scholarly journals PROGNOSIS OF ACUTE INFERIOR WALL MI;

2017 ◽  
Vol 24 (03) ◽  
pp. 398-402
Author(s):  
Naeem Asghar ◽  
Hafiz Muhammad Faiq Ilyas ◽  
Touseef Anwar
Keyword(s):  
Hospital Mortality ◽  
Atrioventricular Block ◽  
P Value ◽  
Inferior Wall ◽  
Av Block ◽  
Study Results ◽  
Group A ◽  
Acute Mi ◽  
Group B

Introduction: Atrioventricular (AV) block is a common complication of acuteMyocardial Infarction (MI). In pre-thrombolytic era, high (second or third degree) AV blockwas seen in approximately 5-7% of patients presenting with acute MI. In setting of Inferior MI,this was even as high as 28%. Although, the advent of thrombolytic therapy has substantiallydecreased the mortality associated with acute MI, the incidence of AV block, particularly in thesetting of inferior MI, remains high. AV block in the setting of inferior MI is also associated withhigh in-hospital mortality, however, its effect on long-term mortality is uncertain. Objectives: Tocompare the in-hospital mortality of acute inferior wall myocardial infarction with and withoutcomplete Atrioventricular block. Settings: Department of Cardiology Faisalabad Institute ofCardiology, Faisalabad. Duration of Study: Six months From: 01-05-2014 to 30-11-2014. StudyDesign: Cohort study. Results: In our study, out of 80 cases(40 in each group) 42.5%(n=17)in Group-A and 37.5%(n=15) in Group-B were between 20-50 years of age while 57.5%(n=23)in Group-A and 62.5%(n=25) in Group-B were between 51-70 years of age, mean+sd wascalculated as 52.58+9.83 and 55.43+8.06 years respectively, 40%(n=16) in Group-A and47.5%(n=19) in Group-B were male while 60%(n=24) in Group-A and 52.5%(n=21) inGroup-B were females, comparison of in-hospital mortality in both groups was done showing32.5%(n=13) in Group-A and 7.5%(n=3) while 67.5%(n=27) in Group-A and 92.5%(n=37) hadno findings of in-hospital mortality, Relative Risk was calculated as 4.33 while P value:0.005.Conclusion: We concluded that in-hospital mortality is significantly high in acute inferior wallmyocardial infarction complicated by atrioventricular block.

scholarly journals Surgical treatment of pulmonary sequestration in adults and children: long-term results

2020 ◽  
Vol 31 (1) ◽  
pp. 71-77
Author(s):  
Beatrice Trabalza Marinucci ◽  
Giulio Maurizi ◽  
Camilla Vanni ◽  
Giuseppe Cardillo ◽  
Camilla Poggi ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Respiratory Symptoms ◽  
Pulmonary Sequestration ◽  
Adult Patients ◽  
Long Term Results ◽  
Study Results ◽  
Group A ◽  
Group B ◽  
Histological Results

Abstract OBJECTIVES Few experiences comparing paediatric and adult patients treated for pulmonary sequestration (PS) have been reported. Surgical treatment is considered the best choice, but the time of surgery is still controversial. We present our experience in this setting, comparing characteristics, histological results and outcome of paediatric and adult patients undergoing PS resection. METHODS Between 1998 and 2017, a total of 74 patients underwent lobectomy or sublobar resection for PS. Sixty patients were children (group A: ≤16 years old) and 14 were adults (group B: >16 years old). Preoperative diagnosis was radiological. PS was intralobar (42 cases) and extralobar (32 cases). The operation was a muscle-sparing lateral thoracotomy or video-assisted thoracoscopic surgery. Preoperative characteristics, histological results and short-/long-term results of the 2 groups were retrospectively analysed and compared. RESULTS Thirty-seven percent of the patients in group A presented with respiratory symptoms and 79% in group B (P = 0.44). Most symptomatic patients were treated with a lobectomy. In group A, 2 patients (3%) had a malignant transformation of the lesion. Patients with a prenatal diagnosis treated after the age of 1 year became more symptomatic than those operated on before the age of 1 year (57% vs 23%; P = 0.08). No differences were found in postoperative complications. Long-term stable remission of respiratory symptoms was obtained in 91% of patients in group A and 100% in group B. Adulthood (P = 0.03) and the association with congenital cystic adenomatoid malformation (P = 0.03) were negative prognostic factors for the development of respiratory symptoms. CONCLUSIONS Surgical treatment of PS is safe and feasible. Despite the small number of patients included, study results indicated that an early operation during childhood may prevent the subsequent development of respiratory symptoms. Surgical treatment is also recommended to prevent the rare transformation into malignancy.

scholarly journals Postoperative recovery; Stapled Hemorrhoidopexy versus Conventional haemorrhoidectomy.

2020 ◽  
Vol 27 (01) ◽  
pp. 166-171
Author(s):  
Ashar Ahmad Khan ◽  
Tania Mahar ◽  
Muhammad Kashif Adnan ◽  
Abdul Rasheed Surahio ◽  
Abdul Manan ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Hospital Stay ◽  
Postoperative Recovery ◽  
Stapled Hemorrhoidopexy ◽  
Anal Stenosis ◽  
P Value ◽  
Group A ◽  
Conventional Haemorrhoidectomy ◽  
Group B

Conventional haemorrhoidectomy, a usual procedure for hemorrhoids in our set up have many short and long term complications. Some patients complained pain many weeks after surgery and are unable to do their routine work. Anal stenosis and recurrence are long term issues. There is need for some other procedure which can decrease postoperative pain and hospital stay. Objectives: To compare the postoperative recovery between stapled hemorrhoidopexy and conventional hemorrhoidectomy. Study Design: Randomized Clinical trial. Setting: Surgery Department of Nishtar Medical University Multan. Period: from 01-01-2018 to 31-12-2018. Material & Methods: Randomly 02 equal groups of the patients, A and B were made. Stapled hemorrhoidopexy (SH) and conventional haemorrhoidectomy was done in group A and B respectively. SPSS version 20 used for data analysis. Mean and standard deviation were used for quantitative variables including postoperative pain, age and hospital stay. Independent Student t test used for comparison of hospital stay and postoperative pain. Effect modifier including gender, age, duration and grade of hemorrhoids were controlled by stratification and Chi square test was applied. P value less than 0.05 was taken as significant. Results: Out of 60 patients, 32 were males and 28 females. In Group A (Stapled Hemorrhoidopexy), mean age was 37.37 + 6.36 years and 39.17 + 5.53 years in Group-B. Postoperative pain in Group A was 3.60 + 1.27 and 6.03 + 1.73 in Group B. Postoperative pain was significantly high in Group B (CH) and P value =0.000. Mean hospital stay was 0.90 + 0.48 days in Group A and 1.87 + 0.57 days in Group B with P value= 0.000. Conclusion: Stapled hemorrhoidopexy is associated with shorter hospital stay and decrease postoperative pain irrespective of age, sex and grade of the hemorrhoids.

P3657Annulus-sparing should be adopted in all suitable patients with Tetralogy of Fallot

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
X Jiang ◽  
Q Wang
Keyword(s):  
Clinical Outcomes ◽  
Pulmonary Stenosis ◽  
P Value ◽  
Z Score ◽  
Technical Performance ◽  
Significant Difference ◽  
Class 1 ◽  
Group A ◽  
Group B

Abstract Background Ongoing controversy focuses on whether relieving obstruction of dysplastic pulmonary valve annulus (PVA) requires transannular patch enlargement (TAPE) in TOF patients. Purpose Aiming to investigate clinical outcomes of annulus-sparing (AS) repair in nonselective TOF patients. Methods 87 TOF patients was included, underwent AS repair and traditional TAPE and PV-specific technical performance score (TPS) was selected to evaluate adequacy of PV. Results One patient died and one required reintervention. 100% patients achieved AS. After a mean follow-up of 24.8 months, there is no significant difference between AS groups in severe pulmonary stenosis (PS) in Class 3 (7.4% vs 3.0%, p=0.583) and a downtrend of annular peak gradient (APG) in PVA z-score <−2 (-3.2±1.9) with AS repair regardless of a higher rate of PS in Class 2 (74.1% vs 42.5%, p=0.014). Compared with TAPE in PVA z-score <−2 (-3.5±0.9), there is no significant difference in PS in Class 3 (7.4% vs 7.4%, p=1.000) but a lower rate in PR in Class 3 (27.3% vs 70.4%, p=0.006), shorter ventilation duration (20.0h vs 29.0h, p=0.039), quicker recovery from ICU (2.0d vs 4.0d, p=0.022) and fewer postoperative hospitalized days (8.0d vs 11.0d, p=0.008), and APG in TAPE group was demonstrated an upward trend. Table 1. Clinical outcomes Outcomes AS P value (A vs. B) TAPE P value (B vs. C) Group A Group B Group C Z-score ≥−2 (N=33) Z-score <−2 (N=27) Z-score <−2 (N=27) Repump 2 (6.1) 2 (7.4) 1.000 2 (7.4) 1.000 Hospital mortality 0 (0.0) 0 (0.0) 1.000 1 (3.7) 1.000 Reintervention 1 (3.0) 0 (0.0) 0.413 0 (0.0) 0.601 Adequacy of PV repair TPS for degree of PS   Class 1 (APG <20 mmHg) 18 (54.5) 5 (18.5) 0.004 19 (70.4) <0.001   Class 2 (APG 20–40 mmHg) 14 (42.5) 20 (74.1) 0.014 6 (22.2) <0.001   Class 3 (APG >40 mmHg) 1 (3.0) 2 (7.4) 0.583 2 (7.4) 1.000 TPS for degree of PR   Class 1 (none/trivial PR) 18 (54.5) 9 (33.3) 0.100 3 (11.1) 0.050   Class 2 (mild/mild-moderate PR) 12 (36.4) 9 (33.3) 0.807 5 (18.5) 0.214   Class 3 (moderate or greater PR) 3 (9.1) 9 (33.3) 0.020 19 (70.4) 0.006 Moderate PR 0 (0.0) 8 (29.6) 0.008 11 (40.7) 0.393 Severe PR 2 (6.1) 1 (3.7) 1.000 7 (25.9) 0.048 Figure 1. The trend of RVOT or APG. Conclusions AS remained higher APG at discharge but had a downtrend over time and long-term reintervention was rare and minimally invasive, as an alternative to TAPE in dysplastic PVA.

scholarly journals ATRIO-VENTRICULAR BLOCK

2018 ◽  
Vol 23 (08) ◽  
pp. 1017-1021
Author(s):  
Muhammad Zafar Majeed Babar ◽  
Abdul Majid ◽  
Abdul Waheed Chaudhary ◽  
Mirza Ahmad Raza Baig
Keyword(s):  
Myocardial Infarction ◽  
Hospital Mortality ◽  
Atrioventricular Block ◽  
Positive Family History ◽  
Anterior Wall ◽  
P Value ◽  
Inferior Wall ◽  
Chi Square ◽  
College Hospital ◽  
High Degree

Objectives: The incidence of high degree atrioventricular block (HAVB) variesfrom 2.7 to 14% after acute STEMI. The aim of this study was to evaluate the incidence of highdegree atrioventricular block (HAVB) in patients of acute myocardial infarction. Study Design:Observational study. Setting: Sheikh Zayed Medical College/Hospital Rahim Yaar Khan. Period:March 2016 to May 2016. Material and Methods: Two hundred patients of acute myocardialInfarction were included in this study. Patients suffering from 2nd degree Mobitz type II or 3rddegree heart block were labelled as High Degree Atrioventricular Block (HAVB). Data Analysiswas made using Statistical Package for Social Sciences Software V17. Chi-square test wasused to compare in-hospital mortality between the groups taking p-value <0.05 as significantdifference. Results: The mean age of patients who presented with myocardial Infarction inour hospital was 50.13+6.97 years. Out of 200 patients, 35 (17.5%) were smokers, 83 (41.5%)hypertensives, 69 (34.5%) diabetics and 48 (24.0%) were with positive family history of IschemicHeart Disease. Most common type of MI was anterior wall present in 50.5% patients and 2ndmost common was inferior wall MI presented in 26.5% patients. High degree atrio-ventricularblock was present in 9 (4.5%) patients. In-hospital mortality was significantly high in patientswith HAVB, in these patients in-hospital mortality was 2 (22.2%) as compared to only 8 (4.2%)in patients of without HAVB (p-value 0.01). Conclusion: Myocardial infarction complicated withhigh degree atrio-ventricular block (HAVB) is associated with higher rate of in-hospital mortality

scholarly journals Outcome of Stone Fragmentation with Pneumatic and Ultrasonic Lithotripter During Percutaneous Nephrolithotomy

2020 ◽  
Vol 23 (2) ◽  
pp. 129-135
Author(s):  
Shariful Islam Khan ◽  
Md Nurul Hooda ◽  
Md Safiul Alam Babul ◽  
Mohammad Habibur Rahman ◽  
Anup Roy Chowdhury ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Percutaneous Nephrolithotomy ◽  
P Value ◽  
Pneumatic Lithotripsy ◽  
Stone Fragmentation ◽  
Study Results ◽  
Wide Range ◽  
Ultrasonic Lithotripsy ◽  
Group A ◽  
Group B

Background of the study: Percutaneous nephrolithotomy (PCNL) is the gold standard treatment for kidney stones larger than 2 cm. PCNL has replaced open surgical removal of large or complex calculi at the most institutions. The success of PCNL is related to the ability to achieve an optimum access tract and proper fragmentation. A wide range of lithotripsy techniques are currently available. One of these is ultrasonic lithotripsy, in which the stones are fragmented and sucked out simultaneously. This technique induces minimal tissue injury and could be considered as a standard modality for PCNL. The pneumatic lithotripter uses pneumatic ballast, which crushes the stones without producing any thermal effects. Because this mechanical energy passes along the metal wire to the stone, the probe works like a chisel on the stone surface. This modality destroys all stones, regardless of their composition. There were very few studies had been done in this context in our country, so I had decided to do this study to compare the outcome of stone fragmentation with pneumatic and ultrasonic lithotripter during percutaneous nephrolithotomy. Objective: To compare the outcome of stone fragmentation with pneumatic and ultrasonic lithotripter during percutaneous nephrolithotomy. Materials & Methods: This Prospective Interventional Study (Quasi Experimental Trial) was performed in Department of Urology, National Institute of Kidney Diseases and Urology, Sher-E- Bangla Nagar, Dhaka during the period from December 2014 to May 2016. A total of 60 subjects will be selected with renal calculi (as per inclusion & exclusion criteria), among these, half of the patients will be group A (using pneumatic lithotripsy) & rest of the patients will be group B (using ultrasonic lithotripsy). The study subjects were underwent PCNL under general anesthesia, half of which used pneumatic lithotripter and rest used ultrasonic lithotripter for stone fragmentation. Above mentioned outcome variables were assessed both per-operative and post-operatively. Data were collected, processed & analyzed. Statistical analysis of relevant variables was done by unpaired Student’s T test and Chi Square test. P value Â0.05 was considered significant. Results: Total 60 patients were selected for study according to the selection criteria. Of the 60 subjects, 30 patients, those who were done PCNL by pneumatic lithotripsy were labeled as Group A and 30 patients, those who were done PCNL by ultrasonic lithotripsy, were labeled with Group B. Distribution of respondents in terms of different parameters is shown in tabulated form and statistical analysis was done in both groups to see statistical significance, p value less than 0.05 was considered significant. The mean stone fragmentation time was 27.23±4.78 (18-38) min in PCNL by pneumatic lithotripsy and those were 23.80±5.30 (13-34) min in by ultrasonic lithotripsy which is statistically significant. Other variables of interest which includes stone clearance rate, post operative haematuria and post operative hospital stay, were not statistically significant. Conclusion: Comparing the findings of the present study, results indicate that stone fragmentation time is lesser in ultrasonic lithotripsy than pneumatic lithotripsy in PCNL which decreases the overall operative time. Bangladesh Journal of Urology, Vol. 23, No. 2, July 2020 p.129-135

scholarly journals COMPARISON OF TWO WIDELY USED ATYPICAL ANTIPSYCHOTICS OLANZAPINE VERSUS RISPERIDONE IN TERMS OF METABOLIC OUTCOMES

2021 ◽  
Vol 71 (Suppl-1) ◽  
pp. S147-52
Author(s):  
Shiraz Hussain ◽  
Nomita Imtiaz ◽  
Malik Awais Amin ◽  
Sana Khan ◽  
Siddique Kakar
Keyword(s):  
Metabolic Syndrome ◽  
Psychiatric Patients ◽  
Armed Forces ◽  
Study Data ◽  
P Value ◽  
Metabolic Outcomes ◽  
Quasi Experimental ◽  
Group A ◽  
Group B

Objective: To compare the metabolic outcomes in psychiatric patients treated with Olanzapine and Risperidone. Study Design: Quasi experimental study. Place and Duration of Study: The study was conducted at Armed Forces Institute of Mental Health, Rawalpindi,from Aug 2016 to Jan 2017. Methodology: In this study 114 newly diagnosed psychiatric patients taking atypical anti-psychotics were selected and placed randomly into two groups i.e. group A (Olanzapine) andgroup B (Risperidone), 57 patients each. Patients of either gender, 20 to 60 years’ age, clinically diagnosed new cases having psychiatric illness using DSMV were selected consecutively. Baseline and six months’ end study data were collected and compared. Results: Total 14 out of 109 (5 patients lost follow up) patients developed metabolic syndrome. Among these 10(18.18%) were in group A while 4 (7.41%) were in group B. Patients receiving Olanzapine were 2.58 times moreprone to develop metabolic syndrome compared to the Risperidone receiving [RR= 2.58 {C.I. 0.85009, 7.62703}].Weight gain (p-value = 0.0048), increased Waist circumference (p-value = 0.00867) and elevated Blood Pressure (pvalue = 0.0563) were seen more significantly with use of Olanzapine. Conclusion: Olanzapine although associated with good efficacy but indeed with more serious and long-term side effects like impaired blood glucose tolerance, dyslipidemia and increase weight. Psychiatrist must screen and continuously monitor such patients.

Comparative Study of effectiveness of mobilization with movement (MWM) and End range mobilization (ERM) techniques in frozen shoulder

2018 ◽  
Vol 4 (4) ◽  
pp. 519-522
Author(s):  
Jeyakumar S ◽  
Jagatheesan Alagesan ◽  
T.S. Muthukumar
Keyword(s):  
Range Of Motion ◽  
Frozen Shoulder ◽  
Type I ◽  
Mean Values ◽  
Functional Activities ◽  
Group A ◽  
The Mean ◽  
Group B

Background: Frozen shoulder is disorder of the connective tissue that limits the normal Range of motion of the shoulder in diabetes, frozen shoulder is thought to be caused by changes to the collagen in the shoulder joint as a result of long term Hypoglycemia. Mobilization is a therapeutic movement of the joint. The goal is to restore normal joint motion and rhythm. The use of mobilization with movement for peripheral joints was developed by mulligan. This technique combines a sustained application of manual technique “gliding” force to the joint with concurrent physiologic motion of joint, either actively or passively. This study aims to find out the effects of mobilization with movement and end range mobilization in frozen shoulder in Type I diabetics. Materials and Methods: 30 subjects both male and female, suffering with shoulder pain and clinically diagnosed with frozen shoulder was recruited for the study and divided into two groups with 15 patients each based on convenient sampling method. Group A patients received mobilization with movement and Group B patients received end range mobilization for three weeks. The outcome measurements were SPADI, Functional hand to back scale, abduction range of motion using goniometer and VAS. Results: The mean values of all parameters showed significant differences in group A as compared to group B in terms of decreased pain, increased abduction range and other outcome measures. Conclusion: Based on the results it has been concluded that treating the type 1 diabetic patient with frozen shoulder, mobilization with movement exercise shows better results than end range mobilization in reducing pain and increase functional activities and mobility in frozen shoulder.

COMPARISON OF EFFECTIVENESS OF MOBILIZATION AND SELF-EXERCISES IN ADHESIVE CAPSULITIS OF SHOULDER

2018 ◽  
Vol 7 (1) ◽  
pp. 35-41
Author(s):  
Muhammad Usman Khan ◽  
Ghazala Noor Nizami ◽  
Ali Farhad
Keyword(s):  
Pain Intensity ◽  
Adhesive Capsulitis ◽  
Descriptive Analysis ◽  
Tertiary Care ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
T Test ◽  
P Value ◽  
Group A ◽  
Group B

OBJECTIVE To compare the effectiveness of mobilization and self-exercises in the management of adhesive capsulitis of shoulder STUDY DESIGN Randomized Control Trial SAMPLE SELECTION 30 patients of adhesive capsulitis of shoulder from physiotherapy department of tertiary care hospitals of Karachi were selected through simple random sampling technique. PROCEDURE Treatment was continued for 5 days per week for the period of 3 weeks followed by assessment. Patients were randomly divided into two equal groups. Group A was treated with midrange mobilization while group B performed self-exercises. Both groups received TENS and hot pack prior to the exercises. Mean ± SD, frequencies and percentages were used for descriptive analysis. ROM via goniometry and pain intensity through VAS was analyzed by paired t-test within the groups and by independent t-test between the groups, using SPSS. P-value of less than 0.05 was considered significant. RESULTS 60% were females (n=18) and 40% were males (n=12) with mean age of 50.17±6.37 years. Significant improvement (p-value <0.05) in pain and shoulder ROM was observed among patients of Group A as compared to Group B. Pain intensity was decreased to 1.67 ± 0.62 in group A, whereas ROMs in these patients were also better than other group.

Laparoscopic Incisional and Ventral Hernia Repair with Absorbable Tacks in a Long Term Follow-up: A Retrospective Control Study

2019 ◽  
Vol 14 (2) ◽  
pp. 141-146
Author(s):  
Simone Zanella ◽  
Enrico Lauro ◽  
Francesco Franceschi ◽  
Francesco Buccelletti ◽  
Annalisa Potenza ◽  
...  
Keyword(s):  
Hernia Repair ◽  
Ventral Hernia ◽  
Ventral Hernia Repair ◽  
The Elderly ◽  
Long Term Follow Up ◽  
Group A ◽  
Group B ◽  
Absorbable Tacks

Background: Laparoscopic Incisional and Ventral Hernia Repair (LIVHR) is a safe and worldwide accepted procedure performed using absorbable tacks. The aim of the study was to evaluate recurrence rate in a long term follow-up and whether the results of laparoscopic IVH repair in the elderly (≥65 years old) are different with respect to results obtained in younger patients. Methods: One hundred and twenty-nine consecutive patients (74 women and 55 men, median age 67 years, range = 30-87 years) with ventral (N = 42, 32.5%) or post incisional (N = 87, 67.5%) hernia were enrolled in the study. Patients were divided into two groups according to their age: group A (N = 55, 42.6%) aged <65 years and group B (N = 74, 57.4%) aged ≥65 years. Results: The mean operative time was not significantly different between groups (66.7 ± 37 vs. 74 ± 48.4 min, p = 0.4). To the end of 2016, seven recurrences had occurred (group A = 3, group B = 4, p = 1). Complications occurred in 8 (16%) patients in group A and 21 (28.3%) patients in group B. Conclusion: In conclusion, our results confirm that the use of absorbable tacks does not increase recurrence frequency and laparoscopic incisional and ventral repair is a safety procedure also in elderly patients.

CONVENTIONAL VERSUS THREE-DIMENSIONAL CONFORMAL EXTERNAL RADIOTHERAPY IN CANCER CERVIX: A COMPARATIVE STUDY FOR COMPLIANCE, RESPONSE AND TOXICITY

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Richa Gupta ◽  
Piyush Kumar ◽  
D. P. Singh ◽  
Arvind Kumar Chauhan ◽  
Kamal Sahni
Keyword(s):  
Clinical Response ◽  
Three Dimensional ◽  
Common Side Effect ◽  
P Value ◽  
High Dose ◽  
Cancer Cervix ◽  
Conventional Radiotherapy ◽  
Radiation Fields ◽  
Group A ◽  
Group B

INTRODUCTION: Cervical cancer is the second most frequent cancer among Indian women. Radiotherapy is the cornerstone of treatment in all its stages. Three-dimensional conformal radiotherapy (3DCRT) combines multiple radiation fields to deliver precise dose of radiation to the affected area. Tailoring each of the radiation fields to focus on the tumor delivers a high dose of radiation to the tumor and avoids nearby healthy tissue. The present study is done to compare conventional radiotherapy versus 3DCRT in cancer cervix for compliance, clinical response and toxicity. MATERIAL AND METHODS: Fifty patients were enrolled and randomised into two radiotherapy plans with radical intent - Group A treated by conventional radiotherapy and group B treated by 3DCRT. Concurrent cisplatin was delivered on weekly (35mg/m2) or tri-weekly (75mg/m2) basis during external beam Radiotherapy and was followed by High Dose Radiotherapy Brachytherapy. Clinical response and complication assessment were evaluated.Collected data was analyzed using standard statistical methods and softwares to calculate level of significance using “p” value by chi square test. RESULTS: In this study mean age of the patients was 48 years (26-67 years). The anemia was the most common side effect seen in both groups (96% vs 88%, p=0.29). Neutropenia was more in group B (36% vs 44%, p= 0.56). Lower GI toxicity was seen only in patients in group A (20% vs 0%, p=0.018). In follow up there were no significant early rectal and bladder reactions in both groups and 2 patients in each group had late rectal reactions of grade I and II (p= 0.312). No significant skin, bladder and small intestinal toxicity were seen in both groups. CONCLUSION: Conventional radiotherapy gives equally efficacious response though accompanied by toxicities which were acceptable.

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