scholarly journals Surgical treatment of the thyroid nodes of uncertain cytological structure

2019 ◽  
Vol 86 (5) ◽  
pp. 59-63
Author(s):  
Yu. M. Таrashchenko ◽  
А. E. Коvalenko ◽  
M. V. Оstafiychuk ◽  
I. R. Yanchiі ◽  
M. D. Melnyk ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
High Risk ◽  
Cystic Degeneration ◽  
Cytological Investigation ◽  
Clinical Factors ◽  
Risk Of Malignancy ◽  
Irregular Form ◽  
Malignant Changes ◽  
Node Size

Objective. To determine the clinical factors of the enhanced risk of malignancy in patients, having categories of cytological conclusions III (AUS/FLUS) and IV (FN/SFN). Маterials and methods. There were 11 621 patients examined with cytological investigation of thyroidal nodes under ultrasonographic control. Cytological conclusions of category ІІІ (AUS/FLUS) have characterized 621 nodes, while conclusions of category IV (FN/SFN) - 1215 nodes. There were operated 150 patients, owing cytological conclusions of category III, 436 patients - with cytological conclusions of category IV, and 11 patients, having categories of cytological conclusions III and IV. Results. Papillary and follicular carcinomas were revealed in 36% patients, suffering thyroidal nodes of the Bethesda III category, what is trustworthily more frequently (р < 0.01), than in the patients, suffering thyroidal nodes of the Bethesda category IV (25.1%). There were revealed such factors of risk for malignant properties in patients, suffering thyroidal nodes with the Bethesda category III, as: the node size 2 сm and less, its hypoechogeneicity, uneven borders, irregular form, and presence of hyperechogenic foci (р < 0.01). Cystic degeneration of a node constitutes the sign of its benign origin (р < 0.01). Conclusion. High risk of malignant changes (36%) in thyroidal nodes, in accordance to cytological conclusion of the Bethesda category III revealed, trusts the need for enhanced oncological suspicion and conduction of surgical treatment. Тhe additional factors of malignant changes must be taking into account as well, such as the node size 2 сm and less, its hypoechogeneicity, uneven borders, irregular form, and presence of hyperechogenic foci.

Correlation of high-risk human papillomavirus genotypes persistence and risk of residual or recurrent cervical disease after surgical treatment

2008 ◽  
Vol 80 (8) ◽  
pp. 1434-1440 ◽  
Author(s):  
Simona Venturoli ◽  
Simone Ambretti ◽  
Monica Cricca ◽  
Elisa Leo ◽  
Silvano Costa ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Surgical Treatment ◽  
High Risk ◽  
Cervical Disease

New possibilities of the use of surgical lasers in obstetrics

1997 ◽  
Vol 78 (6) ◽  
pp. 434-438
Author(s):  
I. F. Fatkullin
Keyword(s):  
Surgical Treatment ◽  
High Risk ◽  
Postoperative Complications ◽  
Cesarean Section ◽  
Laser Welding ◽  
Comparison Group ◽  
Obstetrics And Gynecology ◽  
Septic Complications ◽  
Basic Group ◽  
Section Operation

The laser welding suture of peritoneum in pregnants and in women in labor with high risk of pyo-septic complications is used in cesarean section operation. In the basic group the postoperative complications are three times as little than in the comparison group. The promise of the use of the biological laser @welding@ in obstetrics and gynecology to improve technology and results of surgical treatment especially in delivery of women with high risk of pyo-septic complications is noted.

Experience of using the drug Glutoxim in patients with benign and borderline epithelial ovarian tumors after performing conservative surgical treatment

2018 ◽  
pp. 79-86
Author(s):  
A.A. Sukhanova ◽  
◽  
M.Yu. Yegorov ◽  
Keyword(s):  
Surgical Treatment ◽  
High Risk ◽  
Ovarian Tumors ◽  
Molecular Profile ◽  
Control Group ◽  
Profile Data ◽  
Ki 67 ◽  
Risk Of Recurrence ◽  
Relapse Therapy ◽  
E Cadherin

The objective: to increase the effectiveness of treatment of patients with benign and borderline epithelial ovarian tumors (EOT) after conservative operations performed based on the definition of a high risk group for recurrence and malignancy according to the molecular expression profile of the markers p53, Ki-67, estrogen receptors (ER), CD34 and E-cadherin and inclusion in the complex anti-relapse therapy of the immunomodulating drug Glutoxim. Materials and methods. A clinical examination of 60 patients of reproductive age with EOT was performed, which were treated with organ-sparing surgical treatment (main group). Of these 60 patients, 30 women (subgroup I) were diagnosed with benign EOT (BEOT), the remaining 30 women (subgroup II) were diagnosed with borderline EOT (BoEOT) Ia and Ib stages in FIGO. In removed tumors after routine histopathological examination, the molecular profile was determined by immunohistochemically determining the protein regulator of apoptosis p53, proliferation index (PI) by Ki-67 expression, estrogen receptors — ER, microvessel density by CD34 expression and E-cadherin intercellular adhesion protein. Based on the molecular profile determination data, the removed tumor was ranked as high or low risk of recurrence and malignancy. Patients from the high-risk group for relapse and malignancy according to the molecular profile data included the immunomodulating drug Glutoxim in the complex anti-relapse therapy - intramuscularly 10 mg daily for 2 weeks with a course repeated every six months for 3 years. The control group consisted of 64 patients with BEOT and BoEOT, who underwent conservative surgical treatment without further anti-relapse treatment. Results. During the molecular profile study, it was found that high risk of recurrence and malignancy had EOT with p53 expression (LI ≥15%), high proliferative activity of cells with Ki-67 expression (PI ≥10%), low estrogen reception (LI ER < 49.5%), high density of microvessels on the expression of CD34 (IM ≥40 mv /mm2), low level of intercellular adhesion on the expression of E-cadherin (LI <59%). Molecular profile characterizing a high risk of recurrence and malignancy, in most cases was inherent in BoEOT. The purpose of a comprehensive anti-relapse treatment with the inclusion of the immunomodulatory drug Glutoxim (intramuscularly daily at 10 mg for 2 weeks) after performing of sparing conservative surgical treatment with a repetition of the course every six months in patients at high risk of relapse and malignancy according to molecular profile data has reduced the relapse of EOT to 6.7% in patients of the main group compared with 20.3% in the control group during three years of follow-up observation of patients. The difference is statistically significant (p <0.05). Conclusion. In order to prevent cases of recurrence and malignancy in patients with EOT at high risk of relapse and malignancy according to molecular profile data after a sparing surgical treatment that preserves their reproductive function, it is recommended that Glutoxim is administered in complex anti-relapse therapy at 10 mg intramuscularly per every day for 2 weeks with a repetition of the course every six months for 3 years. Key words: benign epithelial ovarian tumors, borderline epithelial ovarian tumors, high risks of recurrence and malignancy, anti-relapse therapy, reproductive function, Glutoxim.

Surgical Treatment following Bail-Out Stenting for High-Risk Patients with Critical Neonatal Coarctation of the Aorta

2021 ◽  
Author(s):  
P. Grieshaber ◽  
M. Merbecks ◽  
C. Jaschinski ◽  
E. Fonseca-Escalante ◽  
M. Gorenflo ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
High Risk ◽  
Coarctation Of The Aorta ◽  
High Risk Patients ◽  
Risk Patients ◽  
Bail Out

scholarly journals COMPARISON RESULTS OF SURGICAL TREATMENT LOCALIZED AND EXTENDED UTERINE CANCER

2010 ◽  
Vol 1 (3) ◽  
pp. 56-61
Author(s):  
I I Ushakov ◽  
E A Artoshina ◽  
P G Brousov ◽  
I V Nazvantsev ◽  
S A Levakov ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
High Risk ◽  
Adjuvant Radiotherapy ◽  
Primary Outcome ◽  
Outcome Measure ◽  
Uterine Cancer ◽  
Primary Outcome Measure ◽  
Pelvic Lymphadenectomy ◽  
Peritoneal Washing ◽  
Comparison Results

We selected 145 patients with endometrial carcinoma who had been treated with standard surgery (hysterectomy and BSO, peritoneal washing, palpation pelvic and para-aortic nodes) and with complete systematic pelvic lymphadenectomy (n=30 patients) or combined pelvic and para-aortic lymphadenectomy (n=30). Patients at intermediate or high risk of recurrence were offered adjuvant radiotherapy. The primary outcome measure was results of the surgical therapy.

Intraspinal Sparganosis Diagnosed by Metagenomics Next Generation Sequencing：An Uncommon Infection

2021 ◽  
Author(s):  
Rongming Wang ◽  
Bobin Hu ◽  
Jianning Jiang ◽  
Minghua Su
Keyword(s):  
Surgical Treatment ◽  
High Risk ◽  
Lower Limb ◽  
Poor Prognosis ◽  
High Dose ◽  
Next Generation ◽  
Praziquantel Treatment ◽  
Long Course ◽  
Generation Sequencing ◽  
Complex Lesions

Abstract In this paper, we report a case of lumbago with lower limb fatigue. After a series of biochemical, immunological, imaging, and pathological examinations, the patient was diagnosed with intraspinal sparganosis based on metagenomics next generation sequencing. Due to the length of infection, the presence of multiple complex lesions, and the high risk of surgical treatment with poor prognosis, we did not advocate surgical treatment, but chose to administer a high dose and long course of praziquantel treatment for this case.

Surgical treatment of high-risk patients with severe ulcerative colitis

2019 ◽  
pp. 60-62
Author(s):  
A. A. Yanishev ◽  
A. V. Bazaev ◽  
A. I. Abelevich ◽  
E. A. Babushkina
Keyword(s):  
Ulcerative Colitis ◽  
Surgical Treatment ◽  
High Risk ◽  
Severe Ulcerative Colitis ◽  
High Risk Patients ◽  
Risk Patients

scholarly journals Aggressive angiomyxoma of the perineal region

2019 ◽  
Vol 7 ◽  
pp. 2050313X1984339 ◽  
Author(s):  
Clémence Raptin ◽  
Jean-Philippe Lucot ◽  
Alfred Bassil ◽  
Edouard Poncelet ◽  
Jean-François Prolongeau ◽  
...  
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
High Risk ◽  
Genital Prolapse ◽  
Aggressive Angiomyxoma ◽  
Rare Tumour ◽  
Long Term Follow Up ◽  
Perineal Region

Aggressive angiomyxoma is a rare tumour that frequently involves the perineal region with a high risk of local recurrence. This is a case report of a 24-year-old female patient with a genital prolapse. We performed a surgical treatment. Histological examination found an aggressive angiomyxoma. The tumour recurred 1 year after surgery. Long-term follow-up is necessary.

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