Hubungan Indeks Massa Tubuh dan Angka Kejadian Akne Vulgaris pada Siswa-siswi di SMA Frater Don Bosco Manado

Abstract: Acne vulgaris is a chronic inflammatory disease of the pilosebasea follicle. Although the cause of acne vulgaris is not known for certain but there are several pathogenesis suspected to have some effects on the occurrence of acne vulgaris, inter alia the increase in sebum production which is controlled by androgen hormones. Stimulation of androgen hormone production is associated with elevated level of insulin-like growth factor-1 (IGF-1). Increased IGF-1 is correlated positively with body mass index (BMI). In general, acne vulgaris begins at age 12-15 years and most occur in adolescents aged 15-18 years. This study was aimed to determine the relationship between BMI and the incidence rate of acne vulgaris in students at SMA Frater Don Bosco Manado (senior high school). This was an analytical survey observation with a cross sectional design. Subjects were 69 students obtained by using systematic random sampling. Of the 69 students suffered from acne vulgaris, there were 8 (11.6%) with thin BMI; 50 (72.5%) with normal BMI; and 11 (15.9%) with fat and obese BMI. Conclusion: There was no significant association between BMI and the incidence of acne vulgaris among the students at SMA Frater Don Bosco Manado.Keywords: body mass index, acne vulgaris Abstrak: Akne vulgaris adalah penyakit radang kronis pada folikel pilosebasea. Walaupun penyebab dari akne vulgaris belum diketahui pasti namun terdapat beberapa patogenesis yang diduga berpengaruh pada timbulnya akne vulgaris, salah satunya yaitu peningkatan produksi sebum di bawah kontrol hormon androgen. Stimulasi produksi hormon androgen berhubungan dengan peningkatan kadar insulin-like growth factor-1 (IGF-1). Peningkatan IGF-1 berkorelasi positif dengan indeks massa tubuh (IMT). Umumnya akne vulgaris dimulai pada usia 12-15 tahun dan terbanyak pada remaja usia 15-18 tahun. Penelitian ini bertujuan untuk mengetahui hubungan antara IMT dan angka kejadian akne vulgaris pada siswa-siswi di SMA Frater Don Bosco Manado. Jenis penelitian ialah observasi analitik survei dengan desain potong lintang. Subyek penelitian ialah siswa-siswi di SMA Frater Don Bosco Manado diperoleh dengan pengambilan sampel secara acak sistematis. Pada 69 subyek dengan akne vulgaris, terdapat 8 orang (11,6%) dengan IMT kurus; 50 orang (72,5%) dengan IMT normal; dan 11 orang (15,9%) dengan IMT gemuk dan obesitas. Simpulan: Tidak terdapat hubungan bermakna antara IMT dan angka kejadian akne vulgaris pada siswa-siswi di SMA Frater Don Bosco Manado.Kata kunci: indeks massa tubuh, akne vulgaris

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Role of insulin-like growth factor 1 in pathogenesis of acne vulgaris: relation to acne severity and body mass index

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20200593 ◽

2020 ◽

Vol 6 (2) ◽

pp. 147

Author(s):

Shereen Adel ◽

Talal A. Abd-El-Raheem ◽

Ghada Ezzat ◽

Nermeen M. Ismail

Keyword(s):

Body Mass Index ◽

Growth Factor ◽

Body Mass ◽

Scientific Evidence ◽

Acne Vulgaris ◽

Elevated Serum ◽

Insulin Like Growth Factor ◽

Dermatological Examination ◽

Relationship Of

<div class="Section1">Background: Acne vulgaris is a multifactorial skin disease. A potential role for insulin-like growth factor-1 (IGF-1) has been suggested in the pathogenesis of acne. Several studies have shown that elevated levels of serum IGF-1 correlate with overproduction of sebum and acne. Objective: Measurement of the serum level of IGF-1 in acne patients in comparison to normal controls and evaluating the relationship of these levels to severity of acne and body mass index (BMI), in order to investigate the role of this factor in the pathogenesis of acne.Methods: Fifty-four patients with acne vulagaris and 42 healthy controls were included. History taking, dermatological examination, clinical assessments of acne severity, calculation of BMI were performed for patients. Blood samples were collected from all participants for estimation of serum IGF-1 level using enzyme linked immunosorbant assay.Results: There was a significantly higher serum IGF-1 level in acne patients (p<0.05) than controls. Authors didn’t find a relation of significance between elevated serum IGF-1 level and degree of acne severity and BMI (p>0.05). There was a significant positive correlation between serum IGF-1 level and age of the patients.Conclusions: There is a significantly higher serum IGF-1 in acne patients than controls not related to acne severity and BMI. That is adding to the scientific evidence of IGF-1 role in pathogenesis of acne vulgaris.</div>

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Association between Acne and Body Mass Index: A Hospital Based Cross Sectional Study

Nepal Journal of Dermatology Venereology & Leprology ◽

10.3126/njdvl.v16i1.19408 ◽

2018 ◽

Vol 16 (1) ◽

pp. 53-56

Author(s):

Saraswoti Neupane ◽

Binamra Basnet ◽

Tara Devi Sharma

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Acne Vulgaris ◽

Cross Sectional Study ◽

Normal Weight ◽

P Value ◽

Cross Sectional ◽

Middle Income ◽

Medical College ◽

Middle Income Countries

Introduction: Acne vulgaris is a common and chronic inflammatory skin disease of pilosebaceous unit. Obesity is one of the biggest problems in western life style but nowadays, the problem is increasing even in low and middle-income countries. Body Mass Index (BMI) is used to accurately measure obesity.Objective: To find out the association between different categories of BMI and severity of acne.Materials and methods: This was a cross sectional prospective study conducted in the outpatient department of Gandaki Medical College from January to July, 2017. All the newly diagnosed patients with acne were included in the study. Height and weight of the patients was recorded and BMI was calculated. BMI was categorized as underweight, normal weight, overweight and obese. Type of lesions were noted and severity of acne was graded from 1 to 4.Statistical analysis was performed using SPSS version 17.0 for windows. One-way Analysis of Variance between groups (ANOVA) test was applied. P value of less than 0.05 was considered significant.Results: There were altogether 249 patients with acne. Age of the patients ranged from 10 to 44 years with mean age of 20.82 ±5.9 years. Most of the patients were in the age group of 11-20 years. Female: male ratio was 1:1.4. Majority of patients (65.5%) had normal BMI. Most of the patients had Grade 2 acne (52.6%). There was no significant association between the BMI and severity of acne (p=0.129).Conclusion: There was no significant association between BMI and severity of acne.

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Postnatal growth in children born small and appropriate for gestational age during the first years of life

Medicina ◽

10.3390/medicina45010008 ◽

2008 ◽

Vol 45 (1) ◽

pp. 51 ◽

Cited By ~ 2

Author(s):

Margarita Valūnienė ◽

Agnė Danylaitė ◽

Dovilė Kryžiūtė ◽

Giedrė Ramanauskaitė ◽

Danutė Lašienė ◽

...

Keyword(s):

Body Mass Index ◽

Growth Factor ◽

Body Mass ◽

Gestational Age ◽

Small For Gestational Age ◽

Binding Protein ◽

Insulin Like Growth Factor ◽

Appropriate For Gestational Age ◽

Igf Binding ◽

Igf Binding Protein

The aim of the study was to evaluate growth pattern of small- and appropriate-for-gestationalage children and to identify prenatal and postnatal risk factors for short stature and development of components of metabolic syndrome. A total of 109 small- and 239 appropriate-for-gestational-age infants were enrolled in the study. Within 24 hours after birth and at 2, 5, 9, 12, 18, 24 months, and 6 years of age, anthropometric data were recorded for study children. Cord blood samples from study infants were collected, and insulin-like growth factor-1 (IGF), IGF-binding protein-3, and leptin levels were measured. Birth weight and height (P<0.001) and insulin-like growth factor-1, IGF-binding protein-3, and leptin levels (P<0.05) were lower in children born small for gestational age vs. children born appropriate for gestational age. At 2, 5, 12, 18, and 24 months and 6 years of age, children born small for gestational age remained shorter and weighed less (P<0.001). Waist-to-hip ratio, heart rate at 6 years of age and gain in body mass index from birth up to 6 years of age was higher in children born small for gestational age. Height gain during the first year of life was mainly influenced by birth length and target height. Maternal weight before pregnancy and cord leptin levels were the most significant factors influencing postnatal weight gain during the first years of life. Conclusions. During the first 6 years of life, children born small for gestational age remained shorter and lighter. A greater catch-up in body mass index and tendency towards central pattern of fat distribution during the first years of life might be predisposing factors for the development of long-term metabolic complications in these individuals.

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Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.78.3.744 ◽

1994 ◽

Vol 78 (3) ◽

pp. 744-752 ◽

Cited By ~ 150

Author(s):

A. Juul

Keyword(s):

Body Mass Index ◽

Growth Factor ◽

Body Mass ◽

Serum Insulin ◽

Healthy Children ◽

Insulin Like Growth Factor ◽

Factor I ◽

Adolescents And Adults ◽

Testicular Size ◽

Growth Factor I

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Hubungan Indeks Masa Tubuh (IMT) dengan Persen Lemak Tubuh, dan Lemak Viscelar di Kota Semarang

Jurnal Gizi ◽

10.26714/jg.10.1.2021.51-59 ◽

2021 ◽

Vol 10 (1) ◽

pp. 51

Author(s):

Purwanti Susantini

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Body Fat ◽

Percent Body Fat ◽

Obese People ◽

Cross Sectional ◽

Metabolic Complications ◽

Regional Leadership ◽

Cross Sectional Design ◽

The Relationship

Indonesia is predicted to experience a demographic bonus period, namely the number of productive age population (aged 15-64 years) of 64%. The prevalence of obesity at productive age from 2007 to 2018 has increased from 8.6% to 13.6%. Obesity will result in high percent body fat andvisellar fat, and will result in various non-communicable diseases such as type 2 diabetes, cardiovascular disease, stroke, cancer and other non-metabolic complications such as arthritis. The onset of this disease in obese people is preceded by a group of symptoms such as hypertension, insulinresistance, dyslipidemia. Objectives: To determine the relationship between Body Mass Index and Percent body fat and to determine the relationship between Body Mass Index and Viscelar Fat. Methods: This study used a cross sectional design with purposive sampling method, namely thosevisiting the Aisyiyah Regional Leadership Stand in Semarang City at the Expo of Community Organizations in Semarang City. The sample is 115 people. Results: This study found that 35 (30.4%) men and 80 (69.6%) women, Average Age: (45.14 ± 14.55) years, Body Mass Index (25.39 ± 3.96), mean percent body fat (32.63 ± 6.68) mean viscelar fat (7.93 ± 5.13). There is a relationship between BMI and percent body fat (p = 0.000) and there is a relationship between BMI and Viscelar fat (p = 0.000).Keywords: Body Mass Index, percent body fat, Viscelar fat

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Neue Entwicklungen und Perspektiven in der Akromegalie

DMW - Deutsche Medizinische Wochenschrift ◽

10.1055/a-1495-2715 ◽

2021 ◽

Vol 146 (15) ◽

pp. 950-954

Author(s):

Mario Detomas ◽

Miriam Reuter ◽

Timo Deutschbein

Keyword(s):

Body Mass Index ◽

Growth Factor ◽

Body Mass ◽

Ältere Patienten ◽

Insulin Like Growth Factor ◽

Sich Eine ◽

Diagnostik Und Therapie ◽

Neue Entwicklungen ◽

Diagnostisches Vorgehen

Was ist neu? Diagnostik Bei Verdacht auf eine Akromegalie wird zunächst das Hormon Insulin-like growth factor 1 (IGF-1) als wesentlicher Mediator des Wachstumshormons (GH) bestimmt. Ist es erhöht, schließt sich eine Bestätigungsdiagnostik mittels GH-Suppressionstest an. Neue Arbeiten empfehlen für diesen Test niedrigere GH-Grenzwerte als früher, zudem sollen potenzielle Einflussgrößen (z. B. Body-Mass-Index) stärker berücksichtigt werden. Perspektivisch könnten Erkrankte mittels einer automatisierten Gesichtserkennung ggf. leichter identifiziert werden. Komorbiditäten Bei einem unkontrollierten GH-Exzess sind Lebensqualität und -erwartung zum Teil erheblich reduziert. Eine Akromegalie sowie deren typische Folgeerkrankungen (z. B. Schlafapnoe, Kardiomyopathie, Arthropathie) müssen daher frühzeitig erkannt werden. Kürzlich wurden neue Empfehlungen für ein standardisiertes diagnostisches Vorgehen publiziert. Therapie Die operative Adenomentfernung durch einen erfahrenen Hypophysenchirurgen ist Therapie der Wahl. Bei residueller Erkrankung kann perspektivisch eine Kombination aus volumetrischer Magnetresonanztomografie (MRT) und 11C-Methionin-Positronen-Emissions-Tomografie (PET) eine Folgeoperation erleichtern. Für die typische Zweitlinientherapie mit Somatostatin-Analoga (SSA) ist nun erstmals auch ein oral einzusetzendes Präparat verfügbar. Neue Daten belegen die Wirksamkeit und Sicherheit einer Hypophysenbestrahlung. Spezielle Patientenpopulationen Schwangere und ältere Patienten bedürfen besonderer Aufmerksamkeit. Gemäß aktueller Daten wirkt sich die COVID-Pandemie auch bei einer Akromegalie nachteilig auf Diagnostik und Therapie aus.

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Profile of the body mass index and associated factors in active elderlies

Revista Brasileira de Enfermagem ◽

10.1590/0034-7167-2016-0683 ◽

2018 ◽

Vol 71 (suppl 2) ◽

pp. 876-883

Author(s):

Pollyana Viana Lima ◽

Arianna Oliveira Santana Lopes ◽

Stênio Fernando Pimentel Duarte ◽

Alessandra Souza de Oliveira ◽

Gefter Thiago Batista Correa ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Motor Performance ◽

Associated Factors ◽

Descriptive Analysis ◽

Binary Logistic Regression ◽

The Body ◽

Excess Weight ◽

Cross Sectional ◽

Cross Sectional Design

ABSTRACT Objective : Identifying the profile of Body Mass Index and associated factors in active elderlies. Method: This is an analytical type of research with cross-sectional design and quantitative approach, with sample represented by 105 elderly people. The research instrument consisted of Cognitive assessment, Sociodemographic data, Health conditions and Motor performance evaluation. The data were analyzed by using descriptive analysis and binary logistic regression. Results: The elderlies without partners have 7.753 times the chance of presenting excess weight when compared to those with partners. Having an income higher than a minimum wage represents 6.014 times the chance of being overweight. Not having health problems amounts to 0.015 times the chance of being overweight. In the motorperformance, not presenting limitation of balance represents 6.785 times the possibility of being affected by excess weight.

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The Insulin-Like Growth Factor Axis and Plasma Lipid Levels in the Elderly1

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem.83.2.4548 ◽

1998 ◽

Vol 83 (2) ◽

pp. 499-502

Author(s):

Gian Paolo Ceda ◽

Elisabetta Dall’Aglio ◽

Andrea Magnacavallo ◽

Nicola Vargas ◽

Vittorio Fontana ◽

...

Keyword(s):

Body Mass Index ◽

Regression Analysis ◽

Growth Factor ◽

Body Mass ◽

Elderly Population ◽

Elderly Subjects ◽

Insulin Like Growth Factor ◽

Lipid Levels ◽

Igf I ◽

Igfbp 3

The activity of the hypothalamic-GH-insulin-like growth factor (IGF) network declines with age. It has recently been shown that increased cardiovascular mortality occurs in adults with GH deficiency. As hypercholesterolemia is common in GH-deficient adults, and because there is experimental evidence that GH may play a role in regulating plasma cholesterol, we decided to investigate the activity of the GH-IGF axis in an elderly population by measuring serum IGF-I, IGF-II, and IGF-binding protein-3 (IGFBP-3) levels and to study their relationship with blood lipid levels. One hundred and thirty-two elderly subjects, 52 men and 80 women, were studied (age range, 60–91 yr). Men had significantly lower levels of IGFBP-3, high density lipoprotein cholesterol (HDL-C) and apoprotein A1 (ApoA1) compared to the women, whereas IGF-I and IGF-II were only slightly lower. Using linear regression analysis, we observed an inverse relationship of age with IGF-I (r = −0.35; P < 0.001), IGF-II (r = 0.40; P < 0.001), IGFBP-3 (r = 0.52; P < 0.001), body mass index, and lipid levels. Univariate regression analysis showed a strong and positive correlation of both IGF-I and IGFBP-3 with HDL-C and ApoA1. Partial correlation analysis, after adjustment for age and body mass index, showed that IGFBP-3 and IGF-II were still significantly and positively related to HDL-C and ApoA1. Furthermore, a strong association was documented among IGF-I, IGF-II, and IGFBP-3. These data demonstrate that even in an elderly population, further aging is accompanied by a progressive decline in circulating IGF-I, IGF-II, and IGFBP-3, suggesting a continuing diminution of the GH-IGF axis throughout aging. Moreover, the strong correlation between HDL-C and an index of GH secretion, such as IGFBP-3, suggests that GH might play an important role in lipid metabolism in healthy elderly subjects.

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