Ketogenic diet in the treatment of pharmacoresistent epilepsy. Domestic experience and perspectives

2021 ◽  
Vol 26 (5) ◽  
pp. 52-60
Author(s):  
E. G. Lukyanova ◽  
E. A. Pyr'yeva ◽  
T. N. Sorvacheva ◽  
S. O. Aivazyan ◽  
K. V. Osipova ◽  
...  

The article concentrates on the experience of using the ketogenic diet (KD) in neurological practice in children with epilepsy resistant to anticonvulsant treatment. Prescription of KD in combination with drug therapy or without it allowed to achieve 100% control over seizures (confirmed by electroencephalographic study), significant progress in psycho-speech, cognitive, motor development in 21% of cases, which increased the chances of socialization of children and improved family life quality.

2020 ◽  
Vol 42 (2) ◽  
pp. 326-330
Author(s):  
Yann-Eric Nisse ◽  
Sophie Robert ◽  
Sophie Menetre ◽  
Emmanuel Raffo ◽  
Béatrice Demore

1991 ◽  
Vol 24 (3) ◽  
pp. 269-299 ◽  
Author(s):  
Kathryn D. Rettig ◽  
Sharon M. Danes ◽  
Jean W. Bauer

Author(s):  
E. N. Nenashkina

Introduction. The presence of somatic diseases during pregnancy leaves a serious imprint on the emotional state of a woman, significantly worsens the quality life indicators and affects the clinical characteristics of pregnancy. One of these diseases is chronic pyelonephritis. There are a fairly large number of recommendations for the treatment of this pathology. However the focus is mainly on drug therapy. At the same time the existing restrictions on the number of drugs using during pregnancy, the problem of polypragmasia, and the increase in the number of allergic complications of drugs using dictate the need to search alternative methods of treatment, primarily non-drug ones. Moreover, the problems of pregnant women life quality with chronic pyelonephritis during complex drug therapy are often not given due attention.The goal of research — to assess the impact of osteopathic correction on the psycho-emotional state and life quality of pregnant women with concomitant pathology of the urinary system.Materials and methods. A prospective controlled randomized study was conducted in the period 03.2016– 01.2018 on the basis of medical clinics of LLC «Mokhov Institute of osteopathy» and LLC «Vasileostrovskaya clinic of reproduction and genetics». There were observed work 48 pregnant women with chronic pyelonephritis aged 25–45 years, with a gestation period 13–27 weeks. During the processing of the clinical material, 8 patients were eliminated. As a result of the selection process, a group of 40 people was formed. All pregnant women with chronic kidney disease, depending on the used treatment method, were divided into two groups using a simple randomization method with a random number generator. There was formed the main group (20 people), and the control group (20 people). Patients of the main group received medication and osteopathic correction (3 procedures with an interval of 7–10 days). Patients in the control group received only traditional drug therapy. All pregnant women with chronic pyelonephritis had an osteopathic examination before and after treatment with forming an osteopathic conclusion, and the assessment of the pain syndrome severity by a visual analog scale (VAS), the general psycho-emotional state (the method of rapid assessment of health, activity and mood — HAM), and the level of life quality (Questionnaire Medical Outcomes Study — Short Form).Results. Pregnant women with chronic pyelonephritis were characterized by a weak pain syndrome, a psychoemotional state violations in the categories «well-being» and «activity», and a decrease in both the physical and mental components of life quality. After the complex treatment including the additional to traditional drug therapy osteopathic correction methods, the statistically significant decrease of the pain severity degree (p=0,001), increase of psychoemotional state rates in the category of «activity» (p=0,05) and the increase of physical and mental components of life quality (p=0,02) were observed in the main group compared with the control.Conclusion. Chronic pathology of the kidneys during pregnancy affects the emotional state of a woman, significantly worsens life quality indicators. The use of osteopathic correction as a part of the complex therapy of pregnant women with chronic pyelonephritis can improve the emotional state and life quality; reduce the pain severity, and so can be used to improve medical care for this population category. 


2020 ◽  
Author(s):  
shan chen

Based on the pandemic of COVID-19 in 2020, to avoid crowds and mass infection, web-based learning takes the place of traditional class teaching to become the main learning method for adults, teachers, and students, the study aims to check the relationship between web-based learning tools, self-efficacy, depression-anxiety-stress, family life quality, and general health in Chinese sample. Through a questionnaire and measurement scale to collect data in June to July 2020, adopted SPSS 25.0 and Mplus 8.3 to test the reliability and validity, structural equation modeling (SEM), multiple regression model (MRM), and other methods are used for statistical analysis and conclusions.<p></p>


Author(s):  
Detlev Boison

Increased clinical interest in the ketogenic diet and similar metabolic treatments has naturally spurred research into mechanisms underlying their anticonvulsant/antiepileptogenic efficacy; significant progress and new insights are being made after many decades of relative obscurity. This section, “Ketogenic Diet in the Laboratory,” includes discussions of a number of molecular targets that are affected by ketogenic diet feeding. New insights into mechanisms, combined with clinical observations, are potentially expanding the utilitiy of this metabolic approach. In parallel, several alternative experimental methods to either elucidate or mobilize ketogenic diet mechanisms are explored. Based on this laboratory research, putative and novel uses for metabolic treatments are proposed.


2020 ◽  
Vol 8 (2) ◽  
pp. 103-113
Author(s):  
Mohammad Tohirin Hasan ◽  
Iswandi Iswandi

Since its launch in 2016, the Family Planning Village (Kampung KB) has experienced interesting dynamics in the field. The number of KB Kampung is increasing every year. One of the goals of the KB Village is to improve the family quality of life. Quality of life consist of the physical, emotional, social, intellectual, spiritual, and environmental dimensions. This literature review research explores two questions: (1) how is the implementation of KB Kampung in the field; (2) What are the implications of Kampung KB for the quality of family life. By using Crossref and Google Scholar, 97 writings on the theme of Kampung KB were obtained. After the exclusion, there were 33 papers that were relevant to the purpose of this study, only 23 papers were obtained which were used as exploration material. The results of the analysis show several things. First, Kampung KB has been implemented with various obstacles and opportunities. Some that are often encountered are: lack of understanding of the managers, lack of budget support, and low continuity of activities. Second, although the community has felt the benefits, the programs and activities have not had too many implications for the family quality of life.


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