scholarly journals Kawasaki syndrome: the Iranian experience

2001 ◽  
Vol 7 (1-2) ◽  
pp. 16-25 ◽  
Author(s):  
E. Sadeghi ◽  
R. Amin ◽  
G. H. Ajamee
Keyword(s):  
Clinical Evidence ◽  
Significant Risk ◽  
Kawasaki Syndrome ◽  
C Reactive Protein ◽  
Female Ratio ◽  
Reactive Protein ◽  
Male Female Ratio ◽  
Infection And Inflammation ◽  
Islamic Republic Of Iran ◽  
Artery Disease

Experience with 50 cases of Kawasaki syndrome in the Islamic Republic of Iran is presented. The syndrome occurred mostly in winter and spring with a 2.1: 1 male: female ratio. In 72% of cases, the disease occurred between 1 and 5 years of age, and 80% had an antecedent viral or bacterial illness. Eight patients [16%] had microbiological evidence of infection and 19 [38%] had clinical evidence. Five patients had clinical and radiological evidence of sinusitis. Leukocytosis, neutrophilia, bandaemia, elevated erythrocyte sedimentation rate, positive C-reactive protein, reversed albumin/globulin ratio and increased antistreptolysin O titre were other indications of infection and inflammation. Male gender, prolonged fever, white blood cell count > 15, 000/mm3 and absolute granulocyte count > 10, 000/mm3 were significant risk factors for the development of coronary artery disease [10 patients].

Chlamydia pneumoniaeinfection is associated with elevated body mass index in young men

2009 ◽  
Vol 138 (9) ◽  
pp. 1267-1273 ◽  
Author(s):  
A. RANTALA ◽  
T. LAJUNEN ◽  
R. JUVONEN ◽  
A. BLOIGU ◽  
M. PALDANIUS ◽  
...  
Keyword(s):  
Military Service ◽  
Chlamydia Pneumoniae ◽  
Significant Risk ◽  
Young Men ◽  
C Reactive Protein ◽  
Serum Samples ◽  
Reactive Protein ◽  
Military Recruits ◽  
New Information ◽  
Infection And Inflammation

SUMMARYChlamydia pneumoniaeinfection is said to be associated with obesity. We studied the association betweenC. pneumoniaeinfection and inflammation and increased BMI in 891 Finnish military recruits. IgG seropositivity in arrival and departure serum samples during 6–12 months of military service was considered as persistence of antibodies and a possible indication of chronic infection. Persistently high C-reactive protein (CRP) level (elevated on arrival and departure) (OR 2·2, 95% CI 1·3–3·9), and persistentC. pneumoniaeantibodies (OR 2·1, 95% CI 1·5–2·8) were significant risk factors for overweight (BMI ⩾25 kg/m2). In addition, those who had persistent antibodies and persistently elevated CRP levels, or those who had either of them, had a significantly higher BMI (kg/m2) compared to those who had neither of them (25·8vs. 24·6vs. 23·5, respectively;P<0·001). These results provide new information about the association between possible chronicC. pneumoniaeinfection and obesity in young men.

Pentraxin-3 as a more sensitive marker of coronary artery disease severity than C-reactive protein

2013 ◽  
Author(s):  
Janusz Szkodzinski ◽  
Bartosz Hudzik ◽  
Aleksander Danikiewicz ◽  
Anna Pietka-Rzycka ◽  
Andrzej Lekston ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Disease Severity ◽  
Pentraxin 3 ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Coronary Artery Disease Severity ◽  
Artery Disease ◽  
Sensitive Marker

scholarly journals Direct Versus Calculated LDL Cholesterol and C-Reactive Protein in Cardiovascular Disease Risk Assessment in the Framingham Offspring Study

2019 ◽  
Vol 65 (9) ◽  
pp. 1102-1114 ◽  
Author(s):  
Hiroaki Ikezaki ◽  
Virginia A Fisher ◽  
Elise Lim ◽  
Masumi Ai ◽  
Ching-Ti Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Ldl Cholesterol ◽  
Disease Risk ◽  
Univariate Analysis ◽  
Significant Risk ◽  
C Reactive Protein ◽  
Cox Regression Analysis ◽  
Reactive Protein ◽  
Standard Risk

AbstractBACKGROUNDIncreases in circulating LDL cholesterol (LDL-C) and high-sensitivity C-reactive protein (hsCRP) concentrations are significant risk factors for cardiovascular disease (CVD). We assessed direct LDL-C and hsCRP concentrations compared to standard risk factors in the Framingham Offspring Study.METHODSWe used stored frozen plasma samples (−80 °C) obtained after an overnight fast from 3147 male and female participants (mean age, 58 years) free of CVD at cycle 6 of the Framingham Offspring Study. Overall, 677 participants (21.5%) had a CVD end point over a median of 16.0 years of follow-up. Total cholesterol (TC), triglyceride (TG), HDL cholesterol (HDL-C), direct LDL-C (Denka Seiken and Kyowa Medex methods), and hsCRP (Dade Behring method) concentrations were measured by automated analysis. LDL-C was also calculated by both the Friedewald and Martin methods.RESULTSConsidering all CVD outcomes on univariate analysis, significant factors included standard risk factors (age, hypertension, HDL-C, hypertension treatment, sex, diabetes, smoking, and TC concentration) and nonstandard risk factors (non-HDL-C, direct LDL-C and calculated LDL-C, TG, and hsCRP concentrations). On multivariate analysis, only the Denka Seiken direct LDL-C and the Dade Behring hsCRP were still significant on Cox regression analysis and improved the net risk reclassification index, but with modest effects. Discordance analysis confirmed the benefit of the Denka Seiken direct LDL-C method for prospective hard CVD endpoints (new-onset myocardial infarction, stroke, and/or CVD death).CONCLUSIONSOur data indicate that the Denka Seiken direct LDL-C and Dade Behring hsCRP measurements add significant, but modest, information about CVD risk, compared to standard risk factors and/or calculated LDL-C.

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