scholarly journals SARS CoV-2 Replication and Neoplasm Pathogenesis Attributed to Guanylate kinase 1: Could it be A New Horizon for Pharmacotherapeutics?

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Crucial Role ◽  
Swot Analysis ◽  
Physiological Function ◽  
Short Term ◽  
Guanylate Kinase

A recent study has suggested that guanylate kinase 1 (GK1) plays a crucial role in SARS CoV-2 replication and recommended to test GK 1 inhibitors for invitro experiments and previous studies have suggested a role in the pathogenesis of some neoplasms. We are providing a concise strengths, weaknesses, opportunities, and threats (SWOT) analysis of this study while discussing guanylate kinase physiological function, pharmacological importance. Importantly, we suggest that though this hypothesis might prove valid, the available experimental GK 1 inhibitors might not, at least for the short term, be safely used to manage COVID-19. Moreover, we recommend conducting genetic, physiological, and immunological studies to explore the long-term potentials of GK-1 inhibitors suggesting they might eventually lead to a new horizon of both COVID-19 and cancer pharmacotherapeutics.

scholarly journals Role of Guanylate kinase 1 in SARS CoV-2 Replication and tumorigenesis: Potential Role for Amantadine and Novel Therapeutics in COVID-19 and Cancer Management.

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Crucial Role ◽  
Potential Role ◽  
Swot Analysis ◽  
Physiological Function ◽  
Potential Interaction ◽  
Short Term ◽  
Guanylate Kinase ◽  
Cancer Management

A recent study has suggested that guanylate kinase 1 (GK1) plays a crucial role in SARS CoV-2 replication and recommended to test GK 1 inhibitors for invitro experiments and previous studies have suggested a role in the pathogenesis of some neoplasms. We are providing a concise strengths, weaknesses, opportunities, and threats (SWOT) analysis of this hypothesis while discussing guanylate kinase physiological function, pharmacological importance. Importantly, we suggest assessing another potential interaction between SARS CoV-2 and the non-authentic membrane-associated guanylate kinases as we suggest this might add to consider the potential role of amantadine in COVID-19 management. Moreover, though GK1 role in SARS CoV-2 replication might prove valid, the available experimental inhibitors of GK 1 might not, at least for the short term, be safely used to manage COVID-19. Finally, we recommend conducting genetic, physiological, and immunological studies to explore the long-term potentials of GK-1 inhibitors suggesting they might eventually lead to a novel COVID-19 and cancer pharmacotherapeutics.

scholarly journals SARS CoV-2 Replication Attributed to Guanylate kinase 1: A SWOT Analysis

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Clinical Management ◽  
Crucial Role ◽  
Swot Analysis ◽  
Physiological Function ◽  
Morbidity And Mortality ◽  
Short Term ◽  
Guanylate Kinase ◽  
Genetic Studies ◽  
Interesting Study

A recent interesting study has suggested that guanylate kinase 1 (GK1) plays a crucial role in SARS CoV-2 replication and recommended to test GK 1 inhibitors for invitro experiments. We are providing a concise strengths, weaknesses, opportunities, and threats (SWOT) analysis while discussing guanylate kinase physiological function, pharmacological importance. Importantly, we argue that though this hypothesis might prove valid, GK 1 inhibitors are very unlikely, at least for the short term, to be beneficial in clinical management of COVID-19. However, we recommend conducting focused genetic studies to test their suggested hypothesis as it might add to our knowledge of some COVID-19 encountered idiosyncratic morbidity and mortality outcomes.

scholarly journals Repurposing Amantadine and Memantine for COVID-19: Guanylate Kinases Might Pave the Road towards Novel SARS CoV-2 and Anti Neoplastic Therapeutics.

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Potential Role ◽  
Swot Analysis ◽  
Physiological Function ◽  
Potential Interaction ◽  
Nmda Antagonists ◽  
Short Term ◽  
Guanylate Kinase ◽  
The Road

Guanylate kinase 1 (GK1) was suggested to play a crucial role in SARS CoV-2 replication and previous studies have suggested a role in the pathogenesis of some neoplasms. We are providing a concise strengths, weaknesses, opportunities, and threats (SWOT) analysis of this hypothesis while discussing guanylate kinase physiological function, pharmacological importance. Importantly, though GK1 role in SARS CoV-2 replication might prove valid, the available experimental inhibitors of GK 1 might not, at least for the short term, be safely used to manage COVID-19. However, we suggest assessing another potential interaction between SARS CoV-2 and the non-authentic membrane-associated guanylate kinases as we suggest this might add to consider the potential role of the NMDA antagonists amantadine and memantine in COVID-19 management for and we have recommended clinical trials for selected described COVID-19 patients. Finally, we also recommend conducting genetic, physiological, and immunological studies to explore the long-term potentials of novel GK-1 inhibitors suggesting they might eventually lead to a novel COVID-19 and cancer pharmacotherapeutics.

Evaluating the Financial Performance Through ‘Consumer Centric Decision’ Approach in Pharmaceutical Companies of Bangladesh: a Business Planning Perspective

2017 ◽  
Vol 9 (1) ◽  
pp. 168
Author(s):  
Md Mostafizur Rahman ◽  
Mahmud Uz Zaman
Keyword(s):  
Market Share ◽  
Swot Analysis ◽  
Financial Analysis ◽  
Pharmaceutical Companies ◽  
Short Term ◽  
The Public ◽  
Investment Choice ◽  
Good Investment ◽  
Business Analysis

Pharmaceuticals agglomerations consistently use their brand image and versatile product portfolios to consolidate their position in the financial sector, which is evident in their continuous profit making and expansion in market share. This paper explores the short-term and long-term investment attractiveness through ‘consumer centric decision’ approach in two selected pharmaceutical companies, Renata Limited and Orion Pharma Limited, of Bangladesh over the last three years’ period. This research adopts a systematic approach which primarily addresses the various concerns of investors to illustrate the decision-making process of the existing and future investors. Using primarily domestic transaction data, this study explores how the leading pharmaceuticals companies of Bangladesh effectively use the wide array of drug portfolios mix with appropriate branding techniques to increase their financial profit and market share simultaneously. Both SWOT analysis and Porters Five Forces Model explore the business analysis of Renata Limited in compare to Orion Pharma Limited that provides a conclusion regarding investors’ decision to invest in Renata Limited. Considering the financial analysis, Renata’s financial liquidity is not very satisfactory and could have been improved further if management is prudent on financial strategy settings. Findings of the business analysis indicate that Renata Limited would be a good investment choice for existing and prospective shareholders based on its opportunities for long term and short term growth and further expansion in developing the market. The results suggest that even lower liquidity coupled with higher interest borrowings can be balanced by posing positive picture to the public shareholders by returning the positive dividend to them.

scholarly journals Analisis Peluang Penyertaan Modal Pemerintah Daerah Kota XYZ pada PT Bank Jawa Barat dan Banten (Bank BJB)

2016 ◽  
Vol 2 (1) ◽  
pp. 54
Author(s):  
Dian Yudo Palupi ◽  
Farida Ratna Dewi ◽  
R. Dikky Indrawan
Keyword(s):  
Swot Analysis ◽  
Financial Analysis ◽  
Risk Exposure ◽  
Regional Government ◽  
Government Bond ◽  
Short Term ◽  
Small Risk ◽  
Short Term Investment ◽  
Stock Share

Economic growth and public welfare are the reason of regional autonomy regulation policy (UU No 22 year 1999). The policy allows regional economic resources managed by regional government to achieve its goal. One of the regional government strategies is investment strategy, which in this case investing in banking industry. The purposes of the study are 1) to identify the investment regulation on regional government 2) to identify the Bank BJB business and investment environment 3) to identify the comparison of investment feasibility on Bank BJB versus other banks 4) to identify the position of Stock Share A series owned by XYZ at Bank BJB. The data collection methods are using structured interview, in depth interview, field survey and literature study. The analysis tools are using institutional analysis, SWOT analysis and financial analysis. Institutional analysis showed XYZ regional government investment management is limited to regulation as follow 1) long term capital (stock share) investment limited only at BUMD (e.g. Bank BJB) 2) short term investment e.g. saving and deposit is limited only at healthy and feasible bank, and government bond which has small risk exposure. The financial analysis also showed the increasing performance of BJB Earning per Share (EPS) and Return on Equity (ROE) from 2006 until 2010. The SWOT analysis support other analysis that BJB Bank position in financial industry is suitable for long term and short term investment for XYZ regional government. Base on explanation above, the conclusions are the autonomy regulation limited XYZ regional government to invest as shareholders in A series (stock share) or B series (stock share) at BJB Bank only, and for short term investment is limited only at healthy and feasible bank, and government bond which has small risk exposure.

Using Knowledge to Cope with Stress in the NICU: How Parents Integrate Learning to Read the Physiologic and Behavioral Cues of the Infant

2003 ◽  
Vol 22 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Kek Khee Loo ◽  
Michael Espinosa ◽  
Rachelle Tyler ◽  
Judy Howard
Keyword(s):  
Parental Stress ◽  
Crucial Role ◽  
Parent Child Relationship ◽  
Short Term ◽  
Learning To Read ◽  
Behavioral Cues ◽  
Child Relationship ◽  
Learning As A Process ◽  
Development Outcomes

Parental stress in the NICU has at least a short-term impact on the establishment of the parent-child relationship and potential repercussions on long-term child development outcomes. One way to help parents mitigate stress is to help them learn what they need to know about their infant’s condition and care. In this article, we examine how learning to read the infant’s physiologic and behavioral cues helps parents cope with stress. We view parental learning as a process in which parents target specific domains of information for learning according to the temporal relevance of the domain to their concerns. It is important that we recognize the fluidity of the process and anticipate what parents need to learn at different times during hospitalization. The NICU staff assumes a crucial role in reducing parental stress by delivering information that is relevant to the parents’ needs and by helping parents understand this information.

scholarly journals Tatmadaw’s Crackdown on The Rohingyas: A SWOT Analysis

2021 ◽  
Author(s):  
Sarwar J. Minar
Keyword(s):  
Swot Analysis ◽  
International Community ◽  
Short Term ◽  
Research Attention ◽  
Political Success ◽  
Intense Research

The recent Rohingya crisis has drawn intense research attention worldwide lately, but the Tatmadaw’s perspective in the crackdown has not received much attention. Thus, this article analyses Tatmadaw’s perspective on its crackdown decision on the Rohingyas. The article avails SWOT framework (Strength, Weakness, Opportunity, and Threat) for the analysis. The article argues that the Tatmadaw is militarily successful in achieving its goal. However, even though Tatmadaw is successful in the short-term, sustaining it in the long-term or converting military success into political success will be challenging, especiallyif international community comes into the stage with robust action.

Kolaborasi Karang Taruna Dalam Tata Kelola Zakat Menuju Jabar Juara

2020 ◽  
Vol 12 (1) ◽  
pp. 38-46
Author(s):  
Itto Turyandi
Keyword(s):  
Swot Analysis ◽  
Medium Term ◽  
Short Term ◽  
Collaborative Activity ◽  
West Java ◽  
Youth Organization ◽  
The People ◽  
Use Of Social Media ◽  
Management Institutions

This study aims to see and know the positioning and brand of BAZNAS Jabar, as a government agency that requires coordination, distribution, utilization, reporting of zakat management, infaq, shodaqoh and partnership partnerships with social organizations in West Java. The research method uses qualitative analysis with a SWOT analysis from the perspective of the management of the amil zakat body. This research resulted in a strategic planning in the short-term, medium-term and long-term planning as well as amil zakat management institutions to gain trust and acceptance and pride for the people of West Java. One of the efforts suggested is a collaborative activity with Karang Taruna West Java social organization. The conclusion shows, West Java Amil Zakat Board has more opportunities for improvement, distribution, optimization of utilization and reporting through collaboration with Youth Organization. To get human resources who like and have the capacity with capabilities as not the main in getting support, distribution, utilization, and approval of the management of zakat, infaq, shodaqoh through improving the muzaki and mustahik database with its successor, culture and wisdom of each region in West Java. The West Java Amil Zakat Agency should ideally have a tiered zakat education program to the community, to answer the challenges of the industry era 4.0 by implementing a governance regulation that is supported and optimizing the use of social media for social campaigns in zakat, infaq, shodaqoh, and social social assistance funds the other.

scholarly journals Financial markets in the period of uncertainty – focus on the Slovak financial market

2020 ◽  
Vol 1 (1) ◽  
pp. 40-49
Author(s):  
Igor Turuk ◽  
Marcela Passova
Keyword(s):  
Financial Markets ◽  
Economic System ◽  
Financial Market ◽  
Crucial Role ◽  
Economic Environment ◽  
Wide Scope ◽  
Economic Activities ◽  
Short Term ◽  
Great Stress

Economic environment has changed significantly in recent days due to the COVID19 and measures the governments apply to combat it will inevitably cause the substantial shrinkage of economies due to reduced economic activities on the national as well as global levels. As a result, financial markets have been under great stress because there is no prediction on the size, scope, and duration of this situation. Simultaneously this causes a great uncertainty. It is obvious that financial markets play crucial role in the general good standing of economies because they are serving as a channel through which funds are transferred to and between entities on the market. Financial and monetary systems are a part of the economic system whereby for the latter it is important the former to be as stable as possible. In order this to be achieved or at least risks caused by uncertainty to be reduced both in short-term as well as long-term perspectives a wide scope of traditional as well as modern the financial market regulations have been applied and here we are going to present at least some of them.

scholarly journals PROGRAM PEMBERDAYAAN USAHA KECIL MENENGAH (UKM) JAMAAH LIL-MUQORROBIEN UNTUK MENINGKATKAN PEREKONOMIAN

2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Nur Wakit ◽  
Agustin Sukarsono ◽  
Retno Eka Pramitasari
Keyword(s):  
Social Action ◽  
Social Problems ◽  
Swot Analysis ◽  
Analysis Method ◽  
Short Term

AbstrakPemberdayaan masyarakat merupakan suatu tindakan sosial dimana penduduk sebagai komunitas mengorganisasikan diri dalam membuat perencanaan dan tindakan kolektif untuk memecahkan masalah sosial atau memenuhi kebutuhan sesuai dengan kemampuan dan sumber daya yang dimilikinya. Analisa SWOT merupakan suatu bentuk analisis di dalam manajemen perusahaan atau di dalam organisasi yang secara sistematis dapat membantu dalam usaha penyusunan suatu rencana yang matang untuk mencapai tujuan,baik tujuan jangka pendek maupun jangka panjang. Dengan menggunakan metode analisa SWOT, jumlah jamaah yang sudah diberdayakan berdasarkan umur 30-35 tahun sebanyak 7 orang sebesar 25%, 36-40 tahun sebanyak 10 orang sebesar 35%, 41-45 tahun sebanyak 1 orang sebesar 3%, 46-50 tahun sebanyak 5 orang sebesar 17%, 51-55 tahun sebanyak 2 orang sebesar 7%, 56-60 tahun sebanyak 1 orang sebesar 3%,umur 61-65 tahun sebanyak 3 orang sebesar 10%. Dapat diambil kesimpulan bahwa sebagian besar jamaah yang diberdayakan Komit Jawatan Uswatan berumur 36-40 tahun sebesar 35%.Kata kunci : pemberdayaan,ekonomi, analisa swot, komit jawatan.AbstractCommunity empowerment is a social action in which the population as a community organizes itself in making collective planning and action to solve social problems or meet the needs in accordance with the capabilities and resources it has. SWOT Analysis is a form of analysis within the management of the company or within the organization that systematically can help in the effort of preparation of a mature plan to achieve goals, both short-term and long-term goals, By using swot analysis method, the number of pilgrims who have been empowered based on age 30-35 years as many as 7 people by 25%, 36-40 years as many as 10 people by 35%, 41-45 years as much as 1 person by 3%, 46-50 years as many as 5 people by 17%, 51-55 years as many as 2 people by 7%, 56-60 years as much as 1 person by 3%, age 61-65 years as many as 3 people by 10%. It can be concluded that most of the pilgrims who are empowered by the Commitment of the Bureau of Uswatan are 36-40 years old by 35%.Keywords: empowerment, economy, swot analysis, committing service

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