Acute effect of cigarette smoking on frontal planar QRS-T angle in apparently healthy subjects with habitual smoking

Background:Cigarette smoking induced increased sympathetic activity is one of the major independent risk factor for cardiac morbidity and mortality. Objective:To assess acute effects of smoking on neuro cardiovascular regulation by analysis of time domain measures of HRV in current regular healthy male cigarette smoker. Methods:This comparative analytical study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from July 2011 to June 2012. 120 apparently healthy male current regular cigarette smoker aged 20-55 years were participated in the study group. Age and BMI matched 70 apparently healthy male non smoker subjects were studied as control. To observe the acute effects data were recorded 5 and 30 min after finishing a cigarette. Time domain measures of HRV were recorded by a RMS digital polyrite D. Statistical analysis was done by independent sample t test and paired sample t test. Results: Resting pulse rate, SBP, DBP, mean heart rate were significantly higher (p<0.001) and mean R-R interval, SDNN, RMSSD and total power were significantly lower (p<0.001) in all smokers in comparison to those of healthy control.In addition, all time domain parameters were significantly decreased from their corresponding baseline value just 5 minutes after smoking and returned close to their baseline value after 30 minutes of smoking but it remained significantly lower than control value. Conclusion: The result of this study concludes that cigarette smoking had acute effect on cardiac autonomic function causing depressed vagal activity and overbalance of sympathetic function. DOI: http://dx.doi.org/10.3329/jbsp.v9i2.22798 Bangladesh Soc Physiol. 2014, December; 9(2): 59-64

Download Full-text

Concentrations of non-glucose polyols in serum and cerebrospinal fluid from apparently healthy adults and children.

Clinical Chemistry ◽

10.1093/clinchem/30.2.188 ◽

1984 ◽

Vol 30 (2) ◽

pp. 188-191 ◽

Cited By ~ 6

Author(s):

S Yoshioka ◽

S Saitoh ◽

S Seki ◽

K Seki

Keyword(s):

Mass Spectrometry ◽

Cerebrospinal Fluid ◽

Liquid Chromatography ◽

Healthy Subjects ◽

Metabolic Diseases ◽

Gas Liquid Chromatography ◽

Liquid Chromatography Mass Spectrometry ◽

Adults And Children ◽

Healthy Persons ◽

Apparently Healthy

Abstract Six non-glucose polyols--mannose, fructose, 1-deoxyglucose, mannitol, glucitol, and inositol--were identified and evaluated in human serum and cerebrospinal fluid by gas-liquid chromatography and by gas-liquid chromatography/mass spectrometry. Concentrations of fructose, mannose, and inositol in the serum of healthy persons or children without metabolic diseases varied with age, as already reported for 1-deoxyglucose. Fructose, inositol, and glucitol concentrations in cerebrospinal fluid significantly exceeded those in serum. The method described here for determining polyols and for evaluating polyol patterns in serum, as well as the resulting data on children and healthy subjects, should be useful in investigations of the clinical and physiological significance of polyols.

Download Full-text

Simultaneous measurement of two major prostacyclin metabolites in urine

Clinical Chemistry ◽

10.1093/clinchem/36.11.1978 ◽

1990 ◽

Vol 36 (11) ◽

pp. 1978-1980 ◽

Cited By ~ 5

Author(s):

S Zureick ◽

J Nadler ◽

J Yamamoto ◽

R Horton

Keyword(s):

Angiotensin Ii ◽

Blood Vessels ◽

Simultaneous Measurement ◽

Healthy Subjects ◽

High Accuracy ◽

High Concentration ◽

Accuracy And Precision ◽

Overall Evaluation ◽

Excretion Rates ◽

Apparently Healthy

Abstract We describe a combined HPLC-RIA technique to measure both major metabolites of prostacyclin (PGI2): 6-keto PGF1 alpha and 2,3-dinor-6 keto PGF1 alpha. The measurement of the former, which originates from renal blood vessels, and the latter, from systemic vessels and the liver, may provide a better overall evaluation of production than measurement of one metabolite. An aliquot of acidified urine with added 3H-labeled metabolites is adsorbed and then eluted from a C18 Bond-Elut column. The sample is then passed through an HPLC system by use of an isocratic solvent combination that separates the two metabolites from known prostaglandins. The purified metabolites are then quantified by RIA. Using a logit-log10 transform, one can measure between 12 and 250 pg of either metabolite, with high accuracy and precision (CVs of 12% for a low concentration and 7% for a high concentration). Reference values for apparently healthy subjects were, respectively, 107 (SD 45) and 171 (SD 69) ng/g creatinine for 6-keto PGF1 alpha and the dinor metabolite in men (n = 18) and 45 (SD 22) and 141 (SD 28) ng/g creatinine, respectively, in women (n = 15). Indomethacin in standard doses reduced both metabolite values by 50%. Intravenous administration of angiotensin II (5 ng/kg of body wt per minute) did not alter excretion rates, but equipressor doses of norepinephrine (0.1 microgram/kg per minute) increased the production of both metabolites (6-keto greater than dinor).

Download Full-text

Exercise-Induced Release of Cardiac Troponins in Adolescent vs. Adult Swimmers

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18031285 ◽

2021 ◽

Vol 18 (3) ◽

pp. 1285

Author(s):

Rafel Cirer-Sastre ◽

Francisco Corbi ◽

Isaac López-Laval ◽

Luis Enrique Carranza-García ◽

Joaquín Reverter-Masià

Keyword(s):

Cardiac Troponin ◽

Healthy Subjects ◽

Troponin T ◽

Training Experience ◽

Post Exercise ◽

Baseline Values ◽

Exercise Induced ◽

Cardiac Troponins ◽

Similar Peak ◽

Apparently Healthy

To examine the exercise-induced release of cardiac troponin T (cTnT) in adolescent and adult swimmers. Thirty-two trained male (18 adolescents, 14 adults) swam at maximal pace in a 45 min distance trial, and blood samples were drawn before, immediately and 3 h after exercise for subsequent cTnT analysis and comparison. Having comparable training experience and baseline values of cTnT (p = 0.78 and p = 0.13), adults exercised at lower absolute and relative intensity (p < 0.001 and p < 0.001, respectively), but presented higher immediate cTnT after exercise than adolescents (p < 0.001). Despite that, peak concentrations were observed at 3 h post exercise and peak elevations were comparable between groups (p = 0.074). Fourteen (44%) apparently healthy subjects exceeded the cutoff value for myocardial infarction (MI). Adolescents presented a delayed elevation of cTnT compared with adults, but achieved similar peak values.

Download Full-text