scholarly journals Radix entomolaris in permanent molars: Report of two cases

2020 ◽  
Vol 5 (2) ◽  
pp. 37-39
Author(s):  
Monalisa Das ◽  
◽  
Lopamoodra Das ◽  
◽  
Keyword(s):  
Treatment Outcome ◽  
Tooth Loss ◽  
Case Reports ◽  
Anatomical Variation ◽  
Internal Anatomy ◽  
Stepping Stones ◽  
Successful Treatment Outcome ◽  
Oral Environment ◽  
Permanent Molars ◽  
Early Tooth Loss

Molars are frequently affected by caries among children and adolescents. An efficient endodontic intervention is crucial for their successful preservation in oral environment. Proper knowledge of the internal anatomy of a tooth is the stepping stones for successful treatment outcome in regular endodontic practice. Improper diagnosis with inaccurate treatment planning often result a failure in case of molars with extra roots leading to early tooth loss and development of inevitable functional, esthetic, and psychological problems. Though anatomical variation of tooth morphology is common, incidence of an extra lingual root distally in case of mandibular molars i.e. Radix entomolaris is relatively rare. In this article, two case reports of endodontic management of Radix entomolaris (RE) are presented.

scholarly journals Intermittent treatment interruption and its effect on multidrug resistant tuberculosis treatment outcome in Ethiopia

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Habteyes H. Tola ◽  
Kourosh Holakouie-Naieni ◽  
Mohammad A. Mansournia ◽  
Mehdi Yaseri ◽  
Ephrem Tesfaye ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Treatment Interruption ◽  
Multidrug Resistant ◽  
Considerable Proportion ◽  
Adjusted Risk ◽  
Successful Treatment Outcome ◽  
Resistant Tuberculosis ◽  
Unsuccessful Treatment ◽  
Poor Treatment Outcome

AbstractTreatment interruption is one of the main risk factors of poor treatment outcome and occurrence of additional drug resistant tuberculosis. This study is a national retrospective cohort study with 10 years follow up period in MDR-TB patients in Ethiopia. We included 204 patients who had missed the treatment at least for one day over the course of the treatment (exposed group) and 203 patients who had never interrupted the treatment (unexposed group). We categorized treatment outcome into successful (cured or completed) and unsuccessful (lost to follow up, failed or died). We described treatment interruption by the length of time between interruptions, time to first interruption, total number of interruption episodes and percent of missed doses. We used Poisson regression model with robust standard error to determine the association between treatment interruption and outcome. 82% of the patients interrupted the treatment in the first six month of treatment period, and considerable proportion of patients demonstrated long intervals between two consecutive interruptions. Treatment interruption was significantly associated with unsuccessful treatment outcome (Adjusted Risk Ratio (ARR) = 1.9; 95% CI (1.4–2.6)). Early identification of patients at high risk of interruption is vital in improving successful treatment outcome.

Pseudogenized Amelogenin Reveals Early Tooth Loss in True Toads (Anura: Bufonidae)

2021 ◽  
Author(s):  
John Shaheen ◽  
Austin B Mudd ◽  
Thomas G H Diekwisch ◽  
John Abramyan
Keyword(s):  
Tooth Loss ◽  
Tooth Enamel ◽  
Synonymous Substitution ◽  
Bufo Bufo ◽  
Molecular Dating ◽  
Bufo Gargarizans ◽  
The Family ◽  
Synonymous Substitution Rates ◽  
Mandibular Teeth ◽  
Early Tooth Loss

Abstract Extant anurans (frogs and toads) exhibit reduced dentition, ranging from a lack of mandibular teeth to complete edentulation, as observed in the true toads of the family Bufonidae. The evolutionary timeline of these reductions remains vague due to a poor fossil record. Previous studies have demonstrated an association between the lack of teeth in edentulous vertebrates and the pseudogenization of the major tooth enamel gene amelogenin (AMEL) through accumulation of deleterious mutations and the disruption of its coding sequence. In the present study we have harnessed the pseudogenization of AMEL as a molecular dating tool to correlate loss of dentition with genomic mutation patterns during the rise of the family Bufonidae. Specifically, we have utilized AMEL pseudogenes in three members of the family as a tool to estimate the putative date of edentulation in true toads. Comparison of AMEL sequences from Rhinella marina, Bufo gargarizans and Bufo bufo, with nine extant, dentulous frogs, revealed mutations confirming AMEL inactivation in Bufonidae. AMEL pseudogenes in modern bufonids also exhibited remarkably high 86–93% sequence identity among each other, with only a slight increase in substitution rate and relaxation of selective pressure, in comparison to functional copies in other anurans. Moreover, using selection intensity estimates and synonymous substitution rates, analysis of functional and pseudogenized AMEL resulted in an estimated inactivation window of 46-60 MYA in the lineage leading to modern true toads, a timeline that coincides with the rise of the family Bufonidae.

T-29 Early NK cell activation predicts successful treatment outcome in chronic HCV infection

2011 ◽  
Vol 43 ◽  
pp. S86 ◽  
Author(s):  
B. Oliviero ◽  
D. Mele ◽  
E. Degasperi ◽  
E. Cremonesi ◽  
S. Varchetta ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Successful Treatment ◽  
Cell Activation ◽  
Nk Cell ◽  
Hcv Infection ◽  
Successful Treatment Outcome ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

scholarly journals Bilateral Anatomical Variation in the Formation of Trunks of the Brachial Plexus - A Case Report

2018 ◽  
Vol 35 (01) ◽  
pp. 9-13
Author(s):  
E. Lasch ◽  
M. Nazer ◽  
L. Bartholdy
Keyword(s):  
Case Report ◽  
Brachial Plexus ◽  
Upper Limb ◽  
Scientific Literature ◽  
Case Reports ◽  
Anatomical Variation ◽  
Male Cadaver ◽  
Motor Nerves ◽  
The Right

AbstractThis study presents a bilateral variation in the formation of trunks of brachial plexus in a male cadaver. The right brachial plexus was composed of six roots (C4-T1) and the left brachial plexus of five roots (C5-T1). Both formed four trunks thus changing the contributions of the anterior divisions of the cervical nerves involved in the formation of the cords and the five main somatic motor nerves for the upper limb. There are very few case reports in the scientific literature on this topic; thus making the present study very relevant.

scholarly journals APPLICATIONS OF NANOTECHNOLOGY IN INTERDISCIPLINARY DENTISTRY

2020 ◽  
pp. 70-72
Author(s):  
Keerthivasan Arumugam ◽  
Vidhya Sampath ◽  
Rajkumar Kothandaraman ◽  
Mahalaxmi Sekar
Keyword(s):  
Treatment Outcome ◽  
Successful Treatment ◽  
Review Article ◽  
Successful Treatment Outcome ◽  
Interdisciplinary Dentistry

Nanotechnology has brought revolutionary changes in the fields of medicine and dentistry. The application of nanoparticles in dentistry is termed as nanodentistry. Researchers worldwide experiment and employ suitable nanoparticles to overcome the existing drawbacks associated with various materials and techniques used in dentistry. Dentistry is finely segregated into various disciplines, yet still closely interwoven and interdependent to achieve a successful treatment outcome. This approach forms the backbone of interdisciplinary dentistry. From combating infections caused by microbes to improving anchorage of implants, nanotechnology and nanomaterials find multitude of use in interdisciplinary dentistry. This review article summaries the plethora of nanoparticles and their application in interdisciplinary dentistry.

scholarly journals Childhood Tuberculosis Treatment Outcome and Its Association with HIV-Co infection in Ethiopia, A Systematic Review and Meta-analysis

2019 ◽  
Author(s):  
Getaneh Mulualem Belay ◽  
Chalachew Adugna Wubneh
Keyword(s):  
Systematic Review ◽  
Treatment Outcome ◽  
Successful Treatment ◽  
Meta Analysis ◽  
Tuberculosis Treatment ◽  
World Health ◽  
Successful Treatment Outcome ◽  
Poor Treatment ◽  
Poor Treatment Outcome ◽  
Tuberculosis Treatment Outcome

Abstract Introduction Globally around one million children are infected with Tuberculosis. Childhood Tuberculosis is underestimated due diagnosis challenge. HIV infection can affect the TB disease progression and treatment outcome.Objectives The aim of this systematic review and meta-analysis is to determine the pooled estimates of childhood tuberculosis treatment outcome and to analyze the impact of HIV-co infection.Methods We searched all available articles using PubMed, Google scholar and a web of science. Additionally, reference lists of included studies and Ethiopian institutional research repositories were used. Searching was limited to studies conducted in Ethiopia and published in English language. Cohort, cross-sectional and case-control studies were included. A weighted inverse variance random effects- model was used. The overall variations between studies were checked by heterogeneity test Higgins’s method (I 2 ). All included studies were assessed with the JBI quality appraisal criteria. Publication bias was checked with the funnel plot and Egger’s regression test.Result A total of 6 studies with 5,389 participants were included in this systematic review and meta-analysis. The overall pooled estimate of successful treatment outcome was found to be 79.54% (95% CI: 73.00, 86.07). Of which 72.44% were treatment completed. Moreover, this study revealed that the treatment failure, defaulter and death were 0.15%, 5.36%, and 3.54%, respectively. Poor treatment outcome was higher among children with HIV co infection with an odds ratio of 3.15 (95% CI: 1.67, 5.94) as compared to HIV negative children.Conclusion The rate of successful treatment outcome of childhood tuberculosis in Ethiopia found to be low compared to the threshold suggested by the world health organization. HIV co infection is significantly associated with poor treatment outcome. Therefore, special attention better to be given for children infected with HIV.

scholarly journals Frequency and distribution of early tooth loss and endodontic treatment needs of permanent first molars in a Turkish pediatric population

2013 ◽  
Vol 07 (S 01) ◽  
pp. S099-S104 ◽  
Author(s):  
Sezer Demirbuga ◽  
Oznur Tuncay ◽  
Kenan Cantekin ◽  
Muhammed Cayabatmaz ◽  
Asiye Nur Dincer ◽  
...  
Keyword(s):  
Tooth Loss ◽  
Statistical Difference ◽  
Pediatric Population ◽  
Age Groups ◽  
Endodontic Treatment ◽  
Treatment Needs ◽  
Endodontically Treated Teeth ◽  
Chi Square ◽  
Gender Factor ◽  
Early Tooth Loss

ABSTRACT Objectives: The objective of this study is to evaluate the frequency and distribution of early tooth loss and endodontic treatment needs of permanent first molars in a Turkish pediatric population. Materials and Methods: A total of 7,895 panoramic radiographs taken for routine dental examination at the Department of Oral Maxillofacial Radiology between 2008 and 2012 years were investigated. Two independent specialists evaluated early tooth loss and endodontic treatment needs of permanent first molars using panoramic radiography and patient anamnesis forms. The teeth were classified according to the following data: (a) Missing teeth, (b) teeth requiring extraction, (c) endodontically treated teeth (ETT), (d) teeth requiring endodontic therapy. The data also classified according to four factors: Age group (6-12 and 13-16), gender (boy and girl), jaw (mandible and maxilla) and side (right and left). A Chi-square test was used for statistical analyses. Results: A total of 19,488 and 12,092 teeth were evaluated in the child group and adolescent group respectively. All data were higher in adolescents than children (p < 0.001). For gender factor, only ETT was higher in girls than it was in boys (p < 0.001). For the jaw factor, all data were higher (p < 0.001) in mandible than in the maxilla. For the side factor, no statistical difference existed between right and left. Conclusions: Early tooth loss and endodontic treatment needs of permanent first molars showed variability according to age groups and jaws. When the results were compared according to the side and gender factors, no statistical difference was found (p > 0.05) except with the data of ETT in gender groups.

Cardiac changes in anorexia nervosa

2016 ◽  
Vol 26 (4) ◽  
pp. 623-628 ◽  
Author(s):  
Michael A. Spaulding-Barclay ◽  
Jessica Stern ◽  
Philip S. Mehler
Keyword(s):  
Weight Loss ◽  
Anorexia Nervosa ◽  
Treatment Outcome ◽  
Eating Disorder ◽  
Medical Complications ◽  
Cardiac Complications ◽  
Successful Treatment Outcome ◽  
Comprehensive Literature Review ◽  
Life Threatening ◽  
Weight Restoration

AbstractIntroductionAnorexia nervosa is an eating disorder, which is associated with many different medical complications as a result of the weight loss and malnutrition that characterise this illness. It has the highest mortality rate of any psychiatric disorder. A large portion of deaths are attributable to the cardiac abnormalities that ensue as a result of the malnutrition associated with anorexia nervosa. In this review, the cardiac complications of anorexia nervosa will be discussed.MethodsA comprehensive literature review on cardiac changes in anorexia nervosa was carried out.ResultsThere are structural, functional, and rhythm-type changes that occur in patients with anorexia nervosa. These become progressively significant as ongoing weight loss occurs.ConclusionCardiac changes are inherent to anorexia nervosa and they become more life-threatening and serious as the anorexia nervosa becomes increasingly severe. Weight restoration and attention to these cardiac changes are crucial for a successful treatment outcome.

Nevus Lipomatosus Superficialis Unseen or Unrecognized: A Report of Eight Cases

2013 ◽  
Vol 17 (5) ◽  
pp. 335-339 ◽  
Author(s):  
Muthu Sendhil Kumaran ◽  
Tarun Narang ◽  
Sunil Dogra ◽  
Uma Nahar Saikia ◽  
Amarinder Jit Kanwar
Keyword(s):  
Treatment Outcome ◽  
Health Care Providers ◽  
Case Reports ◽  
Case Series ◽  
Care Providers ◽  
Reticular Dermis ◽  
Disease Characteristics ◽  
Long Term Follow Up

Background: Nevus lipomatosus superficialis (NLS) is a unique developmental anomaly or nevoid form of lipoma characterized by the ectopic presence of mature adipocytes in reticular dermis. The condition is rare; apart frrom isolated case reports, there are no large case series dealing with the clinicoepidemiologic characteristics and posttreatment long-term follow-up in patients with NLS and little published information on treatment outcome. Objective: To study the clinicoepidemiologic characteristics and long-term posttreatment follow-up in patients with NLS. Methods: This was an 11-year retrospective study analyzing disease characteristics and treatment outcome in eight patients with NLS. Results: There were eight (six males, two females) patients with NLS, of whom three were children. The classic variant of NLS was the predominant presentation. One patient demonstrated a combination of both classic and solitary variants. Most patients, especially those with solitary variants, were commonly misdiagnosed before presenting to us. Four patients, including two with the solitary variant, one each with the classic and the combined type, underwent surgical resection without any recurrence over 8 years of follow-up. Conclusions: The rare nature of the disorder, which is commonly misdiagnosed, and the absence of long-term follow-up data prompted us to share our experience about NLS to increase its awareness among health care providers.

Dentoalveolar Cleft Treatment Outcome Using Modified Huddart-Bodenham Index and Regression Analysis of Associated Factors

2018 ◽  
Vol 55 (5) ◽  
pp. 682-687 ◽  
Author(s):  
Anas Imran Arshad ◽  
Mohammad Khursheed Alam ◽  
Mohammad Fadhli Khamis
Keyword(s):  
Treatment Outcome ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Chi Square ◽  
Total Occlusion ◽  
Final Model ◽  
History Of ◽  
Permanent Molars ◽  
Dental Models ◽  
Postnatal Factors

Objectives: The aim of this study is to assess the treatment outcome of complete unilateral cleft lip and palate (CUCLP) patients using modified Huddart/Bodenham scoring system (MHB). To determine whether there is an association of congenital and postnatal factors with the treatment outcome. Design: Retrospective observational study. Setting: Two regional cleft-referral centers. Main Outcome Measures: In the current study, 101 pairs of dental models of non-syndromic CUCLP patients were retrieved from hospital archives. Each occlusal relationship from central incisor till the first permanent molars were scored except the lateral incisor. Sum of 10 occlusal relationships in each study sample gave a total occlusion score. The primary outcome was the mean total occlusion score. Results: According to MHB, a mean (standard deviation) total occlusion score of –8.92 (6.89) was determined. Based on treatment outcome, 66 cases were favorable (grades 1, 2, and 3) and 35 cases were unfavorable (grades 4 and 5). Chi-square tests indicated, difference of cheiloplasty ( P = .001) and palatoplasty ( P < .001) statistically significant. Five variables—gender, family history of cleft, cleft side, cheiloplasty, and palatoplasty—were analyzed with a logistic regression model. Conclusions: Final model indicated that cases treated with modified Millard technique (cheiloplasty) and Veau-Wardill-Kilner method (palatoplasty) had higher odds of unfavorable treatment outcome.

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