presenting symptom of RCC in our centre is flank pain, and abdominal mass. Majority of the patients presented with advanced disease with less than five year survival rate. Clear cell type was the predominant histological type.

Electrocution deaths reported in South Delhi, India: A retrospective analysis of 16 years of data from 2002 to 2017

2019 ◽  
Vol 59 (4) ◽  
pp. 240-246
Author(s):  
Chittaranjan Behera ◽  
Asit Kumar Sikary ◽  
Ravi Rautji ◽  
Sudhir Kumar Gupta
Keyword(s):  
Retrospective Analysis ◽  
Low Voltage ◽  
Monsoon Season ◽  
Time Of Day ◽  
The Body ◽  
New Delhi ◽  
Adult Males ◽  
Medical Sciences ◽  
Female Ratio ◽  
Male Female Ratio

This study is a retrospective analysis of 428 cases of electrocution deaths in the region of South Delhi, India, which were autopsied at the All India Institute of Medical Sciences, New Delhi, during the 16-year period 2002–2017. The cases were analysed with regard to the age and sex of the victim, season of the year, site of the body, time of day, place of occurrence and presence of entry and exit wounds on the body. The cases represented approximately 1.8% of all autopsy cases during the period. The main findings of the study showed that the majority of cases involved adult males at home during the monsoon season, with a low-voltage electrical supply affecting the upper extremities. This study also confirms that not all cases of electrocution show electrocution marks. Comparison with an older study undertaken within the same population showed no difference in the pattern of cases, apart from a decreasing male-female ratio.

scholarly journals Histomorphological Study of Renal Tumours – A Single Centre Experience

2020 ◽  
Vol 7 (49) ◽  
pp. 2943-2947
Author(s):  
Vinay Kyasakkala Sannaboraiah ◽  
Sujatha Siddappa
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Pathological Stage ◽  
Malignant Tumours ◽  
Renal Tumours ◽  
Common Grade ◽  
Grade Ii ◽  
Benign Tumours

BACKGROUND Renal tumours encompass a wide spectrum as distinct entities both in adults and in children. Renal cell carcinomas constitute majority of all renal neoplasms. Proper typing of renal tumours is not possible before surgery and histopathological examination. Accurate histopathological diagnosis and proper tumour typing is very important for early and proper surgical treatment. We wanted to study the various histomorphological patterns of renal tumours. METHODS We studied nephrectomy specimens with renal tumours received in the department of pathology from January 2018 to June 2020 (2 years 6 months, retrospective study). A total of 29 cases with renal tumours were included. Relevant Clinical details along with gross findings were recorded from the histopathology forms. Nephrectomy specimens were fixed overnight in 10 % formalin. Gross examination was done, representative tissue bits taken, routinely tissue processed, embedded and the sections were cut (4 – 5 microns). Haematoxylin and Eosin staining was done. Pathological diagnosis was done by two pathologists and arrived at a common consensus. RESULTS A total of 29 cases were included in our study. Of these 16 patients were male and 13 were female, with a male to female ratio of 1.2: 1. Most common age group affected was 5th decade. Mean age was 48 years. Out of 29 cases, 24 cases were malignant (82.75 %) and 5 cases were benign (17.24 %). Renal cell carcinoma (RCC) accounted for 18 cases out of 24 malignant tumours. Clear cell RCC was common subtype with 13 cases followed by 3 cases of chromophobe RCC and 2 cases of papillary RCC. In benign tumours, we had 4 cases of angiomyolipoma and 1 case of oncocytoma. Right sided kidney was affected with 17 cases (58.62 %) and left sided kidney 12 cases (41.7 %). Common tumour location was in upper pole. Pathological stage pT1 was seen in 9 cases followed pT2-5 cases, pT3-4 and pT4-2 cases. WHO / ISUP nuclear grading was noted. Grade II was seen in 11 cases followed by grade III seen in 4 cases. CONCLUSIONS Malignant renal tumours were most common than the benign tumours. Renal cell carcinoma was most common of the malignant tumours. Clear cell RCC was the most common subtype. Pathological stage pT1 was most common. Grade II was the most common grade. Proper histological typing, staging and grading are important for appropriate surgical treatment of renal tumours. KEYWORDS Renal Tumours, Renal Cell Carcinoma, Nephrectomy

scholarly journals KIDNEY OPEN RESECTION IN RENAL CELL CARCINOMA

2018 ◽  
Vol 6 (2) ◽  
pp. 54-61 ◽  
Author(s):  
S. V. Shkodkin ◽  
Yu. B. Idashkin ◽  
S. A. Fironov ◽  
V. V. Fentisov ◽  
A. N. Udovenko
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Open Resection ◽  
Open Partial Nephrectomy ◽  
Female Ratio ◽  
Bladder Drainage ◽  
Nephron Sparing ◽  
Male Female Ratio ◽  
Oncological Results

Introduction.Generally recognized critical moments in kidney resection are the time of ischemia and the adequacy of hemostasis. Until now, one of the main contraindications to nephron-sparing treatment is the inability to provide hemostasis in middle-segment tumors, especially when they are intrarenal.Purpose of research.To evaluate the effectiveness of open resection of the kidney.Materials and methods.For the period 2005 to 2018 us made 152 open partial nephrectomy (OPN) for renal cell carcinoma. The algorithm OPN included extra peritoneal lumbotome access in the IX intercostal space with resection of the X rib resection under conditions of warm ischemia for compression of the blood vessel, in 92.8% of cases completed the clamping of segmental or aberrant arteries. Resection was performed, retreating from the tumor 0.5-1 cm within the unchanged renal parenchyma.Results.The mean age of patients was 55.4±16.2 years; male/female ratio was 52.6/47.4%; right-sided/ left-sided tumor localization was 42.1/57.9%, respectively. The duration of the operation was 109.6±56.7 min, the time of partial ischemia was 15.1±8.3 min, the volume of blood loss was 258±93 ml the Discharge along the drains lasted for 4-12 hours after the operation and averaged 35.7±22.1 ml. Patients were activated after 24 hours, when the urethral catheter was removed, in 59 (38.8%) cases, bladder drainage was not performed. Average postoperative hospital stay was 10.1±4.2 per day.Conclusion.The technique of open resection of the kidney with a margin from the border of the visible tumor and visual control of the surgical edge provides good oncological results, does not require the «Express» histology and is an alternative to nephrectomy in patients with high risk of complications, calculated on morphometric scales.Disclosure: The study did not have sponsorship. The authors declare no conflict of interest.

A Clinicopathological Study of Ossifying Fibromas and Comparison between Central and Peripheral Ossifying Fibromas

2012 ◽  
Vol 13 (4) ◽  
pp. 509-514 ◽  
Author(s):  
Santosh Hunasgi ◽  
Vandana Raghunath
Keyword(s):  
Statistical Significance ◽  
Female Ratio ◽  
Histopathological Features ◽  
Significant Difference ◽  
Predominant Cell Type ◽  
Clinicopathological Study ◽  
Male Female Ratio ◽  
The Mean ◽  
Radiographic Changes ◽  
Larger Sample

ABSTRACT Aims and objectives To study the clinical, histological features of peripheral and central ossifying fibromas and also to compare between them. Materials and methods The sample comprised a total 50 cases of ossifying fibromas [25 central ossifying fibromas (COF) and 25 peripheral ossifying fibromas (POF)] inclusive of cemento-ossifying fibromas. Results The mean age is 28.2 years in POF and 24.7 years in COF. The male: female ratio was 1:1.5 in POF and 1:1.8 in COF. The size of the lesions varied from 0.45 to 2.75 cm in cases of POF and in COF, it ranged from 1.25 to 13.5 cm. COF showed more duration (1-8 years) when compared with POF (1-3). Majority of cases of COF showed radiolucent, mixed radiolucent and radiopaque unilocular lesions. The predominant cell type in both POF and COF was a combination of both ovoid and spindle cells. Regarding vascularity it showed mild, moderate and intense vascularity. On comparison of all stromal changes between POF and COF showed no statistically significant difference. Conclusion The clinical parameters and radiographic changes of POF and COF in our study were similar to the previous studies. Histopathological features like type of cells, cellularity and vascularity in POF and COF were similar to previous studies. However, when clinical and histopathological features were compared between POF and COF showed no statistical significance except for site of the lesion. These features signify the behavior of two lesions. Further research on larger sample might give more insights into these lesions. How to cite this article Hunasgi S, Raghunath V. A Clinicopathological Study of Ossifying Fibromas and Comparison between Central and Peripheral Ossifying Fibromas. J Contemp Dent Pract 2012;13(4):509-514.

Homicide patterns for the last 20 years in South and South East Delhi, India

2019 ◽  
Vol 59 (2) ◽  
pp. 83-94
Author(s):  
Chittaranjan Behera ◽  
Asit Kumar Sikary ◽  
Sudhir Kumar Gupta
Keyword(s):  
Head Injury ◽  
Social Stress ◽  
Monsoon Season ◽  
Age Groups ◽  
New Delhi ◽  
Medical Sciences ◽  
Female Ratio ◽  
Younger Age ◽  
Male Female Ratio ◽  
Head Neck

Homicide patterns are a useful indicator of social stress in a community, and they provide law-enforcement authorities with helpful information. This study was undertaken at the All India Institute of Medical Sciences, New Delhi, India, in order to understand the regional pattern of homicide. Data from the last 20 years were analysed. There were a total of 1048 male and 323 female homicide cases. The male/female ratio was about 3:1, and the proportion of total autopsies was approximately 4% for both sexes. The most common age group was 11–40 years old. Female cases were more common during the monsoon season, but male cases did not show any such variation. Blunt-force head injury, stabbing, strangulation and shooting were the most common methods, and the head, neck and chest were the most commonly targeted areas. Defence injuries were seen in 7.9% cases, significantly more often amongst men, most of which were active and in the form of incised wounds. About 17% of cases survived in hospital for up to a month before succumbing to their injuries, with males being in their 50s and 60s and females in younger age groups. Most of these cases suffered a gunshot wound, followed by a head injury and a stab wound.

scholarly journals A clinical study of respiratory distress in neonates

2019 ◽  
Vol 6 (6) ◽  
pp. 2292
Author(s):  
Ramkesh Meena ◽  
Mallikarjun R. Kobal ◽  
Sharanabasappa S. Dhanwadkar ◽  
Ashwini Kumari N. B.
Keyword(s):  
Respiratory Distress ◽  
Neonatal Period ◽  
Neonatal Morbidity ◽  
Hyaline Membrane Disease ◽  
Medical Emergency ◽  
Premature Delivery ◽  
Female Ratio ◽  
Medical College ◽  
Male Female Ratio ◽  
Male Preponderance

Background: Respiratory distress is a medical emergency responsible for most of the admissions in NICUs during neonatal period. It is a major contributor to neonatal morbidity and mortality and results from a variety of respiratory and non-respiratory etiology. It occurs in 0.96 to 12% of live births and responsible for about 20% of neonatal mortality. Aim of study to find out the proportion of patients with different etiology of respiratory distress in neonates.Methods: The present study is a prospective, descriptive study which was carried out at neonatal units attached to SMS Medical College, Jaipur. All the neonates with respiratory distress admitted in NICU admitted from April 2012 to March 2013were selected for the present study. Detailed history including antenatal history, natal history, postnatal history with thorough clinical examinations and investigations done in each case and were recorded in the performa.Results: A total of 500 neonates were admitted and among them 375 were inborn (delivered in our hospitals) and 125 out-born (referred to our hospitals from outside). In inborn group hyaline membrane disease (HMD) was the most common cause (32%) of respiratory distress and in out-born congenital pneumonia/septicaemia (34.4%). There was male preponderance in both inborn and out-born groups with male: female ratio 1.45:1 and 1.6:1 respectively.Conclusions: Majority of cases in both inborn and out-born groups were preterm (56.8% and 54.4% respectively) which emphasises the need for care of mother during antenatal period for prevention of premature delivery.

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