Association of serum uric acid with systemic blood pressure – A Cross Sectional study.

Objective: To determine association of Serum Uric Acid levels (SUA) in subjects suffering Systemic Blood Pressure and to determine its association with systolic and diastolic blood pressure. Study Design: Cross Sectional Study. Setting: Department of Faculty of Medicine and Allied Medical Sciences, Isra University, Hyderabad, Sindh, Pakistan. Period: January 2018 to September 2019. Material & Methods: 150 diagnosed cases of systemic hypertension and 150 controls were selected though non-probability purposive sampling according to inclusion and exclusion criteria. 2 ml venous blood was taken, centrifuged and sera were used for uric acid. Data was saved in a pre- structured Performa. Statistical software (SPSS v 21.0, IBM, Incorporation, USA) of data variables was analyzed at 95% CI (P ≤ 0.05). Results: Serum uric acid in controls was 2.93±0.72 compared to cases 4.25±1.44 mg/dl (P=0.0001). Hyperuricemia was observed in 58 (38.6%) cases compared to 23 (15.3%) controls. Uric acid shows strong positive association with Systolic BP (r= 0.52*, p=0.0001) and Diastolic BP (r= 0.46**, p=0.0001). Conclusion: We found hyperuricemia in 58 (38.6%) of systemic hypertension cases. Systolic and Diastolic Blood pressure show positive association with uric acid.

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Predictive effect of serum uric acid and blood pressure on the left atrial size in Chinese south population

10.21203/rs.2.22740/v1 ◽

2020 ◽

Author(s):

danhong Fang ◽

Gaojun Wu ◽

Qinfen Chen ◽

Jiansheng Wu ◽

Shengjie Wu ◽

...

Keyword(s):

Blood Pressure ◽

Uric Acid ◽

Serum Uric Acid ◽

Left Atrial ◽

Blood Pressure Level ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Atrial Size ◽

Predictive Effect

Abstract Background: Serum uric acid (SUA) is strongly associated with hypertension and is associated with a variety of cardiovascular diseases. In this study we aimed to investigate the predictive effect of SUA and blood pressure on the left atrial (LA) size in Chinese south population. Methods: In this cross-sectional study, we investigated the association between SUA and LA diameter and studied the risk of LA enlargement among subjects with and without hyperuricemia (HU) in different grades of blood pressure in a single-center database (n=5392). Results: The LA diameter was significantly correlated with SUA(r=0.31, P<0.001). The incidence of LA enlargement was significantly greater in subjects with HU than in those without HU [25.7% vs. 14.2%, P<0.001; odds ratio (OR) = 2.09, 95% confidence interval (CI) = (1.78,2.45)], especially in women [21.8% vs. 7.4%, P<0.001; OR=3.50, 95%CI= (2.35, 5.22)]. In subjects with hypertension (≥140/90 mmHg) and HU, the risk of LA enlargement was 7.90 times higher than those with ideal blood pressure (< 120/80 mmHg) and normal SUA [33.1% vs. 5.9%; P<0.001, OR=7.90, 95% CI= (5.87,10.63)]. At the same blood pressure level, the risk of LA enlargement in HU subjects was higher than that in normal SUA (P<0.01). After adjustment for blood pressure, the effect of HU on LA size still exists[public OR=1.82, 95% CI=(1.54,2.14), P<0.001]. Conclusions: HU is an independent risk factor of LA enlargement in Chinese south population. SUA and blood pressure play a synergistic role in predicting the increase of LA diameter. Keywords: Uric acid, Hyperuricemia, Blood pressure, Left atrium

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Abstract P122: The Identification Of New Serum Uric Acid Levels Cut-off Point To Prevent Prehypertension And Hypertension Based On Jnc 7 And Acc/aha 2017 Classification: A Cross-sectional Study

Hypertension ◽

10.1161/hyp.78.suppl_1.p122 ◽

2021 ◽

Vol 78 (Suppl_1) ◽

Author(s):

Mochammad Sja'bani ◽

Lucky Aziza Bawazier ◽

Fredie Irijanto ◽

Zulaela Zulaela ◽

Agus Widiatmoko ◽

...

Keyword(s):

Blood Pressure ◽

Uric Acid ◽

Confidence Interval ◽

Serum Uric Acid ◽

Simple Random Sampling ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

History Of ◽

Stage 1

Background: Serum uric acid levels have been reported to be associated with elevated blood pressure and hypertension events. It is needed to determine the prognostic serum uric acid (SUA) cut-off point to prevent the incidents of prehypertension and hypertension. Methods: This was a cross-sectional study involving a total of 733 participants who a had history of prehypertension in 2007. These participants were selected from “Mlati Study Database” in 2007 by simple random sampling using statistical software. Participants underwent both physical and laboratorical examination. Data were analyzed based on JNC 7 and ACC/AHA 2017 guideline. Results: Based on JNC 7 classification, the analysis using ROC curve showed that the prognostic SUA cut-off point of 4.85 mg/dL was able to indicate the incidents of prehypertension or hypertension in the database (95% confidence interval, CI, 0.532-0.629, p=0.001). Additional analysis using ACC/AHA 2017 guideline as the blood pressure classification was also performed for comparison. Based on ACC/AHA 2017 classification, the ROC curved showed a slightly higher SUA cut-off points than the previous analysis using JNC 7. The prognostic SUA cut-off point of 4.95 mg/dL was able to indicate the events of hypertension stage 1 and stage 2 in the database (95% confidence interval, CI, 0.532-0.615, p=0.001). These results were parallel with the previous study which reported that SUA cut-off points of 5-7 mg/dL (high-normal SUA) and ≥7 mg/dL (high SUA) were associated with the incidents of prehypertension and hypertension. Conclusion: The new SUA cut-off points may be used as an early warning for the development of prehypertension and hypertension in the future.

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Association of Serum Uric Acid with Lung Function in the National Health and Nutrition Examination Survey (NHANES), 2007-2012: A Cross-Sectional Study.

10.21203/rs.3.rs-955214/v1 ◽

2021 ◽

Author(s):

Wen Luo ◽

Wanyu Wang ◽

Xiangyang Yao ◽

Yonghong Shi ◽

Fang Lu ◽

...

Keyword(s):

Blood Pressure ◽

Uric Acid ◽

Lung Function ◽

General Population ◽

Serum Uric Acid ◽

Cross Sectional Study ◽

Nutrition Examination Survey ◽

Sectional Study ◽

Cross Sectional ◽

Health And Nutrition

Abstract Background Evidence regarding the relationship between serum uric acid and lung function was controversial. Therefore, this study is designed to investigate whether serum uric acid was independently related to lung function in the National Health and Nutrition Examination Survey (NHANES) (2007-2012) after adjusting for other covariates. Methods The present study was a cross-sectional study. The total participants from NHANES (2007-2012) were 30442. After exclusion of subjects, 9474 subjects remained for the final analysis. The target independent variable and the dependent variable were serum uric acid measured at baseline and lung function respectively. Covariates involved in this study included age, sex, race, income-poverty ratio, body mass index, systolic blood pressure, diastolic blood pressure, blood urea nitrogen, cholesterol, creatinine, total protein, FeNO, calcium, alcohol drinking, smoke, phosphorus and total bilirubin. Results The average age of 9626 selected participants was 37.12 ± 16.03 years old, and about 49.19% of them were male. Result of fully adjusted linear regression showed serum uric acid was negatively associated with FEV1, FEV and PEF after adjusting confounders (Odds ratio (OR)= for FEV1 [-21.28 (-32.26, -10.30)], for FVC [-26.79 (-40.56, -13.01)] and for PEF [-72.19 (-101.93, -42.46)]). FEV1 and PEF were found a non-linear relationship with serum uric acid and the inflection points was 6.5mg/dl and 7.3 mg/dl respectively. The effect sizes and the confidence intervals in FEV1 and PEF of the left and right sides of inflection point were -11.50 (-25.55, 2.54) and -48.07 (-74.49, -21.66), -38.17 (-71.91, -4.43) and -311.11 (-427.28, -194.94) respectively. Conclusions We find serum uric acid was negatively associated with FEV1, FVC and PEF in a general population. Besides, there is a threshold effect on the independent association between serum uric acid and FEV1 and PEF. Those results are only found in the general population. Further epidemiologic studies will still be required to confirm this reverse association between serum uric acid and lung function.

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Serum Uric Acid and Triglycerides in Chinese Patients with Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study

BioMed Research International ◽

10.1155/2019/9792412 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Wenyuan Ma ◽

Changmeng Cui ◽

Song Feng ◽

Genhua Li ◽

Guangkui Han ◽

...

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Moyamoya Disease ◽

Smoking Status ◽

Positive Association ◽

Cross Sectional Study ◽

Chinese Patients ◽

Newly Diagnosed ◽

Sectional Study ◽

Cross Sectional

Background. Evidence regarding the relationship between serum uric acid and triglycerides is limited. Therefore, the specific objective of this study was to investigate whether serum uric acid was independently related to triglycerides in Chinese patients with newly diagnosed moyamoya disease after adjusting for other covariates. Methods. The present study was a cross-sectional study. A total of 261 Chinese patients with newly diagnosed moyamoya disease were recruited from a hospital in China from 24 March 2013 to 24 December 2018. The independent variable and the dependent variable were serum uric acid measured at baseline and triglycerides, respectively. The covariates involved in this study included age, sex, body mass index, smoking status, and alcohol consumption. Results. The average age of the 227 selected participants was 47.5 ± 12.6 years old, and approximately 48.5% of them were male. The results of the fully adjusted linear regression showed that serum uric acid (10 μmol/L) was positively associated with triglycerides (mmol/L) after adjusting for confounders (β 0.048, 95% CI 0.032, 0.064). Conclusions. In patients with moyamoya disease, there seemed to be a positive association between serum uric acid and triglycerides.

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