scholarly journals Effect of Octopine on Oxidative Stress Indices and Serum Levels of Lipids and Trace Elements in Mice with Breast Cancer

2020 ◽  
Vol 14 (5) ◽  
pp. 13-18
Author(s):  
Abdolrasoul Hakim Elahi ◽  
Rasoul Sharifi ◽  
minoo Mahmoodi ◽  
Seyed Mehrdad Kassaee ◽  
◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Trace Elements ◽  
Serum Levels ◽  
Stress Indices

Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong, China

2014 ◽  
Vol 22 (10) ◽  
pp. 7930-7935 ◽  
Author(s):  
Xiao Ding ◽  
Meng Jiang ◽  
Haiyan Jing ◽  
Wei Sheng ◽  
Xingwen Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Trace Elements ◽  
Cancer Patients ◽  
Serum Levels ◽  
Breast Cancer Patients

scholarly journals Serum Trace Elements and Their Associations with Breast Cancer Subgroups in Korean Breast Cancer Patients

Nutrients ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 37 ◽  
Author(s):  
Rihwa Choi ◽  
Min-Ji Kim ◽  
Insuk Sohn ◽  
Serim Kim ◽  
Isaac Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Trace Elements ◽  
Trace Element ◽  
Cancer Patients ◽  
Distant Metastasis ◽  
Inductively Coupled Plasma ◽  
Serum Levels ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Trace Element Levels

The relationships between serum levels of trace elements and breast cancer remain relatively unknown. In this study, we investigate serum levels of seven trace elements in Korean breast cancer patients compared to controls without breast cancer. Serum trace element levels were determined using inductively coupled plasma mass spectrometry in Korean breast cancer patients before initiation of breast cancer treatment. Korean females without breast cancer served as a control group. Trace element levels were measured in the discovery cohort (n = 287) and were validated in an independent cohort (n = 142). We further investigated possible associations between trace element levels and the presence of lymph node metastasis, distant metastasis, or triple-negative breast cancer among breast cancer patients in subgroup analyses. Serum manganese and molybdenum levels were significantly higher (p < 0.05) in breast cancer patients than in controls. Serum copper levels were significantly higher in breast cancer patients with distant metastasis, while selenium levels were significantly lower. Other trace elements were neither significantly different between breast cancer patients and controls nor between subgroups of breast cancer patients. Our study provides insights about the potential roles and impacts of trace elements through an assessment of the associations between trace elements and breast cancer.

scholarly journals Dietary Intake and Serum Levels of Iron in Relation to Oxidative Stress in Breast Cancer Patients

2009 ◽  
Vol 45 (3) ◽  
pp. 355-360 ◽  
Author(s):  
Yun-Jung Bae ◽  
Jee-Young Yeon ◽  
Chung-Ja Sung ◽  
Hyun-Sook Kim ◽  
Mi-Kyung Sung
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Dietary Intake ◽  
Cancer Patients ◽  
Serum Levels ◽  
Breast Cancer Patients

scholarly journals Determination of Some Trace Elements in Breast Cancer Serum by Atomic Absorption Spectroscopy

2016 ◽  
Vol 9 (1) ◽  
pp. 1 ◽  
Author(s):  
Safaa Sabri Najim
Keyword(s):  
Breast Cancer ◽  
Trace Elements ◽  
Atomic Absorption ◽  
Cancer Patients ◽  
Absorption Spectroscopy ◽  
Atomic Absorption Spectroscopy ◽  
Serum Levels ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Flame Atomic Absorption

In the breast cancer significant differences occurs in the normal distribution of the trace elements, playing an important role in carcinogenic process. The aim of this study was to investigate the serum levels of some trace elements (Chromium, Cadmium, Manganese, Cobalt, Nickel, Selenium, Zinc, Iron, Copper and Magnesium) by using flame atomic absorption spectroscopy (FAAS). The present study included 150 females, the participates were divided into two main groups, control group which consisted of 75 apparently healthy females, 75patients with breast cancer group .The serum levels of Chromium (tcal2.9631 ,ttab1.960), Cadmium (tcal2.0798 ,ttab1.960), Manganese (tcal18.5676, ttab1.960), Selenium (tcal2.2759,ttab1.960), Iron (tcal2.9296,ttab1.960), Copper (tcal4.0869, ttab1.960),Magnesium (tcal2.6648, ttab1.960), Cobalt (tcal3.8615 , ttab1.960) and Zinc (tcal7.0160, ttab1.960) were statistically significant higher in the breast cancer patients group than the control group. Similarly, Nickel (tcal1.5988,ttab1.960) levels showed significant lower level in breast cancer patients group. On the other hand, the higher levels of trace elements could lead to formation of free radicals or other reactive oxygen species. The evaluation of these trace elements in serum maybe used as helpful tool in diagnosis of the breast cancer.

Association between oxidative stress and changes of trace elements in patients with breast cancer

1999 ◽  
Vol 32 (2) ◽  
pp. 131-136 ◽  
Author(s):  
Yeou-Lih Huang ◽  
Jenn-Yuan Sheu ◽  
Te-Hsien Lin
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Trace Elements

scholarly journals Evaluation of some trace elements status in females type 1 diabetics patients and its relationship with oxidative stress

2019 ◽  
Vol 10 (4) ◽  
pp. 2792-2799
Author(s):  
Seenaa kadhum Ali ◽  
Elham Abed Mahdi ◽  
Zinah Kadhim Kareem ◽  
Mohanad Kadhim Ali ◽  
Ayad Kadhim Ali
Keyword(s):  
Oxidative Stress ◽  
Trace Elements ◽  
Glucose Metabolism ◽  
Serum Level ◽  
Atomic Absorption ◽  
Serum Levels ◽  
Diabetic Patients ◽  
Insulin Dependent

Disorders of trace elements in diabetic patients with type 1 are possibly led to glucose metabolism disturbance and increased oxidation, which may promote the development of diabetes and insulin resisting. We aim to clarify the role of the serum level of zinc (Zn), copper (Cu), cobalt (Co), iron  (Fe), Zn/Cu ratio and their relations with the degree of oxidative stress in females   T1D. The study included 30 healthy women and 54 women   with insulin-dependent diabetes. Serum levels of trace element have determined by atomic absorption spectrophotometer.  Results showed a decrease levels of Cu, Fe,  Zn and MDA in diabetes patients compared to controls (p <0.000), (p < 0.000)  (p< 0.001) (p <0.001) correspondingly. Significance in correlations amid Zn and age (r= -0.449, p <0.032), significance in correlations among Co in addition to age (r= -0.434, p <0.038) with significances in correlation amid Fe and MDA (r= 0.024, p <0.366).  

scholarly journals Effects of Chronic Kidney Disease on levels of Oxidative Stress and Trace Elements

2021 ◽  
Author(s):  
Xiaojing Zhu ◽  
Yuan Zhang ◽  
Jin Han ◽  
Dan Xiao ◽  
Dan Zhu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Trace Elements ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
Control Group ◽  
Obvious Effect ◽  
The Relationship ◽  
Group Serum ◽  
Lower Expression

Abstract Introduction: The relationship between trace elements and OS in CKD patients is still not completely elucidated. The aim of this work is to determine the serum levels of OS and the trace elements in CKD patients.Methods: A total of 91 patients were enrolled and then divided into 3 groups at the basis of CKD stages. Healthy volunteers were included as a control group. Serum levels of SOD, MDA, Zn, Cu, Ca, Fe, and Mg were determined , and the correlation among these datas were analyzed.Results: The MDA level in the patients’ sera was significantly higher than the controls’ (P<0.05); however, their sera level of SOD was obviously lower (P<0.05). Meanwhile, the creatinine level in CKD patients’ sera was positively correlated with the MDA level (r = 0.534, P<0.01), while negatively with the expression of SOD (r = -0.427, P < 0.01). A lower expression of Zn and Ca values could be seen in the cases’ sera (P<0.05). Besides that, it showed a significant negative correlation between serum levels of MDA and Ca (r=-0.282, P<0.01), MDA and Zn (r=-0.358, P<0.01), while a positive correlation between MDA and Cu (r = 0.236, P=0.022). Adversely, the expression of SOD in the sera of cases was positively related to the levels of Ca (r=0.273, P<0.01) and Zn (r=0.277, P<0.01).Conclusion: Abnormalities of OS and Zn、Ca existed in CKD patients; and elevated OS may play a role in the trace elements imbalance. Dialysis seems to have no obvious effect on plasma trace elements.

scholarly journals Relationships Between Serum Expression of IGF-1 and Metabolic Syndrome Metrics in Syrian Women with Breast Cancer

2019 ◽  
Vol 26 (4) ◽  
pp. 435-443
Author(s):  
Husseina Khaddour ◽  
Yahya I. Elshimali ◽  
Rucsandra Dănciulescu-Miulescu ◽  
Daniela Gradinaru
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Cancer Progression ◽  
Breast Tumor ◽  
Ldl Cholesterol ◽  
Serum Levels ◽  
Benign Tumors ◽  
Control Group ◽  
Tumor Group

Abstract Background and aims: Insulin-like Growth Factors (IGF-1) plays as mediator between metabolic syndrome (MetS), oxidative stress and breast cancer (BrCa) progression. The objective of this study was to examine the relationships between IGF-1 serum levels and metabolic profile biomarkers in a population group of BrCa patients. Material and methods: 126 Syrian women with breast lesions were assigned in 3 study groups: I. Malignant breast tumor group, II. Benign breast tumor group and a Normal (control) group. The following biochemical parameters were measured: IGF-1, HDL-cholesterol, LDL-cholesterol, triglycerides (TG) and glucose. Results: The mean levels of serum IGF- 1 in patients with breast cancer was significantly higher than those with benign tumors but we did not find any correlation between IGF-1 serum levels and tumor stage or lymph nodes metastases. Total cholesterol and LDL-cholesterol levels, along with TG were significantly higher in patients with BrCa versus benign and normal subjects. Conclusion: Results support the link of metabolic dysregulation and oxidative stress in BrCa progression as elevation of serum IGF-1 levels in BrCa patients are associated with metabolic syndrome markers which eventually adds more risk in cancer progression.

scholarly journals Association of Omentin-1 with Oxidative Stress and Clinical Significances in Patients with Breast Cancer

2019 ◽  
Vol 10 (1) ◽  
pp. 106-113
Author(s):  
Nahideh Tahmasebpour ◽  
Mohammad Ali Hosseinpour Feizi ◽  
Nasrin Ziamajidi ◽  
Naser Pouladi ◽  
Vahid Montazeri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Gene Expression ◽  
Inverse Correlation ◽  
Serum Levels ◽  
Diagnostic Value ◽  
Healthy Controls ◽  
Normal Tissues ◽  
Oncogenic Pathways ◽  
Total Antioxidant

Purpose: Breast cancer (BC) is globally the main reason of cancer-related deaths in women. Omentin-1, an anti-inflammatory and antioxidant adipokine, plays different roles in tumorigenesis and anti-oncogenic pathways. In present study, we investigated the association of omentin-1 with oxidative stress and clinical significances in healthy controls and BC patients to assess the prognostic and diagnostic value of omentin-1 in this cancer. Methods: This case-control study included 88 BC patients and 86 healthy controls. The serum levels of omentin-1 were assessed by enzyme-linked immunosorbent assays methods. Also, total antioxidant capacity (TAC), total oxidant status (TOS) and malondialdehyde (MDA) serum levels were measured by spectrophotometer. quantitative real-time polymerase chain reaction (qRT-PCR) was applied to the measurement of gene expression of omentin-1. Results: the serum levels of omentin-1 were significantly lower in the BC patients compared to the healthy controls (P<0.001). Moreover, gene expression of omentin-1was significantly downregulated in the BC tissues compared to the adjacent normal tissues (P<0.001). Gene expression of omentin-1and its serum levels were significantly higher in grade I compared with grade II and III (P=0.001, P<0.001, respectively). Additionally, the serum levels of omentin-1 in the p53-positive BC patients were significantly higher than the p53-negative BC patients (P=0.001). There was an inverse correlation between the serum levels of MDA and TOS with the serum levels of omentin-1 (r=-0.436, r=-461, respectively). Conclusion: We conclude that omentin-1 may have a good prognostic and diagnostic roles in the BC patients and decreases oxidative stress in these patients.

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