Evaluate the effectiveness and safety of proton pump inhibitors (PPIs) in the treatment of upper GIT disorders

Introduction: Proton pump inhibitors (PPIs) are most prescribed medication classes and have similar efficacy between generic and brand names. PPIs are used for treatment upper GIT disorders. The aim of the present study was to evaluate the effectiveness and safety of proton pump inhibitors (PPIs). Methods: A cross sectional study conducted randomly on pharmacies, patients and Doctors to collect a data regarding the effectiveness and safely use of PPI through predesigned questionnaire containing information about dosage, types, side effect, effectiveness and safety of PPIs. The collected data was analysis by using Chi-square for determine the significant differences at α < 0.05. Result: The result of present study revealed numbers of points in which the questionnaire were intended for pharmacies, patients and doctors knowledge, effectiveness and safety of PPIs. The data gathered from pharmacy shown PPI dispensed without prescription (P< 0.05) in dose of 20 mg of omeprazole and for treatment of gastritis, stomachache and on medication use (P< 0.05). No side effect or any problem, safe, and effective of PPIs was from patients seeking PPIs to the drug dispensers. Furthermore, questionnaire for patients whom seeking treatment shown some similarity to pharmacies answers, however lack the knowledge about side effect of PPIs, and PPIs withdraw among patients. PPIs was found to be used by patients due to the advices of friends (P< 0.05). The last part in this study was doctors involved in which some common similarity were also identified between doctors, patients and pharmacies responses. Although, Doctors responses were revealed that PPIs should be used by prescription in single dose of common types of PPIs (P< 0.05). Conclusion: Due to the short time use of PPIs have been reported. This study suggested that, even no side effect and highly effective of PPIs reported, the PPIs should be monitoring and use under prescription.

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Prevalence and Associations of the Use of Proton-Pump Inhibitors in Nursing Homes: A Cross-Sectional Study

Journal of the American Medical Directors Association ◽

10.1016/j.jamda.2012.10.018 ◽

2013 ◽

Vol 14 (4) ◽

pp. 265-269 ◽

Cited By ~ 31

Author(s):

Philipe de Souto Barreto ◽

Maryse Lapeyre-Mestre ◽

Céline Mathieu ◽

Christine Piau ◽

Catherine Bouget ◽

...

Keyword(s):

Nursing Homes ◽

Proton Pump Inhibitors ◽

Proton Pump ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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The Burden of Potentially Inappropriate Medications in Chronic Polypharmacy

Journal of Clinical Medicine ◽

10.3390/jcm9113728 ◽

2020 ◽

Vol 9 (11) ◽

pp. 3728

Author(s):

Jordan Guillot ◽

Sandy Maumus-Robert ◽

Alexandre Marceron ◽

Pernelle Noize ◽

Antoine Pariente ◽

...

Keyword(s):

Older Adults ◽

Proton Pump Inhibitors ◽

Proton Pump ◽

Cross Sectional Study ◽

Potentially Inappropriate Medications ◽

Middle Aged ◽

Cross Sectional ◽

Long Acting ◽

Chronic Use ◽

Inappropriate Medications

We aimed to describe the burden represented by potentially inappropriate medications (PIMs) in chronic polypharmacy in France. We conducted a nationwide cross-sectional study using data from the French National Insurance databases. The study period was from 1 January 2016 to 31 December 2016. Chronic drug use was defined as uninterrupted daily use lasting ≥6 months. Chronic polypharmacy was defined as the chronic use of ≥5 medications, and chronic hyperpolypharmacy as the chronic use of ≥10 medications. For individuals aged ≥65 (older adults), PIMs were defined according to the Beers and Laroche lists, and for individuals aged 45–64 years (middle-aged) PIMs were defined according to the PROMPT (Prescribing Optimally in Middle-aged People’s Treatments) list. Among individuals with chronic polypharmacy, 4009 (46.2%) middle-aged and 18,036 (64.8%) older adults had at least one chronic PIM. Among individuals with chronic hyperpolypharmacy, these figures were, respectively, 570 (75.0%) and 2544 (88.7%). The most frequent chronic PIM were proton pump inhibitors (43.4% of older adults with chronic polypharmacy), short-acting benzodiazepines (older adults: 13.7%; middle-aged: 16.1%), hypnotics (6.1%; 7.4%), and long-acting sulfonylureas (3.9%; 12.3%). The burden of chronic PIM appeared to be very high in our study, concerning almost half of middle-aged adults and two-thirds of older adults with chronic polypharmacy. Deprescribing interventions in polypharmacy should primarily target proton pump inhibitors and hypnotics.

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Prevalence and risk factors of long-term proton pump inhibitors-associated hypomagnesemia: a cross-sectional study in hospitalized patients

Internal and Emergency Medicine ◽

10.1007/s11739-020-02501-1 ◽

2020 ◽

Author(s):

Delfina Ana Recart ◽

Augusto Ferraris ◽

Carla Ines Petriglieri ◽

Marina Alonso Serena ◽

Maria Belen Bonella ◽

...

Keyword(s):

Risk Factors ◽

Proton Pump Inhibitors ◽

Proton Pump ◽

Cross Sectional Study ◽

Hospitalized Patients ◽

Sectional Study ◽

Cross Sectional

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A Cross-Sectional Study on Single-Day Use of Proton Pump Inhibitors in Tertiary Care Hospitals of South India

Hospital Pharmacy ◽

10.1177/0018578719873876 ◽

2019 ◽

pp. 001857871987387

Author(s):

Zabiuddin Ahad M ◽

Alekhya Lavu ◽

Maria Ansari ◽

Raviraj Acharya V ◽

Rajesh Vilakkathala

Keyword(s):

Drug Interactions ◽

Proton Pump Inhibitors ◽

Proton Pump ◽

South India ◽

Tertiary Care ◽

Cross Sectional Study ◽

Teaching Hospitals ◽

Intravenous Route ◽

Sectional Study ◽

Cross Sectional

Background: Proton pump inhibitors (PPIs) are the most potent antacids used in clinical practice with greater safety and efficacy. Limited data are available on the usage of PPIs in Indian health-care settings. Our aim was to understand the usage pattern and potential drug interactions with concurrently administered medications employing a single-day cross-sectional study design. Methods: A prospective observational cross-sectional study conducted on a single day, at two tertiary care teaching hospitals in South India. Inpatients of above 18 years of age were included. Case profiles were reviewed and data were collected in predesigned forms and analyzed. Drug interactions were identified using Micromedex and Medscape drug-interaction databases. Results: A total of 797 case profiles screened from both the centers; 714 were prescribed with PPIs. In intensive care units (ICUs), the use of PPIs was highest with 95% of cases getting these drugs. A PPI was seen in about 93% of patients, who had more than or equal to 4 drugs in their prescriptions. Pantoprazole was the mostly prescribed PPI in around 90% of the cases. Around 33% of the PPIs usage was through IV (intravenous) route, and 75% of that use was seen in wards. Around 134 drug interactions were identified, of which 10 were of major severity. Conclusions: Around 90% of inpatients were prescribed with PPIs. Pantoprazole is the most commonly prescribed PPI (90%). The IV administration was seen more in wards than ICUs, and 10 major drug interactions were observed in this single-day study. Careful monitoring is needed to avoid serious drug interactions involving PPIs, and training programs should sensitize the clinicians on the evidence-based use of PPIs.

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Hypomagnesemia in hemodialysis patients taking proton pump inhibitors

Journal of Fatima Jinnah Medical University ◽

10.37018/dezk2659 ◽

2020 ◽

Vol 14 (2) ◽

pp. 55-58

Author(s):

Abdul Malik ◽

Syed Mohkumuddin ◽

Humaira Rahim ◽

Shamima Hanif

Keyword(s):

Proton Pump Inhibitors ◽

Proton Pump ◽

Serum Magnesium ◽

Cross Sectional Study ◽

Hemodialysis Patients ◽

Mean Value ◽

Female Dominance ◽

P Value ◽

Cross Sectional ◽

The Mean

Background: Proton pump inhibitors (PPIs) are in routine widely prescribed to hemodialysis patients. Recent studies have reported the association of PPIs use with hypomagnesemia in patients with long term hemodialysis. This study aims to determine the frequency of hypomagnesemia in patients of hemodialysis taking proton pump inhibitors. Patients and methods: This cross-sectional study was conducted in the Department of Nephrology of Sandman Provincial Hospital Quetta from 01-6-2019 till 01-9-2019. A total of 120 patients (52 PPI users and 68 non-PPI users) who were on HD for more than 06 months were included. Data regarding age, gender, duration of hemodialysis and taking PPIs were collected. Determination of serum magnesium was made by taking 3 different samples at 2 weeks’ interval and the mean value of serum magnesium was calculated. Serum Mg2+ levels <2.0 mg/dL was taken as hypomagnesemia. A Chi-square test was applied to determine the association of PPI use with hypomagnesemia. Results: Demographic variables such as age and gender were not significantly different between the groups. There was female dominance in both groups (73% in PPI groups and 66.1% in the non-PPI group (p-value 0.65). The mean duration of dialysis was 45.3±13.8 months in PPI users versus 48.9±12.9 months in non-PPI users (p-value 0.14). There was a significantly higher frequency of hypomagnesemia in PPI users; 36 (69.3%) versus 27 (39.7%) in non-PPI users (p-value 0.001). Conclusion: The use of PPI is associated with a significant reduction in serum magnesium levels. So serum magnesium levels should be advised as routine monitoring in patients of hemodialysis taking PPIs.

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The magnitude of prescribing medicines by brand names at Muhimbili National Hospital, Tanzania

Medicine Access Point of Care ◽

10.1177/2399202619900148 ◽

2020 ◽

Vol 4 ◽

pp. 239920261990014

Author(s):

Ombeni Kisamo ◽

Manase Kilonzi ◽

Wigilya P Mikomangwa ◽

George M Bwire ◽

Hamu J Mlyuka ◽

...

Keyword(s):

Treatment Guidelines ◽

Cross Sectional Study ◽

Brand Names ◽

World Health ◽

P Value ◽

Muhimbili National Hospital ◽

Prescribing Practices ◽

National Hospital ◽

Chi Square ◽

Cross Sectional

Background: Tanzania National Treatment Guidelines and National Therapeutic Committee circular of 2012 requires prescribers to prescribe medicines using their generic names as recommended by the World Health Organization. The implementation of the aforementioned recommendations by prescribers is not well documented in our settings. Therefore, this study aimed to explore the compliance on the use of generic names by prescribers at Muhimbili National Hospital. Methods: A descriptive cross-sectional study was conducted at Muhimbili National Hospital from January to May 2019 in both inpatient and outpatient pharmacy units. Data were analyzed using SPSS, version 23. Chi-square test was used to analyze proportions between the different variables of the study. A p-value for significance was <0.05. Results: Of 1001 prescriptions analyzed, 71.6% contained medicines prescribed using brand names. The mean (±standard deviation (SD)) number of medicines per prescription was 2.98 (±1.5). The most frequently prescribed medicines by brand names were a combination of vitamin and mineral supplements (34.4%) followed by antibiotics (26.7%). Medical doctors (25.6%) and medical specialists (21.6%) prescribed ⩾2 medicines using brand names per prescription compared to interns (15.0%) and residents (6.9%) ( p < 0.001). Conclusion: Prescribing medicines using brand names was highly observed in this study. Supplements and antibiotics were among the products that were highly prescribed using their brand names. Qualitative studies to explore reasons for brand name prescribing practices are recommended.

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HUBUNGAN KONDISI OVERCROWDED DENGAN KETEPATAN PELAKSANAAN TRIASE DI INSTALASI GAWAT DARURAT RSU GMIM PANCARAN KASIH MANADO

JURNAL KEPERAWATAN ◽

10.35790/jkp.v7i1.22880 ◽

2019 ◽

Vol 7 (1) ◽

Author(s):

Vianthy Kundiman ◽

Lucky Kumaat ◽

Maykel Kiling

Keyword(s):

Cross Sectional Study ◽

P Value ◽

Sectional Study ◽

Chi Square ◽

Cross Sectional ◽

Consecutive Sampling ◽

Chi Square Test ◽

Short Time ◽

Relationship Of ◽

The Relationship

Abstract: Triage is a patient sorting activity based on the severity of trauma or illness that iscarried out immediately in a short time. Overcrowded conditions by patients in the ED due tothe incompatibility of patients with the number of overcrowded nurses have an impact on theaccuracy implementation of triage in patients aimed at reducing morbidity and mortality.Thepurpose was to identify the relationship of overcrowded conditions and the accuracyimplementation of triage at ED of Pancaran Kasih GMIM Hospital Manado. The design studyis analytic survey with cross sectional.Samples 105 respondents with a Non Probabilitysampling technique namely Consecutive sampling. Results used the Chi square test with asignificance level of 95% so that the value of p value is 0,000 smaller than the significant valueof 0.05.Conclusion there is a relationship of overcrowded conditions and the accuracyimplementation of the truage at Emergency Department of Pancaran Kasih GMIM HospitalManado..Keywords: Triage, Overcrowded, AccuracyAbstrak: Triase merupakan kegiatan pemilahan pasien berdasarkan berat dan ringannya traumaatau penyakit yang diderita yang dilakukan segera dalam waktu yang singkat. Kondisiovercrowded oleh pasien di IGD disebabkan karena tidak sesuainya jumlah pasien denganjumlah perawat Overcrowded berdampak pada ketepatan pelaksanaan triase pada pasien yangbertujuan menurunkan angka morbiditas dan mortalitas. Tujuan untuk mengetahui hubunganantara kondisi overcrowded dengan ketepatan pelaksanaan triase di IGD RSU GMIM PancaranKasih Manado. Metode menggunakan desain penelitian cross sectional study. Sampel terdiridari 105 responden dengan tehnik pengambilan sampel Non Probability sampling yaituConsecutive sampling. Hasil menggunakan uji Chi square dengan tingkat kemaknaan 95%sehingga didapatkan nilai p value yaitu 0,000 lebih kecil dari nilai signifikan 0,05. Kesimpulanterdapat hubungan antara kondisi overcrowded dengan ketepatan pelaksanaan triase di IGDRSU GMIM Pancaran Kasih Manado.Kata Kunci: Triase, Overcrowded, Ketepatan

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