scholarly journals Kajian Manfaat Senyawa Aktif dalam Ekstrak Kulit Buah Coklat (Theobroma Cacao )

2020 ◽  
Vol 15 (2) ◽  
pp. 13
Author(s):  
Sukatik - ◽  
Rahmi Hidayati ◽  
Roni Tri Putra ◽  
Ratih Paramitha
Keyword(s):  
Mass Spectrometry ◽  
Corrosion Inhibitors ◽  
Condensed Tannin ◽  
Gas Chromatography Mass Spectrometry ◽  
Phytochemical Screening ◽  
Liquid Chromatography Mass Spectrometry ◽  
Active Compounds ◽  
Chromatography Mass Spectrometry ◽  
Polar Extracts ◽  
Hydroxy Groups

Identification of active compounds in cacao pod rind has been done. Cacao pod rind contained active compound alkaloid, theobromine (3,7-dimethylxanthine). Cacao pod rind extract contained some other active compounds mixed flavonoid or condensed tannin such as anthocyanin, anthocyanidin, catechin, epicatechin, epigallocatechin, and leucoanthocyanidin. Cacao pod rind was extracted by maceration using methanol 70% and fractionated with hexane and ethyl acetate to obtain polar extracts. This study used an experimental method that was analyzed descriptively using Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid Chromatography-Mass Spectrometry (LC-MS). Phytochemical screening test showed cocoa pod rind extracts contained alkaloids, flavonoids, tannins, terpenoids, and saponins. GC-MS analysis showed that cacao pod rind extracts contained 24 compounds. Polar extracts analysis with LC-MS obtained 10 compounds contained hydroxy groups, which can be used as corrosion inhibitors on metal. The result of this study showed that cocoa pod rind has potential as corrosion inhibitor. It also has potential as an anti-bacterial and antioxidant.

scholarly journals Kajian Manfaat Senyawa Aktif dalam Ekstrak Kulit Buah Coklat (Theobroma Cacao )

2020 ◽  
Vol 15 (2) ◽  
pp. 13
Author(s):  
Sukatik - ◽  
Yuli Yetri ◽  
Rahmi Hidayati ◽  
Roni Tri Putra ◽  
Ratih Paramitha
Keyword(s):  
Mass Spectrometry ◽  
Corrosion Inhibitors ◽  
Condensed Tannin ◽  
Gas Chromatography Mass Spectrometry ◽  
Phytochemical Screening ◽  
Liquid Chromatography Mass Spectrometry ◽  
Active Compounds ◽  
Chromatography Mass Spectrometry ◽  
Polar Extracts ◽  
Hydroxy Groups

Identification of active compounds in cacao pod rind has been done. Cacao pod rind contained active compound alkaloid, theobromine (3,7-dimethylxanthine). Cacao pod rind extract contained some other active compounds mixed flavonoid or condensed tannin such as anthocyanin, anthocyanidin, catechin, epicatechin, epigallocatechin, and leucoanthocyanidin. Cacao pod rind was extracted by maceration using methanol 70% and fractionated with hexane and ethyl acetate to obtain polar extracts. This study used an experimental method that was analyzed descriptively using Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid Chromatography-Mass Spectrometry (LC-MS). Phytochemical screening test showed cocoa pod rind extracts contained alkaloids, flavonoids, tannins, terpenoids, and saponins. GC-MS analysis showed that cacao pod rind extracts contained 24 compounds. Polar extracts analysis with LC-MS obtained 10 compounds contained hydroxy groups, which can be used as corrosion inhibitors on metal. The result of this study showed that cocoa pod rind has potential as corrosion inhibitor. It also has potential as an anti-bacterial and antioxidant.

scholarly journals Mechanistic Insights into Alzheimer’s Disease Unveiled through the Investigation of Disturbances in Central Metabolites and Metabolic Pathways

Biomedicines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 298
Author(s):  
Raúl González-Domínguez ◽  
Álvaro González-Domínguez ◽  
Ana Sayago ◽  
Juan Diego González-Sanz ◽  
Alfonso María Lechuga-Sancho ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Metabolic Pathways ◽  
Gas Chromatography Mass Spectrometry ◽  
Liquid Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry ◽  
Multiple Primary ◽  
Human Disorders ◽  
Direct Mass Spectrometry

Hydrophilic metabolites are closely involved in multiple primary metabolic pathways and, consequently, play an essential role in the onset and progression of multifactorial human disorders, such as Alzheimer’s disease. This review article provides a comprehensive revision of the literature published on the use of mass spectrometry-based metabolomics platforms for approaching the central metabolome in Alzheimer’s disease research, including direct mass spectrometry, gas chromatography-mass spectrometry, hydrophilic interaction liquid chromatography-mass spectrometry, and capillary electrophoresis-mass spectrometry. Overall, mounting evidence points to profound disturbances that affect a multitude of central metabolic pathways, such as the energy-related metabolism, the urea cycle, the homeostasis of amino acids, fatty acids and nucleotides, neurotransmission, and others.

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