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2021 ◽  
Vol 5 (2) ◽  
pp. 178-187
Author(s):  
Yulian Dinihari ◽  
Zuriyati Zuriyati ◽  
Ninuk Lustyantie

Film is one of the effective and popular media in cultural learning, both local and foreign cultures. The film that is used as the object of research by the researcher is the film 'Marak: Mresani Panji Sekar'”. This film becomes an interesting study material because it explains the Javanese culture of the courtiers of the Yogyakarta Palace who will focus more on culture in the film. This research uses descriptive qualitative research method. Analyzing cultural values by means of observation and study of documents in films in an effort to gain an overview and understanding of what is being studied. The values obtained are in the form of many values contained in it, namely the values of honor, trust, politeness, responsibility, and art. Describe the Javanese values of the Yogyakarta Palace which are shown in the film 'Marak: Mresani Panji Sekar' and reveal and understand the meaning contained in these traditional values.Keywords: Film, Values, Javanese Cultural


Author(s):  
Mohammad Noorizzuddin Nooh

Objective - This study presents a bibliometric analysis on the publications of VUCA research from Scopus database for an unspecified period. However, it has been determined that VUCA only emerges in Scopus publications starting from 2012. Methodology/Technique - A Bibliometric analysis using R-Studio software was performed using the Scopus database as atMarch 2021.Based on keywords used, which is related to VUCA in the article title, the study retrieved 108 documents and after one document was excludeddue to relevancy issues, only 107 documents were further analyse usingvarious tools. Findings - Emerging concerns such as leadership and management in COVID-19 and post-COVID-19 could be interesting study topics to pursue in the coming years. Overall, due to the scarcity of publications on this topic, the prospects to publish in this area are plentiful.This topic's publication has only emerged since 2012. Novelty - The publication trend has been on the rise since 2019 and is projected to continue if the COVID-19 pandemic is considered one of the most pressing challenges in the VUCA field of study. This provided future researchers with many opportunities to publish in SCOPUS on a recent VUCA topic. Issues of leadership and management in the new COVID-19 Pandemic standards could be a fascinating subject to explore in terms of publication possibilities. Type of Paper - Empirical Keywords: VUCA; Volatility; Uncertainty; Complexity; Ambiguity; Bibliometric; R; Management JEL Classification: M10, M14


2021 ◽  
Vol 13 (22) ◽  
pp. 12875
Author(s):  
Marcelo Enrique Conti ◽  
Massimo Battaglia ◽  
Mario Calabrese ◽  
Cristina Simone

Adopting an interdisciplinary approach and framing sustainability issues from a resilience perspective, our paper first aimed to highlight nature-based solutions (NBSs) as levers to foster sustainable cities consistent with Agenda 2030-SDG 11 (2015) and the New Urban Agenda (Habitat III, 2016). Second, we empirically analyzed two Italian municipalities that are experimenting with initiatives of sustainable urban management and planning based on NBSs: the Municipality of Lucca in Tuscany and the Municipality of Latina in the Latium Region. These municipalities present institutional and socioeconomic similarities, making them an interesting study setting that allows us to draw significant lessons. We conducted four research steps: (1) theoretical background analysis, including resilience thinking in sustainable urban management. We investigated the role of NBSs in enabling urban resilience according to the last level of resilience, i.e., the transformative level. (2) We studied the contributions of NBSs to sustainable cities and resilience thinking. (3) We analyzed the NBSs’ projects of Lucca and Latina, and (4) we proposed an urban managerial tool: the NBSs’ curve, which facilitates the estimation of the NBS ecosystem endowment. The results of the NBS initiatives presented in this study have a two-fold value. First, they aim to combine citizens’ well-being with ecological and environmental aspects by better managing urban spaces that facilitate interpersonal relationships and resource sharing. Second, they are developed to meet the needs of local groups by serving as a stimulus (Fridays For Future movement) and as enablers (local associations) of managed actions. The lessons learned about the enhancement of sustainable cities through NBSs were thoroughly debated.


2021 ◽  
Vol 58 ◽  
pp. 146-160
Author(s):  
Frank D. Steinheimer

Grottenolme Proteus anguinus (Laurenti, 1768) zeigen eine sehr geringe Fortpflanzungsrate, werden sehr alt und haben eine im Vergleich zum Menschen verzögerte Generationenfolge. Damit sind Olme Lebewesen für spannende evolutionsbiologische Fragestellungen, die sich um Populationswachstum drehen. Die vorliegende Arbeit zeigt auf, dass eine stabile Umwelt, wenig Krankheiten, das Fehlen von Fressfeinden und ausreichende Nahrungsressourcen evolutiv einen starken Einfluss auf das fehlende Populationswachstum beim Olm haben. Ein Vergleich mit dem Menschen eröffnet, neben der Bildung und dem Aufbrechen von Bräuchen, auch Wege naturgegebener Mechanismen, wie das Wachstum der Weltbevölkerung sich stabilisieren ließe. Der verzögerte Eintritt in die Reproduktion zeigt beim Grottenolm zudem einen positiven Effekt auf die Langlebigkeit. Human fish and human beings – European Cave Salamander Proteus anguinus (Laurenti, 1768) explains longevity and population growth Abstract: European Cave Salamanders, more specifically olms, show a low reproduction rate, reach methuselah ages and exhibit extended generation frequencies in comparison to humans. Olms are therefore considered an interesting study object for evolutionary questions about population growth. The paper discusses stable environment, good health, top predator position and continuous basic food supply as the key factors for stagnation of population growth in olms as well, if combined with education, as in humans. A late start of reproduction triggers in turn a positive impact on longevity.


Blood ◽  
2021 ◽  
Vol 138 (Supplement 1) ◽  
pp. 1029-1029
Author(s):  
Anirban Sen Gupta ◽  
Aditya Girish ◽  
Ketan Jolly ◽  
Maria de la Fuente ◽  
Xu Han ◽  
...  

Abstract Non-compressible uncontrolled hemorrhage remains a major cause of mortality from traumatic injuries. Additionally, patients with congenital, disease-associated or drug-induced hemostatic dysfunctions, may often be at risk of excessive bleeding. Therefore, treatments that render rapid hemostasis are clinically significant in potentially saving lives. The clinical gold standard for this is the transfusion of whole blood (WB) or blood components (e.g. controlled ratios of platelets, RBCs, and plasma), as evidenced by several clinical studies (e.g. PROPPR, PROMMTT and PAMPer). However, the availability of such blood products is donor-dependent, their shelf-life is limited due to contamination risks, and, their portability and storage is often challenging. While extensive research efforts are currently being focused on addressing these challenges, e.g. using low titer Group O whole blood, cold-storage and freeze-drying of platelets and plasma, in vitro generation of platelets from iPSCs etc., a parallel research focus has emerged in designing biomaterials-based I.V.-administrable technologies (nanoparticles, polymers etc.) that can provide specific functional attributes of hemostasis while allowing donor-independent manufacturing, scale-up, and on-demand availability. Prominent examples of these are 'synthetic platelet' (SynthoPlate) nanoparticles that recapitulate platelet's binding interactions with von Willebrand Factor (vWF), collagen and active platelet integrin GPIIb-IIIa, flexible platelet-like particles (PLP) that bind fibrin to recapitulate platelet's biomechanical properties, fibrinogen function-mimicking nanoparticles that amplify the aggregation of active platelets, peptide-modified synthetic polymers (e.g. PolySTAT, HAPPI etc.) that render clot stabilization etc. In this framework, we present the design and evaluation of I.V.-administrable unique platelet-inspired nanoparticles that render injury site-targeted, enzyme-responsive direct delivery of thrombin, to site-specifically augment fibrin generation for hemostasis. Our design is inspired by platelets' crucial hemostatic mechanisms of : (i) rapidly accumulating at the injury site to form a plug and (ii) serving as a coagulation amplifier via presenting anionic phospholipids on the activated platelet surface to render tenase and prothrombinase factor assemblies leading to thrombin (FIIa) burst, which can then site-specifically convert fibrinogen to fibrin. Thrombin delivery to augment hemostasis is clinically well-accepted, as exemplified by products like Tisseel where thrombin and fibrinogen are co-delivered by syringe directly at wound site. Researchers have also studied thrombin-loaded topical dressings and topical administration of thrombin-loaded particles on wounds to mitigate bleeding, but these cannot be used intravenously. A recent interesting study has explored encapsulation of thrombin-loaded nanoparticles inside actual platelets with the idea of the particles being released (analogous to granule secretion) upon platelet activation, but this was only demonstrated in vitro because optimizing this complex strategy for consistent in vivo function may be challenging. Our approach circumvents these challenges by: (i) loading consistent amount of thrombin in I.V.-administrable lipid nanoparticles (LNPs), (ii) directly targeting the thrombin-loaded LNPs (TLNPs) to the injury site via specific binding to vWF and collagen, and (iii) releasing the loaded thrombin via particle destabilization by the action of injury site-specific enzyme phospholipase A2 for in situ fibrin production. We evaluated the TLNPs in vitro in human blood and plasma where hemostatic defects were created by platelet depletion and anticoagulant treatment. Spectrophotometric studies of fibrin generation, rotational thromboelastometry (ROTEM) based studies of clot characteristics and BioFlux microfluidics based real-time imaging of fibrin generation under simulated vascular flow conditions, confirmed the ability of TLNPs to restore fibrin generation in hemostatic dysfunction settings. Subsequently, the in vivo feasibility of these TLNPs was tested in a mouse tail-clip bleeding model where a combination of platelet depletion plus anticoagulant treatment was used to render significant hemostatic defect. TLNPs were able to effectively reduce tail-bleeding in mice. Figure 1 Figure 1. Disclosures Sen Gupta: Haima Therapeutics: Other: Co-founder, Patents & Royalties: US 9107845, US 9107963.


Author(s):  
Rialdo Rezeky Manogari L. Toruan ◽  
Radja Erland Hamzah ◽  
Muhammad Saifulloh

Digital literacy is an interesting study at this time in the midst of the development of Information and Communication Technology (ICT), especially for SMEs. Through socialization and digital literacy training, MSME actors can apply in their business so that they are skilled and can market their products as well as increase income and improve the economy. The purpose of this study is to identify the actions of MSME actors in Kuningan Barat, South Jakarta. The research approach is qualitative and the method used is Stephen Kemmis's Action Research (PRA), and the concept used is the digital literacy stage of Steve Wheeler. The results show that digital literacy can be implemented through socialization and training that is realized in a digital product. Through action participation, MSME actors can be digitally literate and use digital media well. In this case, MSME actors create a website product www.plazakuninganbarat.com as a medium for digital marketing.


2021 ◽  
Vol 9 (10) ◽  
pp. 1148
Author(s):  
Irene Cinelli ◽  
Giorgio Anfuso ◽  
Enrico Bartoletti ◽  
Lorenzo Rossi ◽  
Enzo Pranzini

This paper presents the history and evolution of the different projects carried out from 1999 to 2008 at Cavo beach in the Elba Island, Italy. The village of Cavo almost completely lost its beach in the 1970s due to the reduction of sedimentary input, and the backing coastal road was defended by a revetment and two detached breakwaters. Such severe erosion processes continued in the following years and impeded any possibility of beach tourist development. In 1999, a project based on the removal of existing breakwaters and beach nourishment works based on the use of gravel as borrow sediment and the construction of two short groins to maintain nourished sediment, raised environmental concern and did not find the approval of the stakeholders. They were worried about the characteristics of the sediments, i.e., waste materials from iron mining rich in red silt and clay. Such sediment fractions made the sea red during the nourishment and deposited on the Posidonia oceanica meadow in front of the beach, with a potential environmental impact. Furthermore, they cemented the gravel fraction forming a beach rock. Between 2006 and 2008, these materials were covered with better quality gravel, extending and raising the beach profile, which required the elevation and lengthening of the two existing groins. Beach evolution monitoring following the second project, based on morphological and sedimentological data acquired before, during and after the works, demonstrated the great stability of the newly created beach. The wider beach has allowed the construction of a promenade and the positioning, in summer, of small structures useful for seaside tourism, increasing the appeal of this village. Data presented in this paper shows an interesting study case, since few examples exist in international literature regarding gravel nourishment projects monitoring and evolution.


2021 ◽  
Author(s):  
E. Edwin

Cibulakan Formation as one of the prolific hydrocarbon-bearing intervals has become an interesting study object for many researchers. The continuous outcrop of the Cibulakan Formation in the Cipamingkis River comprises claystone, sandstone, and subordinate limestone of grainstone, packstone, and wackestone facies. The outcrop should be able to give a clearer vertical and spatial variation of sandstone and limestone geometry compared to the conventional core alone. Field observations followed by measuring the section is conducted to distinguish lithofacies and to create a stratigraphic profile from the chosen interval. Samples and thin sections from sandstone and limestone lithofacies are observed further to determine fragment type variation, matrix, cement, texture, and porosity types qualitatively. Fourteen (14) lithofacies have been recognized from the observation, i.e., Slumped Sandstone (A1), Claystone (A2), Slightly-bioturbated Sandstone (B1), Cross-laminated Sandstone (B2), Parallel-laminated Siltstone (B3), Calcareous Claystone (B4), Moderately-bioturbated Sandstone (C1), Hummocky Cross-stratified Sandstone (C2), Skeletal – Coral clast Wackestone (C3), Skeletal-clast Packstone (C4), Coralline Foraminiferal Boundstone (C5), Low-angle Planar Cross-bedded Sandstone (D1), Intensely-bioturbated Sandstone (D2), and Trough Cross-bedded Sandstone (D3). There are four architectural facies in the research interval and each of them is composed of different and specific lithofacies. An ideal parasequence is composed of all Architectural Facies namely : (A) Offshore-Transition (B) Lower Shoreface (C) Upper Shoreface with the whole thickness range between 15 to 25 m and the parasequence shows thickening upward succession. The detailed information about the lithofacies and architectural facies hopefully will provide a better understanding of the facies modelling of the mixed carbonate-siliciclastic depositional setting, new insights for parasequence recognition in clastic shoreline depositional environment and become a reference for other areas lacking in core data and/or outcrop analogue.


2021 ◽  
Author(s):  
Johanna Kreuter ◽  
Georg Stark ◽  
Robert L Mach ◽  
Astrid R Mach-Aigner ◽  
Christian Derntl

Aureobasidium pullulans is a ubiquitous, polyextremotolerant, yeast-like ascomycete used for the industrial production of pullulan and other products and as biocontrol agent in the agriculture. Its application potential and its wide-spread occurrence make A. pullulans an interesting study object. The availability of a fast and efficient genome editing method is an obvious advantage for future basic and applied research on A. pullulans. In this study, we describe the development of a CRISPR/Cas9-based genome editing method using ribonucleoproteins (RNPs). We demonstrate that this method can be used for single and multiplex genome editing using only RNPs by targeting ura3 (encoding for orotidine-5'-phosphate decarboxylase), praics (encoding for phosphoribosyl aminoimidazole-succinocarboxamide synthase) and asl (encoding for arginine succinate lyase). We demonstrate the applicability of Trichoderma reesei pyr4 and Aspergillus fumigatus pyrG to complement the ura3 deficiency. Further, we show that the usage of RNPs can boost the homologous recombination rate up to nearly 100%, even when using only 20bp long homologous flanks. Therefore, the repair cassettes can be constructed by a single PCR, abolishing the need for laborious and time-consuming cloning. The here presented method allows fast and efficient genome editing for gene deletions, modifications, and insertions in A. pullulans.


2021 ◽  
Vol 12 ◽  
Author(s):  
Alejandro Tejada-Arranz ◽  
Hilde De Reuse

Helicobacter pylori is a Gram-negative bacterial pathogen that colonizes the stomach of about half of the human population worldwide. Infection by H. pylori is generally acquired during childhood and this bacterium rapidly establishes a persistent colonization. H. pylori causes chronic gastritis that, in some cases, progresses into peptic ulcer disease or adenocarcinoma that is responsible for about 800,000 deaths in the world every year. H. pylori has evolved efficient adaptive strategies to colonize the stomach, a particularly hostile acidic environment. Few transcriptional regulators are encoded by the small H. pylori genome and post-transcriptional regulation has been proposed as a major level of control of gene expression in this pathogen. The transcriptome and transcription start sites (TSSs) of H. pylori strain 26695 have been defined at the genome level. This revealed the existence of a total of 1,907 TSSs among which more than 900 TSSs for non-coding RNAs (ncRNAs) including 60 validated small RNAs (sRNAs) and abundant anti-sense RNAs, few of which have been experimentally validated. An RNA degradosome was shown to play a central role in the control of mRNA and antisense RNA decay in H. pylori. Riboregulation, genetic regulation by RNA, has also been revealed and depends both on antisense RNAs and small RNAs. Known examples will be presented in this review. Antisense RNA regulation was reported for some virulence factors and for several type I toxin antitoxin systems, one of which controls the morphological transition of H. pylori spiral shape to round coccoids. Interestingly, the few documented cases of small RNA-based regulation suggest that their mechanisms do not follow the same rules that were well established in the model organism Escherichia coli. First, the genome of H. pylori encodes none of the two well-described RNA chaperones, Hfq and ProQ that are important for riboregulation in several organisms. Second, some of the reported small RNAs target, through “rheostat”-like mechanisms, repeat-rich stretches in the 5′-untranslated region of genes encoding important virulence factors. In conclusion, there are still many unanswered questions about the extent and underlying mechanisms of riboregulation in H. pylori but recent publications highlighted original mechanisms making this important pathogen an interesting study model.


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