To study the effect of gene polymorphism MLN bulls of Holstein breed on the frequency of occurrence of displacement of abomasum in the offspring

2018 ◽  
pp. 142-146
Author(s):  
N. Kovalyuk ◽  
◽  
V. Satsuk ◽  
E. Machulskaya ◽  
◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Frequency Of Occurrence ◽  
Holstein Breed

scholarly journals INFLUENCE OF LEPTIN (LEP) GENE POLYMORPHISM ON DAIRY AND MEAT PRODUCTIVITY OF HOLSTEIN HEIFERS

2021 ◽  
Vol 245 (1) ◽  
pp. 24-28
Author(s):  
E.R. Gaynutdinova ◽  
◽  
N.Yu. Safina ◽  
Sh.K. Shakirov ◽  
M.I. Varlamova ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Holstein Cows ◽  
Holstein Cattle ◽  
Frequency Of Occurrence ◽  
Dna Testing ◽  
Economic Traits ◽  
Blood Samples ◽  
Testing Frequency ◽  
Lep Gene ◽  
Meat Productivity

The aim of this study was to research the association between leptin gene polymorphism in Holstein cows with their dairy and meat traits of productivity. To conduct DNA testing on the LEP gene blood samples were selected from 228 Holstein heifers. Animal genotyping according to the leptin gene was performed by AC-PCR. All possible genotypes of the LEP gene were identified in the course of DNA testing. Frequency of occurrence of genotypes and alleles was ranked as fol-lows: CC – 32.5 %, TC – 49.1 %, TT – 18.4 % and C – 0.57, T – 0.43. The results of this study show that animals with genotype TT of LEP gene can be useful in breeding for the improvement of population of Holstein cattle by economic traits associated to the dairy and meat productivity. This research was supported by the FASO Russia project АААА-А18-118031390148-1.

scholarly journals THE ROLE OF THE HIF1A GENE IN THE DEVELOPMENT OF ENDURANCE ATHLETES

2021 ◽  
Author(s):  
A.O. Zaitseva ◽  
◽  
M.O. Aksenov
Keyword(s):  
Gene Polymorphism ◽  
High Intensity ◽  
The Body ◽  
Endurance Athletes ◽  
Frequency Of Occurrence ◽  
Huge Number ◽  
Electronic Resource ◽  
Number Of Factors ◽  
Hif1a Gene

The sports phenotype is extremely complex, it includes a huge number of factors that depend on a combination of various traits and characteristics. The article contains information on one of the important genes involved in the adaptation of the body to hypoxia, which occurs during high-intensity aerobic loads. An analysis of the Ensemble electronic resource is presented, during which the frequency of occurrence of the HIF1A gene polymorphism was determined in various population groups. The results of the study of sports training of athletes, specializing in middle distance running, are shown.

Genetic characteristics of the Pechora type of Kholmogorsky cattle based on microsatellites and DNA markers

2021 ◽  
pp. 61-66
Author(s):  
S. V. Nikolayev
Keyword(s):  
Genetic Analysis ◽  
Dna Markers ◽  
Tandem Repeats ◽  
Frequency Of Occurrence ◽  
Common Allele ◽  
Significant Excess ◽  
Genetic Characteristics ◽  
Holstein Breed ◽  
Holstein Bulls ◽  
F Statistics

The Pechora zonal type (PH-1) was obtained by absorbing crossbreeding of local Northern komolog cattle with the Kholmogorsky breed. Currently, Kholmogorsky cattle are on the verge of extinction, which is due to the widespread metisation of domestic Holstein breeds. The paper presents the characteristics of the allelofond of the Kholmogorsky herd of the Pechora type (n=66) by 11 polymorphic loci of microsatellites. It was found that the polymorphism of tandem repeats in the Pechora type of Kholmogorsky cattle is observed in all 11 loci, the most polymorphic is the tgla53 locus (10 alleles). The most common allele SPS115 248 occurs with a frequency of 0.606. The average number of alleles for 11 loci was 6.2, and the number of effective alleles was 3.4. the obtained indicators were compared with the values published for Yakut [1], Holstein [2, 3] and Ayrshire cattle [4]. It was found that the Pechora type of Kholmogorsky breed has a higher number of effective alleles than Yakut cattle (by 1.0), and lower than other breeds (by 0.3...1.6). Analysis of F-statistics showed that on average, the deviation of the actual heterozygosity from the expected one is insignificant Fis=-0.004, while other breeds, excluding the sample of Holstein bulls, had a more significant excess of heterozygotes. The smallest genetic distance of the studied population was established with the Holstein breed (d=0.221 to cows and d=0.200 to bulls). A more detailed genetic analysis of individual loci showed that the frequency of occurrence of alleles BM2113 Pechora type is closer to the Yakut (r=0.935) and Ayrshire (r=0.875) than to the Holstein breed (r=316...357).

scholarly journals THE PREVALENCE OF GENETIC POLYMORPHISMS FOR REGULATION OF VASCULAR TONE, PLATELET RECEPTORS, VASCULAR WALL REMODELING AND PROTHROMBOTIC FACTORS IN DIABETIC FOOT SYNDROME

2021 ◽  
Vol 29 (5) ◽  
pp. 549-557
Author(s):  
N.I. Troitskaya ◽  
◽  
K.G. Shapovalov ◽  
V.A. Mudrov ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Diabetic Foot ◽  
Gene Polymorphisms ◽  
Vascular Tone ◽  
Vascular Wall ◽  
Mthfr Gene ◽  
Diabetic Foot Syndrome ◽  
Frequency Of Occurrence ◽  
Allelic Variants

Objective. To analyze the frequency of occurrence of eNOS 786C>T, END1 Lys198Ash, ITGB3 1565T>C (Leu33Pro), F5 1691G>A, F2 20210G>A, MMP9 8202A>G, MTHFRA 1298 C,VEGFA 634C>G gene polymorphisms in diabetic foot syndrome. Methods. The study included patients (n=198) with uncomplicated diabetes mellitus and patients (n=199) with the development of diabetic foot syndrome. Genotyping of the studied gene polymorphisms was performed by the polymerase chain reaction method. Results. In patients with uncomplicated diabetes mellitus and in patients with diabetic foot, no significant differences were found in the frequency of occurrence of polymorphisms 786C>T of the eNOS3 gene, Lys198Ash of the END1 gene, 1691G>A of the F5 gene, 20210G>A of the F2 gene, 8202A>G of the MMP9 gene, 634C> G of the VEGFA gene and their allelic variants. Associative relationship between the polymorphisms of the NOS 786C>T, END1 Lys198Ash, F5 1691G>A, F2 20210G>A, MMP9 8202A>G, VEGFA 634C>G genes and the development of diabetic foot syndrome was not found. With the development of a diabetic foot, a heterozygous variant of the 1565TС polymorphism of the ITGB3 gene was more common than in uncomplicated diabetes mellitus (37.7% and 28.3%, respectively (χ²=6.243, p=0.045)). The risk of developing a diabetic foot with the carriage of this polymorphism is 1.5 times higher than with other variants of gene polymorphism ((OR=1.534 (95% Cl 1.006 - 2.338), p<0.05). Polymorphism 1298 AS of the MTHFR gene was more often detected in the group of patients with uncomplicated diabetes mellitus than in the group with the development of diabetic foot (45.4% and 29.1%), (χ²=11.55, p=0.004). Conclusion. The development of diabetic foot syndrome is associated with the carriage of the heterozygous 1565TС polymorphism of the ITGB3 gene, in which the likelihood of developing this complication increases 1.5 fold. In diabetes mellitus without complications, a more frequent carriage of the heterozygous polymorphism 1298 AC of the MTHFR gene was revealed, which may have a protective effect against the development of diabetic foot syndrome. What this paper adds The frequency of occurrence of genetic polymorphisms for regulating vascular tone, platelet receptors, vascular wall remodeling and prothrombotic factors and their allelic variants in diabetic foot syndrome was studied. It was found that the frequency of heterozygous 1565TС polymorphism of the ITGB3 gene in the development of diabetic foot is 1.3 fold higher than in the uncomplicated course of the disease. It was revealed that the fregnency of this variant of the ITGB3 gene polymorphism is associated with the risk of developing this complication of diabetes mellitus. In the presence of the heterozygous 1565TС polymorphism of the ITGB3 gene, the risk of developing diabetic foot syndrome increases by 1.5 fold than with the carriage of other variants of the T1565С polymorphism of the ITGB3 gene. It was found that in the uncomplicated course of the disease, the heterozygous genotype 1298 AC of the MTHFR gene occurs 1.6 fold more often than in the development of diabetic foot syndrome.

scholarly journals Features of polymorphism of calpastatin and somatotropin genes in young sheep, obtained from crossing ewes of Kalmyk fat-rumped sheeps and dorper rams

2020 ◽  
Vol 175 ◽  
pp. 03020
Author(s):  
Vladimir Pogodaev ◽  
Bator Aduchiev ◽  
Lydia Kononova ◽  
Maya Aslanukova ◽  
Irina Kardanova
Keyword(s):  
Gene Polymorphism ◽  
Blood System ◽  
Allele Frequencies ◽  
Biological Characteristics ◽  
Frequency Of Occurrence ◽  
Equal Distribution ◽  
Genotype Frequencies ◽  
Gh Gene ◽  
Cast Gene

The article presents the study of polymorphism of the CAST and GH genes, which determine the features of the manifestation of the productive and biological characteristics of sheep with ½ Kalmyk + ½ Dorper blood system. Calpastatin gene polymorphism represented by alleles M and N, whose frequency was 0,65 and 0,35; genotypes MM, MN – 30 and 70% accordingly. The desired NN genotype has not been identified. A relatively uniform incidence of allele N (0,35) CAST gene and B (0,40) GH was established, what contributed to an almost equal distribution of allele frequencies М (0,65) and А (0,60) genes of calpastatin and somatotropin accordingly. The frequency of heterozygous genotypes occurrence by CAST gene composed 0,7. By GH gene the following distribution of genotype frequencies is observed. Frequency of occurrence homozygous АА and heterozygous AB genotypes was equal to and is 0,4, wherein the frequency of occurrence advised homozygous ВВ genotype was 0,2. Among the animals studied, sheep with a complex genotype are most common CASTMN GHAB (40 %). The amount of percent CASTMM GHAA and CASTMN GHAA is in 22,2%. 10% is for genotypes CASTMM GHBB and CASTMN GHBB.

ОСОБЕННОСТИ РАЗВИТИЯ ПОПУЛЯЦИИ ЧЕРНО-ПЕСТРОГО СКОТА НА УРАЛЕ

2019 ◽  
pp. 23-27
Author(s):  
S.V. MYMRIN ◽  
O.A. TKACHUK ◽  
L.A. KALUGINA
Keyword(s):  
Life Expectancy ◽  
Economic Efficiency ◽  
Reproductive Function ◽  
Ural Region ◽  
Frequency Of Occurrence ◽  
Genomic Evaluation ◽  
Holstein Breed ◽  
Breeding Populations ◽  
Female Line

Повышение экономической эффективности разведения племенной популяции чернопестрого скота в Уральском регионе неизменно сопряжено со сложной селекционной работой по увеличению продуктивной жизни коров. Использование научно обоснованной системы выращивания молодняка и нанотехнологий должно быть направлено на поддержание репродуктивной функции племенного поголовья. При подборе быков необходимо учитывать качество предков быка по женской линии с учетом показателей продуктивности, продолжительности жизни и других функциональных характеристик, определяющих экономическую эффективность производства. Генофонд Уральского типа чернопестрой породы содержит аллели, характерные как для голштинской, так и для чернопестрой породы. С увеличением крови частота встречаемости аллелей улучшаемой породы не уменьшается, точно так же как и не происходит увеличения частоты встречаемости аллелей улучшающей породы.The increase of economic efficiency of breeding populations of blackandwhite cattle in the Ural region to be challenging selection work to increase of productive life of cows. The use of sciencebased system of rearing young and nanotechnology should be aimed at maintaining the reproductive function of the breeding stock. When selecting bulls, it is necessary to study the quality of the ancestors of the bull in the female line, taking into account the indicators of productivity, life expectancy and other functional characteristics that determine the economic efficiency of production. Scientific studies have shown that the correlation between the productivity of genomic evaluation and the improving effect of daughters of the bull ranges from15 to 15. The allele population of cattle blackmotley breed of the Ural type holsteinized contain alleles typical for improving (Holstein) breed and improved (blackandwhite) breed. With the increase in blood, the frequency of occurrence of alleles of the improved breed does not decrease, exactly as, and there is no increase in the frequency of occurrence of alleles of the improved breed.

Возможности селекции крупного рогатого скота по локусам csn2 и csn3

2019 ◽  
pp. 9-11
Author(s):  
N.B. KOVALYUK ◽  
V.F. SATSOUK ◽  
E.V. MACHULSKAYA ◽  
L.I. JAKUSHEVA ◽  
A.A. KASEM
Keyword(s):  
World Wide ◽  
Frequency Of Occurrence ◽  
Holstein Breed ◽  
Ayrshire Breed ◽  
Domestic Breeding

С целью оценки возможности отечественных и зарубежных племенных предприятий для ведения селекции на повышение сыропригодности и безопасности молока проведено генотипирование по локусу CSN2 (бетаказеина) 308 быковпроизводителей голштинской и айрширской пород. Учтена информация о CSN2 генотипах 390 быковпроизводителей. По локусу CSN3 (каппаказеина) генотипировано 73 производителя айрширской и голштинской пород, учтена информация о CSN3 генотипах 615 быковпроизводителей. Установлено, что быкипроизводители голштинской породы не имеют существенных отличий в частоте встречаемости желательного CSN2 генотипа А2А2 (3642) быки голштинской породы отечественных племенных предприятий в 24 раза уступают по распространенности желательного CSN3 генотипа ВВ (частота встречаемости составляет 713) производителям компании World Wide Sires (28) быкипроизводители айрширской породы отечественных племенных предприятий в 23 раза уступают быкам компании VikingGenetics по распространенности желательных CSN2 и CSN3 генотипов. Считаем, что отечественным племенным предприятиям с целью повышения конкурентоспособности необходимо увеличить долю быков с генотипами А2А2 (локус CSN2), АВ и ВВ (локус CSN3).In order to assess the possibility of domestic and foreign breeding enterprises for breeding to improve the cheese suitability and safety of milk, genotyping of 308 Holstein and Ayrshire bulls by CSN2 (betacasein) locus was carried out. Information on CSN2 genotypes of 390 bulls was taken into account. 73 producers of Ayrshire and Holstein breeds were genotyped by CSN3 locus (kappacasein), information on CSN3 genotypes of 615 bulls was taken into account. Found that bulls of Holstein breed are not significant differences in the frequency of occurrence of desirable CSN2 genotype А2А2 (3642) bulls Holstein breeding enterprises in 24 times inferior to the prevalence of desirable genotype CSN3 the BB (the frequency of occurrence is 713) manufacturers company World Wide Sires (28) bulls Ayrshire breed of domestic breeding enterprises is 23 times the yield of the company VikingGenetics bulls on the prevalence of desirable CSN2 and CSN3 genotypes. We believe that domestic breeding enterprises in order to increase competitiveness need to increase the proportion of bulls with genotypes A2A2 (locus CSN2), AB and BB (locus CSN3).

АССОЦИАТИВНЫЕ СВЯЗИ ГЕНА ТИРЕОГЛОБУЛИНА С ПРОДУКТИВНЫМ ДОЛГОЛЕТИЕМ МОЛОЧНОГО СКОТА

2020 ◽  
Author(s):  
Yu.R. YULMETEVA ◽  
SH.K. SHAKIROV
Keyword(s):  
Gene Polymorphism ◽  
Milk Production ◽  
Milk Yield ◽  
Genetic Profile ◽  
Frequency Of Occurrence ◽  
Heterozygous Genotype ◽  
Homozygous State ◽  
High Productivity ◽  
Thyroglobulin Gene ◽  
Economic Use

Изучен полиморфизм гена тиреоглобулина в ассоциации с продолжительностью хозяйственного использования и продуктивностью коров. Генетический профиль популяции по совокупности частот встречаемости аллелей локуса тиреоглобулина выглядит следующим образом выявлено большинство коров-носителей аллеля С в гомозиготном состоянии до 7 лактации, однако увеличение животных с гетерозиготным генотипом наблюдалось в подвыборках 8 и 9 лактаций. В целом по изученной популяции распределение полиморфных генотипов было: TG5CС 63,5, TG5CT 32,1, TG5ТT 4,4 частота встречаемости по аллелям равна: С 0,80, Т 0,20. С увеличением возраста лактации продуктивность различается у коров с разными полиморфными генотипами. У первотелок наибольшая продуктивность установлена у особей с генотипом TG5ТT, от которых надоено на 77 кг больше, чем от гетерозиготных. Однако в дальнейшем высокая продуктивность была характерна для коров с генотипом TG5СС и TG5СT. Средний возраст в лактациях по всему изученному поголовью составляет 2,7. В динамике возраста удой в изученном стаде животных повышался до 7 лактации, максимальные значения которого по ней составили 72947300 кг. Для повышения рентабельности производства молока необходимо принимать меры по повышению продуктивного долголетия.Thyroglobulin gene polymorphism was studied in association with the duration of economic use and productivity of cows. The genetic profile of the population in terms of the frequency of occurrence of alleles of the thyroglobulin locus is as follows - the majority of cows carrying the C allele in a homozygous state up to 7 lactation were detected, however, an increase in animals with a heterozygous genotype was observed in subsamples of 8 and 9 lactations. In general, for the studied population, the distribution of polymorphic genotypes was: TG5CC - 63.5, TG5CT - 32.1, TG5TT - 4.4 the frequency of occurrence in alleles is: C - 0.80, T - 0.20. With increasing age of lactation, productivity differs in cows with different polymorphic genotypes. In heifers, the highest productivity was found in individuals with the TG5TT genotype, from which 77 kg more were fed than from heterozygous ones. However, in the future, high productivity was characteristic for cows with the genotypes TG5CC and TG5CT. The average age in lactations throughout the studied population is 2.7. In the dynamics of age, milk yield in the studied herd of animals increased to 7 lactation, the maximum values of which amounted to 7294-7300 kg. To increase the profitability of milk production, it is necessary to take measures to increase productive longevity.

TEM studies of tweed microstructures in annealed amelia albite

1990 ◽  
Vol 48 (4) ◽  
pp. 1064-1065
Author(s):  
Y. J. Kim ◽  
D. M. Henderson
Keyword(s):  
Annealing Time ◽  
The Other ◽  
Frequency Of Occurrence ◽  
Systematic Trend ◽  
Tweed Structure

Natural Amelia albite (Ab99.3An0.1Or0.6) annealed at 1073° and 924°C for various periods up to 140 days has been studied by NMR. TEM studies of the same sample revealed a distinct tweed microstructure in some samples annealed at both 1073°C and 924°C. On the whole, the quasi-regular tweed has a periodicity of 100 - 200 Å in both directions, one nearly normal to b* and the other approximately parallel to b*, which gives rise to two-directional streaking in SADP’s (Fig. 1 and 2). However, there are some differences in the tweed structure developed on annealing at 1073°C and at 924°C in albite.Albite samples annealed at 1073° show a systematic trend in their development of tweed structures: the regularity, periodicity, and frequency of occurrence increase with annealing time during the first 3 days, and then decrease gradually until no tweed microstructures are seen in samples annealed for more than 15 days. The tweed structure proceeds locally to form one-directional twin-like microstructures.

An Investigation of the Assumptions Underlying the Scoring System of the Arizona Articulation Proficiency Scale: Revised

1979 ◽  
Vol 10 (4) ◽  
pp. 241-245
Author(s):  
Richard J. Schissel ◽  
Linda B. James
Keyword(s):  
Scoring System ◽  
Frequency Of Occurrence

This study examines the assumptions underlying the scoring system of the Arizona Articulation Proficiency Scale: Revised. Twenty-one children between the ages of four years two months and six years 11 months were administered the Arizona Articulation Proficiency Scale: Revised and the Screening Deep Test of Articulation. The subjects' performance on the two tests was compared for the phones: [s], [l], [r], [t∫], [θ], [∫], [k], [f], and [t]. Results suggested that 1) the production of most sounds in only two contexts does not necessarily reflect the accuracy of production of those sounds in other contexts, and 2) for the sounds tested, the weightings assigned on the basis of their frequency of occurrence rather than the frequency with which they were misarticulated overestimated the extent of many articulation errors.

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