Influence of demographic profile and symptoms on insight among people with schizophrenia

2020 ◽  
Vol 11 (1) ◽  
pp. 12
Author(s):  
Manem Atchyuta Rao ◽  
Sojan Antony ◽  
Boban Joseph
Keyword(s):  
Negative Symptoms ◽  
Treatment Resistance ◽  
Demographic Variables ◽  
Exclusion Criteria ◽  
Demographic Profile ◽  
Descriptive Research ◽  
Good Treatment Outcome ◽  
Gender Education ◽  
Positive And Negative Symptoms ◽  
Study Inclusion

Introduction: Insight facilitation is an integral step to achieve good treatment outcome in schizophrenia. Low insight always leads to poor drug adherence and treatment resistance. The study aimed to examine how demographic profile and symptoms influencing the insight among people with schizophrenia. Methods and Materials: Objectives were to assess socio-demographic variables, the symptoms, and insight among people with Schizophrenia and to understand the influence of those variables on the insight. The descriptive research design opted for the study. Sample size of the quantitative study was 53, and subjects were selected as per the study inclusion and exclusion criteria. The population of the study was patients who were attending the outpatient department of psychiatry at the National Institute of Mental Health and Neuro Sciences (NIMHANS). Results: Age and age at the onset of illness were not associated with insight. Male participants had better insight compared to female participants. Persons with middle school or primary school education reported better insight than illiterate, graduates or professional graduates. Participants from the urban area had better insight than participants from the rural area. Insight and positive and negative symptoms were negatively correlated. Conclusion: The demographic factors and symptoms influence the insight among people with Schizophrenia. Hence such factors must be considered while insight facilitation for increasing the adherence to the treatment.   Keywords: Insight, schizophrenia, positive, negatives symptoms, age, gender, education, domicile 

Tardive Dyskinesia and Positive and Negative Symptoms of Schizophrenia

1996 ◽  
Vol 168 (6) ◽  
pp. 702-708 ◽  
Author(s):  
Owen Yuen ◽  
Michael P. Caligiuri ◽  
Richard Williams ◽  
Ruth A. Dickson
Keyword(s):  
Risk Factor ◽  
Tardive Dyskinesia ◽  
Negative Symptoms ◽  
Factor Model ◽  
Female Gender ◽  
Demographic Variables ◽  
Positive Symptoms ◽  
Clinical Measures ◽  
The Relationship ◽  
Positive And Negative Symptoms

BackgroundControversy surrounds the relationship between tardive dyskinesia (TD) and symptoms of schizophrenia. While some studies reported that negative symptoms of schizophrenia may be a risk factor for TD, others reported a relationship between TD and positive symptoms.MethodEighty-four patients were studied, of whom 47 met criteria for TD. Clinical and instrumental procedures were used to increase the sensitivity of our assessments of the presence and severity of TD. Stepwise logistic and linear regression procedures were used to identify demographic variables, psychopathology, and motor parameters associated with the presence and severity of TD.ResultsA 3-factor model consisting of age, clinical tremor, and negative symptoms explained 25% of the variance in clinical TD severity. A 6-factor model consisting of female gender, instrumental and clinical measures of parkinsonism, positive, and negative symptoms explained 49% of the variance in severity of instrumentally derived dyskinesia.ConclusionsThese results suggest that the presence of TD may be associated with positive symptoms; that the severity of TD may be related to negative symptoms; and that the relationship between negative symptoms and TD severity may be influenced by the presence of parkinsonism.

scholarly journals Cytokine Level and Symptoms of Schizophrenia

2021 ◽  
Vol 9 (T3) ◽  
pp. 87-91
Author(s):  
Mustafa Mahmud Amin ◽  
Elmeida Effendy
Keyword(s):  
Negative Symptoms ◽  
Sampling Methods ◽  
Tnf Alpha ◽  
Control Groups ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Alpha Level ◽  
And Control ◽  
Necrosis Factor ◽  
Positive And Negative Symptoms

BACKGROUND: The study was intended to find one of the cytokines, that is, tumor necrosis factor (TNF)-alpha correlation with PANSS scores of people with schizophrenia (PwS) and their differences compared to the healthy people of Malayan- Mongoloid Race. AIM: The aim of this study was providing a profile of TNF-alpha level in PwS of Malayan-Mongoloid race and its correlation with positive and negative symptoms in schizophrenia. METHODS: It was conducted using cross-sectional and following sampling methods, with inclusion and exclusion criteria set for the PwS and control groups. RESULTS: The result was no correlation between TNF-alpha levels with PANSS scores on PwS (p > 0.005), with very weak correlation and positive correlation direction, and there were differences in TNF-alpha levels.between PwS and control groups. CONCLUSION: It can be concluded that the higher levels of TNF-alpha would impact on the severity symptoms experienced by PwS.

scholarly journals Heterogeneity and efficacy of antipsychotic treatment for schizophrenia with or without treatment resistance: a meta-analysis

2019 ◽  
Vol 45 (4) ◽  
pp. 622-631 ◽  
Author(s):  
Yuya Mizuno ◽  
Robert A. McCutcheon ◽  
Stefan P. Brugger ◽  
Oliver D. Howes
Keyword(s):  
Negative Symptoms ◽  
Meta Analysis ◽  
Treatment Resistance ◽  
Study Groups ◽  
Antipsychotic Treatment ◽  
Double Blind ◽  
Significant Difference ◽  
Randomised Controlled ◽  
Positive And Negative Symptoms ◽  
Relative Variability

AbstractTwo important clinical questions are whether there is a subtype of schizophrenia which responds differently to clozapine relative to other antipsychotics, and whether greater efficacy of clozapine is dependent on the degree of treatment-resistance. The authors address this by examining both variability and magnitude of response in patients treated with clozapine and other antipsychotics for both treatment-resistant schizophrenia (TRS) and non-resistant schizophrenia. Double-blind randomised controlled trials comparing clozapine with other antipsychotics in patients with schizophrenia were identified using five databases. Standard deviations and means of change in total, positive, and negative symptoms were extracted. Variability ratio (VR) and coefficient of variation ratio (CVR) were used to quantify relative variability in symptom change. Hedges’ g was used to quantify mean differences. Ten TRS studies (n = 822) and 29 non-TRS studies (n = 2566) were meta-analysed. Relative variability in change of total symptoms did not differ significantly between clozapine and other antipsychotics in TRS studies (VR = 1.84; 95%CI, 0.85–4.02). These findings were similar with CVR, and for positive and negative symptoms. Clozapine was superior to other antipsychotics in improving total symptoms in both TRS (g = 0.34; 95%CI, 0.13–0.56) and non-TRS (g = 0.20; 95%CI, 0.08–0.32) studies. Furthermore, clozapine was superior in improving positive symptoms in both study groups, but not for negative symptoms. Pooled effect sizes showed no significant difference between TRS and non-TRS studies. These findings do not support a subtype of schizophrenia which responds specifically to clozapine. Clozapine is more effective than other antipsychotics irrespective of treatment-resistance, arguing for its use more generally in schizophrenia. PROSPERO CRD42018086507

MOTIVATION AND PLEASURE IN THE SCHIZOPHRENIA SPECTRUM–FINDINGS FROM THE PRODROME

2008 ◽  
Vol 31 (4) ◽  
pp. 10
Author(s):  
G Foussias ◽  
G Remington ◽  
R Mizrahi
Keyword(s):  
Cognitive Deficits ◽  
Negative Symptoms ◽  
Sampling Method ◽  
Personal Digital Assistant ◽  
Prodromal Phase ◽  
Daily Lives ◽  
Schizophrenia Spectrum ◽  
Influence Functional ◽  
The Moment ◽  
Positive And Negative Symptoms

Background: Schizophreniais a chronic and debilitating illness that affects approximately one percent of the population. The symptoms of schizophrenia are typically thought of in separate domains, including positive symptoms (hallucinations and delusions), negative symptoms (diminished emotional expression and amotivation), and cognitive deficits. Importantly, the negative symptoms have been consistently found to adversely influence functional outcomes, in particular due to markedamotivation.^1 There have been suggestions that these individuals also experience deficits in the experience of pleasure, especially in their capacity to anticipate pleasure.^2 However, such investigations have not included the examination of these symptoms in those in the prodromal phase ofthis illness, a time that holds promise for early intervention and altering thecourse of schizophrenia.^3 Methods: In an effort to examine deficits in motivation and pleasure in the prodromal phase of schizophrenia, we have used an experience sampling method to assess “in the moment” motivation and pleasure in individuals at high risk of developing schizophrenia and healthy controls. Subjects completed baseline assessments including evaluation of their positive and negative symptoms. Subsequently, through the use of a personal digital assistant, subjects rated their motivation and experience of consummatory and anticipatory pleasure in their daily lives, multiple times over the course of four days. Results and Conclusions: Preliminary data will be presented, as well as the importance of these findings in the context of understanding the underlying pathobiology of this illness, and guiding our search for effective treatments to improvefunctional outcomes in schizophrenia. References: 1. Sayers SL, Curran PJ, Mueser KT. Psychol Assessment 1996;8:269-80. 2. Gard DE, Kring AM, Gard GM, et al.. Schizophr Res 2007;93:253-60.

Conceptual disorganization and redistribution of resting state cortical hubs in untreated first episode psychosis: A 7T MRI study

2020 ◽  
Author(s):  
Avyarthana Dey ◽  
Kara Dempster ◽  
Michael Mackinley ◽  
Peter Jeon ◽  
Tushar Das ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
Superior Temporal Gyrus ◽  
Brain Regions ◽  
First Episode Psychosis ◽  
Cortical Reorganization ◽  
First Episode ◽  
Formal Thought Disorder ◽  
Whole Brain ◽  
Episode Psychosis ◽  
Positive And Negative Symptoms

Background:Network level dysconnectivity has been studied in positive and negative symptoms of schizophrenia. Conceptual disorganization (CD) is a symptom subtype which predicts impaired real-world functioning in psychosis. Systematic reviews have reported aberrant connectivity in formal thought disorder, a construct related to CD. However, no studies have investigated whole-brain functional correlates of CD in psychosis. We sought to investigate brain regions explaining the severity of CD in patients with first-episode psychosis (FEPs) compared with healthy controls (HCs).Methods:We computed whole-brain binarized degree centrality maps of 31 FEPs, 25 HCs and characterized the patterns of network connectivity in the two groups. In FEPs, we related these findings to the severity of CD. We also studied the effect of positive and negative symptoms on altered network connectivity.Results:Compared to HCs, reduced hubness of a right superior temporal gyrus (rSTG) cluster was observed in the FEPs. In patients exhibiting high CD, increased hubness of a medial superior parietal (mSPL) cluster was observed, compared to patients exhibiting low CD. These two regions were strongly correlated with CD scores but not with other symptom scores.Discussion:Our observations are congruent with previous findings of reduced but not increased hubness. We observed increased hubness of mSPL suggesting that cortical reorganization occurs to provide alternate routes for information transfer.Conclusion:These findings provide insight into the underlying neural processes mediating the presentation of symptoms in untreated FEP. A longitudinal tracking of the symptom course will be useful to assess the mechanisms underlying these compensatory changes.

Supernatural norm enforcement: Thinking about Karma and God reduces selfishness among believers

2018 ◽  
Author(s):  
Cindel White ◽  
John Michael Kelly ◽  
Azim Shariff ◽  
Ara Norenzayan
Keyword(s):  
Social Norms ◽  
Framing Effects ◽  
Demographic Variables ◽  
Exclusion Criteria ◽  
Total N ◽  
Norm Enforcement ◽  
Dictator Games ◽  
Within Subjects

Four experiments (total N = 3591) examined how thinking about Karma and God increases adherence to social norms that prescribe fairness in anonymous dictator games. We found that (1) thinking about Karma decreased selfishness among karmic believers across religious affiliations, including Hindus, Buddhists, Christians, and non-religious Americans; (2) thinking about God also decreased selfishness among believers in God (but not among non-believers), replicating previous findings; and (3) thinking about both karma and God shifted participants’ initially selfish offers towards fairness (the normatively prosocial response), but had no effect on already fair offers. These supernatural framing effects were obtained and replicated in high-powered, pre-registered experiments and remained robust to several methodological checks, including hypothesis guessing, game familiarity, demographic variables, between- and within-subjects designs, and variation in data exclusion criteria. These results support the role of culturally-elaborated beliefs about supernatural justice as a motivator of believer’s adherence to prosocial norms.

Performance of patients with different schizophrenia subtypes on the Synthetic House–Tree–Person Test

2019 ◽  
Vol 47 (11) ◽  
pp. 1-8 ◽  
Author(s):  
AiBao Zhou ◽  
Pei Xie ◽  
ChaoChao Pan ◽  
Zhe Tian ◽  
Junwei Xie
Keyword(s):  
Negative Symptoms ◽  
Positive Symptoms ◽  
Study Results ◽  
Symptom Type ◽  
Positive And Negative Symptoms

We explored differences in performance on the Synthetic House–Tree–Person Test between people with mainly positive symptoms and those with mainly negative symptoms of schizophrenia and, further, aimed to provide a basis for the diagnosis of schizophrenia symptom type. Participants were 58 people receiving treatment for schizophrenia, and we asked them to complete the Scale for the Assessment of Positive Symptoms, the Scale for the Assessment of Negative Symptoms, and the Synthetic House–Tree–Person Test. There were significant differences in results on the Synthetic House–Tree–Person Test between the group with positive symptoms, the group with a mix of positive and negative symptoms, and the group with negative symptoms. There were 12 features of participants' drawings, such as big hands, which were correlated with hallucinations and delusions in positive symptoms, and 9 features, such as trees in a landscape, which were correlated with avolition and anhedonia in negative symptoms. Our study results suggest differences in performance on the Synthetic House–Tree–Person Test between these different symptom subtypes of schizophrenia; hence, the features that appear in drawings made during the test may contribute to the diagnosis of symptoms of people with schizophrenia.

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