Reevaluation of the Relationship Between Within-Day Bronchial Variability and Bronchial Responsiveness in Asthmatic Children

1997 ◽  
Vol 14 (1) ◽  
pp. 61-69 ◽  
Author(s):  
Shinya Kondo ◽  
Masaki Ito
Keyword(s):  
Bronchial Responsiveness ◽  
Asthmatic Children ◽  
The Relationship

scholarly journals Urinary Cotinine and Exposure to Parental Smoking in a Population of Children with Asthma

1999 ◽  
Vol 45 (4) ◽  
pp. 505-509 ◽  
Author(s):  
Christiane Oddoze ◽  
Jean Christophe Dubus ◽  
Monique Badier ◽  
Xavier Thirion ◽  
Anne Marie Pauli ◽  
...  
Keyword(s):  
Tobacco Smoke ◽  
Parental Smoking ◽  
Test Results ◽  
Ultraviolet Detection ◽  
Bronchial Responsiveness ◽  
Urinary Cotinine ◽  
Asthmatic Children ◽  
Smoking Exposure ◽  
Children With Asthma ◽  
The Relationship

Abstract Background: Studies of the effects of tobacco smoke often rely on reported exposure to cigarette smoke, a measure that is subject to bias. We describe here the relationship between parental smoking exposure as assessed by urinary cotinine excretion and lung function in children with asthma. Methods: We studied 90 children 4–14 years of age, who reported a confirmed diagnosis or symptoms of asthma. In each child, we assessed baseline pulmonary function (spirometry) and bronchial responsiveness to carbachol stimulation. Urinary cotinine was measured by HPLC with ultraviolet detection. Results: Urinary cotinine concentrations in the children were significantly correlated (P <0.001) with the number of cigarettes the parents, especially the mothers, smoked. Bronchial responsiveness to carbachol (but not spirometry test results) was correlated (P <0.03) with urinary cotinine in the children. Conclusion: Passive smoke exposure increases the bronchial responsiveness to carbachol in asthmatic children.

scholarly journals The Role of Interferons in Driving Susceptibility to Asthma Following Bronchiolitis: Controversies and Research Gaps

2021 ◽  
Vol 12 ◽  
Author(s):  
Heidi Makrinioti ◽  
Andrew Bush ◽  
James Gern ◽  
Sebastian Lennox Johnston ◽  
Nikolaos Papadopoulos ◽  
...  
Keyword(s):  
Immune Responses ◽  
Acute Infection ◽  
Respiratory Viruses ◽  
Future Research ◽  
Innate Immune Responses ◽  
Asthmatic Children ◽  
Recurrent Wheeze ◽  
The Relationship

Bronchiolitis is the most common cause of hospitalization in infancy and is associated with a higher risk for the development of childhood asthma. However, not all children hospitalized with bronchiolitis will develop asthma. The mechanisms underlying asthma development following bronchiolitis hospitalization are complex. Immune responses to respiratory viruses may underlie both bronchiolitis severity and long-term sequela (such as asthma). Interferons (IFNs) are important components of innate immune responses to respiratory viruses and could influence both asthma development and asthma exacerbations. However, the nature of the relationship between interferon production and wheezing illnesses is controversial. For example, low peripheral blood IFN responses at birth have been linked with recurrent wheeze and asthma development. In contrast, there is evidence that severe illnesses (e.g., hospitalization for bronchiolitis) are associated with increased IFN responses during acute infection (bronchiolitis hospitalization) and a higher risk for subsequent asthma diagnosis. Furthermore, mechanistic studies suggest that bronchial epithelial cells from asthmatic children have impaired IFN responses to respiratory viruses, which may enable increased viral replication followed by exaggerated secondary IFN responses. This review aims to discuss controversies around the role of IFNs as drivers of susceptibility to asthma development following bronchiolitis hospitalization. Past evidence from both mechanistic and cohort studies are discussed. We will highlight knowledge gaps that can inform future research study design.

THE RELATIONSHIP BETWEEN PARENTAL AND CHILDREN'S SERUM IMMUNOGLOBULIN E (IgE) AND ASTHMA

PEDIATRICS ◽  
1996 ◽  
Vol 98 (2) ◽  
pp. 329-329
Author(s):  
Stanley P. Galant
Keyword(s):  
Bronchial Asthma ◽  
Immunoglobulin E ◽  
Skin Tests ◽  
Z Score ◽  
Significant Determinant ◽  
Positive Skin ◽  
Asthmatic Children ◽  
Children With Asthma ◽  
Z Scores ◽  
The Relationship

Purpose of the Study. To examine parental factors that influence bronchial asthma and immunoglobulin E (IgE) levels in their children. Methods. The data in this study were derived from the Tucson Epidemiological Study of Airways Obstructive Diseases since 1972. Eleven evaluation periods have been performed since that time. Asthma histories were established by questionnaire. IgE levels were obtained in 738 children, 1043 fathers, and 1261 mothers. IgE levels were determined by paper radioimmunosorbent (PRIST) technique. IgE Z scores were established. An IgE Z score is the number of standard deviations IgE differs from matched age and sex-matched subjects and log corrected. Skin tests were performed by prick technique to house dust, mold, grass, tree and weed mix and appropriate controls. Results. The percentage of children with bronchial asthma increased with the presence of asthma in parents so that 11.5% of children with asthma occurred in families with no parental asthma compared with 48.6% when both parents had asthma. The rate of childhood bronchial asthma was significantly related to parental IgE levels only when the mother and father had bronchial asthma (43% vs 20%) and much less so (22% vs 10%), when there was no parental asthma. In addition, asthma in the child proved to be a highly significant determinant of the child's IgE Z score, even after correcting for parental IgE Z score. The presence of atopy (ie, positive skin tests) was also not a significant determinant of IgE levels in asthmatic children. Discussion. The authors conclude that the inheritance of IgE is only one factor related to the development of asthma, and is limited as a predictor.

Relationship between spontaneous dyspnoea and lability of airway obstruction in asthma

1992 ◽  
Vol 82 (6) ◽  
pp. 717-724 ◽  
Author(s):  
C. Peiffer ◽  
M. Toumi ◽  
H. Razzouk ◽  
J. Marsac ◽  
A. Lockhart
Keyword(s):  
Visual Analogue Scale ◽  
Airway Obstruction ◽  
Peak Expiratory Flow ◽  
Flow Rate ◽  
Peak Expiratory Flow Rate ◽  
Analogue Scale ◽  
Forced Expiratory Volume ◽  
Bronchial Responsiveness ◽  
Expiratory Flow ◽  
The Relationship

1. As marked lability of bronchial obstruction is a risk factor for asthma severity, it may influence dyspnoea, the most common subjective complaint in asthma. We therefore studied the relationship between spontaneous dyspnoea and the degree of bronchial lability, as assessed by the daily variability in peak expiratory flow rate and the bronchial responsiveness to either carbachol or salbutamol, in 33 stable symptomatic asthmatic patients. 2. Three times daily, for 10 consecutive days, the patients rated the intensity of their dyspnoea on a visual analogue scale and immediately afterwards recorded their peak expiratory flow rate. Within the next 5 days, we determined the bronchial response by measuring the forced expiratory volume in 1 s and the specific resistance of airways to either carbachol or salbutamol according to baseline airway obstruction. 3. We characterized dyspnoea for each patient by using two parameters: (1) the relationship with underlying airway obstruction, as assessed by the correlation coefficient r between dyspnoea scores and corresponding values of peak expiratory flow rate (r DSc-PEFR), and (2) the intensity, as assessed by the mean visual analogue scale dyspnoea score adjusted for comparable airway obstruction. Bronchial lability was characterized by (1) variability in mean daily peak expiratory flow rate and (2) bronchial responsiveness to either carbachol (as assessed by the threshold dose and the slope of the dose-response curve) or salbutamol (as assessed by the threshold dose and maximal response). We assessed the relationship between dyspnoea and bronchial lability by correlating each of their respective characteristics. 4. We found large inter-subject differences in both characteristics of dyspnoea, r DSc-PEFR was unrelated to variability in mean daily peak expiratory flow rate and to all characteristics of bronchial responsiveness used, except for maximal salbutamol-induced increase in forced expiratory volume in 1 s (as a percentage of predicted). Adjusted visual analogue scale dyspnoea scores were unrelated to all characteristics of bronchial lability. 5. Our results suggest that spontaneous dyspnoea, as characterized by its intensity at comparable levels of airway obstruction and by its relationship with underlying airway obstruction, is poorly related to the degree of bronchial lability in stable symptomatic asthmatic patients.

scholarly journals Circadian change in bronchial responsiveness and airflow obstruction in asthmatic children.

Thorax ◽  
1989 ◽  
Vol 44 (10) ◽  
pp. 803-807 ◽  
Author(s):  
W M van Aalderen ◽  
D S Postma ◽  
G H Koeter ◽  
K Knol
Keyword(s):  
Airflow Obstruction ◽  
Bronchial Responsiveness ◽  
Asthmatic Children ◽  
Circadian Change

scholarly journals Volatile organic breath components and exercise induced bronchoconstriction in asthmatic children

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
M. R. van der Kamp ◽  
J. M. M. Driessen ◽  
M. P. van der Schee ◽  
B. J. Thio ◽  
F. H. C. de Jongh
Keyword(s):  
Pilot Study ◽  
Challenge Test ◽  
P Value ◽  
Breath Sample ◽  
Asthmatic Children ◽  
Non Invasive ◽  
Molecular Features ◽  
Volatile Organic ◽  
Exercise Induced ◽  
The Relationship

Abstract Introduction Asthma is one of the most common chronic diseases in childhood and is generally characterized by exercise induced bronchoconstriction (EIB). Assessing EIB is time consuming and expensive as it requires a fully equipped pulmonary function laboratory. Analysis of volatile organic compounds (VOCs) in breath is a novel technique for examining biomarkers which may associate with asthma features. The aim of this pilot study was to identify potential markers in the relationship between EIB and VOCs. Methods Children between four and 14 years old were asked to provide a breath sample prior to undergoing an exercise challenge test to assess for EIB. Results Breath samples were collected and analyzed in 46 asthmatic children, 21 with EIB and 25 without EIB (NO-EIB). Molecular features (MFs) were not significantly different between EIB and NO-EIB controls. 29 of the 46 children were corticosteroid naïve, 10 with EIB and 13 without. In the corticosteroid naïve group EIB was associated with increased MF23 and MF14 in the lower breath sample (p-value < 0.05). Conclusion This pilot study shows that EIB was related to an increased MF14 and MF23 in corticosteroid naïve children. The tentative identities of these compounds are octanal and dodecane/tetradecane respectively. These candidate biomarkers have a potential to enable non-invasive diagnosis of EIB in steroid-naïve children. Trial registration This study is registered in the Netherlands trial register (trial no. NL6087) at 14 February 2017.

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