scholarly journals The effect of feeding a diet naturally contaminated with deoxynivalenol on production traits and selected biochemical indicators of broiler chickens

2011 ◽  
Vol 80 (3) ◽  
pp. 287-292 ◽  
Author(s):  
Márta Erdélyi ◽  
Mária Weber ◽  
Krisztián Balogh ◽  
Zsolt Ancsin ◽  
Miklós Mézes
Keyword(s):  
Blood Plasma ◽  
Broiler Chickens ◽  
Reduced Glutathione ◽  
Lipid Peroxide ◽  
Redox Status ◽  
Production Traits ◽  
Treatment Groups ◽  
Effect Of Feeding ◽  
Glutathione Redox ◽  
In Blood Plasma

The effect of feeding a diet naturally contaminated with deoxynivalenol (DON) (0-21 days: 1.50 mg·kg-1; 22-39 days: 1.54 mg·kg-1) was studied in 40 broiler chickens. Birds were divided into two groups fed a control diet and a diet contaminated with DON (n = 20 in each). Feed intake was measured daily and individual live weight weekly; daily weight gain and feed to gain ratio were calculated. Five animals from each group were euthanized on days 21and 39 when blood (blood plasma and red blood cell haemolysates) and liver samples were collected. Concentration of triglyceride, uric acid and glucose and activities of ALT, AST and LDH were measured in blood plasma. Indicators of lipid peroxide and glutathione redox status, malondialdehyde and reduced glutathione concentration and glutathione-peroxidase activity were measured in blood plasma, red blood cell haemolysates and liver homogenates. The low dose of DON did not cause difference in the production traits, but caused significantly lower concentration of uric acid and glucose, and significantly higher concentration of triglyceride in blood plasma on day 21. Enzyme activities in blood plasma did not differ significantly between the treatment groups. Among the markers of lipid peroxide and glutathione redox status, malondialdehyde content was significantly higher in liver homogenate on day 21 in the group fed with DON contaminated diet, but reduced glutathione content and glutathione peroxidase activity did not differ significantly between the treatment groups. The results showed that diet contaminated even with a low content of deoxynivalenol caused alterations in selected biochemical indicators of blood and liver of broiler chicken.

Effect of combined treatment with aflatoxin B 1 and T-2 toxin and metabolites on some production traits and lipid peroxide status parameters of broiler chickens

2009 ◽  
Vol 57 (1) ◽  
pp. 75-84 ◽  
Author(s):  
László Pál ◽  
Károly Dublecz ◽  
Mária Weber ◽  
Krisztián Balogh ◽  
Márta Erdélyi ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Reduced Glutathione ◽  
Body Weight Gain ◽  
Control Diet ◽  
Combined Treatment ◽  
Lipid Peroxide ◽  
Control Group ◽  
Production Traits ◽  
Feed Conversion ◽  
Aflatoxin B

Three groups of cockerels were fed with a control diet, with a diet contaminated with T-2 and HT-2 toxin (0.31 and 0.26 mg/kg) or with that containing a combination of T-2 and HT-2 toxin (0.32 and 0.25 mg/kg) and aflatoxin B1(AFB1, 0.38 mg/kg) for 21 days. Body weight gain and feed conversion ratio did not differ significantly among the groups. Malondialdehyde concentration of the liver was lower in the group fed the diet contaminated with the combination of T-2 + HT-2 toxin and aflatoxin B1as compared to the control group or the group fed T-2 + HT-2 toxins. Reduced glutathione (GSH) content of the liver was lower in the T-2 + HT-2 group than in the group fed a combination of T-2, HT-2 and aflatoxin. Reduced glutathione content of the heart was higher in the T-2 + HT-2 group than in the control group. Mycotoxin contamination had no effect on glutathione peroxidase (GSH-Px) activity in comparison to the control, but significantly lower GSH-Px activity was found in the heart of chickens in the T-2 + HT-2 + AFB1group than in the T-2 + HT-2 group. In this study, T-2 + HT-2 toxin and aflatoxin B1contamination of the diets did not affect the production traits adversely and did not exert additive effects on lipid peroxidation and on the glutathione redox system.

scholarly journals Effects of Long-term Feeding of Graded Levels of T-2 Toxin-contaminated Diets on Performance, Some Lipid Peroxide and Glutathione Redox Status Parameters of Broiler Chickens

2015 ◽  
Vol 52 (3) ◽  
pp. 176-182 ◽  
Author(s):  
Krisztián Balogh ◽  
Andrea Bócsai ◽  
Csilla Pelyhe ◽  
Erika Zándoki ◽  
Márta Erdélyi ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Lipid Peroxide ◽  
Redox Status ◽  
Glutathione Redox

scholarly journals The Effectiveness of Glutathione Redox Status as a Possible Tumor Marker in Colorectal Cancer

2021 ◽  
Vol 22 (12) ◽  
pp. 6183
Author(s):  
Delia Acevedo-León ◽  
Lidia Monzó-Beltrán ◽  
Segundo Ángel Gómez-Abril ◽  
Nuria Estañ-Capell ◽  
Natalia Camarasa-Lillo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Redox State ◽  
Reduced Glutathione ◽  
Redox Status ◽  
Oxidation Products ◽  
Interventional Study ◽  
Thiol Redox State ◽  
Thiol Redox ◽  
Glutathione Redox

The role of oxidative stress (OS) in cancer is a matter of great interest due to the implication of reactive oxygen species (ROS) and their oxidation products in the initiation of tumorigenesis, its progression, and metastatic dissemination. Great efforts have been made to identify the mechanisms of ROS-induced carcinogenesis; however, the validation of OS byproducts as potential tumor markers (TMs) remains to be established. This interventional study included a total of 80 colorectal cancer (CRC) patients and 60 controls. By measuring reduced glutathione (GSH), its oxidized form (GSSG), and the glutathione redox state in terms of the GSSG/GSH ratio in the serum of CRC patients, we identified significant changes as compared to healthy subjects. These findings are compatible with the effectiveness of glutathione as a TM. The thiol redox state showed a significant increase towards oxidation in the CRC group and correlated significantly with both the tumor state and the clinical evolution. The sensitivity and specificity of serum glutathione levels are far above those of the classical TMs CEA and CA19.9. We conclude that the GSSG/GSH ratio is a simple assay which could be validated as a novel clinical TM for the diagnosis and monitoring of CRC.

Effect of Feeding on Vitamin A Concentrations in Blood Plasma of Dogs

1990 ◽  
Vol 37 (1-10) ◽  
pp. 605-609 ◽  
Author(s):  
F. J. Schweigert ◽  
Stephanie Uehlein-Harrell ◽  
H. Zucker
Keyword(s):  
Vitamin A ◽  
Blood Plasma ◽  
Effect Of Feeding ◽  
In Blood Plasma

scholarly journals Effect of T-2 and HT-2 Toxin during the Growing Period on Body Weight, Lipid Peroxide and Glutathione Redox Status of Broiler Chickens

2010 ◽  
Vol 79 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Mária Weber ◽  
Krisztián Balogh ◽  
Judit Fodor ◽  
Márta Erdélyi ◽  
Zsolt Ancsin ◽  
...  
Keyword(s):  
Body Weight ◽  
Glutathione Peroxidase ◽  
Blood Cell ◽  
Blood Plasma ◽  
Red Blood Cell ◽  
Peroxidase Activity ◽  
Broiler Chickens ◽  
Reduced Glutathione ◽  
Liver Homogenate ◽  
Glutathione Peroxidase Activity

The effect of T-2 and HT-2 toxin using different doses in the starter (0-21 days: 1.04 mg T-2 toxin and 0.49 mg HT-2 toxin kg-1feed), and finisher diets (22-39 days: 0.12 mg T-2 toxin and 0.02 mg HT-2 toxin kg-1feed) was investigated in broiler chickens. Birds were divided into two groups fed with control and T-2 and HT-2 toxin contaminated diets. Pathological signs of toxicity were investigated on days 21 and 39 of the trial, individual liveweight was measured weekly. Five birds from each group were sacrificed on the 21st and 39th days of treatment, when blood plasma, red blood cell, liver and kidney samples were taken, in which malondialdehyde and reduced glutathione concentration and glutathione-peroxidase activity were determined. Pathological signs (lesions in the oral cavity and on the tongue, inflammation in the small intestine) were found in the group fed T-2 and HT-2 toxin contaminated feed on day 21 compared to control. Body weight was significantly lower as a result of feeding T-2 and HT-2 toxin contaminated diet. However, the contamination did not cause a significant increase of malondialdehyde content in the analysed tissues. Reduced glutathione content was significantly lower in the liver homogenate on day 39 than that of the control. Glutathione peroxidase activity also did not differ significantly in blood plasma, red blood cell haemolysates and kidney homogenates, while it was significantly higher in the liver homogenates of the mycotoxin-challenged birds. In conclusion, it can be stated that T-2 and HT-2 toxin exposure has long-term effects in broiler chickens.

scholarly journals Role of glutathione redox system on the susceptibility to deoxynivalenol of pheasant (Phasianus colchicus)

2019 ◽  
Vol 36 (2) ◽  
pp. 175-182 ◽  
Author(s):  
Csaba Fernye ◽  
Zsolt Ancsin ◽  
Márta Erdélyi ◽  
Miklós Mézes ◽  
Krisztián Balogh
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Blood Plasma ◽  
Reduced Glutathione ◽  
Redox System ◽  
Phasianus Colchicus ◽  
Glutathione Peroxidase Activity ◽  
Glutathione Redox System ◽  
Dose Dependent ◽  
Glutathione Redox

AbstractThere are only a few reports on the effects of mycotoxins on pheasant (Phasianus colchicus) and the susceptibility to deoxynivalenol of these birds have never been reported before. The present experiment focuses to investigate the effects of different dietary concentrations of deoxynivalenol on blood plasma protein content, some parameters of lipid peroxidation and glutathione redox system and on the performance of pheasant chicks. A total of 320 1-day-old female pheasants were randomly assigned to four treatment groups fed with a diet contaminated with deoxynivalenol (control, 5.11 mg/kg, 11.68 mg/kg and 16.89 mg/kg). Birds were sacrificed at early (12, 24 and 72 h) and late (1, 2 and 3 weeks) stages of the experiment to demonstrate the oxidative stress-inducing effect of deoxynivalenol. Feed refusal was dose dependent, especially in the last third of the trial, but only minor body weight gain decrease was found. Lipid-peroxidation parameters did not show dose-dependent effect, except in blood plasma during the early stage of the trial. The glutathione redox system, reduced glutathione content and glutathione peroxidase activity, was activated in the liver, but primarily in the blood plasma. Glutathione peroxidase activity has changed parallel with reduced glutathione concentration in all tissues. Comparing our results with literature data, pheasants seem to have the same or higher tolerance to deoxynivalenol than other avian species, and glutathione redox system might contribute in some extent to this tolerance, as effective antioxidant defence against oxidative stress.

Metoprolol and Nebivolol Prevent the Decline of the Redox Status of Low-Molecular-Weight Aminothiols in Blood Plasma of Rats During Acute Cerebral Ischemia

2018 ◽  
Vol 72 (4) ◽  
pp. 195-203 ◽  
Author(s):  
Alexander Vladimirovich Ivanov ◽  
Valery Vasilʼevich Alexandrin ◽  
Alexander Alexandrovich Paltsyn ◽  
Edward Danielevich Virus ◽  
Ksenya Alexandrovna Nikiforova ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Cerebral Ischemia ◽  
Blood Plasma ◽  
Redox Status ◽  
Low Molecular Weight ◽  
Acute Cerebral Ischemia ◽  
In Blood Plasma
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