Effect of appointment of a complex of amino acids on the level of human-beta-defensin-1 and liver function on the background of antituberculosis therapy

2020 ◽  
Vol 0 (4) ◽  
pp. 9-16
Author(s):  
O.S. Shevchenko ◽  
O.O. Pohorielova
2012 ◽  
Vol 42 (7) ◽  
pp. 658-667 ◽  
Author(s):  
Daisuke Morihara ◽  
Kaoru Iwata ◽  
Takayuki Hanano ◽  
Hideo Kunimoto ◽  
Shizuka Kuno ◽  
...  

2014 ◽  
Vol 19 (3) ◽  
pp. 189-194 ◽  
Author(s):  
Santosh Kumar Jatav ◽  
Archana Kulshrestha ◽  
Anish Zacharia ◽  
Nita Singh ◽  
G. Tejovathi ◽  
...  

Hepatotoxicity associated with isoniazid and rifampicin is one of the major impediments in antituberculosis therapy. The present study explored the prophylactic and therapeutic efficacies of Spirulina maxima in isoniazid and rifampicin induced hepatic damage in a rat model. Hepatic damage induced in Wistar rats by isoniazid and rifampicin resulted in significant alterations in biomarkers of liver function, namely, bilirubin, aspartate transaminase, alanine transaminase, alkaline phosphatase, and oxidative stress markers such as superoxide dismutase, catalase, glutathione, and thiobarbituric acid reactive substances. Co-administration of Spirulina maxima along with antituberculosis drugs protected liver from hepatotoxicity due to isoniazid and rifampicin. Administration of Spirulina maxima consecutively for 2 weeks to hepatodamaged animals resulted in restoration of hepatic function as evident from normalization of serum markers of liver function. Thus, the present study revealed remarkable prophylactic and therapeutic potential of Spirulina maxima. Co-administration of Spirulina maxima and antituberculosis drugs is advantageous as it provides extra nutritional benefit.


2014 ◽  
Vol 33 ◽  
pp. S73
Author(s):  
P. Jegatheesan ◽  
S.D. Beutheu ◽  
G. Ventura ◽  
P. Marquet-de-Rougé ◽  
G. Sarfati ◽  
...  

Biomeditsina ◽  
2021 ◽  
Vol 17 (2) ◽  
pp. 46-57
Author(s):  
K. A. Pazinenko  ◽  
N. N. Chuchkova ◽  
M. V. Smetanina ◽  
O. A. Pazinenko ◽  
K. E. Panteleev ◽  
...  

Under the conditions of a chronic methionine diet (daily addition of amino acids to food (0.15 g/100 g) and water (1% solution)) during 2–12 weeks, the dynamics of liver tests, infl ammatory changes in the blood and blood lipids was monitored. It was found that a methionine diet (MD) leads, starting from 4 weeks of MD, to medium hyperhomocysteinemia, an increase in liver enzymes (AsAT – 1.73, AlAT – 1.5 times, p<0.05) and bilirubin (by 62.25%), which indicates the formed hepatopathy. Further (12 weeks of MD), the condition is aggravated by an abnormality of excretory liver function and the development of cholestasis (an increase in alkaline phosphatase by 1.65, bilirubin – by 3.31 times, p<0.05).


2020 ◽  
pp. 1-5
Author(s):  
Nugzar G Aleksidze ◽  

Recently, the noteworthy results have been published regarding the uptake and degradation of biologically active substances, neurotransmitters, amino acids and carbohydrates by neuroglial cells and their inactivation as it takes place in the liver of living organisms. Based on the above-said, an assumption was made that the neuroglial cells in the brain, presented in biologically active glial-synaptic and neuron-neuroglial regions, should perform a similar function as the liver does. The functions of the liver are well known and determined by the excess accumulation of metabolic and physiologically active substances in the organism by means of inactivation, degradation and detoxication. For this purpose, the neurolectins existing in glial cells were specially studied. Based on the preliminary data, by means of them, the inhibition of agglutination of blood trypsinized erythrocytes took place via biologically active substances, neurotransmitters and aminoacids. This indicates that by means of neuroglial cells it is possible to uptake the above-said substances and then their degradation and inactivation in the cell. Based on the obtained data, it should be recognized that the neuroglial cells in glial-synaptic and neuron-neuroglial regions, the neuroglia should be considered as a structural formation having liver function in the brain


1997 ◽  
Vol 161 ◽  
pp. 505-510
Author(s):  
Alexandra J. MacDermott ◽  
Laurence D. Barron ◽  
Andrè Brack ◽  
Thomas Buhse ◽  
John R. Cronin ◽  
...  

AbstractThe most characteristic hallmark of life is its homochirality: all biomolecules are usually of one hand, e.g. on Earth life uses only L-amino acids for protein synthesis and not their D mirror images. We therefore suggest that a search for extra-terrestrial life can be approached as a Search for Extra- Terrestrial Homochirality (SETH). The natural choice for a SETH instrument is optical rotation, and we describe a novel miniaturized space polarimeter, called the SETH Cigar, which could be used to detect optical rotation as the homochiral signature of life on other planets. Moving parts are avoided by replacing the normal rotating polarizer by multiple fixed polarizers at different angles as in the eye of the bee. We believe that homochirality may be found in the subsurface layers on Mars as a relic of extinct life, and on other solar system bodies as a sign of advanced pre-biotic chemistry. We discuss the chiral GC-MS planned for the Roland lander of the Rosetta mission to a comet and conclude with theories of the physical origin of homochirality.


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