scholarly journals Modern ultrasound methods for the diagnosing vibration disease

2021 ◽  
Vol 100 (8) ◽  
pp. 803-806
Author(s):  
Nadezhda I. Kuprina ◽  
Ekaterina V. Ulanovskaya ◽  
Viktor V. Shilov
Keyword(s):  
Vascular System ◽  
Peripheral Resistance ◽  
Pulse Velocity ◽  
Pathological Process ◽  
Upper Extremities ◽  
Local Vibration ◽  
Pronounced Increase ◽  
Vibration Disease ◽  
Critical Problems ◽  
The Impact

Introduction. According to the latest statistical data analysis, vibration disease (VD) remains the leading pathology in the structure of occupational morbidity in the Russian Federation. The main symptom of VD is peripheral angiodystonic syndrome, which develops as a result of peripheral vessels angiospasm of extremities, which is clinically manifested in the form of pain in hands, temperature decrease and pallor of the skin. Materials and methods. The article presents the results of an ultrasound assessment of the velocity and anatomical parameters of the main arteries of upper extremities in patients with stage 2 VD from exposure to general and local vibration. Results. According to the data of sanitary and hygienic characteristics, in all examined patients with stage 2 VD from exposure to general and local vibration, the class of working conditions was assessed as class 3 (harmful). In contrast, the excess in local vibration along the X, Y, Z axes ranged from 1 to 7 dBA. Ultrasound of the main arteries of upper extremities shows a decrease in the velocity parameters along the radial and ulnar arteries symmetrically, a significant increase in the tone of the wall of the forearm arteries. Discussion. One of the most critical problems in solving expert questions is assessing pathological process severity due to the lack of transparent and objective methods. Ultrasound research is the most affordable and safest method for evaluating the vascular system of upper extremities in stage 2 VD. It also significantly increases the objectification of expert decisions on the connection of this disease with occupation. Conclusion. VD II from the impact of general and local vibration is characterized by decreased pulse velocity on the ulnar and radial arteries symmetrically on both sides with a pronounced increase of peripheral resistance, indicating a severe angiospastic syndrome to generalized.

Ultrasound features of peripheral angiodistonic syndrome of the upper extremities in vibration disease

2020 ◽  
Vol 60 (11) ◽  
pp. 815-817
Author(s):  
Nadezhda I. Kuprina ◽  
Ekaterina V. Ulanovskaya ◽  
Olga A. Kochetova
Keyword(s):  
Blood Flow ◽  
Heart Defects ◽  
Peripheral Resistance ◽  
Resistance Index ◽  
Ulnar Artery ◽  
Upper Extremities ◽  
Disease Stage ◽  
Peripheral Blood Flow ◽  
Pronounced Increase ◽  
Vibration Disease

Introduction. Vibration disease (VD) is an example of the most common pathology due to the systematic exposure of the worker to intense vibration with sufficient work experience, the main manifestation of which is peripheral angiodystonic syndrome. The aim of study was to learn the features of peripheral blood flow in the arteries of the forearm in vibration disease using the ultrasound method. Materials and methods. The radial and ulnar arteries in patients with vibration disease were examined by ultrasound in B- and PW-mode. These materials present the results of an ultrasound assessment of the speed indicators of the main arteries of the forearm in vibration disease stages 1 and 2. The selection criteria for patients in the study ware the presence of pronounced clinical manifestations of angiodystonic syndrome in vibration disease, confirmed by instrumental research methods and data on the sanitary and hygienic characteristics of working conditions, the absence of cardiovascular chronic diseases (ischemic heart disease, heart defects, rhythm and conduction disturbances), rheumatic, oncological, infectious diseases, osteo-traumatic changes in the upper extremities. Results. The groups of patients with the established diagnosis of vibration disease of 1 and 2 degrees were studied. With vibration disease stage 1 a decrease in the pulse velocity of blood flow was observed in isolation on the ulnar artery and an increase in peripheral resistance (pulsation index and resistance index) in the radial and ulnar arteries symmetrically on both upper extremities. The second stage of vibration disease differed from the first by a more significant decrease in speed indicators both on the ulnar and radial arteries on both sides, symmetrically in combination with a more pronounced increase in peripheral resistance indicators on both main arteries of the forearm (pulsation index and resistance index). The revealed changes were determined with the same frequency in men and women. Conclusions. A significant decrease in speed indicators on the ulnar artery and an increase in peripheral resistance indicators are detected already at the initial stages of vibration disease. Thus, the method of ultrasound examination of the main arteries of the middle caliber of the upper extremities is currently the only available and objective method for examining the vascular system in vibration disease.

Vibration disease: erectile dysfunction as a comorbidity problem

2020 ◽  
pp. 36-43
Author(s):  
S. Babanov ◽  
N. Tatarovskay
Keyword(s):  
Erectile Dysfunction ◽  
Questionnaire Survey ◽  
Erectile Function ◽  
Control Group ◽  
Local Vibration ◽  
Vibration Disease ◽  
Male Patients ◽  
And Control ◽  
The Impact ◽  
Second Degree

The article presents data (based on a questionnaire survey) on the impact of vibration disease from the action of local and General vibration on the erectile function of men. The main changes in the parameters of erectile function (frequency, need, etc.) are described in the case of first and second-degree vibrational disease caused by local vibration, and in the case of first-and second-degree vibrational disease caused by General vibration based on data from a questionnaire survey of male patients and control group.

Vibration disease: quality of life

2020 ◽  
pp. 24-31
Author(s):  
Sergey Babanov ◽  
Nataliya Tatarovskaya
Keyword(s):  
Quality Of Life ◽  
Physical Functioning ◽  
The Body ◽  
Systemic Effects ◽  
Local Vibration ◽  
Vibration Disease ◽  
Sf 36 ◽  
The Impact

The article presents data on the impact of vibration disease on the quality of life of patients. The main changes in the quality of life parameters of patients based on the results of the study using the SF-36 questionnaire are described. The quality of life of patients with various types of vibration disease is compared. It is established that industrial vibration (both General and local) in addition to the classical changes characteristic of vibration disease from exposure to local vibration (WBL), vibration disease from exposure to vibration (VBOW) first and second degrees (vascular, neurological) substantially violates the quality of life of patients, with the most pronounced changes are characteristic for WBOW, which confirms the systemic effects of vibration and its effects on the body working. The quality of life of sick WIDOWS is significantly reduced, although significant differences are observed only on the scales of «physical functioning» and «physical component of health».

scholarly journals EVALUATION OF CYTOKINES AND HEAT SHOCK PROTEIN IN VIBRATION DISEASE

2018 ◽  
Vol 20 (6) ◽  
pp. 895-898 ◽  
Author(s):  
G. M. Bodienkova ◽  
S. I. Kurchevenko
Keyword(s):  
Heat Shock ◽  
Defense Mechanism ◽  
Vascular System ◽  
Negative Impact ◽  
Cell Damage ◽  
Statistical Processing ◽  
The Body ◽  
Immunological Study ◽  
Local Vibration ◽  
The Impact

The prolonged impact of industrial vibration on workers leads to the development of a vibrational disease (VB), which occupies a leading position in the structure of occupational pathology. VB from the impact of local vibration is a chronic occupational disease characterized by a predominant lesion of the nervous, vascular system and musculoskeletal system of the upper and lower extremities. One of the real ways to reduce the incidence is the early detection of the negative impact of vibration on the body of workers. In this regard, cytokines and heat shock proteins (HSP70) can be early and sensitive indicators that reflect the severity of health disorders from exposure to vibration. The aim of the study was to study changes in the content of pro- and antiinflammatory cytokines, extracellular HSP70 and their relationship in patients with VB. In the immunological study included 43 male patients with a diagnosis of VB. The criteria for inclusion in this group were: a verified diagnosis, written informed consent to participate in the study, the harmful effects of local vibration in the workplace. According to the data of hygienic control, the working conditions of workers in dangerous occupations by vibration belong to the 4 (dangerous) class due to intensive local vibration. The content of cytokines: IL-1β, IL-8, IL-10, TNFα and HSP70 in the serum of patients was determined by enzyme immunoassay. The blood sampling for the study was taken from patients only once on admission to the hospital before the treatment. Statistical processing of data was carried out with the help of packages of application programs Statistica for Windows 6.0 and Microsoft Excel. It was established that the development of VB disease is accompanied by imbalance of the cytokine profile, characterized by a decrease in the levels of IL-1β, IL-10 and an increase in IL-8. The inhibition of production of IL-1β and IL-10 is a consequence of the chronic process that has developed in the body of the patients examined. And the revealed decrease in extracellular concentration of HSP70 in comparison with practically healthy people can be caused by the accumulation of it inside the cell or on its surface. Correlation analysis revealed the relationship between a decrease in HSP70 and an increase in IL-1β, and a decrease in IL-10 levels. Synthesis of HSP is an intracellular defense mechanism that prevents cell damage by activating the synthesis and secretion of pro-inflammatory cytokines. The obtained relationships between cytokines and HSP70 testify to the involvement of HSP70 in immunoinflammatory processes in VB. The revealed changes contribute to the chronic inflammatory process and justify the progressive course of the VB.

Psychological defenses and problems of comorbidity in a vibration disease from the effects of local vibration

2020 ◽  
pp. 25-33
Author(s):  
S. Babanov ◽  
R. Baraeva
Keyword(s):  
Psychological Profile ◽  
Local Vibration ◽  
Vibration Disease ◽  
Situational Anxiety ◽  
Personal Anxiety ◽  
The Impact ◽  
Psychological Defenses

The article presents data on the impact of vibration disease from the impact of local vibration on the psychological profile, the formation of personal anxiety and situational anxiety, as well as the development of comorbid States in vibration disease from the impact of local vibration.

scholarly journals Features of distal lesion of the peripheral nerves in the upper extremities in vibration disease due to local vibration

2020 ◽  
Vol 99 (7) ◽  
pp. 699-703
Author(s):  
Anastasia V. Yamshchikova ◽  
Arnold N. Fleishman ◽  
Margarita O. Gidayatova ◽  
Alla A. Kungurova
Keyword(s):  
Peripheral Nerves ◽  
Prolonged Exposure ◽  
Main Group ◽  
Upper Extremities ◽  
Control Group ◽  
Local Vibration ◽  
Cross Sectional ◽  
Vibration Disease ◽  
Ultrasound Study ◽  
Functional Features

Introduction. The relevance of the study is dictated by the difficulties of differential diagnosis of neural lesions of the upper extremities in vibration disease induced by local vibration. The most frequent involvement of the distal nerves of the upper extremities can be due to both a polyneuropathic diffuse disturbance without compression and a compression tunnel lesion. Taken into account the different approaches to the treatment of these conditions, there is a need to study the features of distal nerve damage in the case of vibration damage.Aim of the study was to investigate the macrostructural and functional features of distal lesions of the peripheral nerves of the upper extremities in vibration disease patients.Material and methods. 57 men aged 40-60 years were examined at the clinic of the Research Institute for Complex Problems of Hygiene and Occupational Diseases in Novokuznetsk, 30 patients with a proven diagnosis of vibration disease were included in the main group, 27 cases who had never worked in contact with industrial vibration were included in the control group. An electroneuromyographic and ultrasound study of the median and ulnar nerve were performed in all cases.Results. A significant increase in the distal latency of the median nerves and a decrease in the speed of sensory conduction along the nerves of the upper extremities in the main group were revealed. According to the ultrasound examination of the nerves, there was no statistical difference in the nerve cross-sectional area at the level of the wrist in the main and control groups. The frequency of compression lesions of the median nerve in the carpal canal in the main group accounted for 16%.Conclusions. With prolonged exposure to local vibration, a distal polyneuropathic diffuse lesion of the nerves of the upper extremities often develops. A combination of vibration disease due to local vibration and carpal tunnel syndrome occurs in 16% of cases.

Abstract 420: Delineating the Caspase-dependent Targets and Signal Pathways That Promote Pathological Cardiac Hypertrophy

2015 ◽  
Vol 117 (suppl_1) ◽  
Author(s):  
Charis Putinski ◽  
Mohammad Abdul-Ghani ◽  
Rebecca Stiles ◽  
Steve Brunette ◽  
Sarah A Dick ◽  
...  
Keyword(s):  
Cardiac Hypertrophy ◽  
Pathological Process ◽  
Signal Pathways ◽  
Caspase Cleavage ◽  
Substrate Protein ◽  
Cell Death Pathway ◽  
Effector Caspase ◽  
The Impact

Although cardiac hypertrophy is initially an adaptive response, chronic stress on the heart is a maladaptive process that inevitably leads to end-stage heart failure. Interestingly, this pathological process is also characterized by cell behaviors associated with apoptosis. We previously demonstrated the essential role of the intrinsic cell death pathway during cardiac hypertrophy; however, the caspase-dependent pathways and cleavage targets remain elusive. To this aim, we evaluated a myocyte enhancer factor 2 (MEF2) transcription factor inhibitor, histone deacetylase 3 (HDAC3), and gelsolin as potential caspase cleavage substrates involved in the induction and/or maintenance of cardiac hypertrophy. In vitro cleavage assays were completed with effector caspase and recombinant substrate protein which demonstrated caspase-dependent cleavage. HDAC3 cleavage was observed during early stages of hypertrophy and reduced in the presence of a caspase inhibitor. Luciferase assays demonstrated that the transcriptional activity of MEF2 is dependent on intact caspase function suggesting caspase-directed HDAC3 cleavage may serve as a novel regulatory mechanism to alleviate MEF2 suppression to engage the hypertrophy gene expression program. Unlike HDAC3, caspase mediated gelsolin cleavage occurs at latter stages and is coincident with the cytoskeletal alterations that occur during this process. As gelsolin is a potent actin capping/severing enzyme, we hypothesize that caspase-mediated gelsolin activation acts as a key regulatory step in the structural rearrangements that allow for hypertrophy to occur. We have generated adenoviral vectors containing caspase cleavage mutants and cleaved forms of HDAC3 and gelsolin and will discuss the impact of these modified substrates on the hypertrophy process in vitro and in vivo. Collectively, this work suggests that caspase signalling acts to engage both the transcriptional program and cytoskeletal accommodations that characterize cardiac hypertrophy. Importantly, these observations suggest that identification of inhibitors that suppress caspase activity and/or activity of its cognate substrates may offer novel therapeutic targets to limit the development of pathological hypertrophy.

Study of the vessels of the upper extremities and the rhythm of heart activity in patients with vibration disease in the post-СOVID period

2021 ◽  
Vol 61 (7) ◽  
pp. 431-435
Author(s):  
Nadezhda I. Kuprina ◽  
Ekaterina V. Ulanovskaya ◽  
Viktor V. Shilov ◽  
Dina N. Serdyukova
Keyword(s):  
Atrial Fibrillation ◽  
Sinus Tachycardia ◽  
Upper Extremities ◽  
Vascular Pathology ◽  
Ultra Sound ◽  
Daily Monitoring ◽  
Vibration Disease ◽  
Arterial Blood ◽  
Large Numbers ◽  
Coronavirus Infection

Currently, there are many consequences of the new coronavirus infection. We shall study the actual long-term consequences of this disease for population health in the coming years. It is necessary to consider concomitant chronic diseases in patients who are particularly dangerous in the post-COVID period. Vibration disease is one of the leading occupational pathologies in the Russian Federation. Symptoms of vibration disease are vegetative-vascular disorders, cold, cyanosis, paresthesia, violation of regional blood circulation of the extremities. As is known from numerous sources, the defeat of the cardiovascular system (CVS) against the background of COVID-19 infection occurs through angiotensin-converting enzyme (ACE-2) receptors, which presents in large numbers in the endothelium of veins and arteries. The study aims to research hemodynamics features in patients with vibration disease after a new coronavirus infection. In the clinic of occupational pathology, the researchers examined 28 patients with a previously established diagnosis of VD after a coronavirus infection. We did a Holter ECG, ultra-sound examination of the arteries and veins of the upper extremities. Arrhythmias in the form of supraventricular extrasystoles, paroxysms of atrial fibrillation, positional sinus tachycardia occur in patients with VB after a new coronavirus infection on an ECG and daily monitoring of the ECG by Holter. As is known, cardiac arrhythmias are essential in the development of acute and chronic vascular pathology, characterized by a decrease in arterial blood filling and changes. Ultrasound of the vessels of the upper extremities revealed moderate expansion of the radial and ulnar veins, insufficiency of the valve apparatus during functional tests, increased venous outflow. There was also an increase in the indicators of peripheral vascular resistance, which indicates violations of the tonic properties of the vessels of the upper extremities and violations of vasodilation. Scientists identified violations of the tonic properties of blood vessels in patients with vibration disease in the post-COVID period on ultrasound, arrhythmias in the form of supraventricular extrasys-toles, paroxysms of atrial fibrillation, positional sinus tachycardia on daily ECG monitoring.

Upper Extremity Disorders in Professional Female Milkers

2000 ◽  
Vol 44 (22) ◽  
pp. 608-611 ◽  
Author(s):  
Marianne Stål
Keyword(s):  
Special Reference ◽  
Psychosocial Factors ◽  
Well Being ◽  
Upper Extremities ◽  
Nursing Assistants ◽  
Study Group ◽  
Vibration Exposure ◽  
Musculoskeletal Complaints ◽  
Upper Extremity Disorders ◽  
The Impact

The prevalence of and the impact of selected factors on self-reported musculoskeletal complaints in Swedish female milkers with special reference to symptoms in the upper extremities were investigated using on data from mail-in surveys. An agricultural study group was formed of three subgroups: 161 active milkers, 108 non-milkers and 62 ex-milkers, women who had been milkers earlier but were no longer doing that kind of work. In the course of the analysis these subgroups were compared with each other and also, separately or in combinations, with a non-agricultural population consisting of 166 nursing assistants. Problems in the upper extremities were significantly more common in the agricultural group than in the non-agricultural group. Milkers had a higher risk of developing symptoms in the wrists and hands than non-milking women. Symptoms like numbness, coldness in the wrists and white fingers were more common in all agricultural subgroups than in the non-agricultural group. Numbness and white fingers were related to vibration exposure in the ex-milking and the non-milking groups but not in the milking group. Psychosocial factors such as occupational well being were not related to the occurrence of symptoms. Milking in modernised barn gave fewer problems in the elbows than milking in a traditional barn. Milkers who had received ergonomic instruction on how to work in order to reduce muscle stress had fewer problems in the elbow region than those who had not.

scholarly journals Performance Evaluation of Concrete using Marble Mining Waste

2016 ◽  
Vol 11 (2) ◽  
pp. 53-66 ◽  
Author(s):  
Sudarshan Dattatraya Kore ◽  
A. K. Vyas
Keyword(s):  
Compressive Strength ◽  
Coarse Aggregate ◽  
Ultrasonic Pulse Velocity ◽  
Ultrasonic Pulse ◽  
Pulse Velocity ◽  
Mining Waste ◽  
Partial Replacement ◽  
Infrastructure Development ◽  
The Impact ◽  
Marble Waste

Abstract A huge amount waste (approximately 60%) is generated during mining and processing in marble industries. Such waste can be best utilized in infrastructure development works. Coarse aggregate 75% by weight was replaced by aggregate obtained from marble mining waste. The impact of marble waste as a partial replacement for conventional coarse aggregate on the properties of concrete mixes such as workability, compressive strength, permeability, abrasion, etc. was evaluated. The test results revealed that the compressive strength was comparable to that of control concrete. Other properties such as workability of concrete increased, water absorption reduced by 17%, and resistance to abrasion was marginally increased by 2% as compared to that of control concrete. Ultrasonic pulse velocity and FTIR results show improvement in quality of concrete with crushed marble waste. From the TGA analysis it was confirmed that, aggregate produced from marble waste shows better performance under elevated temperature than that of conventional aggregates.

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