scholarly journals The use of extemporal dosage form with pyroctone olamine in the complex treatment of patients with seborrheic dermatitis

2021 ◽  
Vol 26 (1) ◽  
pp. 191-196
Author(s):  
I.V. Odintsova ◽  
A.D. Diudiun
Keyword(s):  
Therapeutic Efficacy ◽  
Dosage Form ◽  
Comparison Group ◽  
Seborrheic Dermatitis ◽  
Local Treatment ◽  
Clinical Manifestations ◽  
Main Group ◽  
Long Term Results ◽  
Comprehensive Treatment ◽  
Complex Treatment

The purpose of the work is to evaluate the efficacy and tolerance of extemporal dosage form with pyroctone olamine in the local treatment of patients with seborrheic dermatitis. Under our supervision there were 78 patients with seborrheic dermatitis aged 18 to 57 years. The average age of the patients was 29.5±2.1 years. Comprehensive treatment of patients with seborrheic dermatitis in both groups depended on the severity of clinical manifestations, the duration of the disease, and information on the effectiveness of previous therapy. For external treatment of the main group of patients with seborrheic dermatitis, an extemporaneously prepared gel with pyrocton olamine was used. Local treatment of patients in the comparison group consisted of the appointment of 1% cream of clotrimazole. An analysis of the results shows good therapeutic, microbiological effectiveness and good tolerance of extemporaneously prepared gel with pyrocton olamine in the complex treatment of patients with seborrheic dermatitis. The period for resolving the clinical manifestations of seborrheic dermatitis among patients in the main group was 2.5±0.1 days shorter compared with patients in the comparison group. The intensity of clinical manifestations in patients with seborrheic dermatitis of the main group decreased twice on the second day of complex treatment. In control patients with comparative seborrheic dermatitis, similar therapeutic efficacy was achieved on the fourth to fifth day. Long-term results of the study showed that the recurrence of the disease among patients of the main group was 5 (6.4%), and in patients of in the comparison group was 14 (17.9%). Clinical studies have shown good therapeutic efficacy and tolerance of the extemporal gel with pyroctone olamine in the complex treatment of patients with seborrheic dermatitis, which gives reason to recommend this dosage form for wider use in the practice of dermatovenerologists.

scholarly journals ALGORITHM OF COMPLEX TREATMENT OF DESTRUCTIVE FORMS OF PULMONARY TUBERCULOSIS AND ITS RATIONALE

2021 ◽  
Vol 19 (1) ◽  
pp. 36-39
Author(s):  
Yu. A. Sheifer ◽  
◽  
I. S. Gelberg ◽  
Keyword(s):  
Drug Resistance ◽  
Pulmonary Tuberculosis ◽  
Comparison Group ◽  
Main Group ◽  
Long Term Results ◽  
Complex Treatment ◽  
Results Of Treatment ◽  
Artificial Pneumothorax ◽  
Cavity Closure

Background. In destructive forms of pulmonary tuberculosis, especially in the presence of drug resistance of mycobacteria, one of the ways to increase the effectiveness of therapy is the use of collapse therapeutic techniques in various modifications. Purpose of the study: to develop and substantiate an algorithm for complex treatment of destructive forms of pulmonary tuberculosis, using artificial pneumothorax (AP). Material and methods: A cohort of 84 people with destructive pulmonary tuberculosis was formed. It was divided into two groups: 42 patients in the main group (chemotherapy (ChT) + AP) and 42 in the comparison group (ChT). Results: an algorithm for the treatment of patients with destructive forms of pulmonary tuberculosis was formulated. Within a period of up to 6 months, abacillation was achieved in 61.9% of cases in the main group (MG), and in 18.9% (p <0.05) in the comparison group (CG). By the 10th month of treatment, the closure of decay cavities was achieved in 78.7% of cases in the MG and in 42.8% (p <0.05) in the CG. By 12 months the closure of decay cavities was observed in 92.1 and 52.4% of cases respectively (p <0.05). Conclusions: The use of the algorithm for the complex treatment of destructive forms of pulmonary tuberculosis makes it possible to achieve abacillation at an earlier time (up to 6 months - in 61.9%). It also allows to increase the frequency of cavity closure by 39.6% as well as achieve an increase in clinical cure (according to long-term results of treatment) by 23.8% and a decrease in the amplification of drug resistance and mortality by 14.3% and 11.9% correspondingly.

scholarly journals OPTIMIZATION OF THE VACUUM-ASSISTED TREATMENT FOR COMPLICATIONS OF DIABETIC FOOT SYNDROME

2019 ◽  
Vol 23 (5-6) ◽  
pp. 15-19
Author(s):  
V.I. Liakhovskyi ◽  
O.O. Kyzymenko ◽  
O.H. Krasnov ◽  
O.I. Krasnov ◽  
T.V. Horodova-Andrieieva
Keyword(s):  
Diabetic Foot ◽  
Topical Treatment ◽  
Comparison Group ◽  
Local Treatment ◽  
Main Group ◽  
Diabetic Foot Syndrome ◽  
Comprehensive Treatment ◽  
Vacuum Therapy ◽  
Second Phase ◽  
Wide Range

The nature of reparative and morphological changes in wounds was examined against the background of vacuum therapy in the comprehensive treatment of purulent and necrotic lesions of diabetic foot syndrome. We conducted comprehensive examination and treatment of 107 patients with DFS of grade II-IV according to Meggit-Wagner. The average age of patients was 53.2–4.3 years; there were 39 (36.4%) male and 68 (63.6%) female patients. Depending on the methods of topical treatment, patients were divided into two groups. The main group consisted of 55 (51.4%) subjects who underwent vacuum therapy during the topical treatment, and the comparison group comprised 52 (48.6%) patients who received standardized local treatment depending on the course of the wound process. In addition to the clinical studies, all patients underwent a comprehensive laboratory and instrumental examination, as well as measuring the area and pH of wounds on the 1st, 4th, 7th, 10th and 13th day after surgery. The analysis of the obtained results gives ground to establish that at a certain level of pH, there is a corresponding cytological pattern. The wide range of fluctuations in the pH of the wound medium in patients with purulent and necrotic lesions of diabetic foot syndrome leads to corresponding changes in cells, which is manifested by a long-lasting inflammatory process. In the main group, the rate of wound reduction was greatest on the 8th-10th days, and in the comparison group – on the 14th-15th days. Inpatient treatment was 14.2 bed-days in the main group and 23.5 ± 2.9 in the comparison group (p <0.05), respectively. Therefore, there is an acceleration of positive changes in clinical manifestations, cytological, morphological and pH-metric pattern against the background of conducting VT for an average of 5-7 days. The use of vacuum therapy makes it possible to accelerate the transition to the second phase of the wound process, which affects not only the time of treatment but also the outcome – preservation of the lower extremity in patients with diabetic foot syndrome.

PECULIARITY OF ADAPTATION OF BABIES ARE BORN PREMATURELY FROM MOTHERS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA

2021 ◽  
Vol 74 (10) ◽  
pp. 2566-2568
Author(s):  
Tunzala V. Ibadova ◽  
Vitalii V. Maliar ◽  
Volodymyr V. Maliar ◽  
Vasyl V. Maliar
Keyword(s):  
Connective Tissue ◽  
Premature Infants ◽  
Distress Syndrome ◽  
Comparison Group ◽  
Clinical Manifestations ◽  
Main Group ◽  
Phenotypic Markers ◽  
Group I ◽  
Neonatal Respiratory Distress ◽  
Connective Tissue Dysplasia

The aim: To evaluate the peculiarity of clinical manifestations of neonatal respiratory distress syndrome (NRDS) in deeply premature infants from mothers with phenotypic markers of undifferentiated connective tissue dysplasia (UCTD). Materials and methods: The study represent the results of a retrospective clinical and statistical analysis of 268 premature birth report card and newborn report sheet. .The main (1 group) included 50 pregnants with obvious phenotypic markers of UCTD, the comparison group (group 2) consisted of 50 pregnant women without phenotypic markers of UDCTD. Results: According to the study, in 12 (24%) pregnant women of the main group at the time of admission to the clinic had contractions,which required specific therapy. Cervical cerclage was performed in 38 (76%) patients of the main group due to the presence of cervical insufficiency (CI). In these cases, the severity of the CI on the Steinber scale was 7.2 &#177; 0.4 points in the main group against 4.4 &#177; 0.2 points in the comparison group (p &#60;0.05). Group I patients were more likely to have complications of labor such as:premature rupture of membranes, uterine contraction abnormalities and fetal distress, which required in most cases cesarean delivery (7% and 2%), respectively (p &#60;0.05). The incidence of neonatal complications requiring respiratory support was 67% in group I and 48% in group II. According to our observations, the clinical manifestations of bronchopulmonary dysplasia were twice as high in infants of the main group (66%) against (44%) of the comparison group (p &#60;0.05). Conclusions:1.Neonatal respiratory distress syndrome in premature infants is more often associated from mothers with UDCTD. 2. The high importance of steroid prophylaxis of NRDS and antioxidant therapy in reducing the frequency of mechanical ventilation and the development of bronchopulmonary pathology, especially in infants from mothers with UDCTD syndrome, has been proven. 3. The possibility of diagnosing disorders of functional maturation of the lungs in the fetal period using a non-invasive method of ultrasonography has been confirmed.

scholarly journals Depression with auto-aggressive manifestations in victims during a radiation disaster and fighting

2020 ◽  
pp. 23-29
Author(s):  
N. Оtroshchenko ◽  
P. Оtroshchenko
Keyword(s):  
Power Plant ◽  
Nuclear Power Plant ◽  
Medical Care ◽  
Nuclear Power ◽  
Comparison Group ◽  
Main Group ◽  
Chernobyl Nuclear Power Plant ◽  
Treatment Programs ◽  
Comprehensive Treatment ◽  
Joint Forces

Purpose. To increase the level of medical care for depression patients with autoaggressive manifestations (AM) in victims during a radiation disaster and fighting by developing new diagnostic and treatment programs. Material and methods. The object and methods of the study were 70 liquidators of the accident consequences at the Chernobyl nuclear power plant aged from 54 to 65 years old and 45 combatants of the Anti-terroristic operation (Joint forces operation) aged from 25 to 59 years old – comparison group, depression patients with AM, psychosomatic pathology were examined. For the main group and the comparisons group were used clinical and paraclinical methods, division into groups, according to diagnostic and treatment programs, therapy and follow-up from 2 months to 2 years. Results. The main group observed increasing depressive frequency disorders with AM in liquidators of the accident consequences at the Chernobyl nuclear power plant. The examination revealed asthenic – in 34 (48.6 %) patients, anxiety – in 13 (18.6 %), apathetic – in 8 (11.4 %), hypochondriac – in 7 (10 %), dysphoric – in 5 (7.1 %), obsessive-phobic – in 3 (4.3 %) variants of depression with AM. These particular disorders are characterized asthenic, anxiety and apathetic symptoms, progressive course, personality changes with organic and psychosomatic traits, cognitive deficit (р <0,05). In the comparison group, asthenic was found in 13 (28.3 %) patients, anxious in 11 (23.9 %), hypochondriac in 10 (21.7 %), dysphoric in 6 (13 %), and obsessive-phobic – in 3 (6.5 %) and apathetic variants – in 2 (4.4 %) depression with AM. After the participation in the Anti-terroristic operation (Joint forces operation) fighters exhibit depression with AM in combination with psychosomatic and personality traits, changes in the bioelectrical activity of the brain. These particular disorders are characterized asthenic, anxiety, hypochondriac symptoms, personality and psychosomatic traits (р <0,05). Conclusions. The proposed comprehensive treatment and diagnostic program will increase the level of medical care of the liquidators of the accident consequences at the Chernobyl nuclear power plant, combatants of the Anti-terroristic operation (Joint forces operation) and prevent the occurrence of suicide. Key words: depression, autoaggressive manifestations, diagnostics, treatment, prevention, combatants of the Anti-terroristic operation (Joint forces operation), liquidators of the consequences of the Chernobyl accident.

scholarly journals Hormonal and ultrasound features of formation of feto-placental complex in women with beneficial tumours of the uterus

2019 ◽  
pp. 184-190
Author(s):  
E. F. Khamidullina ◽  
L. Yu. Davidyan ◽  
D. R. Kasymova ◽  
A. Yu. Bogdasarov
Keyword(s):  
Pregnant Women ◽  
Ultrasound Imaging ◽  
Comparison Group ◽  
Clinical Manifestations ◽  
Uterine Fibroids ◽  
Genetic Mutation ◽  
Main Group ◽  
Biochemical Tests ◽  
Almost All ◽  
Ultrasound Features

The purpose and objectives of the study is to identify the hormonal, biochemical and ultrasound features of the gestation course in women with beneficial tumours of the uterus. Results. We conducted a complete clinical examination and prospective observation of 182 pregnant women. Of which, 98 puerperas with a verified diagnosis of uterine fibroids and/or endometriosis, which developed before gestation, but did not prevent the onset of pregnancy, were included into the main group. The comparison group included 84 women with physiological pregnancy. The studies showed that 14 pregnant women in the main group had C677T (Ala222Val) T/T mutation, while only 2 women in the comparison group had a decrease in enzyme activity due to genetic mutation. Accordingly, the homocysteine level was almost 3 times lower in the comparison group than in the main group. The women with hyperhomocisteinemia (HHC) and uterine fibroid in the main group showed the lowest estriol level and hCG level, while women without HHC had higher estriol level and hCG levels. It was found that almost all patients with HHC had subclinical hypothyroidism. Ultrasound imaging and biochemical tests at the beginning of the 2nd trimester: no ultrasound markers of fetal anomalies were identified in women from both groups; however, signs of retrochorial hematoma were detected in 57 women from the main group, which was confirmed by clinical manifestations and previous ultrasound imaging in earlier gestation periods. Conclusion. Thus, placenta formation in women with HHC and uterine fibroids is accompanied by relative hormonal insufficiency, which is clinically manifested as a threat of miscarriage in the early stages, but carrying a child is possible due to appropriate management of a patient as part of the preserving therapy. However, the issue of preventing the development of fetoplacental insufficiency is a valid one for further investigation.

The use of Dimexide in the complex treatment of Peyronie's disease

1980 ◽  
Vol 61 (6) ◽  
pp. 53-54
Author(s):  
M. G. Muhamadeev ◽  
M. P. Trofimova
Keyword(s):  
Clinical Manifestations ◽  
Disease Recurrence ◽  
Peyronie’S Disease ◽  
Long Term Results ◽  
Complex Treatment ◽  
Results Of Treatment ◽  
Peyronie's Disease

We observed 9 patients with plastic induration of the penis (Peyronie's disease), 3 of them interrupted treatment. Long-term results of treatment were traced in 6 patients (age - from 48 to 60 years): in 5 patients, complaints and clinical manifestations of disease recurrence were not noted for 2-4 years.

scholarly journals Endobronchial valve in complex treatment of patients with drug resistant fibrous cavernous pulmonary tuberculosis

2020 ◽  
Vol 98 (1) ◽  
pp. 35-40
Author(s):  
O. Yu. Askalonova ◽  
E. A. Tseymakh ◽  
A. V. Levin ◽  
P. E. Zimonin
Keyword(s):  
Pulmonary Tuberculosis ◽  
Comparison Group ◽  
Main Group ◽  
Drug Resistant ◽  
Complex Treatment ◽  
X Ray ◽  
Endobronchial Valve ◽  
Sputum Conversion ◽  
Valve Implantation ◽  
Valve Block

The objective of the study: to assess the efficacy of complex treatment with endobronchial valve implantation in the patients suffering from drug resistant fibrous cavernous pulmonary tuberculosis.Subjects and methods. Treatment outcomes in 97 patients with limited fibrous cavernous pulmonary tuberculosis were analyzed. Main Group included 42 patients who had bronchial valve block implanted. Comparison Group included 55 patients. Artificial pneumoperitoneum was used in both groups.Results. In Main Group, sputum conversion was achieved in 12 months in 40 (95.2%) patients, and in 32 patients (58.2%) in Comparison Group (p < 0.01). In 12 months after treatment start, positive X-ray changes were observed in 42 (100%) patients of Main Group and 40 (72.7%) patients of Comparison Group. Healing of cavities in 12 months was observed only in the patients from Main Group (26 (61.9%) patients). Upon completion of the study, surgery was still indicated to 4 (9.5%) of patients from Main Group and to 35 (63.6%) patients from Comparison Group.

scholarly journals Optimization of healing in patients with odontogenic phlegmon of the maxillofacial region

2020 ◽  
Vol 24 (6) ◽  
pp. 387-390
Author(s):  
O. V. Shvets ◽  
Tatiana V. Gaivoronskaya ◽  
E. E. Esaulenko ◽  
N. I. Bykova
Keyword(s):  
Comparative Effectiveness ◽  
Comparison Group ◽  
Clinical Manifestations ◽  
Main Group ◽  
Maxillofacial Region ◽  
Traditional Treatment ◽  
Parameter Group ◽  
Antioxidant Agents ◽  
Complex Therapy ◽  
Group 2

Aim. This study aims to increase the efficiency of the wound process in patients with odontogenic phlegmons of the maxillofacial region by using energotropic and antioxidant agents. Material and methods. The clinical study included 42 patients with odontogenic phlegmons of the maxillofacial region. The patients were divided into two groups: comparison group (patients received traditional treatment) and main group (patients received treatment with Cytoflavin in the treatment regimen). Results. In the main group, the appearance of the first granulations occurred 2.1 times faster (on average on the 3rd day) in comparison with the granulation tissue in patients of the comparison group. Signs of edge epithelialization of wounds appeared almost 3 days earlier (on average on the 6th day) in the main group than in the comparison group; on the 7th day, secondary sutures were already applied, which was 1.6 times faster than the same parameter group 2, clearly suggesting the acceleration of reparative processes. Conclusion. The dynamics of clinical manifestations indicates the comparative effectiveness of using Cytoflavin as part of complex therapy. This finding is confirmed by the accelerated terms of wound healing, the appearance of granulations, epithelialization of the wound edges, and the imposition of secondary sutures.

scholarly journals CLINICAL ASSESSMENT OF THE EFFECTIVENESS APPLICATION "BIOCERULIN" IN THE COMPLEX TREATMENT OF THE PATIENTS WITH ONTOGENIC FLAGMONS OF THE MAXILLOFACIAL AREA

2019 ◽  
pp. 29-32
Author(s):  
D.V. Steblovskyi ◽  
V.V. Bondarenko ◽  
O.S. Ivanytska ◽  
V.M. Skrypnyk ◽  
I.O. Ivanytskyi
Keyword(s):  
General Condition ◽  
Inflammatory Process ◽  
New Technologies ◽  
Comparison Group ◽  
Main Group ◽  
The Body ◽  
Steady Increase ◽  
Complex Treatment ◽  
Maxillofacial Region ◽  
Traditional Therapy

Treatment of odontogenic phlegmon of the maxillofacial region remains an urgent problem of surgical dentistry due to the steady increase in their frequency, tendency to generalize the process and adverse effects. In this regard, there is a constant search for ways to improve the effectiveness of treatment of patients with odontogenic phlegmons of maxillofacial region. New technologies of drug treatment of this pathology are developed and put into practice. In recent years the attention of researchers in various conditions accompanied by the development of oxidative stress began to attract drugs that have antioxidant action, as it became known that the excess of reactive oxygen species in the regenerating wounds in the hearth of purulent inflammation affects the course of the course, wound healing. Interest in the treatment of various pathological conditions of the body is caused by the domestic antioxidant multifunctional enzyme "Bioceruline" which is composed of copper. In this regard, the purpose of our study was to evaluate the effectiveness of the use of "Biocerulin" in the complex treatment of patients with odontogenic phlegmon of maxillofacial region. The object of the clinical study was 45 patients with odontogenic phlegmons of the maxillofacial region from 18 to 55 years old, who were treated in the maxillofacial department of PU "Poltava M.V. Sklifosovskyi regional clinical hospital PRC». All patients were without somatic pathology in compensated clinical condition. Immediately after hospitalization, patients underwent an emergency opening of purulent lesion, revision and adequate drainage of the affected cellular spaces, removal of the "causal" tooth. The extent of surgery and the choice of optimal access depended on the location and prevalence of phlegmon. Depending on the treatment, patients were divided into comparison groups (22 patients) and the main group (23 patients). The traditional therapy was used in the comparison group. "Biocerulin"was prescribed for the patients of the main group in addition to the traditional therapy. Analysis of obtained data in the treatment of patients with phlegmon revealed that both groups of patients had clear differences in the clinical course of purulent-inflammatory process. On the 2nd day after the opening of the phlegmon theweakness, headache, and sleep disorders were noted in the most of the patients of the comparison group who received traditional therapy. Pain with varying degrees of intensity was present in all patients. Improvement of the general condition of patients of this group was noted not earlier than 3-5 days after surgery. The improvement of the general condition and reduction of pain, normalization or decrease in body temperature, the beginning of restoration of function of the jaw apparatuswere notedin patients of the main group on the background of the introduction of "Bioceruline" already on the 2-3rd day after surgery. Thus, on the basis of the conducted researches it is possible to conclude that the basic (traditional) conservative therapeutic measures used for patients of the comparison group are not effective enough for the relief of the local and general inflammatory process, which caused the prolonged nature of organ-specific and functional rehabilitation of patients as a whole. The use of "Bioceruline" in complex therapy of patients with odontogenicphlegmons of the maxillofacial regionprovides rapid and intensive recovery of the general condition of patients and accelerates reparative processes in the wound and shortens the treatment time via 1.4 bed-days.

Physiotherapeutic support of patients with dysplastic coxarthrosis after total hip prosthetics

2020 ◽  
pp. 7-16
Author(s):  
Oleg N. YAMSHCHIKOV ◽  
Nikita I. VORONIN ◽  
Dmitry A. MARKOV ◽  
Ksenia P. Zvereva
Keyword(s):  
Surgical Treatment ◽  
Comparison Group ◽  
Health Indicators ◽  
Main Group ◽  
Long Term Results ◽  
Average Score ◽  
Treatment Technique ◽  
Total Hip ◽  
Sf 36 ◽  
Hip Prosthetics

Today, the main method of surgical treatment of dysplastic coxarthrosis among adults is total hip prosthetics. Distant positive results according to foreign authors are 76–89%. One method of rehabilitation is physiotherapeutic treatment. The absence of standardized physiotherapeutic treatment protocols leads to a sharp reduction in the prescription of this type of rehabilitation measures. The aim of the study is to assess the long-term results of hip joint endoprosthetics among patients with dysplastic coxarthrosis using the developed physiotherapeutic treatment technique. Research materials and methods. For the period from 2010 to 2014, 205 patients were performed an operation with dysplastic coxarthrosis 1, 2, 3 degrees of Crowe. In the pre- and postoperative periods, patients of the main group were prescribed physiotherapeutic treatment according to the developed methodology. Evaluation of the results was carried out 12 months after surgical treatment using clinical and radiological methods, questionnaires using the Harris scale, SF-36. The obtained data were processed using statistical methods: Student coefficient, Pearson coefficient, correlation method. Results. When analyzing distant results, the average Harris score in the main group 85.82 (84.93–86.71) was significantly higher than in the comparison group 83.01 (82.02–84.00). The average score of the SF-36 questionnaire in the main group was significantly higher than in the comparison group (p < 0.001). Mental health indicators of patients were not significantly different from those of the postoperative period and were at a high level. Conclusions. Prescription of physiotherapeutic treatment promotes rapid healing of postoperative wounds and improves results of surgical treatment.

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