scholarly journals Study-protocol of the COMPARE-Interaction study: The impact of maternal comorbid depression and anxiety disorders in the peripartum period on child development

2021 ◽  
Author(s):  
Anna-Lena Zietlow ◽  
Christian Franz Josef Woll ◽  
Nora Nonnenmacher ◽  
Mitho Müller ◽  
Verena Labonte ◽  
...  
Keyword(s):  
Child Development ◽  
Anxiety Disorders ◽  
Emotional Development ◽  
Depressive Disorders ◽  
Stress Reactivity ◽  
Parental Psychopathology ◽  
Externalizing Disorders ◽  
Comorbid Anxiety ◽  
Maternity Hospitals ◽  
The Impact

Introduction:To date, there are only few studies which compare the consequences of peripartum maternal depressive disorders (PD) versus depressive with comorbid anxiety disorders (PDCA) for infant and child development. As comorbidity is associated with greater impairment and symptom severity related to the primary diagnosis, comorbidity in mothers might raise their offspring’s risk of developing internalizing or externalizing disorders even more than has been noted in conjunction with PD alone.Methods and analysis:This study aims to analyse the impact of parental psychopathology, particularly peripartum depression in mothers with and without comorbid anxiety disorders according to DSM-5, on child cognitive and socio-emotional development. Maternal/paternal psychopathology, mother/father-infant-interaction, and child development are assessed at four measurement points over the first 2 years (T1: 3–4 months postpartum, T2: 12 months postpartum, T3: 18 months postpartum, and T4: 24 months postpartum). The mediating role of mother/father-infant-interaction and infant stress reactivity in the relationship between PD/PDCA and infant cognitive and socio-emotional development will be analysed.In the ongoing study N=174 families (n=58 mothers with PD, n=58 mothers with PDCA, and n=58 healthy controls) will be recruited in inpatient and outpatient centres as well as maternity hospitals in Munich and Heidelberg.

scholarly journals Affective modulation of the startle response among children at high and low risk for anxiety disorders

2015 ◽  
Vol 45 (12) ◽  
pp. 2647-2656 ◽  
Author(s):  
A. Kujawa ◽  
C. R. Glenn ◽  
G. Hajcak ◽  
D. N. Klein
Keyword(s):  
Anxiety Disorders ◽  
Startle Response ◽  
Depressive Disorders ◽  
Parental Psychopathology ◽  
Affective Modulation ◽  
Early Markers ◽  
History Of ◽  
Picture Viewing ◽  
Underlying Mechanisms ◽  
Development Of Anxiety

BackgroundIdentifying early markers of risk for anxiety disorders in children may aid in understanding underlying mechanisms and informing prevention efforts. Affective modulation of the startle response indexes sensitivity to pleasant and unpleasant environmental contexts and has been shown to relate to anxiety, yet the extent to which abnormalities in affect-modulated startle reflect vulnerability for anxiety disorders in children has yet to be examined. The current study assessed the effects of parental psychopathology on affective modulation of startle in offspring.MethodNine-year-old children (n = 144) with no history of anxiety or depressive disorders completed a passive picture viewing task in which eye-blink startle responses were measured during the presentation of pleasant, neutral, and unpleasant images.ResultsMaternal anxiety was associated with distinct patterns of affective modulation of startle in offspring, such that children with maternal histories of anxiety showed potentiation of the startle response while viewing unpleasant images, but not attenuation during pleasant images, whereas children with no maternal history of anxiety exhibited attenuation of the startle response during pleasant images, but did not exhibit unpleasant potentiation – even when controlling for child symptoms of anxiety and depression. No effects of maternal depression or paternal psychopathology were observed.ConclusionsThese findings suggest that both enhanced startle responses in unpleasant conditions and failure to inhibit startle responses in pleasant conditions may reflect early emerging vulnerabilities that contribute to the later development of anxiety disorders.

Comorbidity of ADHD and Anxiety Disorders in School-Age Children: Impact on Sleep and Response to a Cognitive-Behavioral Treatment

2015 ◽  
Vol 22 (5) ◽  
pp. 414-424 ◽  
Author(s):  
Maxime Bériault ◽  
Lyse Turgeon ◽  
Mélanie Labrosse ◽  
Claude Berthiaume ◽  
Martine Verreault ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Sleep Disturbances ◽  
Behavioral Treatment ◽  
Sleep Onset ◽  
Cognitive Behavioral ◽  
Sleep Onset Latency ◽  
Sleep Habits ◽  
Children With Adhd ◽  
Comorbid Anxiety ◽  
The Impact

Objective: This exploratory study measured the impact of comorbid anxiety disorders on sleep in children with ADHD and tested the effect of cognitive-behavioral therapy (CBT) on these measures. Method: Fifty-seven children (8-12 years old) were assessed with the Child Sleep Habits Questionnaire. Four groups were formed: ADHD ( n = 20), ADHD + Anxiety ( n = 20), Anxiety ( n = 8), and Healthy Controls ( n = 9). A subgroup of 10 children with ADHD + Anxiety underwent CBT for anxiety. Results: The results showed that sleep difficulties were better associated with anxiety than with ADHD. CBT reduced sleep onset latency and marginally decreased the total amount of sleep problems. Conclusion: The present study demonstrates that comorbid anxiety in ADHD children is linked with specific sleep disturbances and is sensitive to CBT aimed at reducing anxiety.

Adolescent Outcome of ADHD: Impact of Childhood Conduct and Anxiety Disorders

CNS Spectrums ◽  
2004 ◽  
Vol 9 (9) ◽  
pp. 668-678 ◽  
Author(s):  
Jeffrey H. Newcorn ◽  
Scott R. Miller ◽  
Iliyan Ivanova ◽  
Kurt P. Schulz ◽  
Jessica Kalmar ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Anxiety Disorders ◽  
Child Behavior Checklist ◽  
Social Problems ◽  
Self Report ◽  
Comorbid Condition ◽  
Behavioral Outcome ◽  
Comorbid Anxiety ◽  
The Impact ◽  
Adolescent Outcome

ABSTRACTObjective: This study examines the impact of comorbidity of attention-deficit/hyperactivity disorder (ADHD) with disruptive and anxiety disorders in childhood on clinical course and outcome. We consider the relative contribution of each comorbid symptom constellation, and also their interaction, to assess the following questions: (1) Does early comorbidity with conduct disorder (CD) and anxiety disorders define specific developmental trajectories?; (2) Is comorbid anxiety disorders in childhood continuous with anxiety disorders in adolescence?; (3) Does comorbid anxiety disorders mitigate the negative behavioral outcome of youth with ADHD?; and (4) Is there an interaction between comorbid CD and anxiety disorders, when they occur simultaneously, that predicts a different outcome than either comorbid condition alone?Method: Thirty-two 15- to 18-year-old adolescent males, diagnosed with ADHD between 7 and 11 years of age, were re-evaluated for assessment of adolescent outcome 4.3–9.2 years later. Hierarchical regression analyses were run with each of the eight Child Behavior Checklist and Youth Self-Report problem scales, and the four anxiety symptom subscales of the Multidimensional Anxiety Scale for Children serving as outcome variables.Results: Findings indicate that comorbid CD at baseline predicteds parent reports of behavior problems in adolescence, while comorbid anxiety disorders in childhood predicted youth reports of anxiety and social problems. Anxiety disorders without CD did not predict poor behavioral outcome. Children with both comorbid CD and anxiety disorder had the highest levels of parent-rated symptoms on follow up. In particular, adolescent social problems were best predicted by the combination of comorbid CD and anxiety disorder in childhood.Conclusion: These data provide evidence that children with ADHD plus anxiety disorder do in fact have anxiety disorders, and that the combination of anxiety disorder and CD predicts a more rather than less severe course.

scholarly journals The impact of postpartum post-traumatic stress disorder symptoms on child development: a population-based, 2-year follow-up study

2016 ◽  
Vol 47 (1) ◽  
pp. 161-170 ◽  
Author(s):  
S. Garthus-Niegel ◽  
S. Ayers ◽  
J. Martini ◽  
T. von Soest ◽  
M. Eberhard-Gran
Keyword(s):  
Child Development ◽  
Emotional Development ◽  
Population Based ◽  
Infant Temperament ◽  
Ptsd Symptoms ◽  
Social Emotional Development ◽  
Post Traumatic Stress ◽  
Social Emotional ◽  
Postpartum Ptsd ◽  
The Impact

BackgroundAgainst the background of very limited evidence, the present study aimed to prospectively examine the impact of maternal postpartum post-traumatic stress disorder (PTSD) symptoms on four important areas of child development, i.e. gross motor, fine motor, communication and social–emotional development.MethodThis study is part of the large, population-based Akershus Birth Cohort. Data from the hospital's birth record as well as questionnaire data from 8 weeks and 2 years postpartum were used (n = 1472). The domains of child development that were significantly correlated with PTSD symptoms were entered into regression analyses. Interaction analyses were run to test whether the influence of postpartum PTSD symptoms on child development was moderated by child sex or infant temperament.ResultsPostpartum PTSD symptoms had a prospective relationship with poor child social–emotional development 2 years later. This relationship remained significant even when adjusting for confounders such as maternal depression and anxiety or infant temperament. Both child sex and infant temperament moderated the association between maternal PTSD symptoms and child social–emotional development, i.e. with increasing maternal PTSD symptom load, boys and children with a difficult temperament were shown to have comparatively higher levels of social–emotional problems.ConclusionsExamining four different domains of child development, we found a prospective impact of postpartum PTSD symptoms on children's social–emotional development at 2 years of age. Our findings suggest that both boys and children with an early difficult temperament may be particularly susceptible to the adverse impact of postpartum PTSD symptoms. Additional studies are needed to further investigate the mechanisms at work.

Cognitive behavioural therapy for anxiety disorders and insomnia: a commentary on future directions

2014 ◽  
Vol 7 ◽  
Author(s):  
Kristin M. Aho ◽  
Scott M. Pickett ◽  
Timothy S. Hamill
Keyword(s):  
Anxiety Disorders ◽  
Behavioural Therapy ◽  
Current Data ◽  
Future Research ◽  
Post Traumatic Stress ◽  
Similar Treatment ◽  
Comorbid Anxiety ◽  
Panic Disorders ◽  
Underlying Mechanisms ◽  
The Impact

AbstractAnxiety disorders and insomnia significantly impair daily functioning. Similar underlying mechanisms may account for the high comorbidity of both disorders, and respective treatments share pharmacological and behavioural features. This review suggests the utility of an integrated CBT approach in the treatment of generalized anxiety, post-traumatic stress, and panic disorders, and comorbid insomnia. Other anxiety disorders were not explored because current data are limited or inconsistent. A comprehensive, non-systematic review of the literature was conducted to evaluate the treatment of comorbid anxiety and insomnia disorders, and data reveal shared pharmacological and behavioural features of insomnia and anxiety disorders treatment. However, research demonstrates that CBT maintains successful treatment results longer than drug therapies. Despite similar treatment approaches, there is a paucity of research that explores integrated CBT approaches for comorbid anxiety and insomnia disorders. This review suggests that future research should assess the impact of combined therapeutic approaches on the simultaneous reduction of anxiety disorders, insomnia, and relapse rates.

scholarly journals Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders

2006 ◽  
Vol 189 (1) ◽  
pp. 20-25 ◽  
Author(s):  
Michael W. Otto ◽  
Naomi M. Simon ◽  
Stephen R. Wisniewski ◽  
David J. Miklowitz ◽  
Jane N. Kogan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bipolar Disorder ◽  
Anxiety Disorders ◽  
Negative Impact ◽  
Mood State ◽  
Comorbid Anxiety ◽  
Depression Risk ◽  
The Impact ◽  
A Current

BackgroundThe impact of anxiety disorders has not been well delineated in prospective studies of bipolar disorder.AimsTo examine the association between anxiety and course of bipolar disorder, as defined by mood episodes, quality of life and role functioning.MethodA thousand out-patients with bipolar disorder were followed prospectively for 1 year.ResultsA current comorbid anxiety disorder (present in 31.9% of participants) was associated with fewer days well, a lower likelihood of timely recovery from depression, risk of earlier relapse, lower quality of life and diminished role function over 1 year of prospective study. The negative impact was greater with multiple anxiety disorders.ConclusionsAnxiety disorders, including those present during relative euthymia, predicted a poorer bipolar course. The detrimental effects of anxiety were not simply a feature of mood state. Treatment studies targeting anxiety disorders will help to clarify the nature of the impact of anxiety on bipolar course.

Familial confounding of the association between maternal smoking during pregnancy and internalizing disorders in offspring

2017 ◽  
Vol 47 (8) ◽  
pp. 1417-1426 ◽  
Author(s):  
S. M. Meier ◽  
K. J. Plessen ◽  
F. Verhulst ◽  
O. Mors ◽  
P. B. Mortensen ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Maternal Smoking ◽  
Depressive Disorders ◽  
Cox Regression ◽  
Severe Depression ◽  
Internalizing Disorders ◽  
Externalizing Disorders ◽  
Smoking During Pregnancy ◽  
Increased Risk ◽  
Maternal Smoking During Pregnancy

BackgroundMaternal smoking has consistently been associated with multiple adverse childhood outcomes including externalizing disorders. In contrast the association between maternal smoking during pregnancy (MSDP) and internalizing (anxiety and depressive) disorders in offspring has received less investigation.MethodWe conducted a nationwide cohort study including 957635 individuals born in Denmark between 1991 and 2007. Data on MSDP and diagnoses of depression or anxiety disorders were derived from national registers and patients were followed up from the age of 5 years to the end of 2012. Hazard rate ratios (HRRs) were estimated using stratified Cox regression models. Sibling data were used to disentangle individual- and familial-level effects of MSDP and to control for unmeasured familial confounding.ResultsAt the population level, offspring exposed to MSDP were at increased risk for both severe depression [HRR 1.29, 95% confidence interval (CI) 1.22–1.36] and severe anxiety disorders (HRR 1.26, 95% CI 1.20–1.32) even when controlling for maternal and paternal traits. However, there was no association between MSDP and internalizing disorders when controlling for the mother's propensity for MSDP (depression: HRR 1.11, 95% CI 0.94–1.30; anxiety disorders: HRR 0.94, 95% CI 0.80–1.11) or comparing differentially exposed siblings (depression: HRR 1.18, 95% CI 0.75–1.89; anxiety disorders: HRR 0.87, 95% CI 0.55–1.36).ConclusionsThe results suggest that familial background factors account for the association between MSDP and severe internalizing disorders not the specific exposure to MSDP.

scholarly journals Mediation model of comorbid anxiety disorders in late-life depression

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Chawisa Suradom ◽  
Nahathai Wongpakaran ◽  
Tinakon Wongpakaran ◽  
Peerasak Lerttrakarnnon ◽  
Surin Jiraniramai ◽  
...  
Keyword(s):  
Family History ◽  
Anxiety Disorders ◽  
Depressive Disorders ◽  
Psychiatric History ◽  
Depression Severity ◽  
Late Life Depression ◽  
Comorbid Anxiety ◽  
History Of ◽  
Family History Of Depression ◽  
History Of Depression

Abstract Background A number of studies have been conducted on risk factors of comorbid anxiety disorders regarding late-life depression (LLD). This study investigated the associated factors and their relationship to comorbid anxiety disorders in LLD. Methods Participants included 190 elderly Thais (73.2% female, with a mean age of 68.39 ± 6.74 years) with depressive disorders, diagnosed according to DSM-IV Diagnosis Axis I disorders assessed by Mini-International Neuropsychiatric Interview. Demographic data, medical and psychiatric history, family psychiatric history, past depression, family history of depression, Neuroticism Inventory and 7-Item Hamilton Depression Rating Scale (HAMD-7) were analyzed for path analysis using Structural Equation Model framework. The bootstrapping method was used for testing indirect effects. Results Being female was associated with comorbid anxiety disorders with an indirect effect (β = − 0.032, P = 0.018) through neuroticism, depression severity, history and family history of depression. Family history of depression had no effect on comorbidity (P = 0.090). Neuroticism had an indirect effect on comorbid anxiety disorders (β = 0.075, P = 0.019) via depression severity as reflected by HAMD-7 score (β = 0.412, P =  < 0.001). Total variance explained from this model was 11%. This model had good-fit index with Chi-square > 0.05, CFI and TLI > 0.95 and RMSEA < 0.06. Conclusion Neuroticism mediates the effect of relationship between sex, family history and history of depressive disorders and comorbid anxiety disorders in LLD. Moreover, depression severity is a mediator for neuroticism and comorbid anxiety disorders. Longitudinal studies are warranted to indicate the importance of effective treatment of depression to lower the risk of developing comorbid anxiety disorders among depressed elderly.

scholarly journals The Impact of Maternal Anxiety on Early Child Development During the COVID-19 Pandemic

2021 ◽  
Vol 12 ◽  
Author(s):  
Ljiljana Jeličić ◽  
Mirjana Sovilj ◽  
Ivana Bogavac ◽  
And̄ela Drobnjak ◽  
Olga Gouni ◽  
...  
Keyword(s):  
Child Development ◽  
Trait Anxiety ◽  
Emotional Development ◽  
Perceived Social Support ◽  
Developmental Outcomes ◽  
General Linear Model ◽  
Maternal Anxiety ◽  
Early Child Development ◽  
Sensory Motor ◽  
The Impact

Background: Maternal prenatal anxiety is among important public health issues as it may affect child development. However, there are not enough studies to examine the impact of a mother's anxiety on the child's early development, especially up to 1 year.Objective: The present prospective cohort study aimed to examine whether maternal trait anxiety, perceived social support, and COVID-19 related fear impacted speech-language, sensory-motor, and socio-emotional development in 12 months old Serbian infants during the COVID-19 pandemic.Methods: This follow-up study included 142 pregnant women (Time 1) and their children at 12 months (Time 2). Antenatal maternal anxiety and children's development were examined. Maternal anxiety was assessed using the State-Trait Anxiety Inventory (STAI). Child speech-language, sensory-motor, and socio-emotional development were assessed using the developmental scale in the form of an online questionnaire that examined the early psychophysiological child development. Information on socioeconomic factors, child and maternal demographics, clinical factors, and perceived fear of COVID-19 viral infection were collected. Multivariable General Linear Model analysis was conducted, adjusted for demographic, clinical, and coronavirus prenatal experiences, maternal prenatal anxiety levels, perceived social support, speech-language, motor skills, and cognitive and socio-emotional development at the infants' age of 12 months.Results: The study revealed the influence of the COVID-19 pandemic on maternal trait anxiety. The association between selected independent factors and infants' development was found in a demographically unified sample except for employment and the number of children. There was a correlation between all observed developmental functions. Univariate General Linear model statistical analysis indicated that linear models with selected independent factors and covariates could account for 30.9% (Cognition) up to 40.6% (Speech-language) of variability in developmental functions. It turned out that two-way and three-way interactions had a dominant role on models, and STAI-T Level and COVID-19 related fear were present in all interaction terms.Conclusion: Our findings reveal important determinants of child developmental outcomes and underline the impact of maternal anxiety on early child development. These findings lay the groundwork for the following interdisciplinary research on pregnancy and child development to facilitate and achieve positive developmental outcomes and maternal mental health.

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