scholarly journals Adjunctive Utility of Toluidine Blue in Detecting Dysplastic Cells in Oral Mucosal Lesions in Comparison with Histopathology

2021 ◽  
Vol 10 (1) ◽  
pp. 26-31
Author(s):  
K.M. Chandrani Somaratne ◽  
S.A.K.J. Kumara ◽  
R.M.N.D. Ratnayake ◽  
Priyantha Liyanage ◽  
N.A.A.P.D. Gunasekera
Keyword(s):  
Sri Lanka ◽  
Clinical Examination ◽  
Toluidine Blue ◽  
Maxillofacial Surgery ◽  
Added Value ◽  
Premalignant Lesions ◽  
Blue Staining ◽  
Oral And Maxillofacial Surgery ◽  
Histopathological Diagnosis ◽  
Predictive Values

Introduction: Oral cancer is one of the most common cancers globally and in Sri Lanka, which follows premalignant lesions. It is curable if it is detected early. Several adjunctive methods to diagnose premalignant lesions early are available. Among these, Toluidine blue staining method before a biopsy is currently receiving much attention. Method: This is a prospective study done by studying 103 patients presented to the Oral and Maxillofacial Surgery Unit, District General Hospital, Gampaha, Sri Lanka. The oral lesions of all the patients are categorized as benign, premalignant, and malignant by clinical examination. Toluidine Blue mouth wash is introduced to all the patients, followed by biopsy from the stained sites and the clinically decided sites in non-stained lesions. Histopathological diagnosis was obtained for all cases. The accuracy of diagnosis of premalignant, malignant, and benign cases by clinical assessment and by using Toluidine blue was assessed and compared statistically in relation to sensitivity, specificity, positive predictive and negative predictive values, and likelihood ratios (LR). Results: Toluidine blue has no added advantage over clinical examination in our setup even though it might be helpful in screening. However, it has an added value to confirm clinically benign cases as benign. Conclusion: Toluidine Blue can be used as an adjunct in screening and to confirm clinically benign cases so that those can be followed up in clinics without doing unnecessary biopsies.

scholarly journals The accuracy value of the dentist’s clinical diagnosis in oral lesions performed on biopsy

2013 ◽  
Vol 25 (2) ◽  
Author(s):  
Galih Fata Anadza ◽  
Endang Syamsudin ◽  
Abel Tasman Yuza
Keyword(s):  
General Hospital ◽  
Clinical Diagnosis ◽  
Clinical Examination ◽  
Oral Surgery ◽  
Histopathological Examination ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Histopathological Diagnosis ◽  
Oral Lesions ◽  
The Difference

Introduction: The diagnosis of a pathological disorder can be made in various stages, namely history taking, clinical examination and supporting examination. Clinical diagnosis is a diagnosis obtained from anamnesis and the results of clinical examination. Histopathological diagnosis is a diagnosis obtained from a microscopic examination of tissue. Clinical diagnosis and histopathological examination results may differ. The aim of the study was to obtain the accuracy value of the dentist’s clinical diagnosis by calculating the number of differences between the clinical diagnosis and the results of the histopathological examination of patients who were biopsied in the Department of Oral Surgery of General Hospital Dr. Hasan Sadikin Bandung. Methods: A retrospective descriptive study of cases of pathological abnormalities biopsied in the Department of Oral and Maxillofacial Surgery of General Hospital Dr Hasan Sadikin Bandung. The total number of study samples was 109 medical records of patients with biopsy. Results: The accuracy value of the clinical diagnosis of dentists was 76%, where the difference between the clinical diagnosis and the histopathological examination was 24%. The most common type of disorder with the greatest difference in diagnosis is ameloblastoma followed by papilloma and mucocele. Conclusion: The accuracy value of the clinical diagnosis of dentists in oral lesions performed biopsy is 76%.

scholarly journals Pneumocystis PCR: It Is Time to Make PCR the Test of Choice

2017 ◽  
Vol 4 (4) ◽  
Author(s):  
Laura Doyle ◽  
Sherilynn Vogel ◽  
Gary W Procop
Keyword(s):  
Toluidine Blue ◽  
Cleveland Clinic ◽  
Fold Increase ◽  
Surgical Pathology ◽  
Blue Staining ◽  
Chi Square ◽  
Predictive Values ◽  
Toluidine Blue Staining ◽  
Specific Pcr ◽  
Radiologic Findings

Abstract Background The testing strategy for Pneumocystis at the Cleveland Clinic changed from toluidine blue staining to polymerase chain reaction (PCR). We studied the differences in positivity rates for these assays and compared each with the detection of Pneumocystis in companion specimens by cytology and surgical pathology. Methods We reviewed the results of all Pneumocystis test orders 1 year before and 1 year after the implementation of a Pneumocystis-specific PCR. We also reviewed the corresponding cytology and surgical pathology results, if performed. Finally, we reviewed the medical records of patients with rare Pneumocystis detected by PCR in an effort to differentiate colonization vs true disease. Results Toluidine blue staining and surgical pathology had similar sensitivities and negative predictive values, both of which were superior to cytology. There was a >4-fold increase in the annual detection of Pneumocystis by PCR compared with toluidine blue staining (toluidine blue staining: 11/1583 [0.69%] vs PCR: 44/1457 [3.0%]; chi-square P < .001). PCR detected 1 more case than surgical pathology and was far more sensitive than cytology. Chart review demonstrated that the vast majority of patients with rare Pneumocystis detected were immunosuppressed, had radiologic findings supportive of this infection, had no other pathogens detected, and were treated for pneumocystosis by the clinical team. Conclusion PCR was the most sensitive method for the detection of Pneumocystis and should be considered the diagnostic test of choice. Correlation with clinical and radiologic findings affords discrimination of early true disease from the far rarer instances of colonization.

scholarly journals Perceived Satisfaction of Patients and Related Factors for Oral Surgery Student Dental Clinic: Evidence From Sri Lanka

2021 ◽  
Vol 8 ◽  
pp. 237437352199881
Author(s):  
Nadeena Sri Swarnagupta Jayasuriya ◽  
Irosha Rukmali Perera ◽  
Chandira Gunasena ◽  
Sakuntha Ratnapreya ◽  
Madhubhashinee Dayabandara ◽  
...  
Keyword(s):  
Sri Lanka ◽  
Dental Treatment ◽  
Oral Surgery ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Dental Clinic ◽  
Related Factors ◽  
Satisfaction Scale ◽  
Validated Questionnaire ◽  
Perceived Satisfaction

We assessed perceived satisfaction of patients and related factors for treatment provided by the oral surgery student dental clinic of the only Sri Lankan dental school. A descriptive cross-sectional study was conducted among 288 consenting patients who received oral surgery treatment at the student dental clinic of Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka. A self-administered, validated questionnaire and a 19-item multidimensional patient satisfaction scale were used for data collection. Patients of all ages were represented, but were dominated by females, aged 30 to 44 years, possessing educational attainment up to General Certificate of Education ordinary or advanced level of which 54.9% were unemployed. They had travelled distances of less than 10 and 10 to 20 km (28.1% and 27.5%, respectively) predominantly to receive tooth extractions exacerbated by symptoms. Overall, 90% of responding patients were highly satisfied with the items of many dimensions of dental treatment. Despite high levels of perceived satisfaction expressed, further improvements were warranted for waiting time, optimal pain control with more kind, and courteous staff.

scholarly journals Comparison of ‘Mental training’ and physical practice in the mediation of a structured facial examination: A quasi randomized, blinded and controlled study 

2021 ◽  
Author(s):  
Arne Nelskamp ◽  
Benedikt Schnurr ◽  
Alexandra Germanyuk ◽  
Jasmina Sterz ◽  
Jonas Lorenz ◽  
...  
Keyword(s):  
Student Performance ◽  
Clinical Examination ◽  
Clinical Skills ◽  
Clinical Skill ◽  
Maxillofacial Surgery ◽  
Training Group ◽  
Controlled Study ◽  
Oral And Maxillofacial Surgery ◽  
Mental Training ◽  
Physical Practice

Abstract Background: The correct performance of a structured facial examination presents a fundamental clinical skill to detect facial pathologies. However, many students are not adequately prepared in this basic clinical skill. Many argue that the traditional ‘See One, Do One’ approach is not sufficient to fully master a clinical skill. ‘Mental Training’ has successfully been used to train psychomotor and technical skills in sports and other surgical fields, but its use in Oral and Maxillofacial Surgery is not described. We conducted a quasi-experimental to determine if ‘Mental Training’ was effective in teaching a structured facial examination. Methods: 67 students were randomly assigned to a ‘Mental Training’ and ‘See One, Do One’ group. Both groups received standardized video instruction on how to perform a structured facial examination. The ‘See One, Do One’ group then received 60 minutes of guided physical practice while the ‘Mental Training’ group actively developed a detailed, stepwise sequence of the performance of a structured facial examination and visualized this sequence subvocally before practicing the skill. Student performance was measured shortly after (T1) and five to ten weeks (T2) after the training by two blinded examiners (E1 and E2) using a validated checklist. Results: Groups did not differ in gender, age or in experience. The ‘Mental Training’ group averaged significantly more points in T1 (pE1 = 0.00012; pE2 = 0.004; dE1 = 0.86; dE2 = 0.66) and T2 (pE1 = 0.04; pE2 = 0.008, dE1 = 0.37; dE2 = 0.64) than the ‘See One, Do One’ group. The intragroup comparison showed a significant (pE1 = 0.0002; pE2 = 0.06, dE1 = 1.07; dE2 = 0.50) increase in clinical examination skills in the ‘See One, Do One’ group, while the ‘Mental Training’ group maintained an already high level of clinical examination skills between T1 and T2.Discussion: ‘Mental Training’ is an efficient tool to teach and maintain basic clinical skills. In this study ‘Mental Training’ was shown to be superior to the commonly used ‘See One, Do One’ approach in learning how to perform a structured facial examination and should therefore be considered more often to teach physical examination skills.

scholarly journals Toluidine Blue Staining Identifies High-Risk Primary Oral Premalignant Lesions with Poor Outcome

2005 ◽  
Vol 65 (17) ◽  
pp. 8017-8021 ◽  
Author(s):  
Lewei Zhang ◽  
Michele Williams ◽  
Catherine F. Poh ◽  
Denise Laronde ◽  
Joel B. Epstein ◽  
...  
Keyword(s):  
High Risk ◽  
Toluidine Blue ◽  
Premalignant Lesions ◽  
Blue Staining ◽  
Toluidine Blue Staining ◽  
Poor Outcome

scholarly journals Multiple Keratocyst Glimpses Falx Cerebri and Bifid Rib- A Case of Gorlin-Goltz Syndrome

2020 ◽  
Author(s):  
Vrushali Baburao Zamare ◽  
Rahul Bhowate ◽  
Vidya Lohe ◽  
Mrunal Meshram
Keyword(s):  
Histopathological Examination ◽  
Maxillofacial Surgery ◽  
Panoramic Radiograph ◽  
Odontogenic Keratocyst ◽  
Oral And Maxillofacial Surgery ◽  
Histopathological Diagnosis ◽  
Imaging Evaluation ◽  
Falx Cerebri ◽  
Cutaneous Manifestations ◽  
Goltz Syndrome

Multiple Odontogenic keratocysts with multi-organ abnormalities are a feature of Gorlin-Goltz Syndrome (GGS) which is an autosomal dominant inherited disorder. The most common oral manifestation of GGS is odontogenic keratocyst. Early diagnosis of GGS without cutaneous manifestations is important as this syndrome has basal cell carcinoma as one of its major criteria. This paper includes a case report of a 24-year-old female who reported with swelling and pus discharge in lower right posterior region. The swelling was clinico-radiologically diagnosed as odontogenic keratocyst on a panoramic radiograph which revealed the presence of multiple cystic lesions in symphysis, parasymphysis, and bilateral maxillary region. Postero-Anterior (PA) chest showed bifid ribs and PA skull showed calcification of falxcerebri. Histopathological diagnosis confirmed the Odontogenic keratocyst. Ultrasonography (USG) abdomen revealed a simple ovarian cyst on the right side. Clinical examination findings and radiological imaging evaluation with histopathological examination of cystic lesion confirms Gorlin-Goltz. Surgical enucleation of the keratocyst, peripheral ostectomy followed by bone graft substitute, and primary closure under General Anaesthesia (GA) were done in the Department of Oral and Maxillofacial Surgery. Follow-up healing was uneventful after one month.

The study of use of toluidine blue as an adjunctive tool to clinical examination in early diagnosis of clinically suspicious oral premalignant and malignant lesions: a study of fifty cases

2019 ◽  
Vol 5 (6) ◽  
pp. 1585 ◽  
Author(s):  
Himanshu Chhagan Bayad ◽  
Sanjeev Bhagat ◽  
Dimple Sahni ◽  
Navneet Kaur ◽  
Ravinder Singh ◽  
...  
Keyword(s):  
Early Detection ◽  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Sensitivity And Specificity ◽  
Toluidine Blue ◽  
Predictive Value ◽  
Blue Staining ◽  
Histopathological Diagnosis ◽  
Toluidine Blue Staining ◽  
Malignant Lesions

<p class="abstract"><strong>Background:</strong> Oral carcinoma is among the most prevalent malignancies of head and neck region and is often diagnosed in the advanced stage with significant morbidity and treatment cost. Thus, there is a need for early detection of oral premalignant and malignant lesions. Toluidine blue staining can be used for early detection of these lesions.</p><p class="abstract"><strong>Methods:</strong> The study included 50 patients with clinically suspicious oral premalignant and malignant lesions. These lesions were subjected to toluidine blue staining and biopsy. Diagnoses were confirmed by histopathological examination.  </p><p class="abstract"><strong>Results:</strong> Sensitivity and specificity of toluidine blue for oral premalignant lesions was 92.30% and 80% respectively with the positive predictive value of 92.30%, negative predictive value of 80% and accuracy of 88.88%. Sensitivity and specificity of toluidine blue for oral malignant lesions was 96.30% and 80% respectively with the positive predictive value of 96.30%, negative predictive value of 80% and accuracy of 93.75%.</p><p class="abstract"><strong>Conclusions:</strong> The simplicity of toluidine blue staining and its accuracy suggest that it can be a useful adjunctive tool to diagnosis of oral lesions. Results should be carefully evaluated and correlated with clinical findings and histopathological diagnosis.</p>

KNOWLEDGE GAPS IN ORAL AND MAXILLOFACIAL SURGERY: A SYSTEMATIC MAPPING

2017 ◽  
Vol 33 (1) ◽  
pp. 93-102 ◽  
Author(s):  
Marie Österberg ◽  
Anders Holmlund ◽  
Bo Sunzel ◽  
Sofia Tranæus ◽  
Svante Twetman ◽  
...  
Keyword(s):  
Systematic Reviews ◽  
Malignant Tumors ◽  
Maxillofacial Surgery ◽  
Premalignant Lesions ◽  
Cochrane Library ◽  
Facial Trauma ◽  
Benign Tumors ◽  
Oral And Maxillofacial Surgery ◽  
Surgical Removal ◽  
Knowledge Gaps

Objectives: The aim of this study was to evaluate available knowledge and identify knowledge gaps within the field of oral and maxillofacial surgery, by systematically collecting and evaluating systematic reviews. Twelve specific domains were selected: surgical removal of teeth, antibiotic and corticosteroid prophylaxis, orofacial infections, dental and facial trauma, orthognathic surgery, reconstructive surgery, benign tumors, cysts, premalignant lesions, oral complications of treatment of malignant tumors, hyperbaric oxygen therapy, temporomandibular joint surgery, cost effectiveness of different surgical treatments, and ethics.Methods: The literature search, covering four databases, was conducted during September 2014: PubMed, The Cochrane library, Centre for Reviews and Dissemination and EBSCO dentistry and oral science source. Retrieved systematic reviews were quality assessed by AMSTAR.Results: In all, 1,778 abstracts were identified, of which 200 met the inclusion criteria. Forty-five systematic reviews were assessed as of high to moderate quality. The results disclosed some existing evidence in a few domains, such as surgical removal of teeth and implant survival after sinus lifts. However, in all domains, the search revealed a large number of knowledge gaps. Also of concern was the lack of data regarding health economics and ethics.Conclusions: In conclusion, there is a need for well-conducted clinical research in the fields of oral and maxillofacial surgery.

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