scholarly journals What shapes public attitudes towards assisted reproduction technologies?

2018 ◽  
Author(s):  
Maja Djundeva ◽  
Ivett Szalma
Keyword(s):  
In Vitro Fertilization ◽  
Assisted Reproduction ◽  
Artificial Insemination ◽  
Fixed Effects ◽  
Age At First Birth ◽  
Vitro Fertilization ◽  
Country Level ◽  
Assisted Reproduction Technologies ◽  
The Impact

This paper contributes to the literature on social acceptance of artificial insemination and in-vitro fertilization, the two most prominent examples of Assisted Reproduction Technologies (ART) in Europe and direct attention to several previously under-researched aspects. The empirical base of this study is the fourth round of the European Values Study (EVS), conducted in 2008-2010 in 43 countries. Using multilevel fixed-effects linear regressions, we examine the impact of several individual and country-level characteristics on the agreement level with the statement that artificial insemination or in-vitro fertilization can always be justified, never be justified or something in between. According to our findings there are strong relationships between attitudes towards ART and socio-demographic variables, as well as religiousness and individual attitudes such as traditional family formation practices, "justification of homosexuality", (non-)preference for homosexual neighbours and acceptance of adoption by homosexual couples. As for the country level variables we found significant effect in case of those variables which are related to social changes within the concept Second Demographic Transitions such as mean age at first birth and secularization but GDP did not have any significant effects.

scholarly journals Reproductive aspects of the male jaguar (Panthera onca): A review

2021 ◽  
Author(s):  
E. López-Pérez ◽  
F. Cortés-Villavicencio ◽  
C. Muñoz-García ◽  
J. Gallegos-Sánchez ◽  
Alejandro Ávalos-Rodríguez
Keyword(s):  
In Vitro Fertilization ◽  
Assisted Reproduction ◽  
Reproductive System ◽  
Artificial Insemination ◽  
Relevant Information ◽  
Panthera Onca ◽  
Leopardus Pardalis ◽  
Assisted Reproduction Techniques ◽  
Vitro Fertilization

Objective: To describe the anatomy, morphology and physiology of the reproductive system of male jaguars, as well as assisted reproduction techniques. Methodology: A literature review on the anatomy and morphology of the jaguar´s reproductive system, its physiological characteristics and assisted reproduction techniques were carried out to document relevant information on the topic. Results: With this review, basic aspects of the morphology of the reproductive system of the jaguars are disclosed, although scarce knowledge is available on their reproduction. The advances in the collection, evaluation and cryopreservation of semen of this feline are shown, in addition to assisted reproduction techniques such as artificial insemination and in vitro fertilization, which have a great potential to safeguard the species. Study limitations: The jaguar, an emblematic species of Latinamerica, is an endangered species, like other wild felids species as ocelot (Leopardus pardalis) and margay (Leopardus wiedii), which makes it necessary to have a national assisted reproduction program. However, for this to be possible, information about their reproductive physiology is necessary, which is complicated in wild animals and even more so because the reproductive mechanisms greatly differ between felids species. There is scarce information in this regard from its free-living or Mexican zoos, it is for this reason necessary to generate such information. Conclusions: It is necessary to continue working on designing protocols for artificial insemination and other assisted reproduction techniques such as in-vitro fertilization specifically for male Panthera onca.

Assisted Reproduction and Reproductive Rights: The Case of In Vitro Fertilization

1997 ◽  
Vol 16 (2) ◽  
pp. 279-288 ◽  
Author(s):  
Robert H. Blank
Keyword(s):  
In Vitro Fertilization ◽  
Assisted Reproduction ◽  
Reproductive Rights ◽  
Full Range ◽  
Current Data ◽  
Rapid Expansion ◽  
Vitro Fertilization ◽  
Assisted Reproduction Technologies ◽  
Fertility Problems

In vitro fertilization (IVF) and other assisted reproduction technologies (ARTs) have become widely accepted as therapy for a wide array of fertility problems and accompanied by the rapid expansion of clinics that provide a full range of ARTs. Although these technologies undoubtedly offer benefits for some individuals, they raise important questions over reproductive rights to safe and effective treatment as well as access. This article analyzes current data concerning the safety, effectiveness, and cost of IVF. It concludes that IVF and related techniques have been transformed too rapidly and easily from experimental to therapy status, despite evidence that suggests considerable caution is warranted. Unfortunately, the widespread diffusion of IVF has preceded rather than followed firm evidence of its value in extending the reproductive rights of women and couples. Resources might better be directed toward prevention of fertility problems and discovering the causes of infertility.

P4467PCSK9 and Lp(a) levels of children born after assisted reproduction technologies: results from a pilot study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
I Koutagiar ◽  
C Vlachopoulos ◽  
D Terentes-Printzios ◽  
I Kosteria ◽  
S Sakka ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Assisted Reproduction ◽  
Age Groups ◽  
Blood Lipid ◽  
Blood Lipid Profile ◽  
Vitro Fertilization ◽  
Assisted Reproduction Technologies ◽  
Patient Series ◽  
The Impact

Abstract Background Since the introduction of Assisted Reproduction Technologies (ART) in clinical practice several studies have addressed concerns regarding the long-term health of the offspring and have revealed indications of an adverse cardiovascular/cardiometabolic outcome. Proprotein convertase subtilisin/kexin type 9 (PCSK9) and lipoprotein (a) (Lp[a]) levels have been associated with cardiovascular risk. Purpose To investigate PCSK9 and Lp(a) levels of children born after ART compared with naturally conceived (NC) controls. Methods In this case-control study, 73 sex- and age-matched children (mean age 98±35 months) of ART (intracytoplasmic sperm injection [ICSI]: n=33, classic in vitro fertilization [IVF]: n=40) and 73 NC children were assessed. Blood lipid profile, including PCSK9 and Lp(a) levels, was measured. Children were grouped according to age (<8 years, 8–10 years, ≥10 years). Results In the univariate model of the overall population, circulating PCSK9 levels were related to total cholesterol (r=0.186, P=0.025), LDL-C (r=0.180, P=0.029) and SBP (r=0.199, P=0.021). Similarly, circulating Lp(a) levels were related to age (r=0.269, P=0.001), apoB (r=0.214, P=0.01), birth weight (r=−0.183, P=0.037), height (r=0.263, P=0.001), waist-to-hip ratio (r=−0.350, P<0.001), HOMA-IR (r=0.319, P<0.001), insulin (r=0.316, P<0.001), and hsCRP (ρ=0.241, P=0.018). No significant differences were observed regarding lipid biomarkers between ART and NC children. (p=0.515 for PCSK9 and p=0.277 for Lp(a) values). It is noteworthy that a significant interaction was found between age groups and conception method (P<0.001) showing that PCSK9 levels increase with age in ART children, while they decline with age in NC offspring (Figure 1). IVF children showed higher levels of adjusted mean Lp(a) than ICSI (13.5 vs. 6.8 mg/dl, P=0.010) and NC children (12.3 vs. 8.3 mg/dl, P=0.048). Mean LogPCSK9 concentrations with the st Conclusions PCSK9 and Lp(a) levels did not differ between ART and NC children. Nonetheless, PCSK9 levels increase with age in ART children indicating a gradual deterioration of lipidemic profile that could lead to increased cardiovascular risk. Moreover, our results imply that ART method may be of importance given that classic IVF is associated with higher levels of Lp(a). The impact of the method of conception on PCSK9 and Lp(a) values should be validated in larger patient series.

scholarly journals Individualized embryo selection strategy developed by stacking machine learning model for better in vitro fertilization outcomes: an application study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Qingsong Xi ◽  
Qiyu Yang ◽  
Meng Wang ◽  
Bo Huang ◽  
Bo Zhang ◽  
...  
Keyword(s):  
Machine Learning ◽  
In Vitro Fertilization ◽  
Endometrial Thickness ◽  
Learning System ◽  
Embryo Selection ◽  
Selection Strategy ◽  
Application Study ◽  
Vitro Fertilization ◽  
The Impact

Abstract Background To minimize the rate of in vitro fertilization (IVF)- associated multiple-embryo gestation, significant efforts have been made. Previous studies related to machine learning in IVF mainly focused on selecting the top-quality embryos to improve outcomes, however, in patients with sub-optimal prognosis or with medium- or inferior-quality embryos, the selection between SET and DET could be perplexing. Methods This was an application study including 9211 patients with 10,076 embryos treated during 2016 to 2018, in Tongji Hospital, Wuhan, China. A hierarchical model was established using the machine learning system XGBoost, to learn embryo implantation potential and the impact of double embryos transfer (DET) simultaneously. The performance of the model was evaluated with the AUC of the ROC curve. Multiple regression analyses were also conducted on the 19 selected features to demonstrate the differences between feature importance for prediction and statistical relationship with outcomes. Results For a single embryo transfer (SET) pregnancy, the following variables remained significant: age, attempts at IVF, estradiol level on hCG day, and endometrial thickness. For DET pregnancy, age, attempts at IVF, endometrial thickness, and the newly added P1 + P2 remained significant. For DET twin risk, age, attempts at IVF, 2PN/ MII, and P1 × P2 remained significant. The algorithm was repeated 30 times, and averaged AUC of 0.7945, 0.8385, and 0.7229 were achieved for SET pregnancy, DET pregnancy, and DET twin risk, respectively. The trend of predictive and observed rates both in pregnancy and twin risk was basically identical. XGBoost outperformed the other two algorithms: logistic regression and classification and regression tree. Conclusion Artificial intelligence based on determinant-weighting analysis could offer an individualized embryo selection strategy for any given patient, and predict clinical pregnancy rate and twin risk, therefore optimizing clinical outcomes.

scholarly journals The Effect of Stress, Anxiety and Depression on In Vitro Fertilization Outcome in Kazakhstani Public Clinical Setting: A Cross-Sectional Study

2021 ◽  
Vol 10 (5) ◽  
pp. 937
Author(s):  
Gauri Bapayeva ◽  
Gulzhanat Aimagambetova ◽  
Alpamys Issanov ◽  
Sanja Terzic ◽  
Talshyn Ukybassova ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Depressed Mood ◽  
Depression Scale ◽  
Anxiety Scale ◽  
Clinical Depression ◽  
Cross Sectional ◽  
Vitro Fertilization ◽  
Scale Scores ◽  
The Impact

Although it is clear that infertility leads to heightened stress for patients, the impact of depressed mood and anxiety on treatment outcome is inconsistently reported. The aim of this study was to evaluate the effect of stress, depression and anxiety on in vitro fertilization (IVF) outcomes in Kazakhstani public assisted reproductive technology (ART) clinics. The prospective cohort study was performed between June 2019 and September 2020 using questionnaires to assess psychological stress, depressed mood and anxiety in women referred to IVF clinics in two public clinical centers in Kazakhstan, Nur-Sultan and Aktobe. Our study sample comprised 142 women with the average age of 33.9 ± 4.9 years, and infertility duration 6.0 ± 3.5 years. More than half of respondents had Center for Epidemiological Studies Depression Scale (CES-D) scores higher than 16, indicating their risk of developing clinical depression. Ninety-one percent of women from Aktobe city were at risk for clinical depression (p < 0.001). Aktobe city respondents had higher stress subscale scores and anxiety scale scores (p < 0.001) than Nur-Sultan respondents. Statistical analysis showed that IVF outcome was not significantly associated with depression and stress, while the higher anxiety scale scores were negatively associated with clinical pregnancy after IVF.

scholarly journals Artificial insemination and in-vitro fertilization using donor spermatozoa: a report on 15 years of experience

1997 ◽  
Vol 12 (4) ◽  
pp. 722-726 ◽  
Author(s):  
G. N. Clarke ◽  
H. Bourne ◽  
P. Hill ◽  
W. I. Johnston ◽  
A. Speirs ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Artificial Insemination ◽  
Years Of Experience ◽  
Vitro Fertilization

scholarly journals Expression of mRNAs for Pro-and Anti-Apoptotic Factors in Granulosa Cells and Follicular Fluid of Women Undergoing in Vitro Fertilization. A Pilot Study

2021 ◽  
Author(s):  
Jozsef Bodis ◽  
Endre Sulyok ◽  
Akos Varnagy ◽  
Viktória Prémusz ◽  
Krisztina Godony ◽  
...  
Keyword(s):  
Gene Expression ◽  
In Vitro Fertilization ◽  
Mrna Expression ◽  
Granulosa Cells ◽  
Follicular Fluid ◽  
Vitro Fertilization ◽  
Expression Levels ◽  
The Impact ◽  
Apoptotic Factors

Abstract BackgroundThis observational clinical study evaluated the expression levels and predictive values of some apoptosis-related genes in granulosa cells (GCs) and follicular fluid (FF) of women undergoing in vitro fertilization (IVF).Methods GCs and FF were obtained at oocyte retrieval from 31 consecutive patients with heterogeneous infertility diagnosis (age: 34.3±5.8 years, body mass index: 24.02±3.12 kg/m2, duration of infertility: 4.2±2.1 years). mRNA expression of pro-apoptotic (BAX, CASP3, CASP8) and anti-apoptotic (BCL2, AMH, AMHR, FSHR, LHR, CYP19A1) factors was determined by quantitative RT-PCR using ROCHE LightCycler 480. Results No significant difference in GC or FF mRNA expression of pro- and anti-apoptotic factors could be demonstrated between IVF patients with (9 patients) or without (22 patients) clinical pregnancy. Each transcript investigated was detected in FF, but their levels were markedly reduced and independent of those in GCs. The number of retrieved oocytes was positively associated with GC AMHR (r=0.393, p=0.029), but the day of embryo transfer was negatively associated with GC LHR (r=-0.414, p=0.020) and GC FSHR transcripts (r=-0.535, p=0.002). When pregnancy positive group was analysed separately the impact of apoptosis- related gene expressions on some selected measures of IVF success could be observed. Strong positive relationship was found between gene expression levels of pro- and anti-apoptotic factors in GCs.ConclusionOur study provides only marginal evidences for the apoptosis dependence of IVF outcome and suggests that the apoptosis process induces adaptive increases of the anti-apoptotic gene expression to attenuate apoptosis and to protect cell survival.

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