scholarly journals Trends for rotavirus acute gastroenteritis in children under 5 years old before and after vaccine introduction, Morocco, 2006–2014

2021 ◽  
Vol 27 (6) ◽  
pp. 553-562
Author(s):  
Hind Ezzine ◽  
Ahmed Rguig ◽  
Mariam Naciri ◽  
I. Jroundi
Keyword(s):  
Acute Gastroenteritis ◽  
Diarrheal Disease ◽  
Public Health Issue ◽  
Rotavirus Vaccine ◽  
Immunization Programme ◽  
National Immunization ◽  
National Immunization Programme ◽  
Before And After ◽  
The Impact ◽  
Children Under 5

Background: In Morocco, acute gastroenteritis in children is a public health issue. Since 1987, several strategies have been conducted to reduce its burden by the Moroccan Ministry of Health, including the introduction of the anti-rotavirus vaccine into the national immunization programme in 2010. Aims: To evaluate the impact of the anti-rotavirus vaccine in outpatients and inpatients with acute gastroenteritis under 5 years old. Methods: We conducted descriptive studies and a retrospective cohort study using data from the hospital’s sentinel surveillance system and the national ambulatory surveillance registry for acute gastroenteritis from 2006 to 2014. This include the period before and after the implementation of the rotavirus (RV) vaccine on children under age 5 years. Results: The decrease in acute gastroenteritis cases was about 5.2%, mainly among children aged 0–11 months. The proportion of acute RV gastroenteritis (RVGE) decreased from 37.0% to 31.1% after the vaccine’s introduction; it was statistically significant among the children aged 0–11 months (38.8% to 28.1%; P = 0.009). The proportion of RVGE among inpatients decreased from 97.0% to 91.7% (P = 0.022). Diarrheal disease cases without dehydration increased from 7.8% to 11.1% (P < 0.001); RVGE was 2.3 times more frequent among unvaccinated children. The vaccine effectiveness was estimated at 57%. The proportion of G1P[8] genotype infections decreased after the introduction of the RV vaccine (56% to 40%; P < 0.001), while the G2P[4] genotype became more frequent (13% to 21%; P = 0.015). Conclusions: The introduction of the RV vaccination into the national immunization programme in Morocco has allowed significant reduction in the incidence and severity of RVGE among children under 5 years old

scholarly journals Tolerability of MenACWY-TT vaccination in adolescents in the Netherlands; a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
J. M. Kemmeren ◽  
L. van Balveren ◽  
A. Kant ◽  
H. de Melker
Keyword(s):  
The Netherlands ◽  
Adverse Events ◽  
Sample Size Calculation ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Immunization Programme ◽  
National Immunization ◽  
National Immunization Programme ◽  
Before And After ◽  
Systemic Symptoms

Abstract Background In 2018, meningococcal ACWY-TT vaccine (MenACWY-TT) was offered to adolescents in the Netherlands within the National Immunization Programme at 14 years of age. A questionnaire study assessed the tolerability of this vaccine. Methods Five thousand adolescents were invited to participate and to fill in two questionnaires about systemic events in the week before vaccination and local reactions and systemic events in the week after vaccination. Frequencies of local and systemic adverse events in the week after vaccination were calculated. Association between the occurrence of systemic symptoms in the week before and after the vaccination was tested by using generalized mixed models (GLMM). Results Of all adolescents, 139 returned one or both questionnaires. Any local reaction within 7 days after vaccination was reported by 55.6% of the adolescents. Pain (50%) and reduced use of the injected arm (21.3%) were most often reported. Any systemic event was reported by 67.6% of the participants, with myalgia as the most often reported event (37.0%). Compared with the week before vaccination, there were no increased odds of experiencing systemic symptoms in the week after vaccination (OR 0.95; 95%CI 0.40–2.27). Conclusions After vaccination with MenACWY-TT vaccine, most adolescents reported one or more adverse events, which were mostly mild and transient. Systemic symptoms were not reported more often in the week after compared to the week before vaccination. Unfortunately, due to a low response rate we were not able to detect the absolute elevated risks the sample size calculation was based on. However, despite limited data, our results are in line with results from prelicensure data, and indicate that MenACWY-TT vaccination is well tolerated in adolescents.

Lower Coverage Rates of Full Rotavirus Vaccine Series in Libyan Children: A Prospective Cross-Sectional Study, 2016

2020 ◽  
Author(s):  
Salem ALKOSHI ◽  
Eyal LESHEM
Keyword(s):  
Cross Sectional Study ◽  
Rotavirus Vaccine ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Third ◽  
Immunization Programme ◽  
Rotavirus Vaccines ◽  
National Immunization ◽  
National Immunization Programme ◽  
Coverage Rates

Background: There are little data on the current condition of national immunization programme (NIP) in Libya. In 2013, pentavalent rotavirus vaccines were added to the NIP. Incomplete rotavirus vaccine series may result in lower vaccine effectiveness. The study aimed to assess timeliness and coverage rates of routine NIP vaccinations including the newly introduced rotavirus vaccine in Libya. Methods: A prospective cross-sectional study of children aged 0 to 18 months was carried out in vaccination centers of two north-western cities. Data were collected during Nov-Dec 2016 from vaccination cards of children. Child age and doses received in previous visits were documented. Results: Overall, we included 1023 children assessed in 29 visits at six vaccination centers. In children aged 18 months, coverage rates for all doses of BCG, OPV, HepB, pneumococcal, Meningococcal and MMR vaccines exceeded 95%. Coverage rates for second and third doses of rotavirus vaccines were 89% and 68%, respectively. Most (75%) children who missed the third dose of rotavirus vaccine were aged >8 months when at the time of appointment for the third dose. Conclusion: Overall, the coverage rate for routine vaccination in children assessed at immunization centers in northwest Libya was high. Lower coverage of full pentavalent rotavirus vaccine series may have been the result of exceeding the age restriction. Measures to improve timeliness of vaccination appointments should be assessed. Lifting the age restriction on rotavirus vaccines should be considered for at-risk population.

Impact of Louisiana’s HPV Vaccine Awareness Policy on HPV Vaccination Among 13- to 17-Year-Old Females

2017 ◽  
Vol 44 (4) ◽  
pp. 548-558 ◽  
Author(s):  
Dudith Pierre-Victor ◽  
Mary Jo Trepka ◽  
Timothy F. Page ◽  
Tan Li ◽  
Dionne P. Stephens ◽  
...  
Keyword(s):  
Hpv Vaccine ◽  
Hpv Vaccination ◽  
Female Adolescents ◽  
Physician Recommendation ◽  
Vaccination Rates ◽  
National Immunization ◽  
Before And After ◽  
The Difference ◽  
Vaccine Information ◽  
The Impact

The Advisory Committee on Immunization Practices recommends routine human papillomavirus (HPV) immunization for 11- to 12-year-old adolescents. In 2008, Louisiana required the school boards to distribute HPV vaccine information to parents or guardian of students in Grades 6 to 12. This article investigates the impact of this policy on HPV vaccination among 13- to 17-year-old female adolescents using National Immunization Survey-Teen (NIS-Teen) data. Drawing on the data from the 2008 to 2012 NIS-Teen, we compared the difference in proportions of females who have been vaccinated before and after the policy. Using difference-indifference estimation, we explored the change in vaccination rates before and after the policy implementation in Louisiana compared with Alabama and Mississippi, two states that did not have such a policy in place. The difference-in-differences estimates for HPV vaccination were not significant. Physician recommendation for HPV vaccination was significantly associated with vaccination among females in Louisiana and Alabama (adjusted odds ratio [aOR] = 7.74; 95% confidence interval [CI; 5.22, 11.5]), and for those in Louisiana and Mississippi (aOR = 7.05; 95% CI [4.6, 10.5]). Compared to the proportion of female adolescents who had received physician recommendation in Alabama or Mississippi, the proportion in Louisiana did not increase significantly in the postpolicy period. HPV vaccination rates did not increase significantly in Louisiana compared to Alabama or Mississippi following the implementation of the policy. Despite Louisiana’s policy, physician recommendation remains the key determinant of HPV vaccination. HPV vaccine awareness does not necessarily result in HPV vaccination.

Impact of Monovalent Rotavirus Vaccine on Rotavirus Hospitalizations among Children Younger Than 5 Years of Age in the Ouest and Artibonite Departments, Haiti, 2013 to 2019

2021 ◽  
Author(s):  
Anne-Marie Desormeaux ◽  
Eleanor Burnett ◽  
Gérard Joseph ◽  
Mentor Ali Ber Lucien ◽  
Negar Aliabadi ◽  
...  
Keyword(s):  
Negative Binomial ◽  
Hospital Admissions ◽  
Absolute Number ◽  
Sensitivity Analyses ◽  
Rotavirus Vaccine ◽  
Vaccine Introduction ◽  
Rotavirus Vaccination ◽  
Before And After ◽  
Rotavirus Diarrhea ◽  
The Impact

Rotavirus is responsible for 26% of diarrheal deaths in Latin America and the Caribbean. Haiti introduced the monovalent rotavirus vaccine in April 2014. The objective of this analysis is to describe the impact of the rotavirus vaccine on hospitalizations among Haitian children younger than 5 years old during the first 5 years after introduction. This analysis includes all children with diarrhea who were enrolled as part of a sentinel surveillance system at two hospitals from May 2013 to April 2019. We compare the proportion of rotavirus-positive specimens in each post-vaccine introduction year to the pre-vaccine period. To account for the potential dilution of the proportion of rotavirus-positive specimens from a waning cholera outbreak, we also analyzed annual trends in the absolute number of positive stools, fit a two-component finite-mixture model to the negative specimens, and fit a negative binomial time series model to the pre-vaccine rotavirus-positive specimens to predict the number of rotavirus diarrhea hospital admissions in the absence of rotavirus vaccination. The overall percentage of rotavirus-positive specimens declined by 22% the first year after introduction, increased by 17% the second year, and declined by 33% to 50% the subsequent 3 years. All sensitivity analyses confirmed an overall decline. We observed a clear annual rotavirus seasonality before and after vaccine introduction, with the greatest activity in December through April, and a biennial pattern, with high sharp peaks and flatter longer periods of increased rotavirus activity in alternating years, consistent with suboptimal vaccination coverage. Overall, our study shows evidence that the introduction of the rotavirus vaccine reduced the burden of severe rotavirus diarrhea.

Training to improve responder attitudes and knowledge of opioid overdose

2021 ◽  
Vol 13 (8) ◽  
pp. 1-18
Author(s):  
Matthew Thomas ◽  
Laura Brady ◽  
Monika Wozniak ◽  
Elizabeth Terranova ◽  
Cheryll Moore ◽  
...  
Keyword(s):  
Training Session ◽  
Educational Background ◽  
Public Health Issue ◽  
Opioid Overdose ◽  
Opioid Use ◽  
Major Public Health Issue ◽  
Knowledge And Attitudes ◽  
Before And After ◽  
Attitudes And Knowledge ◽  
The Impact

Background: Opioid use is a major public health issue and opioid overdose requires rapid response with naloxone. Aims: This study assesses the impact of a training session on the knowledge and attitudes of first responders and members of the community regarding opioid overdose recognition and naloxone use. Methods: A training session was delivered to 2327 participants between July 2019 and March 2020. The study used a paired, pre-/post-analysis to quantify changes. Findings: Nearly all (99.7%) participants completed a survey before and after training. Statistically significant improvements were observed in nearly all attitude and knowledge items. Conclusion: An education session delivered to an educationally and professionally diverse group can improve trainees' knowledge and attitudes. There were some significant differences between sub-groups, particularly regarding their professional and educational background, and whether the location was urban or rural. Further study is needed to examine whether trainees would benefit from a course tailored toward their education and professional experience.

O’Cionnfaola v. the Wellcome Foundation and Daniel McCarthy

2018 ◽  
pp. 126-143
Author(s):  
Michael Dwyer
Keyword(s):  
Public Health ◽  
State Intervention ◽  
Active Immunization ◽  
Free State ◽  
Public Health Issue ◽  
Childhood Immunization ◽  
Immunization Programme ◽  
The Social ◽  
Vaccine Confidence ◽  
The Impact

Chapter six argues that by the end of 1936, the Irish Free State had come close to incepting an operational national anti-diphtheria immunization scheme. This is a noteworthy achievement, as state-backed anti-diphtheria schemes were not introduced as an intervention against this pressing public health issue in the rest of Europe until 1938 and were only pursued with any vigour when wartime conditions exacerbated the problem from 1940 onwards. If it had progressed unimpeded, the Free State intervention seemed destined to eliminate diphtheria, and to become the first established national childhood immunization programme in Europe. However, the death of Siobhán O’Cionnfaola in April 1937, and the subsequent controversy surrounding the Ring incident, asked serious questions of active immunization and ultimately undermined vaccine confidence among parents, practitioners, and politicians. This chapter will evaluate the impact of the Ring controversy and the social, political and medical implications left in the wake of the incident.

National Immunization Programme – Mission Indradhanush Programme: Newer Approaches and Interventions

2019 ◽  
Vol 86 (7) ◽  
pp. 633-638 ◽  
Author(s):  
Ajeet Singh Bhadoria ◽  
Surabhi Mishra ◽  
Mahendra Singh ◽  
Surekha Kishore
Keyword(s):  
Immunization Programme ◽  
National Immunization ◽  
National Immunization Programme
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