ORGANOPHOSPHORUS NEUROTOXINS

Author(s):  
Mariya Andriyanova ◽  
Aslanli Aslanli ◽  
Nataliya Basova ◽  
Viktor Bykov ◽  
Sergey Varfolomeev ◽  
...  

The collective monograph is devoted to discussing the history of creation, studying the properties, neutralizing and using organophosphorus neurotoxins, which include chemical warfare agents, agricultural crop protection chemical agents (herbicides and insecticides) and medicines. The monograph summarizes the results of current scientific research and new prospects for the development of this field of knowledge in the 21st century, including the use of modern physicochemical methods for experimental study and theoretical analysis of biocatalysis and its mechanisms based on molecular modeling with supercomputer power. The book is intended for specialists who are interested in the current state of research in the field of organophosphorus neurotoxins. The monograph will be useful for students, graduate students, researchers specializing in the field of physical chemistry, physicochemical biology, chemical enzymology, toxicology, biochemistry, molecular biology and genetics, biotechnology, nanotechnology and biomedicine.

Radiocarbon ◽  
2009 ◽  
Vol 51 (2) ◽  
pp. 457-470 ◽  
Author(s):  
Sylvain Ozainne ◽  
Laurent Lespez ◽  
Yann Le Drezen ◽  
Barbara Eichhorn ◽  
Katharina Neumann ◽  
...  

At Ounjougou, a site complex situated in the Yamé River valley on the Bandiagara Plateau (Dogon country, Mali), multidisciplinary research has revealed a rich archaeological and paleoenvironmental sequence used to reconstruct the history of human-environment interactions, especially during the Late Holocene (3500–300 cal BC). Geomorphological, archaeological, and archaeobotanical data coming from different sites and contexts were combined in order to elaborate a chronocultural and environmental model for this period. Bayesian analysis of 54 14C dates included within the general Late Holocene stratigraphy of Ounjougou provides better accuracy for limits of the main chronological units, as well as for some particularly important events, like the onset of agriculture in the region. The scenario that can be proposed in the current state of research shows an increasing role of anthropogenic fires from the 3rd millennium cal BC onwards, and the appearance of food production during the 2nd millennium cal BC, coupled with a distinctive cultural break. The Late Holocene sequence ends around 300 cal BC with an important sedimentary hiatus that lasts until the end of the 4th century cal AD.


2015 ◽  
Vol 20 (1) ◽  
pp. 130-137
Author(s):  
Nicoleta Grigoriu ◽  
Gabriel Epure ◽  
Dănuţ Moşteanu

Abstract Chemical warfare agents (CWA’s) induce complex toxicological effects with major adverse consequences for those exposed. For many chemical agents there is a need for research and development of analytical toxicological methods for a rapid and certain confirmation of those exposures. The certain methods will help for establishing the laboratory diagnosis for applying the proper therapy; the treatment of only contaminated people, decreasing the stress level in the medical community in management of crisis situations, increasing the survival rate of the population exposed to the contamination, supervision of professional exposure, judicial analysis in case of suspicious terrorist activities. The paper presents some analytical toxicological methods for detection, identification and confirmation of metabolites from urine samples, based on the metabolism/hydrolysis processes of CWA’s.


2020 ◽  
Vol 5(160) ◽  
pp. 221-228
Author(s):  
Paweł Gotowiecki

The reviewed publication contains post-conference materials, presented during the conference held in 2016 in Warsaw, entitled “The Deposit of Independence. National Council of the Republic of Poland in Exile (1939–1991)”. The volume consists of 18 articles, published in chronological and topical order, devoted to the selected issues of the history of the Polish parliamentarianism in exile during World War II and in the post-war period. The authors of the articles discussed various aspects of the activities of the National Council of the Republic of Poland in Exile, such as the participation of national minorities in the work of the quasi-parliament, biographies of the chosen parliamentarians, or the selected elements of “parliamentary practices”. This publication is not a synthesis but it supplements and develops the current state of research on the activities of the Polish quasi-parliamentary institutions in exile.


2020 ◽  
pp. 3-44
Author(s):  
Thomas Duve

RESUMOEste capítulo introdutório tem por objetivo mostrar o papel da ‘literatura normativa pragmática’ no regime histórico de produção de conhecimento nos impérios ibéricos do início da modernidade (séculos XVI-XVII) e definir esse gênero literário em vista de sua função. Ele começa com uma tentativa de apresentar a história do direito dos impérios ibéricos como parte de uma tradição jurídica que pode ser compreendida como um enorme processo diacrônico de intertextualidade, uma longa história de atos reiterativos de tradução de informação normativa em conhecimento normativo. Ele destaca a razão pela qual o conhecimento normativo produzido por atores religiosos foi de grande significância dentro da economia do conhecimento dos impérios ibéricos nos séculos XVI e XVII e como teologia prática, práticas normativas e literatura pragmática estavam entrelaçadas. Dessa reconstrução de certas características fundamentais, é possível sugerir a definição de ‘literatura normativa pragmática’, resumir o atual estado das pesquisas sobre as formas de comunicação que compuseram o gênero e concluir com alguns comentários sobre porque a literatura pragmática pode ter sido de especial significância para governar um império.PALAVRAS-CHAVEHistória do direito. Teologia moral. História do Conhecimento. América Latina Colonial. História do livro jurídico.ABSTRACTThis introductory chapter aims to show the role of ‘pragmatic normative literature’ in the historical regime of knowledge production in the early modern Iberian Empires during the 16th and 17th centuries and to define this literary genre in the light of this function. It starts with an attempt to present the legal history of the Iberian empires as part of a legal tradition that can be understood as a huge diachronic process of intertextuality, a long history of reiterative acts of translating normative information into normative knowledge. It outlines why normative knowledge produced by religious actors was of overwhelming significance within the knowledge economy of the 16th- and 17th-century Iberian empires and how practical theology, normative practices and pragmatic literature were intertwined. From this reconstruction of certain fundamental characteristics, it is possible to suggest a definition of ‘pragmatic normative literature’, to summarise the current state of research on the media that comprised this genre and to conclude with some remarks on why pragmatic literature might have been of special significance for governing an empire.KEYWORDSLegal History. Moral Theology. History of Knowledge. Colonial Latin America. History of Legal Books.


2021 ◽  
pp. 75-94
Author(s):  
Lesław Cirko

The article warns readers interested in the specialised communication against an uncritical adoption of the term professional language, which is often used in the extensive literature on the subject without care for terminological precision. The lack of awareness of the meaning of the term professional language leads to negative consequences in linguistic argumentation, such as the neglect of the current state of research in general linguistics, the contamination of the scientific term by its naive understanding in everyday communication between laypersons, or the identification of language and its use, which is a serious methodological deficiency. The reader of the specialised literature might therefore, without sufficient linguistic knowledge, mistakenly take the contents presented in the reading as self-evident and corresponding to the current state of knowledge. In the first part of the article, the aforementioned sources of interpretative dangers in reading are pointed out, using the history of research as an example. Subsequently, the reader is offered some constant points of reference fur further interpretation, which allow to recognise a stylistic-functional variety of ethnic language in the concept of professional language, including phenomena that go beyond the reduction of professional language to mere terminology. The author also pointed out the forms of acquisition and existence of the so-called professional languages, as well as the distributional features that distinguish them from other functional-stylistic varieties of the ethnic language. In conclusion, their peculiarity was highlighted, arising from the need for precise naming of phenomena and processes in the field of human activity, which is concluded by the specificity of the field; from the fact that people in the said field communicate at the expert level, and the related need for such a selection of linguistic means from the ethnic language in which communication takes place that its users communicate efficiently in the field of professional communication. The knowledge of these conditions will enable the reader to approach the relationship between language and the so-called professional language with greater understanding.


Author(s):  
Steffen Liebig

In August 2011, England experienced the most serious rioting since 30 years. The unrest started two days after the fatal police shooting of Mark Duggan in Tottenham and quickly spread to other cities. This article opens with a brief sketch of the recent history of rioting in England from 1980-2010 and a comparison of previous riots with the ones in 2011. Subsequently, a more extensive overview of the current state of research focusing on triggers and structural roots of the 2011 riots and a local case study of Greater Manchester are presented. It is argued that broader social reasons (e .g . deprivation), consumerism, policing, male behavior and racialised conflicts constitute the overall causes for the latest riots. Moreover, the article looks at the riots in the context of class. Unlike the well-known ‘underclass’ discourse, the article applies a non-pejorative understanding of class: From this perspective, the 2011 riots are interpreted as a symptom of an ongoing fragmentation of social conflicts. Wide ranges of people are no longer represented by organizations like unions nor do they trust in welfare or state institutions or organise in conventional ways. This results in non-normative collective action beyond established institutions as well as new forms of how class struggles and social conflicts articulate themselves.


Muzealnictwo ◽  
2020 ◽  
Vol 61 ◽  
pp. 80-89
Author(s):  
Agnieszka Bender

The current state of research into the patronage and collecting activities of Prince Stanisław Poniatowski (1754–1833) in Italy with which he was connected for almost 40 years of his life is outlined. Over the period, the Prince made 3 long trips there which preceded 30 years of living in Italy on a permanent basis, first in Rome, and then in Florence where he was buried. Despite his many accomplishments and extraordinary personal history, the Prince has not taken as prominent a position either in academic research or in the collective memory of Poles as his junior cousin Prince Józef who drowned in the Elster River giving his life for the homeland. Although no monograph has as yet been published on Stanisław Poniatowski, he is not entirely forgotten. However, the major studies dedicated to him were published a relatively long time ago. The most extensive, i.e. the book I Poniatowski a Roma (Firenze 1972), speaking of the history of Prince Stanisław and the Poniatowski family, was written by the Italian writer and columnist Andrea Busiri Vici and has never been translated into Polish. As the current state of research shows, very few Polish art historians have taken any in depth interest in the Prince’s activity. Apart from the mentions scattered in different studies, there are merely four articles dealing with some selected aspects of the Prince’s patronage and collecting activity (by Janina Michałkowa, Elżbieta Budzińska, Tadeusz Jaroszewski, Dominika Wronikowska). Historically the most complete study dedicated to Prince Stanisław is to be found in Jerzy Michalski’s paper from 50 years ago published in the Polish Biographical Dictionary. The to-date Polish and foreign publications in history, history of art and archaeology do not exhaust many issues related to the person, activity, and the collecting passion of Prince Stanisław.


This volume presents a research-led, interdisciplinary examination of existing scholarship as well as new research on twentieth-century newspaper and periodical history across Britain and Ireland during a key period of change and development into the twenty-first century. It covers an important period of expansion (1900-2017) in periodical and press history across the four nations of Britain (England, Northern Ireland, Scotland, Wales) and Ireland, concentrating on how the development of twentieth-century print communication can be assessed via cross-border comparisons and contrasts. Its thirty-three chapters are interspersed with case studies specific to the themes covered, allowing synchronic and diachronic coverage via macro as well as micro studies. It is designed to provide readers with a clear survey of the current state of research in the field, drawing on contemporary methodologies, demonstrating the interdisciplinary nature of the field and offering an indication of areas ripe for further work. The impact on the field of digital media and archives will fully inform discussions of the print archive where relevant. While the volume meets a need amongst scholars of British and Irish culture, it will also be of tremendous value to those working in other national traditions, offering insight into press trade connections into European and trans-oceanic counterparts, highlighting matters related to national and trans-national identities, migration, skills and knowledge exchange and the place of such texts in a globalised marketplace.


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