Efficacy and tolerability of methotrexate at a dose of 15 mg/week and 10 mg/week in patients with pulmonary sarcoidosis

The objective of this study is to conduct a comparative study of the efficacy and safety of methotrexate (MT) at a dose of 10 mg/week and 15 mg/week in patients with pulmonary sarcoidosis having contraindications to GCS therapy. Material and Methods. The study involved 44 patients with stage II pulmonary sarcoidosis (26 females and 18 males aged 24 to 70) with contraindications to the appointment of therapy glucocorticosteroid (GCS). In group 1 (28 patients), methotrexate was prescribed at a dose of 10 mg/week, in group 2 (16 patients), methotrexate was prescribed at a dose of 15 mg/week. The diagnosis and assessment of the dynamics of sarcoidosis were carried out taking into account clinical symptoms based on the results of high-resolution computed tomography and body plethysmography. The significance of differences in indicators was determined using the Student's t-test and Fisher's exact test. The number of cases of clinical treatment without residual changes of a fibrous nature in the lung parenchyma in patients after treatment with methotrexate at a dose of 15 mg/week significantly increased compared to the same indicator in the group of patients after treatment at a dose of 10 mg/week (81.3% and 42.4% respectively, p=0.025). An increase in the therapeutic dose of methotrexate from 10 mg/week to 15 mg/week leads to a decrease in the time to achieve a clinical cure (10.1±0.5 months and 12.8±0.8 months respectively, р˂0.02), indicating an accelerating rate of regression of sarcoidosis. Immunosuppressive therapy of patients with pulmonary sarcoidosis using the drug at doses of 10 and 15 mg/week is characterized by satisfactory tolerability.

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Decrease in Driveline Infections with Change in Driveline Management Protocol

The VAD Journal ◽

10.14434/vad.v2i0.27938 ◽

2016 ◽

Cited By ~ 1

Author(s):

Saima Aslam ◽

Jennifer Dan ◽

Amanda Topik ◽

Michael Belyk ◽

Francesca Torriani ◽

...

Keyword(s):

Rank Test ◽

Ventricular Assist ◽

Exact Test ◽

Management Protocol ◽

Group 2 ◽

Student’S T ◽

Optimal Approach ◽

Dressing Change ◽

Group 1

Background Driveline infections (DLI) are a significant cause of morbidity and mortality in ventricular assist device (VAD) recipients. We compared driveline infection (DLI) rate after an institutional change in driveline management protocol. Methods We retrospectively reviewed records of left VAD recipients at our institution, based on driveline management. Group 1: daily driveline dressing change consisting of chlorhexidine cleansing, sterile 4x4 gauze, and use of an abdominal binder. Group 2: Dressing change every 3 days consisting of chlorhexidine cleansing, non-sterile silver-impregnated foam with overlying clear dressing, and use of a driveline anchor. Follow-up was censored at first DLI, device removal, transplant or death. Additionally, Group 1 patients’ follow-up was censored when the change in protocol occurred. Statistical analysis: Student’s t-test, Fisher’s exact test, Kaplan-Meier curve and log-rank test. Results DLI occurred in 16% of 88 VAD recipients (Group 1 n=24, Group 2 n=64). The new driveline management protocol resulted in significantly fewer DLI in Group 2 (6.3% vs. 41.7%, p<0.0001). Conclusions An updated driveline management protocol demonstrated significant reduction in DLI at our institution. Studies evaluating the optimal approach for driveline management are needed in order to develop a standardized regimen aimed at lowering the risk of DLI.

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A IMPORTÂNCIA DO GOLEIRO E SUA PARTICIPAÇÃO TÁTICA COM A BOLA NOS PÉS

Colloquium Vitae ◽

10.5747/cv.2018.v10.n2.v231 ◽

2018 ◽

Vol 10 (2) ◽

pp. 47-53

Author(s):

Wellington Renato Rossi ◽

José Lucas Polizel Fagundes ◽

Lucas da Silva Santos ◽

Guilherme Akio Tamura Ozaki ◽

Everton Alex Carvalho Zanuto ◽

...

Keyword(s):

International Federation ◽

World Cup ◽

Fifa World Cup ◽

The Public ◽

Normality Test ◽

The Mean ◽

Group 2 ◽

Student’S T ◽

Student’S T Test ◽

Group 1

Modern football has become faster and more dynamic due to changes in rules. In this way, with all the tactical modifications, the goalkeeper startedto have even greater importance within his team. This study aimed to analyze the importance of the goalkeeper in professional football matches. Thirteen football matches were analyzed, divided into two groups. Group 1 was comprised of the analysis of ninematches played during the 2014 FIFA World Cup. Group 2 was formed by four matches of other competitions, selected from the participation of goalkeepers with greater skill in the feet, according to the ranking of goal of the International Federation of Football History & Statistics(IFFHS). The games were downloaded on the public domain site of Youtube and then analyzed through the software SKOUT, regarding the tactical positioning and quantification of the numbers of each goalkeeper (technical part) during the matches. The Shapiro-Wilk normality test was used for normality analysis and then the Student's t-test for independent samples (p<0.05). It was verified that the goalkeepers of Group 2 presented greater participation in the fundamentals of pass, reception, finishing, hand replacement, driving and scored goals (p<0.05). However, in the mean of errors in the pass, reception and driving fundamentals the differences were not significant. It is concluded that the goalkeepers of Group 2 presented greater participation in the fundamentals that required skill with the possession of ball.

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Conventional and contrast-enhanced ultrasound features in sclerosing adenosis and correlation with pathology

Clinical Hemorheology and Microcirculation ◽

10.3233/ch-200943 ◽

2020 ◽

pp. 1-9

Author(s):

Sihui Shao ◽

Minghua Yao ◽

Xin Li ◽

Chunxiao Li ◽

Jing Chen ◽

...

Keyword(s):

Imaging Features ◽

Contrast Enhanced Ultrasound ◽

Exact Test ◽

Contrast Enhanced ◽

Chi Squared ◽

Group 2 ◽

Student’S T ◽

Sensitivity Specificity ◽

Sclerosing Adenosis ◽

Group 1

OBJECTIVES: To evaluate the efficacy of conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS) in differential diagnosis of sclerosing adenosis (SA) from malignance and investigate the correlated features with pathology. METHODS: We retrospectively enrolled 103 pathologically confirmed SA. All lesions were evaluated with conventional US while 31 lesions with CEUS. Lesions were divided into SA with or without benign lesions (Group 1, n = 81) and SA with malignancy (Group 2, n = 22). Performance of two methods were analyzed. The ultrasonographic characteristics were compared between two groups with Student’s t-test for measurement and chi-squared or Fisher’s exact test for count data. RESULTS: There were 22 lesions complicated with malignancy, and the mean age of Group 2 was higher than Group 1 (55.27 vs. 41.57, p < 0.001). The sensitivity, specificity and accuracy of conventional US and CEUS were 95.45%, 46.91%, 57.28% and 100%, 62.5%, 70.97%. Angularity (p < 0.001), spicules (p = 0.023), calcification (p = 0.026) and enlarged scope (p = 0.012) or crab claw-like enhancement (p = 0.008) in CEUS were more frequent detected in SA with malignancy. CONCLUSIONS: Though CEUS showed an improved accuracy, the performance of ultrasound in the diagnosis of SA was limited. Awareness and careful review of the histopathologically related imaging features can be helpful in the diagnosis of SA.

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Morphometric Parameters of the Corneal Flap after FemtoLASIK Using Various Femtosecond Laser

Ophthalmology in Russia ◽

10.18008/1816-5095-2018-2-115-123 ◽

2018 ◽

Vol 15 (2) ◽

pp. 115-123

Author(s):

A. V. Doga ◽

I. A. Mushkova ◽

A. D. Semenov ◽

A. N. Karimova ◽

E. V. Kechin ◽

...

Keyword(s):

Corneal Thickness ◽

Morphometric Parameters ◽

Mean Deviation ◽

Flap Thickness ◽

The Mean ◽

Group 2 ◽

Student’S T ◽

Student’S T Test ◽

Total Average ◽

Group 1

Purpose:to make a comparison of the corneal flap parameters after the FemtoLASIK procedure using femtolaser systems Femto Visum (Russia) and Femto LDV Z6 (Switzerland).Patients and methods.The study was carried out in 192 eyes from 192 patients with mild and moderate myopia who had undergone FemtoLASIK prodecure. Group 1 (Femto Visum) included 98 eyes (n = 98) on which flap were formed using femtolaser Femto Visum (“Optosystems”, Russia), group 2 (Femto LDV Z6) included 94 eyes (n = 94) and Femto LDV Z6 was used (“Ziemer Ophthalmic Systems AG”, Switzerland). The Femto Visum and Femto LDV Z6 groups were comparable in terms of pre-operative data (age, sex, corneal curvature, central corneal thickness, sphere, cylinder, spherical equivalent) (p > 0.05). The intended flap thickness was 100 μm and diameter was 9.0 mm in both groups. One month after surgery the achieved flap thickness in the horizontal and vertical meridians (14 measurement points) and the flap diameter in the horizontal meridian were measured using Visante OCT (Carl Zeiss, Germany), also we determined the shape of the flap and the mean deviation of the values from morphometric parameters of the corneal flap relative to the intended values.Results.In group 1 (Femto Visum), the total average thickness of the flap was 98.89 ± 3.96 μm with the mean deviation 2.91 ± 2.91 μm, the mean flap diameter was 8.96 ± 0.13 mm with the mean deviation 0.11 ± 0.07 mm, in group 2 (Femto LDV Z6) the same parameters were 99.11 ± 3.89 μm, 2.99 ± 2.64 μm and 8.91 ± 0.14 mm, 0.13 ± 0.10 mm, respectively. The configuration of the corneal flap was uniform in both groups. For all studied parameters it was no any statistically significant differences between studied groups (p > 0.05, Student’s t-test).Conclusions.The Femto Visum and Femto LDV Z6 femtolaser systems allow to shape the uniform and highly predictable corneal flap morphometric parameters, similar measurements were obtained from both systems.

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Comparison of clinical efficacy and safety between salbutamol-ipratropium bromide nebulization and salbutamol alone in children with asthmatic attack

Paediatrica Indonesiana ◽

10.14238/pi46.6.2006.241-5 ◽

2016 ◽

Vol 46 (6) ◽

pp. 241

Author(s):

Lusiana Kartininingsih ◽

Landia Setiawati ◽

Makmuri M S

Keyword(s):

Ipratropium Bromide ◽

Clinical Score ◽

Efficacy And Safety ◽

First Line ◽

Exact Test ◽

Moderate Asthma ◽

Nebulized Salbutamol ◽

Group 2 ◽

Single Blind ◽

Group 1

Background Indonesian guidelines for childhood asthma recom-mend giving ipratropium bromide when there are no improvementafter 2 times salbutamol nebulization. The efficacy and safety ofearly nebulization of ipratropium bromide combined with salbutamolas first line in moderate asthma exacerbation in children are stillunknown.Objective To compare efficacy and safety between nebulizedsalbutamol-ipratropium bromide and salbutamol alone in childrenwith moderate asthma exacerbation.Methods Fifty-two children (2-6 years) with acute asthma (clinicalscore 5-10) were enrolled into a randomized single blind controlledtrial comparing 2 groups of 2.5 mg nebulized salbutamol (group 1)and 2.5 mg salbutamol combined with 0.5 mg ipratropium bromide(group 2). Nebulization was given until clinical score decreased<5, maximum of 3 doses during 2 hours. Clinical measurementsincluded clinical score, oxygen saturation and side effects whichwere assessed every 20 minutes up to 120 minutes. Statisticaltest for homogeneity and comparison of clinical outcomes and sideeffects used independent t-test, Fisher’s exact test, and Mann-Whitney U test (P<0.05).Results The groups were similar in all baseline measures. Therewere significantly decreasing clinical score in groups 2 at 20, 40,60, 80, 100, and 120 minutes (P<0.05), and the means of oxygensaturation were significantly higher in group 2 at 20, 40, 60, 80,100, and 120 minutes (P<0.05). In group 1, 11.5% of patients werehospitalized after the study and none in groups 2 (P> 0.05). Therewere no toxic effects attributable to ipratropium bromide, and theside effects were not different between these two groups.Conclusion The combination of nebulized ipratropium bromideand salbutamol in a child with acute moderate asthma exacerba-tion was associated with higher reduction of clinical score and higheroxygen saturation, and may reduce hospitalization

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Monosymptomatic Enuresis in Children: Is It Related to Urine pH and Density?

The Journal of Tepecik Education and Research Hospital ◽

10.5222/terh.2021.88709 ◽

2021 ◽

Author(s):

İbrahim Aydoğdu ◽

Erkin Karaca ◽

Ersan Uzun ◽

Yaren Ece Aydoğdu ◽

Uygar Miçooğulları ◽

...

Keyword(s):

Urinary Tract ◽

Current Data ◽

P Value ◽

Urine Ph ◽

Group 2 ◽

Student’S T ◽

Tract Infections ◽

Density Methods ◽

Student’S T Test ◽

Group 1

Objective: To contribute to the explanation of the etiology of enuresis, which is quite prevalent, by investigating its relationship with urine pH and density. Methods: A total of 45558 children were included in the study. Based on screening results, 44201 children without enuresis were assigned to Group 1 and 1357 children with enuresis to Group 2. Complete urinalysis results of all children who had been identified were scanned and values of urine pH and density were obtained. Intergroup differences with regard to urine pH and density were analyzed using Student’s t-test. A p value of <0.05 was considered statistically significant. Results: The group with enuresis was determined to be statistically significantly younger, and has lower urine pH, and density. Conclusion: The results of our study are consistent with current data. Our study, which will be among one of the largest-scale enuresis studies in the literature, provides guidance to physicians by reminding them the importance of urinary tract infections in the etiology of enuresis.

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Features of postoperative period in patients with chronic venous insufficiency: phlebectomy versus thermal ablation

Hirurg (Surgeon) ◽

10.33920/med-15-2001-05 ◽

2020 ◽

pp. 64-75

Author(s):

E. Burleva ◽

O. Smirnov ◽

S. Tyurin

Keyword(s):

Postoperative Period ◽

Chronic Venous Insufficiency ◽

Thermal Ablation ◽

Venous Insufficiency ◽

Clinical Symptoms ◽

Varicose Veins ◽

Statistical Processing ◽

Group 3 ◽

Group 2 ◽

Group 1

The purpose of the study was to conduct a comparative assessment of the course of the postoperative period after phlebectomy and thermal ablation in patients with varicose veins of the lower extremities in the system of the great saphenous vein (GSV) with class C2 of chronic venous insufficiency (CVI) — CEAP class C2. Materials and methods: 455 patients (455 limbs) with CEAP class C2. Group 1 (n = 154) received stripping + minimally invasive phlebectomy; Group 2 — endovenous laser ablation (EVLA) of GSV trunk + sclerotherapy of varicose veins; 3 group (n = 150) — radiofrequency ablation (RFA) of the GSV + sclerotherapy. All patients were united by a single tactical solution — the elimination of pathological vertical reflux in GSV. In each group, patients were with similar hemodynamic profile were selected (Group 1 = 63; Group 2 = 61; Group 3 = 61). The course of the postoperative period (from 2 days to 2 months) was compared for pain (visual analog scale — VAS), clinical symptoms of chronic venous insufficiency, degree of satisfaction (Darvall questionnaire), and duration of disability. Statistical processing was carried out using Excel programs for Windows XP, MedCalc® (version 11.4.2.0., Mariakerke, Belgium). Results: Postoperative pain is more pronounced (during day 1 for Group 1–4.0, Group 2–3.0, Group 3–2.0) and more prolonged (up to 4 days) after open surgeries (p < 0.05). The dynamics of the clinical symptoms of CVI (including varicose syndrome and use of compression therapy) could not be fully evaluated in connection with the ongoing sclerotherapy procedures for patients of Groups 2 and 3. Satisfaction of patients with aesthetic aspects was higher than expected in all groups. Reliable statistical differences proved decrease in days of disability (Group 1–14; Group 2–4; Group 3–3) and earlier return to physical activities and work in patients after thermal ablation in comparison with phlebectomy. Conclusion: The study shows that all three methods for eliminating vertical reflux in the GSV can be proposed for a large category of patients with CEAP of class C3 and C2. Medical and social rehabilitation of patients using endovascular thermal ablation technologies proceeds faster, which is beneficial both for the patients and for society.

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RISKS OF ANEMIA DEVELOPMENT IN DONORS ACCORDING TO INHERITED PREDISPOSITION AND REGULARITY OF BLOOD DONATION

Ulyanovsk Medico-biological Journal ◽

10.34014/2227-1848-2020-1-72-83 ◽

2020 ◽

pp. 72-83

Author(s):

I.M. Vorotnikov ◽

V.A. Razin ◽

I.M. Lamzin ◽

M.N. Sokolova ◽

M.E. Khapman ◽

...

Keyword(s):

Blood Donors ◽

Blood Donation ◽

Hla Antigens ◽

Hla Typing ◽

Main Role ◽

Inherited Predisposition ◽

Group 2 ◽

Student’S T ◽

A Prospective Study ◽

Group 1

Anemia is one of the most common complications of blood donation. Thus, the objective of the paper was to assess the risks of anemia development in donors according to the regularity of donation and inherited predisposition. Materials and Methods. The authors carried out a prospective study, which included 241 blood donors, using random sampling and case-control techniques. Depending on blood donation frequency, the donors were divided into 2 groups: Group 1 consisted of 122 people (51.5 %) frequently donating blood; Group 2 included 119 people (48. 5 %) rarely donating blood. We studied the initial indicators of a general blood test and the same indicators a year after the first blood donation. Additionally, we performed HLA typing of donors. Statistica v. 8.0 software package (Stat Soft Inc., USA) was used for statistical analysis. To compare two independent samples, we used a nonparametric Mann-Whitney U-test and a parametric Student’s t-test (depending on the type of distribution). To assess anemia risks, the odds ratio was calculated. Results. One year after the first blood donation, anemia was diagnosed in 13 people (10.6 %) in Group 1 and in 7 people (5.9 %) in Group 2 (p=0.179). A11 and B7 HLA antigens did not increase anemia risks in group 1 (OS=1.257 (95 % CI 0.318–4.973) and OS=0.240 (95 % CI 0.051–1.134, respectively). HLA-antigens A11 and B7 did not increase anemia risks in Group 1 (OR=1.257 (95 % CI 0.318-4.973) and OR=0.240 (95 % CI 0.051–1.134), respectively). In group 2, antigen-A11 was also an insignificant factor (OS=2.902 (95 % CI 0.606-13.889)) for anemia development. Whereas, antigen-B7 increased anemia risks by 14 times (OS=14.364 (95 % CI 1.644-124.011)). Conclusion. In rare blood donors, it is the genetic factor that plays the main role in anemia development. High prevalence rates of anemia in frequent blood donors are probably determined by other factors. Keywords: anemia, blood donors, HLA typing. Механизмы развития анемий и факторы, их индуцирующие, остаются до конца не изученными. Целью исследования стало изучение риска развития анемии у доноров крови в зависимости от частоты донации и наличия наследственной предрасположенности к развитию анемии. Материалы и методы. Проведено проспективное исследование, выполненное методами случайной выборки и «случай-контроль», в которое вошел 241 донор крови. В зависимости от частоты сдачи доноры были поделены на 2 группы: группу 1 составили 122 чел. (51,5 %), часто сдающие кровь; группу 2 – 119 чел. (48,5 %), редко сдающих кровь. Изучались исходные показатели общего анализа крови и через год от начала донации. Дополнительно проводилось HLA-типирование доноров. Статистический анализ осуществлялся с применением программы Statistica v. 8.0 (Stat Soft Inc., США). Для сравнения двух независимых выборок использовался непараметрический U-критерий Манна–Уитни и параметрический t-критерий Стьюдента (в зависимости от типа распределения). Для оценки риска возникновения анемии рассчитывалось отношение шансов. Результаты. Через год с момента первой сдачи крови в группе 1 выявлено 13 чел. (10,6 %) с анемией, в группе 2 – 7 чел. (5,9 %) (р=0,179). Наличие HLA-антигенов А11 и B7 не повышало риск развития анемии в группе 1 (ОШ=1,257 (95 % ДИ 0,318–4,973) и ОШ=0,240 (95 % ДИ 0,051–1,134 соответственно). В группе 2 наличие гена А11 также являлось незначимым фактором (ОШ=2,902 (95 % ДИ 0,606–13,889), присутствие гена В7 в 14 раз повышало риск развития анемии (ОШ=14,364 (95 % ДИ 1,664–124,011). Выводы. Высокий риск развития анемии у редко сдающих кровь доноров обусловливается генетическими факторами. Высокая распространённость анемии у часто сдающих кровь доноров, вероятно, определяется другими факторами. Ключевые слова: анемия, доноры крови, HLA-типирование.

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Water sorption of heat-polymerized acrylic resins processed in mono and bimaxillary flasks

Brazilian Dental Journal ◽

10.1590/s0103-64402006000200007 ◽

2006 ◽

Vol 17 (2) ◽

pp. 122-125 ◽

Cited By ~ 6

Author(s):

Carolina B. Meloto ◽

Laís R. Silva-Concílio ◽

Cristiane Machado ◽

Margarete C. Ribeiro ◽

Fábio A. Joia ◽

...

Keyword(s):

Water Sorption ◽

Acrylic Resin ◽

Microwave Energy ◽

Water Bath ◽

Acrylic Resins ◽

Energy Processing ◽

Group 3 ◽

Group 2 ◽

Student’S T ◽

Group 1

This study evaluated water sorption in heat-polymerized acrylic resins processed in monomaxillary flasks by water bath and in bimaxillary flasks by microwave energy and water bath. Fifty heat-polymerized acrylic resin specimens were fabricated according to the 12th specification of the American Dental Association and assigned to 3 groups: group 1 was processed by water bath in monomaxillary metallic flask; group 2 was processed by microwave energy in bimaxillary PVC flask; and group 3 was processed by water bath in bimaxillary metallic flask. Specimens were submitted to water sorption test, means were calculated and analyzed statistically by Student's t-test. Means (in g/cm³) were: group 1 - 0.024085, group 2 - 0.025312 and group 3 - 0.022098. Microwave energy processing and the amount of stone and resin used in the bimaxillary PVC flask did not influence water sorption; specimens processed in bimaxillary metallic flask by water bath presented lower water sorption means, suggesting an inadequate polymerization of the acrylic resin mass.

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Intravesical prostaglandin e2 effectiveness in the prevention of urinary retention after transvaginal reconstruction of the pubo-cervical fascia and short arm sling according to Lahodny: a prospective randomized clinical trial

Urogynaecologia ◽

10.4081/uij.2000.15 ◽

2010 ◽

Vol 14 (1) ◽

pp. 15 ◽

Cited By ~ 6

Author(s):

G. QUADRI ◽

N. NATALE ◽

C. SPREAFICO ◽

C. BELLONI ◽

D. BARISANI ◽

...

Keyword(s):

Prostaglandin E2 ◽

Urinary Retention ◽

Study Groups ◽

T Test ◽

Control Group ◽

Fisher Exact Test ◽

Test Results ◽

Exact Test ◽

Student’S T ◽

Student’S T Test

Intravesical prostaglandin E2 is effective in the recovery of spontaneous voiding after transvaginal reconstruction of the pubocervical fascia and short arm sling according to Lahodny. The aim of the study was to compare the effects of intravesical prostaglandin E2 in the prevention of urinary retention after transvaginal reconstruction of the pubocervical fascia and short arm sling according to Lahodny. STUDY DESIGN: From November 1996 to June 1999 fifty women underwent the Lahodny procedure for moderate/severe cystocele and stress urinary incontinence. Women were randomly assigned to 1 of the 2 study groups: intravesical prostaglandin E2 versus controls. Data obtained were analyzed with the Student t test and the Fisher exact test. RESULTS: Two patients of the treatment group had to be excluded from the study, one because of the wrong measurement of the post-voidal residual volume and another due to a fastidious burning sensation which appeared immediately after prostaglandin instillation and required the suspension of the treatment. No other side effects such as nausea, vomiting, diarrhea or hyperthermia were observed. Patients who underwent the prostaglandin E2 treatment showed a recovery of spontaneous voiding after 7.9±6.7 days, whereas this interval was significantly longer in the control group, being 12.9±9.7 days (p=0.04, Two tailed Unpaired Student's T test). CONCLUSION: The effectiveness and the low associated morbidity mark the treatment with intravesical prostaglandin E2 useful in the recovery of normal voiding after transvaginal pubocervical fascia reconstruction and short arm sling with the procedure according to Lahodny.

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