Pituitary-Gonadal Dysfunction in Male Patients with Lung Cancer: Association with serum inhibin levels

Lung cancer is one of the most common and deadly malignancies in the world, which is characterized by uncontrolled division and growth of malignant cells in the pulmonary parenchyma. For the purposes of this paper was used data from the clinical hospital “Dr. Trifun Panovski'' in the Municipality of Bitola, Republic of North Macedonia in the period of 2015-2019. The results show that the most of the cases are male with the leading age of about 55-64 years. However, the disease is becoming more common in the female population at a later age. Regarding the number of male patients treated in the Municipality of Bitola, it can be noted that the highest number of male patients was in 2018, and the lowest in 2017. Most female patients were treated in 2016 and the least in 2018. From the analysis of the Institute of Public Health, the highest number of male deaths in Bitola occurred in 2014 and the lowest in 2015 and 2018, among female patients, the highest number of deaths was in 2014, but the lowest in 2018. Death outcomes in Bitola represent about 6-7% of total number of deaths in the Republic of North Macedonia.

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Gender Differences and Immunotherapy Outcome in Advanced Lung Cancer

International Journal of Molecular Sciences ◽

10.3390/ijms222111942 ◽

2021 ◽

Vol 22 (21) ◽

pp. 11942

Author(s):

Tiziana Vavalà ◽

Annamaria Catino ◽

Pamela Pizzutilo ◽

Vito Longo ◽

Domenico Galetta

Keyword(s):

Lung Cancer ◽

Gender Differences ◽

Immune System ◽

Developed Countries ◽

Gender Disparities ◽

Advanced Lung Cancer ◽

Cancer Evolution ◽

Lung Cancer Patients ◽

Male Patients ◽

Biological Aspects

In developed countries, lung cancer is the leading cause of cancer-related death in both sexes. Although cigarette smoking represents the principal risk factor for lung cancer in females, the higher proportion of this neoplasm among non-smoking women as compared with non-smoking men implies distinctive biological aspects between the two sexes. Gender differences depend not only on genetic, environmental, and hormonal factors but also on the immune system, and all these aspects are closely interconnected. In the last few years, it has been confirmed that the immune system plays a fundamental role in cancer evolution and response to oncological treatments, specifically immunotherapy, with documented distinctions between men and women. Consequently, in order to correctly assess cancer responses and disease control, considering only age and reproductive status, the results of studies conducted in female patients would probably not categorically apply to male patients and vice versa. The aim of this article is to review recent data about gender disparities in both healthy subjects’ immune system and lung cancer patients; furthermore, studies concerning gender differences in response to lung cancer immunotherapy are examined.

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Gonadal dysfunction in adult male patients with thalassemia major: an update for clinicians caring for thalassemia

Expert Review of Hematology ◽

10.1080/17474086.2017.1398080 ◽

2017 ◽

Vol 10 (12) ◽

pp. 1095-1106 ◽

Cited By ~ 2

Author(s):

Vincenzo De Sanctis ◽

Ashraf T. Soliman ◽

Heba Elsedfy ◽

Salvatore Di Maio ◽

Duran Canatan ◽

...

Keyword(s):

Adult Male ◽

Thalassemia Major ◽

Gonadal Dysfunction ◽

Male Patients

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PUB062 Sarcopenia Is a Novel Predictor of Poor Prognosis in Male Patients with Pathological Stage I Non-Small Cell Lung Cancer

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2017.09.1925 ◽

2017 ◽

Vol 12 (11) ◽

pp. S2385-S2386

Author(s):

T. Tsukioka ◽

N. Izumi ◽

K. Chung ◽

H. Komatsu ◽

M. Toda ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Poor Prognosis ◽

Small Cell ◽

Stage I ◽

Pathological Stage ◽

Small Cell Lung ◽

Male Patients

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Stigma, Adjustment, and Quality of Life of Middle-aged Male Patients with Lung Cancer

Korean Journal of Adult Nursing ◽

10.7475/kjan.2020.32.5.494 ◽

2020 ◽

Vol 32 (5) ◽

pp. 494

Author(s):

Miyoung Yoo ◽

Eunyoung E. Suh

Keyword(s):

Quality Of Life ◽

Lung Cancer ◽

Middle Aged ◽

Male Patients ◽

Middle Aged Male

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Mortality of site-specific cancer in patients with schizophrenia: A systematic review and meta-analysis

10.21203/rs.2.12760/v1 ◽

2019 ◽

Author(s):

Liwei Ni ◽

Yuming Long ◽

Xuya Yuan ◽

Jianhao Xu ◽

Jialong Tao ◽

...

Keyword(s):

Prostate Cancer ◽

Lung Cancer ◽

Colon Cancer ◽

High Risk ◽

Mortality Rate ◽

Mortality Risk ◽

Meta Analysis ◽

Site Specific ◽

Risk Of Mortality ◽

Male Patients

Abstract Background: Numerous studies have reported contradicting results on the relationship between cancer mortality and schizophrenia. Our aim is to quantify the mortality rate of common site-specific cancers among patients with schizophrenia and to synthesize the available research evidence. Method: We performed a systemic search of the PubMed, EMBASE and Web of Science databases. Studies reporting the mortality rate of different cancer in patients with schizophrenia were included. A random-effects model was applied to calculate the pooled relative risks (RRs) with 95% confidence intervals (95%CIs). Results: Seven studies consisting of a total of 1,162,971 participants with schizophrenia were included in this meta-analysis. Data regarding mortality risk of breast, colon, lung and prostate cancer among schizophrenia patients were subjected to quantitative analysis. Pooled results showed significant increases in mortality risk of breast cancer (RR = 1.97, 95%CI 1.38–2.83), lung cancer (RR = 1.93, 95%CI 1.46–2.54) and colon cancer (RR = 1.69, 95%CI 1.60–1.80) in patients with schizophrenia compared with those in the general population or control group. The mortality risk of prostate cancer increased in male patients, although no significant difference was detected (RR = 1.58, 95% CI 0.79–3.15). Increased risks of mortality from lung and colon cancer were observed in female patients (RR = 2.49, 95%CI 2.40–2.59 and RR = 2.42, 95%CI 1.39–4.22, respectively) and elevated risks of mortality from lung and colon cancer in male patients (RR = 2.40, 95%CI 2.30–2.50 and RR = 1.90, 95%CI 1.71–2.11, respectively) were detected. Conclusions: Individuals with schizophrenia have a significantly high risk of mortality from breast, colon, and lung cancer and a high risk of mortality from prostate cancer.

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Treatment of Lung Cancer Complicated with Infection of Talaromyces Marneffei Based on Chest Imaging Characteristics Monitoring (Preprint)

10.2196/preprints.21033 ◽

2020 ◽

Author(s):

Yiling Feng ◽

Xiaoping Li ◽

Yanqin Wang ◽

Shar Lenepe

Keyword(s):

Lung Cancer ◽

Control Group ◽

Imaging Features ◽

Observation Group ◽

Chest Imaging ◽

Lung Cancer Patients ◽

Talaromyces Marneffei ◽

Imaging Characteristics ◽

Strip Shape ◽

Male Patients

BACKGROUND Background: At present, although the infection of Talaromyces Marneffei has been known at home and abroad, there are few reports of Talaromyces Marneffei in lung cancer. OBJECTIVE Objective: The objective is to explore the diagnosis and treatment process of lung cancer patients with infection of Talaromyces Marneffei and its chest imaging characteristics, so as to improve the clinicians' realization of the disease. METHODS Method: The patients with lung cancer and infection of Talaromyces Marneffei (observation group) and the patients with infection of Talaromyces Marneffei (control group) are taken as the study objects, and the clinical characteristics and chest CT (computed tomography) imaging characteristics of the two groups are compared and summarized. RESULTS Results: The number of male patients infected with Talaromyces Marneffei is significantly higher than that of female patients (P < 0.05). The symptoms of cough and expectoration in the observation group are more than those in the control group (P < 0.05). The main imaging features of the observation group are obvious enhancement of focus enhancement scanning, strip shape and nodule, and the situation of obvious enhancement of focus enhancement scanning in the observation group is significantly higher than that in the control group (P < 0.05). CONCLUSIONS Conclusion: The clinical and imaging features of lung cancer and Talaromyces Marneffei infection overlap. When the lung lesions of patients with Talaromyces Marneffei have significant malignant signs, the possibility of lung cancer should be considered.

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