scholarly journals Do androids dream of electric sorghum?: Predicting Phenotypes from Multi-Scale Genomic and Environmental Data using Neural Networks and Knowledge Graphs

2020 ◽  
Author(s):  
Ryan Bartelme ◽  
Michael Behrisch ◽  
Emily Jean Cain ◽  
Remco Chang ◽  
Ishita Debnath ◽  
...  

The interplay between an organism's genes, its environment, and the expressed phenotype is dynamic. These interactions within ecosystems are shaped by non-linear multi-scale effects that are difficult to disentangle into discrete components. In the face of anthropogenic climate chance, it is critical to understand environmental and genotypic influences on plant phenotypes and phenophase transitions. However, it is difficult to integrate and interoperate between these datasets. Advances in the fields of ontologies, unsupervised learning, and genomics may overcome the disparate data schema. Here we present a framework to better link phenotypes, environments, and genotypes of plant species across ecosystem scales. This approach utilizing phenotypic data, knowledge graphing, and deep learning, serves as the groundwork for a new scientific sub-discipline: “Computational Ecogenomics”

2020 ◽  
Author(s):  
Marie Déchelle-Marquet ◽  
Marina Levy ◽  
Patrick Gallinari ◽  
Michel Crepon ◽  
Sylvie Thiria

<p>Ocean currents are a major source of impact on climate variability, through the heat transport they induce for instance. Ocean climate models have quite low resolution of about 50 km. Several dynamical processes such as instabilities and filaments which have a scale of 1km have a strong influence on the ocean state. We propose to observe and model these fine scale effects by a combination of satellite high resolution SST observations (1km resolution, daily observations) and mesoscale resolution altimetry observations (10km resolution, weekly observations) with deep neural networks. Whereas the downscaling of climate models has been commonly addressed with assimilation approaches, in the last few years neural networks emerged as powerful multi-scale analysis method. Besides, the large amount of available oceanic data makes attractive the use of deep learning to bridge the gap between scales variability.</p><p>This study aims at reconstructing the multi-scale variability of oceanic fields, based on the high resolution NATL60 model of ocean observations at different spatial resolutions: low-resolution sea surface height (SSH) and high resolution SST. As the link between residual neural networks and dynamical systems has recently been established, such a network is trained in a supervised way to reconstruct the high variability of SSH and ocean currents at submesoscale (a few kilometers). To ensure the conservation of physical aspects in the model outputs, physical knowledge is incorporated into the deep learning models training. Different validation methods are investigated and the model outputs are tested with regards to their physical plausibility. The method performance is discussed and compared to other baselines (namely convolutional neural network). The generalization of the proposed method on different ocean variables such as sea surface chlorophyll or sea surface salinity is also examined.</p>


2019 ◽  
Vol 8 (4) ◽  
pp. 9771-9778

The concept of face recognition is in the emerging trends nowadays ,because of its wide application range .Usually ,the face recognition is used in the surveillance ,security and Here, Face recognition is used to allocate attendance for a candidate.Deep neural networks is a group of artificial intelligence entirely based on neural networks, because the algorithm will imitate the human brain, so deep learning can be a kind of imitation of the human brain.Local Binary Pattern (LBP) is a basic but also very advanced creaminess operator that names image pixels through thresholding every pixel's district and considers the outcome as just a binary number.If the recognised face is not authenticated or if unauthorised person is identified by the system ,it immediately alerts the server and the classroom door remains closed. In this project we have created our own database with faculty and students of our section using Logitech C270 HD camera with resolution of 720p/30fps


2018 ◽  
Author(s):  
William J. Godinez ◽  
Imtiaz Hossain ◽  
Xian Zhang

AbstractLarge-scale cellular imaging and phenotyping is a widely adopted strategy for understanding biological systems and chemical perturbations. Quantitative analysis of cellular images for identifying phenotypic changes is a key challenge within this strategy, and has recently seen promising progress with approaches based on deep neural networks. However, studies so far require either pre-segmented images as input or manual phenotype annotations for training, or both. To address these limitations, we have developed an unsupervised approach that exploits the inherent groupings within cellular imaging datasets to define surrogate classes that are used to train a multi-scale convolutional neural network. The trained network takes as input full-resolution microscopy images, and, without the need for segmentation, yields as output feature vectors that support phenotypic profiling. Benchmarked on two diverse benchmark datasets, the proposed approach yields accurate phenotypic predictions as well as compound potency estimates comparable to the state-of-the-art. More importantly, we show that the approach identifies novel cellular phenotypes not included in the manual annotation nor detected by previous studies.Author summaryCellular microscopy images provide detailed information about how cells respond to genetic or chemical treatments, and have been widely and successfully used in basic research and drug discovery. The recent breakthrough of deep learning methods for natural imaging recognition tasks has triggered the development and application of deep learning methods to cellular images to understand how cells change upon perturbation. Although successful, deep learning studies so far either can only take images of individual cells as input or require human experts to label a large amount of images. In this paper, we present an unsupervised deep learning approach that, without any human annotation, analyzes directly full-resolution microscopy images displaying typically hundreds of cells. We apply the approach to two benchmark datasets, and show that the approach identifies novel visual phenotypes not detected by previous studies.


2019 ◽  
Vol 20 (S16) ◽  
Author(s):  
Min Zeng ◽  
Min Li ◽  
Fang-Xiang Wu ◽  
Yaohang Li ◽  
Yi Pan

Abstract Background Essential proteins are crucial for cellular life and thus, identification of essential proteins is an important topic and a challenging problem for researchers. Recently lots of computational approaches have been proposed to handle this problem. However, traditional centrality methods cannot fully represent the topological features of biological networks. In addition, identifying essential proteins is an imbalanced learning problem; but few current shallow machine learning-based methods are designed to handle the imbalanced characteristics. Results We develop DeepEP based on a deep learning framework that uses the node2vec technique, multi-scale convolutional neural networks and a sampling technique to identify essential proteins. In DeepEP, the node2vec technique is applied to automatically learn topological and semantic features for each protein in protein-protein interaction (PPI) network. Gene expression profiles are treated as images and multi-scale convolutional neural networks are applied to extract their patterns. In addition, DeepEP uses a sampling method to alleviate the imbalanced characteristics. The sampling method samples the same number of the majority and minority samples in a training epoch, which is not biased to any class in training process. The experimental results show that DeepEP outperforms traditional centrality methods. Moreover, DeepEP is better than shallow machine learning-based methods. Detailed analyses show that the dense vectors which are generated by node2vec technique contribute a lot to the improved performance. It is clear that the node2vec technique effectively captures the topological and semantic properties of PPI network. The sampling method also improves the performance of identifying essential proteins. Conclusion We demonstrate that DeepEP improves the prediction performance by integrating multiple deep learning techniques and a sampling method. DeepEP is more effective than existing methods.


Author(s):  
Antonio Greco ◽  
Alessia Saggese ◽  
Mario Vento ◽  
Vincenzo Vigilante

AbstractIn the era of deep learning, the methods for gender recognition from face images achieve remarkable performance over most of the standard datasets. However, the common experimental analyses do not take into account that the face images given as input to the neural networks are often affected by strong corruptions not always represented in standard datasets. In this paper, we propose an experimental framework for gender recognition “in the wild”. We produce a corrupted version of the popular LFW+ and GENDER-FERET datasets, that we call LFW+C and GENDER-FERET-C, and evaluate the accuracy of nine different network architectures in presence of specific, suitably designed, corruptions; in addition, we perform an experiment on the MIVIA-Gender dataset, recorded in real environments, to analyze the effects of mixed image corruptions happening in the wild. The experimental analysis demonstrates that the robustness of the considered methods can be further improved, since all of them are affected by a performance drop on images collected in the wild or manually corrupted. Starting from the experimental results, we are able to provide useful insights for choosing the best currently available architecture in specific real conditions. The proposed experimental framework, whose code is publicly available, is general enough to be applicable also on different datasets; thus, it can act as a forerunner for future investigations.


Information ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 191
Author(s):  
Wenting Liu ◽  
Li Zhou ◽  
Jie Chen

Face recognition algorithms based on deep learning methods have become increasingly popular. Most of these are based on highly precise but complex convolutional neural networks (CNNs), which require significant computing resources and storage, and are difficult to deploy on mobile devices or embedded terminals. In this paper, we propose several methods to improve the algorithms for face recognition based on a lightweight CNN, which is further optimized in terms of the network architecture and training pattern on the basis of MobileFaceNet. Regarding the network architecture, we introduce the Squeeze-and-Excitation (SE) block and propose three improved structures via a channel attention mechanism—the depthwise SE module, the depthwise separable SE module, and the linear SE module—which are able to learn the correlation of information between channels and assign them different weights. In addition, a novel training method for the face recognition task combined with an additive angular margin loss function is proposed that performs the compression and knowledge transfer of the deep network for face recognition. Finally, we obtained high-precision and lightweight face recognition models with fewer parameters and calculations that are more suitable for applications. Through extensive experiments and analysis, we demonstrate the effectiveness of the proposed methods.


2009 ◽  
Vol 8 (3) ◽  
pp. 887-897
Author(s):  
Vishal Paika ◽  
Er. Pankaj Bhambri

The face is the feature which distinguishes a person. Facial appearance is vital for human recognition. It has certain features like forehead, skin, eyes, ears, nose, cheeks, mouth, lip, teeth etc which helps us, humans, to recognize a particular face from millions of faces even after a large span of time and despite large changes in their appearance due to ageing, expression, viewing conditions and distractions such as disfigurement of face, scars, beard or hair style. A face is not merely a set of facial features but is rather but is rather something meaningful in its form.In this paper, depending on the various facial features, a system is designed to recognize them. To reveal the outline of the face, eyes, ears, nose, teeth etc different edge detection techniques have been used. These features are extracted in the term of distance between important feature points. The feature set obtained is then normalized and are feed to artificial neural networks so as to train them for reorganization of facial images.


2020 ◽  
Author(s):  
Dean Sumner ◽  
Jiazhen He ◽  
Amol Thakkar ◽  
Ola Engkvist ◽  
Esben Jannik Bjerrum

<p>SMILES randomization, a form of data augmentation, has previously been shown to increase the performance of deep learning models compared to non-augmented baselines. Here, we propose a novel data augmentation method we call “Levenshtein augmentation” which considers local SMILES sub-sequence similarity between reactants and their respective products when creating training pairs. The performance of Levenshtein augmentation was tested using two state of the art models - transformer and sequence-to-sequence based recurrent neural networks with attention. Levenshtein augmentation demonstrated an increase performance over non-augmented, and conventionally SMILES randomization augmented data when used for training of baseline models. Furthermore, Levenshtein augmentation seemingly results in what we define as <i>attentional gain </i>– an enhancement in the pattern recognition capabilities of the underlying network to molecular motifs.</p>


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