FEMALES HAVE EARLIER DISEASE ONSET THAN MALES AMONG HLA-CW6 POSITIVE PSORIASIS PATIENTS

2021 ◽  
pp. 1-2
Author(s):  
Akhilesh Behra
Keyword(s):  
Age Of Onset ◽  
Care Center ◽  
Tertiary Care ◽  
Disease Onset ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Male And Female ◽  
Female Patients ◽  
Males And Females

Background- Psoriasis is a chronic inammatory relapsing skin disorder. Environmental and genetic factors play an important role in the development of disease. HLA-Cw6 most strongly associated with disease. There is also a difference in HLA-Cw6 positivity in respect to gender, which affect occurrence of disease in males and females. Aims & Objectives- This study was aimed to determine the association of HLA-Cw6 positive and negative psoriasis individuals had any signicant differences in respect to disease onset among male and female Materials & Methods- An Institute based Cross sectional study was done in a tertiary care center in eastern India. All patients attending skin OPD were included in the study. Detailed history and blood samples were collected from patients. HLA-Cw6 typing has done by sequence-specic PCR method. Results- HLA-Cw6 positive female patients had a signicantly early age of onset than male patients (p value-0.009334) (20.88 vs. 27.91yr), while HLA-Cw6 negative patients did not show any signicant difference of age of onset between male and female ( p value- 0.406905) Conclusion- Although men are more commonly affected than female, HLA-Cw6 positive psoriasis female patients show earlier disease onset. This results show that genetic variations in terms of HLA-Cw6 are reected in the age of onset among males and females.

scholarly journals Do Males and Females Differ in Terms of Their KAP Regarding Halal Pharmaceuticals?

2014 ◽  
Vol 3 (3) ◽  
pp. 163
Author(s):  
Saleha Sadeeqa ◽  
Azmi Sarriff
Keyword(s):  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Male And Female ◽  
Males And Females

<p><strong></strong>There is an increasing awareness amongst Muslim consumers to avoid all items containing  non-Halal ingredients including medications. Male and female are different both biologically and psychologically, it therefore, needed for a study to compare KAP of males and females regarding  Halal pharmaceuticals. Methods<strong>:</strong>This was a cross-sectional study using a structured , self-administered questionnaires to compare the knowledge, attitude &amp; perception regarding Halal pharmaceuticals, among males and females in Penang state of Malaysia. Results<strong> </strong>revealed that there is no significance difference in the knowledge, attitude and perception of males and females. This is concluded that males and females are equally aware and have same attitude and perception regarding Halal pharmaceuticals. P value of .05 or less was taken as statistically significant.</p>

scholarly journals Thyroid dysfunction in patients of metabolic syndrome: A study from a tertiary care center in India

2021 ◽  
Vol 12 (10) ◽  
pp. 47-50
Author(s):  
Ritu Gupta ◽  
Akhil K Vijayan ◽  
Sushma Choudhary
Keyword(s):  
Metabolic Syndrome ◽  
Thyroid Dysfunction ◽  
Care Center ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
P Value ◽  
Overt Hypothyroidism ◽  
Free T4 ◽  
Cross Sectional

Background: Metabolic syndrome is characterized by hypertension, dyslipidemia, central obesity, glucose intolerance, insulin resistance. Thyroid hormone acts as general pacemaker, accelerating metabolic process and may be associated with metabolic syndrome. There is no information available in literature regarding the prevalence and association of thyroid dysfunction in metabolic syndrome in this central region of the country. Aims and Objective: To estimate the prevalence of thyroid dysfunction in patients of metabolic syndrome. Materials and Methods: It is a duration based prospective cross sectional study including 200 patients of metabolic syndrome. A detailed history, clinical examination and relevant investigations including serum Free T4 (FT4), Free T3 (FT3), Thyroid Stimulating Hormone (TSH) were done. Range, frequencies, percentage, mean, standard deviation and P value were calculated. P value of < 0.05 was taken as significant. Results: Prevalence of thyroid dysfunction in metabolic syndrome patients was 28.5%. Prevalence of subclinical and overt hypothyroidism was 18.5% and 8.5% respectively. In patients with both metabolic syndrome and thyroid dysfunction, most common components associated are diabetes mellitus and hypertriglyceridemia. Conclusion: Thyroid dysfunction is significantly common in metabolic syndrome patients. It should be aggressively detected and treated in these patients for better outcome.

Do Males and Females Differ in Terms of Their KAP Regarding Halal Pharmaceuticals?

2014 ◽  
Vol 3 (3) ◽  
pp. 163
Author(s):  
Saleha Sadeeqa ◽  
Azmi Sarriff
Keyword(s):  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Male And Female ◽  
Males And Females

<p><strong></strong>There is an increasing awareness amongst Muslim consumers to avoid all items containing  non-Halal ingredients including medications. Male and female are different both biologically and psychologically, it therefore, needed for a study to compare KAP of males and females regarding  Halal pharmaceuticals. Methods<strong>:</strong>This was a cross-sectional study using a structured , self-administered questionnaires to compare the knowledge, attitude &amp; perception regarding Halal pharmaceuticals, among males and females in Penang state of Malaysia. Results<strong> </strong>revealed that there is no significance difference in the knowledge, attitude and perception of males and females. This is concluded that males and females are equally aware and have same attitude and perception regarding Halal pharmaceuticals. P value of .05 or less was taken as statistically significant.</p>

scholarly journals Gender differences in awareness of diabetes mellitus among the rural population

2017 ◽  
Vol 8 (2) ◽  
pp. 44-49
Author(s):  
Iyshwarya Udaya Kumar ◽  
Jaya Prakash Murthy ◽  
Ujwal Upadya ◽  
Mahesh Venkatesh
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Public Awareness ◽  
Care Center ◽  
Tertiary Care ◽  
Education Programme ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Significant Difference ◽  
Males And Females

Background: Diabetes Mellitus is a chronic disorder, which is becoming rapidly epidemic in India.There are many complications occur due to uncontrolled diabetes mellitus.The outcome of diabetes depends mainly on the patient’s self-management like health-related behavior, which is based on his or her knowledge. Awareness on diabetes mellitus is still a lacunae among the Indian population.Aims and Objective: To determine the knowledge regarding awareness of diabetes like the risk factors, symptoms, complications and the management among the males and females in rural population.Materials and Methods: It is a cross sectional study conducted at the tertiary care center in rural Bangalore. A structured questionnaire was used and 300 adults were assessed on their knowledge regarding the awareness of diabetes.Result: Out of 300 adults, 159 adults (53%) had a history of diabetes. There was no gender difference observed regarding the awareness, nor the education played a role. There was significant difference observed in knowledge of diabetes Mellitus among the diabetics with respect to renal complications (p <0.013), symptoms like blurring of vision (p < 0.043) and burning feet (p < 0.009).Conclusion: Both the diabetic and non-diabetic groups had very low awareness regarding diabetes and associated risk factors. Both Males and females awareness levels were poor. Proper Diabetic education programme will help in raising public awareness of the disease.Asian Journal of Medical Sciences Vol.8(2) 2017 44-49

scholarly journals Dermoscopic Characteristics of Melasma in Indians: A Cross-sectional Study

2017 ◽  
Vol 1 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Manas Chatterjee ◽  
Shekhar Neema
Keyword(s):  
Care Center ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Exact Test ◽  
Number Of Patients ◽  
Effect Of Therapy ◽  
Pigmentary Pattern

ABSTRACT Introduction The aim of this study was to assess the various dermoscopic features of melasma in Indian population. Materials and methods A total of 100 cases of clinically diagnosed melasma and 50 controls without melasma or any other facial pigmentation were studied dermoscopically at a tertiary care center in Eastern India. The various described relevant patterns of pigmentation on dermoscopy were recorded. Similar patterns were also looked for in the control population and the two compared. Statistical analysis was done with Fisher's exact test and a p-value of <0.05 was considered statistically significant. Results Cases consisted of 75 females and 25 males with an average age of 36 years as against an average age of 35 years for controls. Of the various patterns of pigmentation, reticuloglobular pigmentation was statistically significant in association with melasma (p < 0.0001). The unpatterned patchy brown black pigment was also significantly associated with melasma as compared to controls (p - 0.0346). A granular pigmentary pattern was also shown to be significantly associated with a diagnosis of melasma (p - 0.0123). Telangiectasia was seen more frequently in patients as compared to controls (p - 0.0327). Perifollicular brown black globules were not significantly correlated with a diagnosis of melasma. More than one pattern was present in a number of patients. Conclusion Dermoscopy of melasma can be used for diagnosis, prognosis, and response or adverse effect of therapy. Study limitations Lack of direct correlation with histopathology and inclusion of therapy naïve as well as patients on therapy were major limitations of this study. How to cite this article Neema S, Chatterjee M. Dermoscopic Characteristics of Melasma in Indians: A Cross-sectional Study. Int J Dermoscop 2017;1(1):6-10.

scholarly journals Common menstrual disorders in adolescent girls attending a tertiary care center

2020 ◽  
Vol 9 (3) ◽  
pp. 1164
Author(s):  
Hibina K. P. ◽  
Nishi Roshini K. ◽  
Andrews M. A.
Keyword(s):  
Adolescent Girls ◽  
Care Center ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
P Value ◽  
Tertiary Care Center ◽  
Menstrual Disorders ◽  
Cross Sectional ◽  
Medical College ◽  
Medical Disorders

Background: Menstrual disorders are an important cause of concern among adolescent girls. Most problems are physiological but few have underlying pathology which has adverse effect on the future reproductive health Aim of the study was to know the prevalence and to evaluate the underlying cause of the menstrual problems in adolescent girls seeking medical care.Methods: This is a cross sectional study conducted in in 215 adolescent girls aged 13-19 years who sought medical care over a period of 12 months for menstrual complaints from the department of obstetrics and gynecology, Govt. Medical College, Thrissur, a tertiary care center in middle of Kerala, South India. Data was analyzed by SPSS software and p value <0.05 was taken statistically significant.Results: Dysmenorrhea was the most common problem (57.5%), followed by scanty menstruation (35.35%) and 25.2% of girls suffered from premenstrual symptoms. Hypothyroidism was seen in 2.4% of girls 40% were anemic. Statistically significant association was found between hypothyroidism and features of hyperandrogenemia with cycle irregularity. Ultrasonographic evidence of polycystic ovarian morphology was identified among 61.9% girls with irregular cycles.Conclusions: Even though majority of menstrual issues are self-limiting proper evaluation and follow up for medical disorders like hypothyroidism and anemia are important and appropriate intervention is crucial for future reproductive and general health of adolescents presenting with Menstrual disorders.

Prehospital Intubations Are Associated with Elevated Endotracheal Tube Cuff Pressures: A Cross-Sectional Study Characterizing ETT Cuff Pressures at a Tertiary Care Emergency Department

2021 ◽  
pp. 1-4
Author(s):  
Ruo S. Chen ◽  
Laurel O’Connor ◽  
Matthew R. Rebesco ◽  
Kara L. LaBarge ◽  
Edgar J. Remotti ◽  
...  
Keyword(s):  
Endotracheal Tube ◽  
Cuff Pressure ◽  
Care Center ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Endotracheal Tube Cuff ◽  
Cross Sectional ◽  
Tube Cuff ◽  
Respiratory Therapists ◽  
Significant Difference

Abstract Introduction: Emergency Medical Services (EMS) providers are trained to place endotracheal tubes (ETTs) in the prehospital setting when indicated. Endotracheal tube cuffs are traditionally inflated with 10cc of air to provide adequate seal against the tracheal lumen. There is literature suggesting that many ETTs are inflated well beyond the accepted safe pressures of 20-30cmH2O, leading to potential complications including ischemia, necrosis, scarring, and stenosis of the tracheal wall. Currently, EMS providers do not routinely check ETT cuff pressures. It was hypothesized that the average ETT cuff pressure of patients arriving at the study site who were intubated by EMS exceeds the safe pressure range of 20-30cmH2O. Objectives: While ETT cuff inflation is necessary to close the respiratory system, thus preventing air leaks and aspiration, there is evidence to suggest that over-inflated ETT cuffs can cause long-term complications. The purpose of this study is to characterize the cuff pressures of ETTs placed by EMS providers. Methods: This project was a single center, prospective observational study. Endotracheal tube cuff pressures were measured and recorded for adult patients intubated by EMS providers prior to arrival at a large, urban, tertiary care center over a nine-month period. All data were collected by respiratory therapists utilizing a cuff pressure measurement device which had a detectable range of 0-100cmH2O and was designed as a syringe. Results including basic patient demographics, cuff pressure, tube size, and EMS service were recorded. Results: In total, 45 measurements from six EMS services were included with ETT sizes ranging from 6.5-8.0mm. Mean patient age was 52.2 years (67.7% male). Mean cuff pressure was 81.8cmH2O with a range of 15 to 100 and a median of 100. The mode was 100cmH2O; 40 out of 45 (88.9%) cuff pressures were above 30cmH2O. Linear regression showed no correlation between age and ETT cuff pressure or between ETT size and cuff pressure. Two-tailed T tests did not show a significant difference in the mean cuff pressure between female versus male patients. Conclusion: An overwhelming majority of prehospital intubations are associated with elevated cuff pressures, and cuff pressure monitoring education is indicated to address this phenomenon.

A Comparison of Falls and Dizziness Handicap by Vestibular Diagnosis

2021 ◽  
pp. 1-10
Author(s):  
Ryan J. Huang ◽  
Sherri L. Smith ◽  
Libor Brezina ◽  
Kristal M. Riska
Keyword(s):  
Care Center ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Demographic Variables ◽  
Vestibular Migraine ◽  
Cross Sectional ◽  
Positional Vertigo ◽  
Increased Risk ◽  
Risk Of Falls ◽  
Paroxysmal Positional Vertigo

Purpose There is a paucity of data that directly compares the falls rate and dizziness handicap of different vestibular diagnoses. The purpose of this study is to compare the falls rate and dizziness handicap of common vestibular diagnoses encountered among a cohort of vestibular patients at a single institution. Method We conducted a retrospective cross-sectional study of patients evaluated for dizziness at a tertiary care center vestibular clinic between August 1, 2017, and March 19, 2019. Vestibular diagnosis, demographic variables, comorbidities, falls status, and Dizziness Handicap Inventory (DHI) were extracted from the medical record for analysis. Associations between vestibular diagnosis and falls history or DHI were evaluated using multivariate logistic and linear regression, respectively. Results A total of 283 patients met our inclusion criteria with the following diagnoses: benign paroxysmal positional vertigo (BPPV; n = 55), acoustic neuroma ( n = 30), Ménière's disease ( n = 28), multiple vestibular diagnoses ( n = 15), vestibular migraine ( n = 135), or vestibular neuritis ( n = 20). After adjusting for age, sex, race, medications, and comorbidities, the odds of falling was 2.47 times greater (95% CI [1.08, 6.06], p = .039) and the DHI score was 11.66 points higher (95% CI [4.99, 18.33], p < .001) in those with vestibular migraine compared to those with BPPV. Other diagnoses were comparable to BPPV with respect to odds of falling and dizziness handicap. Conclusions Patients with vestibular migraine may suffer an increased risk of falls and dizziness handicap compared to patients with BPPV. Our findings highlight the need for timely evaluation and treatment of all patients with vestibular disease.

scholarly journals Transport Factors Affecting the Outcome of Referred Neonates Admitted in A Tertiary Care Hospital

2018 ◽  
Vol 41 (3) ◽  
pp. 159-164 ◽  
Author(s):  
Madhabi Baidya ◽  
Mahfuza Shirin ◽  
Liton Chandra Saha
Keyword(s):  
Perinatal Asphyxia ◽  
Care Center ◽  
Tertiary Care ◽  
Preterm Neonates ◽  
P Value ◽  
Care Hospital ◽  
Cross Sectional ◽  
Neonatal Transport ◽  
Group I ◽  
Group Ii

Background: Adequate neonatal transport is a key component of care of the sick newborns who require referral to tertiary care center. Poor transportation is one of the iatrogenic factors associated with greater neonatal mortality. Neonatal transport is the greatest challenge faced today in our country. The purpose of this study was to find out characteristics of transport of referred neonates and to idention the factors that contribute to mortality.Methodology: This cross sectional study was conducted in Dhaka Shishu (Children) Hospital from June 2013 to November 2013. Both term and preterm neonates who were referred within first seven days of life were included and those with gross congenital abnormalities and left against medical advice were excluded from the study. After enrollment, data were collected using a structured questionnaire including birth details, interventions before transportation, reasons for referral, and details of transportation. Outcome & duration of hospital stay were also recorded. Neonates who were expired considered as group I and who were survived considered as group II. The study variables were analyzed for their association with immediate outcome by applying chi square test and t test. P value <0.05 was considered significant.Results: This study found that out of 332 neonates 181 were expired with 54.5% mortality rate. One eighty one neonates who were expired, considered as group I and one fifty one neonate were survived, considered as group II. The mortality was significantly high in male neonates [RR 0.80 (0.66-0.97)] and neonates those delivered at home [RR 1.34(1.10-1.64)] (p<0.05). Perinatal asphyxia, pre-term low birth weight, neonatal sepsis were the main causes of referral. It was found that transportation without any referral note [RR 1.40 (1.14- 1.71)], no advice regarding maintenance of airway[RR 1.50(1.17- 1.92)]and keeping warm [RR 1.51(1.17-1.950], resuscitation on admission [RR 1.63(1.23-2.17)] and transportation required > 3hours [RR 1.36(1.09-1.69)] were associated with significantly higher mortality among referred transported neonates(p<0.05).Conclusions: This study found that male neonates, home delivery, transportation without any referral note, no advice regarding maintenance of airway and keeping warm, resuscitation needed on admission and prolonged transportation time were significantly associated with mortality of referred transported neonates.Bangladesh J Child Health 2017; VOL 41 (3) :159-164

Sign in / Sign up

Export Citation Format

Share Document