scholarly journals SARS CoV-2 Replication Attributed to Guanylate kinase 1: A SWOT Analysis

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Clinical Management ◽  
Crucial Role ◽  
Swot Analysis ◽  
Physiological Function ◽  
Morbidity And Mortality ◽  
Short Term ◽  
Guanylate Kinase ◽  
Genetic Studies ◽  
Interesting Study

A recent interesting study has suggested that guanylate kinase 1 (GK1) plays a crucial role in SARS CoV-2 replication and recommended to test GK 1 inhibitors for invitro experiments. We are providing a concise strengths, weaknesses, opportunities, and threats (SWOT) analysis while discussing guanylate kinase physiological function, pharmacological importance. Importantly, we argue that though this hypothesis might prove valid, GK 1 inhibitors are very unlikely, at least for the short term, to be beneficial in clinical management of COVID-19. However, we recommend conducting focused genetic studies to test their suggested hypothesis as it might add to our knowledge of some COVID-19 encountered idiosyncratic morbidity and mortality outcomes.

scholarly journals Role of Guanylate kinase 1 in SARS CoV-2 Replication and tumorigenesis: Potential Role for Amantadine and Novel Therapeutics in COVID-19 and Cancer Management.

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Crucial Role ◽  
Potential Role ◽  
Swot Analysis ◽  
Physiological Function ◽  
Potential Interaction ◽  
Short Term ◽  
Guanylate Kinase ◽  
Cancer Management

A recent study has suggested that guanylate kinase 1 (GK1) plays a crucial role in SARS CoV-2 replication and recommended to test GK 1 inhibitors for invitro experiments and previous studies have suggested a role in the pathogenesis of some neoplasms. We are providing a concise strengths, weaknesses, opportunities, and threats (SWOT) analysis of this hypothesis while discussing guanylate kinase physiological function, pharmacological importance. Importantly, we suggest assessing another potential interaction between SARS CoV-2 and the non-authentic membrane-associated guanylate kinases as we suggest this might add to consider the potential role of amantadine in COVID-19 management. Moreover, though GK1 role in SARS CoV-2 replication might prove valid, the available experimental inhibitors of GK 1 might not, at least for the short term, be safely used to manage COVID-19. Finally, we recommend conducting genetic, physiological, and immunological studies to explore the long-term potentials of GK-1 inhibitors suggesting they might eventually lead to a novel COVID-19 and cancer pharmacotherapeutics.

scholarly journals SARS CoV-2 Replication and Neoplasm Pathogenesis Attributed to Guanylate kinase 1: Could it be A New Horizon for Pharmacotherapeutics?

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Crucial Role ◽  
Swot Analysis ◽  
Physiological Function ◽  
Short Term ◽  
Guanylate Kinase

A recent study has suggested that guanylate kinase 1 (GK1) plays a crucial role in SARS CoV-2 replication and recommended to test GK 1 inhibitors for invitro experiments and previous studies have suggested a role in the pathogenesis of some neoplasms. We are providing a concise strengths, weaknesses, opportunities, and threats (SWOT) analysis of this study while discussing guanylate kinase physiological function, pharmacological importance. Importantly, we suggest that though this hypothesis might prove valid, the available experimental GK 1 inhibitors might not, at least for the short term, be safely used to manage COVID-19. Moreover, we recommend conducting genetic, physiological, and immunological studies to explore the long-term potentials of GK-1 inhibitors suggesting they might eventually lead to a new horizon of both COVID-19 and cancer pharmacotherapeutics.

scholarly journals Repurposing Amantadine and Memantine for COVID-19: Guanylate Kinases Might Pave the Road towards Novel SARS CoV-2 and Anti Neoplastic Therapeutics.

2021 ◽  
Author(s):  
Mina Kelleni
Keyword(s):  
Potential Role ◽  
Swot Analysis ◽  
Physiological Function ◽  
Potential Interaction ◽  
Nmda Antagonists ◽  
Short Term ◽  
Guanylate Kinase ◽  
The Road

Guanylate kinase 1 (GK1) was suggested to play a crucial role in SARS CoV-2 replication and previous studies have suggested a role in the pathogenesis of some neoplasms. We are providing a concise strengths, weaknesses, opportunities, and threats (SWOT) analysis of this hypothesis while discussing guanylate kinase physiological function, pharmacological importance. Importantly, though GK1 role in SARS CoV-2 replication might prove valid, the available experimental inhibitors of GK 1 might not, at least for the short term, be safely used to manage COVID-19. However, we suggest assessing another potential interaction between SARS CoV-2 and the non-authentic membrane-associated guanylate kinases as we suggest this might add to consider the potential role of the NMDA antagonists amantadine and memantine in COVID-19 management for and we have recommended clinical trials for selected described COVID-19 patients. Finally, we also recommend conducting genetic, physiological, and immunological studies to explore the long-term potentials of novel GK-1 inhibitors suggesting they might eventually lead to a novel COVID-19 and cancer pharmacotherapeutics.

Evaluating the Financial Performance Through ‘Consumer Centric Decision’ Approach in Pharmaceutical Companies of Bangladesh: a Business Planning Perspective

2017 ◽  
Vol 9 (1) ◽  
pp. 168
Author(s):  
Md Mostafizur Rahman ◽  
Mahmud Uz Zaman
Keyword(s):  
Market Share ◽  
Swot Analysis ◽  
Financial Analysis ◽  
Pharmaceutical Companies ◽  
Short Term ◽  
The Public ◽  
Investment Choice ◽  
Good Investment ◽  
Business Analysis

Pharmaceuticals agglomerations consistently use their brand image and versatile product portfolios to consolidate their position in the financial sector, which is evident in their continuous profit making and expansion in market share. This paper explores the short-term and long-term investment attractiveness through ‘consumer centric decision’ approach in two selected pharmaceutical companies, Renata Limited and Orion Pharma Limited, of Bangladesh over the last three years’ period. This research adopts a systematic approach which primarily addresses the various concerns of investors to illustrate the decision-making process of the existing and future investors. Using primarily domestic transaction data, this study explores how the leading pharmaceuticals companies of Bangladesh effectively use the wide array of drug portfolios mix with appropriate branding techniques to increase their financial profit and market share simultaneously. Both SWOT analysis and Porters Five Forces Model explore the business analysis of Renata Limited in compare to Orion Pharma Limited that provides a conclusion regarding investors’ decision to invest in Renata Limited. Considering the financial analysis, Renata’s financial liquidity is not very satisfactory and could have been improved further if management is prudent on financial strategy settings. Findings of the business analysis indicate that Renata Limited would be a good investment choice for existing and prospective shareholders based on its opportunities for long term and short term growth and further expansion in developing the market. The results suggest that even lower liquidity coupled with higher interest borrowings can be balanced by posing positive picture to the public shareholders by returning the positive dividend to them.

scholarly journals The New SWOT for a Sustainable World

2021 ◽  
Vol 7 (1) ◽  
pp. 18
Author(s):  
Leandro Pereira ◽  
Miguel Pinto ◽  
Renato Lopes da Costa ◽  
Álvaro Dias ◽  
Rui Gonçalves
Keyword(s):  
Open Innovation ◽  
Swot Analysis ◽  
Business Environment ◽  
Short Term ◽  
The Core ◽  
Essential Tool ◽  
Management Positions ◽  
Forward Looking

In today’s complex and changing business environment the concern with sustainability has gained more notoriety. However, companies still do not have a sustainable perspective, but a short-term one, where their values are constantly forgotten and this concept is no longer welcomed. This research demonstrates the need for companies to adapt and to start acting in this direction. Following a set of interviews conducted with professionals with management positions of high responsibility, findings reveal that although sustainability is on the management mind, strategies and tools need to be adapted to be at the core of the organization’s strategic formulation. To support this process, a new SWOT analysis to fit a forward-looking sustainable world is proposed. Furthermore, due to the aggregative nature of the model, it represents an essential tool for an open innovation. “SWOT i” integrates the concern with sustainability as one of its pillars, placing the values and impacts that each decision can have at the center of the strategic formulation, allowing their performance to leverage.

Flavonoids in seeds and grains: physiological function, agronomic importance and the genetics of biosynthesis

1998 ◽  
Vol 8 (4) ◽  
pp. 415-422 ◽  
Author(s):  
Brenda Winkel Shirley
Keyword(s):  
Secondary Metabolites ◽  
Condensed Tannins ◽  
Physiological Function ◽  
Animal Feed ◽  
Molecular Genetic ◽  
Flavonoid Biosynthesis ◽  
Human Consumption ◽  
Genetic Studies ◽  
Plant Seeds ◽  
Reproductive Structures

AbstractFlavonoids are secondary metabolites that are present at high levels in most plant seeds and grains. These compounds appear to play vital roles in defence against pathogens and predators and contribute to physiological functions such as seed maturation and dormancy. At the same time, particular subclasses of flavonoids, such as the proanthocyanidins (condensed tannins), negatively impact the use of seeds and grains in animal feed and can add undesirable qualities to food products for human consumption. This article presents an overview of investigations into the physiological and agronomic aspects of seed and grain flavonoids as well as a review of molecular genetic studies, particularly in maize,Arabidopsisand soybean, where mutants deficient in flavonoid biosynthesis provide useful tools for stydying the metabolic machinery underlying the accumulation of these compounds in reproductive structures.

Influence of immunosuppressive regimens on short-term morbidity and mortality in heart transplantation

2007 ◽  
Vol 0 (0) ◽  
pp. 070806210014002-???
Author(s):  
Jaime Aguero ◽  
Luis Almenar ◽  
Luis Martínez-Dolz ◽  
Jose A Moro ◽  
Joaquin Rueda ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Morbidity And Mortality ◽  
Short Term

scholarly journals Preoperative cigarette smoking and short-term morbidity and mortality after cardiac surgery: a meta-analysis

Heart Asia ◽  
2018 ◽  
Vol 10 (2) ◽  
pp. e011069 ◽  
Author(s):  
Nicholas Gregory Ross Bayfield ◽  
Adrian Pannekoek ◽  
David Hao Tian
Keyword(s):  
Cardiac Surgery ◽  
Smoking Status ◽  
Meta Analysis ◽  
Surgical Site Infections ◽  
Neurological Complications ◽  
Pulmonary Complications ◽  
Morbidity And Mortality ◽  
Surgical Patients ◽  
Short Term ◽  
Increased Risk

Currently, the choice of whether or not to electively operate on current smokers is varied among cardiothoracic surgeons. This meta-analysis aims to determine whether preoperative current versus ex-smoking status is related to short-term postoperative morbidity and mortality in cardiac surgical patients. Systematic literature searches of the PubMed, MEDLINE and Cochrane databases were carried out to identify all studies in cardiac surgery that investigated the relationship between smoking status and postoperative outcomes. Extracted data were analysed by random effects models. Primary outcomes included 30-day or in-hospital all-cause mortality and pulmonary morbidity. Overall, 13 relevant studies were identified, with 34 230 patients in current or ex-smoking subgroups. There was no difference in mortality (p=0.93). Current smokers had significantly higher risk of overall pulmonary complications (OR 1.44; 95% CI 1.27 to 1.64; p<0.001) and postoperative pneumonia (OR 1.62; 95%  CI 1.27 to 2.06; p<0.001) as well as lower risk of postoperative renal complications (OR 0.82; 95%  CI 0.70 to 0.96; p=0.01) compared with ex-smokers. There was a trend towards an increased risk of postoperative MI (OR 1.29; 95%  CI 0.95 to 1.75; p=0.10). No difference in postoperative neurological complications (p=0.15), postoperative sternal surgical site infections (p=0.20) or postoperative length of intensive care unit stay (p=0.86) was seen. Cardiac surgical patients who are current smokers at the time of operation do not have an increased 30-day mortality risk compared with ex-smokers, although they are at significantly increased risk of postoperative pulmonary complications.

scholarly journals Analisis Peluang Penyertaan Modal Pemerintah Daerah Kota XYZ pada PT Bank Jawa Barat dan Banten (Bank BJB)

2016 ◽  
Vol 2 (1) ◽  
pp. 54
Author(s):  
Dian Yudo Palupi ◽  
Farida Ratna Dewi ◽  
R. Dikky Indrawan
Keyword(s):  
Swot Analysis ◽  
Financial Analysis ◽  
Risk Exposure ◽  
Regional Government ◽  
Government Bond ◽  
Short Term ◽  
Small Risk ◽  
Short Term Investment ◽  
Stock Share

Economic growth and public welfare are the reason of regional autonomy regulation policy (UU No 22 year 1999). The policy allows regional economic resources managed by regional government to achieve its goal. One of the regional government strategies is investment strategy, which in this case investing in banking industry. The purposes of the study are 1) to identify the investment regulation on regional government 2) to identify the Bank BJB business and investment environment 3) to identify the comparison of investment feasibility on Bank BJB versus other banks 4) to identify the position of Stock Share A series owned by XYZ at Bank BJB. The data collection methods are using structured interview, in depth interview, field survey and literature study. The analysis tools are using institutional analysis, SWOT analysis and financial analysis. Institutional analysis showed XYZ regional government investment management is limited to regulation as follow 1) long term capital (stock share) investment limited only at BUMD (e.g. Bank BJB) 2) short term investment e.g. saving and deposit is limited only at healthy and feasible bank, and government bond which has small risk exposure. The financial analysis also showed the increasing performance of BJB Earning per Share (EPS) and Return on Equity (ROE) from 2006 until 2010. The SWOT analysis support other analysis that BJB Bank position in financial industry is suitable for long term and short term investment for XYZ regional government. Base on explanation above, the conclusions are the autonomy regulation limited XYZ regional government to invest as shareholders in A series (stock share) or B series (stock share) at BJB Bank only, and for short term investment is limited only at healthy and feasible bank, and government bond which has small risk exposure.

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