Development, optimization, and characterization of polymeric electrospun nanofiber: a new attempt in sublingual delivery of nicorandil for the management of angina pectoris

2015 ◽  
Vol 44 (6) ◽  
pp. 1498-1507 ◽  
Author(s):  
Baljeet Singh ◽  
Tarun Garg ◽  
Amit K. Goyal ◽  
Goutam Rath
RSC Advances ◽  
2015 ◽  
Vol 5 (46) ◽  
pp. 36715-36726 ◽  
Author(s):  
Bakhshali Massoumi ◽  
Somayeh Davtalab ◽  
Mehdi Jaymand ◽  
Ali Akbar Entezami

The aim of this study is the synthesis, and characterization of novel type AB2 Y-shaped miktoarm star conductive polyaniline-modified poly(ethylene glycol), and preparation of its electrospun nanofibers blend with poly(ε-caprolactone).


2017 ◽  
Vol 63 (2) ◽  
pp. 66-69 ◽  
Author(s):  
Noémi Pásztor ◽  
Emőke Rédai ◽  
Zoltán-István Szabó ◽  
Emese Sipos

Abstract Objective: The study aimed at obtaining and characterizing levofloxacin-loaded, poly(ε-caprolactone) electrospun nanofiber formulations to be used as antibacterial wound dressings. Methods: Drug-loaded nanofibers were obtained by the electrospinning process and their morphology was determined using scanning electron microscopy. Structural analysis of the prepared nanofibers was carried out using differential scanning calorimetry and dissolution testing was performed in order to determine drug release. Results: Both nanofiberous formulations (containing 20 % and 50 % w/w levofloxacin) showed dimensions in the range of few hundred nanometers. Thermograms indicated that the formulation containing 20% levofloxacin was totally amorphized, showing a rapid release of the active, in 20 minutes. Conclusions: The poly(ε-caprolactone)-based electrospun nanofibers, containing levofloxacin presented suitable characteristics for obtaining potential antibacterial wound dressings.


2020 ◽  
Vol 27 ◽  
pp. 101053 ◽  
Author(s):  
Fenil Desai ◽  
Neda Seyedhassantehrani ◽  
Marwan Shagar ◽  
Shuang Gu ◽  
Ramazan Asmatulu

2020 ◽  
Vol 58 ◽  
pp. 101726
Author(s):  
Jinghan Li ◽  
Hao Pan ◽  
Qingzhuo Ye ◽  
Caihong Shi ◽  
Xiangrong Zhang ◽  
...  

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