Physical activity, mental health, and well-being in very preterm and term born adolescents. An individual participant data meta-analysis of two accelerometry studies
Preprint manuscriptVery preterm birth is a risk factor for later mental health problems. This study examined whether physical activity is associated with better mental health and well-being among very preterm (≤32 weeks) and term born (≥37 weeks) adolescents alike or whether the associations are stronger in either of the groups. Physical activity was measured with accelerometry in children born very preterm and at term in two cohorts, the Basel Study of Preterm Children (BSPC; 40 adolescents born ≤ 32 weeks of gestation and 59 term born controls aged 12.3 years) and the Millennium Cohort Study (MCS; 45 adolescents born ≤ 32 weeks of gestation and 3,137 term born controls aged 14.2 years). In both cohorts, emotional and behavioural problems were mother-reported using the Strengths and Difficulties Questionnaire. Subjective well-being was self-reported using the Kidscreen-52 Questionnaire in the BSPC and single items in the MCS. Hierarchical regressions with ‘preterm status x physical activity’-interaction effects were subjected to individual participant data (IPD) meta-analysis. IPD meta-analysis showed that higher levels of physical activity were associated with lower levels of emotional symptoms and peer problems, higher levels of psychological well-being, better self-perception/body image, and school related well-being, but also higher levels of hyperactivity/inattention. Overall the effect-sizes were small and the associations did not differ significantly between very preterm and term born adolescents. Physical activity was associated with lower levels of emotional and peer problems and higher levels of subjective well-being among adolescents, irrespective of whether they were born very preterm or at term.