scholarly journals Drug addiction: a general review of new concepts and future challenges

2000 ◽  
Vol 6 (4) ◽  
pp. 723-733
Author(s):  
N. A. Qureshi ◽  
Y. S. Al Ghamdy ◽  
T. A. Al Habeeb

Relevant papers published in peer reviewed journals in the past 2 decades were identified and screened to abstract pertinent information. Substance dependence/addiction, involving both a common brain reward mechanism and longer-lasting molecular and cellular changes, is a preventable chronic, relapsing brain disease and as such a public health problem. Physical and psychological dependence, characterized by withdrawal syndrome, are now given less weight compared with compulsive behaviour and uncontrolled use of drugs in the comprehension of addiction. The challenging components of drug addictions, including counteradaptation, sensitization, abstinence, craving and relapse need further neurobiological and non-neurobiological exploration and understanding, which may be possible through the use of advanced imaging and genetic techniques and animal models of drug addiction together with relevant human studies

2013 ◽  
Vol 26 (6) ◽  
pp. 334-346 ◽  
Author(s):  
Livia C.M. Rodrigues ◽  
Pedro H. Gobira ◽  
Antonio Carlos de Oliveira ◽  
Renan Pelição ◽  
Antonio Lucio Teixeira ◽  
...  

ObjectiveSubstance dependence disorder is a chronically relapsing condition characterised by neurobiological changes leading to loss of control in restricting a substance intake, compulsion and withdrawal syndrome. In the past few years, (endo)cannabinoids have been raised as a possible target in the aetiology of drug addiction. On the other hand, although the exact mechanisms of the genesis of addiction remain poorly understood, it is possible that neuroinflammation might also play a role in the pathophysiology of this condition. Studies demonstrated that (endo)cannabinoids act as immunomodulators by inhibiting cytokines production and microglial cell activation. Thus, in the present review, we explore the possible role of neuroinflammation on the therapeutic effects of cannabinoids on drug addiction.MethodsWe conducted an evidence-based review of the literature in order to assess the role of cannabinoids on the neuroinflammatory hypothesis of addiction (terms: addiction, cannabinoids and inflammation). We searched PubMed and BioMedCentral databases up to April 2014 with no date restrictions.ResultsIn all, 165 eligible articles were included in the present review. Existing evidence suggests that disruption in cannabinoid signalling during the drug addiction process leads to microglial activation and neuroinflammation.ConclusionThe literature showed that inflammation and changes in endocannabinod signalling occur in drug abuse; however, it remains uncertain whether these changes are causally or coincidentally associated with addiction. Additional studies, therefore, are needed to elucidate the contribution of neuroinflammation on the behavioural and neuroprotective effects of cannabinoids on drug addiction.


1998 ◽  
Vol 17 (4) ◽  
pp. 297-301
Author(s):  
Magoroh Maruyama
Keyword(s):  
The Past ◽  

Incipient signs of a change in Zeitgeist are being felt. Under a new Zeitgeist, some theories which have been excluded, ignored or suppressed by the past dominant mainstream theories may emerge into the daylight. This article examines processes of popularization of theories and discusses how they may relate to emergence of hitherto excluded, ignored or suppressed theories. Two new concepts are introduced in this article: metaphorizability and anchorability.


2019 ◽  
Vol 188 (12) ◽  
pp. 2069-2077
Author(s):  
Priya Duggal ◽  
Christine Ladd-Acosta ◽  
Debashree Ray ◽  
Terri H Beaty

Abstract The field of genetic epidemiology is relatively young and brings together genetics, epidemiology, and biostatistics to identify and implement the best study designs and statistical analyses for identifying genes controlling risk for complex and heterogeneous diseases (i.e., those where genes and environmental risk factors both contribute to etiology). The field has moved quickly over the past 40 years partly because the technology of genotyping and sequencing has forced it to adapt while adhering to the fundamental principles of genetics. In the last two decades, the available tools for genetic epidemiology have expanded from a genetic focus (considering 1 gene at a time) to a genomic focus (considering the entire genome), and now they must further expand to integrate information from other “-omics” (e.g., epigenomics, transcriptomics as measured by RNA expression) at both the individual and the population levels. Additionally, we can now also evaluate gene and environment interactions across populations to better understand exposure and the heterogeneity in disease risk. The future challenges facing genetic epidemiology are considerable both in scale and techniques, but the importance of the field will not diminish because by design it ties scientific goals with public health applications.


2015 ◽  
Vol 44 (11) ◽  
pp. 3418-3430 ◽  
Author(s):  
J. Wencel-Delord ◽  
A. Panossian ◽  
F. R. Leroux ◽  
F. Colobert

Over the past decade the field of the synthesis of axially chiral compounds has been rapidly expanding. Not only key advances have been achieved concerning the already established strategies but also new synthetic routes have been devised. This review showcases the recent developments in this domain.


2007 ◽  
Vol 32 (4) ◽  
pp. 808-817 ◽  
Author(s):  
Stephen S. Cheung

Over the past decade, research interest has risen on the direct effects of temperature on exercise capacity and tolerance, particular in the heat. Two major paradigms have been proposed for how hyperthermia may contribute to voluntary fatigue during exercise in the heat. One suggests that voluntary exhaustion occurs upon the approach or attainment of a critical internal temperature through impairment in a variety of physiological systems. An alternate perspective proposes that thermal inputs modulate the regulation of self-paced workload to minimize heat storage. This review seeks to summarize recent research leading to the development of these two models for hyperthermia and fatigue and explore possible bridges between them. Key areas for future research and development into voluntary exhaustion in the heat include (i) the development of valid and non-invasive means to measure brain temperature, (ii) understanding variability in perception and physiological responses to heat stress across individuals, (iii) extrapolating laboratory studies to field settings, (iv) understanding the failure in behavioural and physiological thermoregulation that leads to exertional heat illness, and (v) the integration of physiological and psychological parameters limiting voluntary exercise in the heat.


2021 ◽  

Distracted driving is defined in the Oxford English Dictionary as “the practice of driving a motor vehicle while engaged in another activity, typically one that involves the use of a mobile phone or other electronic device.” However, other distractions not involving the use of a cell phone or texting are important as well, contributing to this burgeoning public health problem in the United States. Examples include talking to other passengers, adjusting the radio or other controls in the car, and daydreaming. Distracted driving has been linked to increased risk of motor vehicle crashes (MVCs) in the United States, representing one of the most preventable leading causes of death for youth ages 16 to 24 years. Undoubtedly, the proliferation of cell phone, global positioning system (GPS), and other in-vehicle and personal electronic device use while driving has led to this rise in distracted driving prevalence. This behavior has impacted society—including individual and commercial drivers, passengers, pedestrians—in countless numbers of ways, ranging from increased MVCs and deaths to the enactment of new driving laws. In 2016, for example, 20 percent of all US pediatric deaths (nearly 4,000 children and adolescents) were due to fatal MVCs. It has been estimated that at any given time, more than 650,000 drivers are using cell phones or manipulating electronic devices while driving. In the United States, efforts are underway to reduce this driving behavior. In the past two decades, state and federal laws have specifically targeted cell phone use and texting while driving as priority areas for legal intervention. Distracted driving laws have become “strategies of choice” for tackling this public health problem, though their enforcement has emerged as a major challenge and varies by jurisdiction and location. Multimodal interventions using models such as the “three Es” framework—Enactment of a law, Education of the public about the law and safety practices, and Enforcement of the law—have become accepted practice or viewed as necessary steps to successfully change this behavior caused by distractions while driving. This Oxford Bibliographies review introduces these and other aspects (including psychological influences and road conditions) of distracted driving through a presentation of annotated resources from peer- and non-peer-reviewed literature. This selective review aims to provide policymakers, program implementers, and researchers with a reliable source of information on the past and current state of American laws, policies, and priorities for distracted driving.


1973 ◽  
Vol 5 (2) ◽  
pp. 199-216 ◽  
Author(s):  
Edward J. Williams

For the past couple of decades the Latin Americans, like their brethren in Africa and Asia, have been hell-bent in search of ‘development’ or ‘modernization’. While the Latin Americans were on the firing line, scholars and policy-makers in both the rich nations and the poor nations were involved in setting out an intellectual framework for analyzing the developmental process. New concepts to explain the meaning of development were devised; innovative measurements to gauge the level of development were proposed; a new vocabulary to capture the nuances of development was put forth.


2010 ◽  
Vol 38 (1) ◽  
pp. 187-191 ◽  
Author(s):  
Irit Gottfried ◽  
Marcelo Ehrlich ◽  
Uri Ashery

HIP1 (huntingtin interacting protein 1) has two close relatives: HIP1R (HIP1-related) and yeast Sla2p. All three members of the family have a conserved domain structure, suggesting a common function. Over the past decade, a number of studies have characterized these proteins using a combination of biochemical, imaging, structural and genetic techniques. These studies provide valuable information on binding partners, structure and dynamics of HIP1/HIP1R/Sla2p. In general, all suggest a role in CME (clathrin-mediated endocytosis) for the three proteins, though some differences have emerged. In this mini-review we summarize the current views on the roles of these proteins, while emphasizing the unique attributes of each family member.


Author(s):  
Elizabeth Tellier ◽  
Ricky Thethi

Deepwater riser selection is a complex evaluation of technical and commercial project drivers. The free standing hybrid riser (FSHR) has evolved in the last 10 years through major use in West Africa and is now gaining serious consideration in other deepwater provinces. The key benefit of the free standing riser is that the steel riser vertical section is offset from the vessel using flexible jumpers, thereby decoupling the riser from vessel dynamic motion. Early FSHR configuration took the hybrid bundle tower form. The very first free standing riser system, installed in 1988, consisted of the Placid hybrid bundle in the Gulf of Mexico. In the late nineties, a hybrid bundle tower was chosen for the Girassol development in West Africa. Since then, the industry has sanctioned numerous developments using multiple single line freestanding risers. Optimization of the FSHR is continuing with new concepts such as the Grouped SLOR developed to offer the combined benefits of both the bundle and single line multiple arrangements. This paper will describe how the FSHR configuration has evolved to meet increasing industry demands over the past 10 years and will discuss the future of this type of riser system. Increasing applications in ultra deepwater regions, hurricane prone locations and tiebacks to existing payload limited production vessels will be discussed with riser system architecture described including interfaces with the vessel and seabed.


Sign in / Sign up

Export Citation Format

Share Document