scholarly journals Influence of Tympanosclerosis on Graft Uptake and Hearing Status in Patients Undergoing Underlay Myringoplasty

1970 ◽  
Vol 7 (2) ◽  
pp. 116-119
Author(s):  
PL Prasad ◽  
H Bhattarai
Keyword(s):  
Otitis Media ◽  
Chronic Suppurative Otitis Media ◽  
Control Group ◽  
P Value ◽  
Suppurative Otitis Media ◽  
Hearing Gain ◽  
Hearing Status ◽  
Health Research Council ◽  
And Control

Background: To assess the influence of tympanosclerosis on graft uptake and hearing status in patients undergoing underlay myringoplasty. Methods: Patients ≥12 years of age with the diagnosis of chronic suppurative otitis media tubo-tympanic type were included in this study. All patients participated in the study had undergone pre and postoperative pure tone audiometric evaluation and were divided into two groups, a study and a control, depending on the presence or absence of tympanosclerotic plaques. All patients underwent underlay myringoplasty and follow up was done after 10 weeks to note graft uptake and postoperative hearing evaluation. Results: Graft uptake was noted to be 96.1% in study group and 94.9% in control group. Similarly, graft uptake was noted in 96.36% where tympanosclerotic plaques were completely removed and in 95.23% where tympanosclerotic plaques were either partially removed or left as such. Post 0perative average hearing gain in study and control group was 12.1dB and 15.9dB respectively. While comparing postoperative hearing gain in cases where tympanosclerotic plaques were completely removed to those in whom tympanosclerotic plaques were either completely removed or left as such, it was 12.31dB in former and 13.67dB in later group, which was statistically non significant with P value of 0.83. Conclusions: Tympanosclerotic plaques, if removed as far as practicable, has no effect on either graft uptake and post operative hearing results in patient under going underlay myringoplasty. Key words: chronic suppurative otitis media tubo tympani type; puretone; audiogram; tympanosclerosis. DOI: 10.3126/jnhrc.v7i2.3019 Journal of Nepal Health Research Council Vol.7(2) Apr 2009 116-119

scholarly journals The Role of Mannose-Binding Lectin Serum Level in Tubotympanic Chronic Suppurative Otitis Media

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Anton Budhi Darmawan ◽  
Marsetyawan H. N. E. Soesatyo ◽  
Ratna Dwi Restuti ◽  
Agus Surono
Keyword(s):  
Serum Level ◽  
Otitis Media ◽  
Control Group ◽  
Suppurative Otitis Media ◽  
Mannose Binding ◽  
The Mean ◽  
And Control ◽  
Binding Lectin ◽  
Mbl Deficiency

Background. Chronic suppurative otitis media (CSOM) is a common public health problem worldwide and a major cause of hearing impairment especially in developing countries. The role of Mannose-Binding Lectin (MBL), a component of innate immunity, in CSOM has not been studied. The aim of the study was to examine whether MBL deficiency was more frequently present in cases group of tubotympanic CSOM patients rather than healthy subjects. Material and Methods. This was an analytic observational study. Subjects were enrolled in the Otorhinolaryngology Clinic at Margono Soekarjo Hospital, Purwokerto, Indonesia. An independent t-test was used to compare the mean of MBL serum concentration between tubotympanic CSOM subjects and control. Results. From 36 tubotympanic CSOM patients, there were 8 (22.22%) patients with MBL deficiency (MBL level < 100 ng/ml), while no deficiency was found in the control group. The mean of MBL level in cases group was 354.88 ng/ml, with the lowest level being 0.001 ng/ml and the highest level 690.24 ng/ml, while in the control group MBL level mean was 376.27 with the lowest level being 188.71 and the highest level 794.54 ng/ml. Conclusion. There was no significant difference of MBL serum level between tubotympanic CSOM and control group. However, the presence of subjects with MBL deficiency in the tubotympanic CSOM group might be considered as playing a role in the tubotympanic CSOM.

scholarly journals Impact of Educational Program on the Management of Chronic Suppurative Otitis Media among Children

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Yousseria Elsayed Yousef ◽  
Essam A. Abo El-Magd ◽  
Osama M. El-Asheer ◽  
Safaa Kotb
Keyword(s):  
Risk Factors ◽  
Otitis Media ◽  
Educational Program ◽  
Chronic Suppurative Otitis Media ◽  
Control Group ◽  
Suppurative Otitis Media ◽  
Complete Cure ◽  
Group I ◽  
Group Ii ◽  
The Impact

Background. Chronic suppurative otitis media (CSOM) remains one of the most common childhood chronic infectious diseases worldwide, affecting diverse racial and cultural groups in both developing and industrialized countries.Aim of the Study. This study aimed to assess the impact of educational program on the management of children with CSOM.Subjects and Methods. An experimental study design was used. This study included 100 children of both sexes of 2 years and less of age with CSOM. Those children were divided into 3 groups: group I: it involved 50 children with CSOM (naive) who received the designed educational program; control group: it involved 50 children who were under the traditional treatment and failed to respond; group II: those children in the control group were given the educational program and followed up in the same way as group I and considered as group II.Tools of the Study. Tool I is a structured questionnaire interview sheet for mothers. It consists of four parts: (1) personal and sociodemographic characteristics of child and (2) data about risk factors of otitis media (3) assessment of maternal practice about care of children with suppurative otitis medi (4) diagnostic criteria for suppurative otitis media. Tool II is the educational program: an educational program was developed by the researchers based on the knowledge and practices needs. This study was carried out through a period of 9 months starting from September 2013 to May 2014. The educational program was implemented for mothers of children with CSOM in the form of 5 scheduled sessions at the time of diagnosis, after one week, 1, 3, and 6 months.Results. There were significant differences between children who received the educational program and control group regarding the response to treatment after one and 3 months. The percentages of complete cure increased progressively 32%, 60%, and 84% after 1, 3, and 6 months in group I while they were 24%, 44%, and 64% in group II, respectively. Cure (dry perforation) was 64%, 36%, and 12% among children of group I after 1, 3, and 6 months while it was 64%, 44%, and 24% in group II, respectively. The percentages of compliance to the educational program improved with time in both groups: 44%, 64%, and 80% in group I and 32%, 48%, and 56% in group II after 1, 3, and 6 months, respectively. The percentages of cure were statistically significantly higher among children with complete compliance with the educational program in both groups in comparison to those with incomplete compliance (P= 0.000 for both).Conclusions. From this study we can conclude that the majority of children with CSOM had one or more risk factors for occurrence of the disease; the educational program is effective for management of CSOM (whether cure or complete cure); the higher the compliance of mothers with the program the higher the response rate; regular followup and explanation of the importance of the program played an important role in the compliance with the program.

scholarly journals Prophylactic Effect of Memantine in Docetaxel Induced Neuropathy in Patients With Breast Cancer

2021 ◽  
Author(s):  
Pegah Mohammadzadeh ◽  
Elnaz Shaseb ◽  
Zohreh Sanaat ◽  
Parvin Sarbakhsh ◽  
Nasrin Gholami ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Peripheral Neuropathy ◽  
Intervention Group ◽  
Metastatic Breast ◽  
Control Group ◽  
P Value ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

Abstract Purpose Peripheral neuropathy is a complication of taxane that in severe cases can limit the optimal treatment. The aim of this study was to evaluate the efficacy of memantine in prevention of docetaxel induced peripheral neuropathy in patients with breast cancer. Methods In this randomized clinical trial, 40 women between the ages of 18 and 64 years with non-metastatic breast cancer (stages I to III) were included (registry number: IRCT20160310026998N9 and registry date: 26 March 2019). All patients were treated with the AC-T regimen (with docetaxel). Patients in intervention group received memantine at a dose of 20 mg for 8 weeks at the beginning of the first cycle of docetaxel. Patients in control group did not take any medication for neuropathy prevention. To assess the neuropathy, DN4 and CTCAE questionnaires were used at baseline, one months, three months and six months after the intervention. Results The DN4 questionnaire score was remarkably less in memantine group in follow up one (p-value: 0.033) and three (p < 00.1). The CTCAE follow up score did not change during study. The Neuropathy duration and Neuropathy onset, were shown significant difference between the intervention and control groups, p = 0.050 and p = 0.001, respectively. From 40 patients, 8 (40%) in memantine group and 2 (10%) in control group, did not experience any kind of neuropathy. Conclusion Data showed that prophylactic administration of memantine 20 mg/day has been effective in prevention of severity and incidence of docetaxel induced neuropathy in patients with breast cancer.

scholarly journals A clinical study of evaluation of tympanoplasty with mastoidectomy in mucosal chronic otitis media

2019 ◽  
Vol 6 (1) ◽  
pp. 163
Author(s):  
Ritesh Mahajan ◽  
Nidhi Abraham ◽  
Nagaraj T. M.
Keyword(s):  
Otitis Media ◽  
Disease Process ◽  
Chronic Otitis Media ◽  
Chronic Suppurative Otitis Media ◽  
Suppurative Otitis Media ◽  
Medical College ◽  
Cortical Mastoidectomy ◽  
A Prospective Study

<p class="abstract"><strong>Background:</strong> Chronic suppurative otitis media (CSOM) is one of the most common ear diseases in developing countries with a varying incidence of 3% to 57%. It the disease process is further divided into mucosal type and squamosal type depending on clinical presentation. The mainstay of therapy in CSOM remains surgery which aims at eradication of disease and restoring the hearing mechanism. The main objective of our study was to evaluate the changes and impact of tympanoplasty with mastoidectomy as a surgical treatment modality in mucosal type of CSOM.</p><p class="abstract"><strong>Methods:</strong> A prospective study was conducted in Rajarajeshwari Medical College and Hospital between November 2015 and June 2017, involving 50 patients with mucosal type of chronic otitis media. These patients, after complete clinical examination and hearing analysis, underwent tympanoplasty with cortical mastoidectomy. Follow-up of the patients was done at one month and three months after the surgery where the parameters recorded preoperatively were assessed.  </p><p class="abstract"><strong>Results:</strong> The graft uptake three months after the surgery was 94%. Patients reported a subjective improvement in symptoms of ear discharge, decreased hearing, earache and tinnitus to 94%, 70%, 86% and 78% respectively. There was hearing improvement in ears that had discharge preoperatively and those ears that did not.</p><p class="abstract"><strong>Conclusions:</strong> Chronic suppurative otitis media is a very common problem and it can lead to recurrent ear discharge and hearing problems. Timely intervention is necessary as early diagnosis results in good surgical outcomes and can make an impact on patient’s quality of life.</p>

Effect of chronic suppurative otitis media on distortion product otoacoustic emission input–output functions in conventional and ultra-high frequencies

2019 ◽  
Vol 133 (11) ◽  
pp. 995-1004
Author(s):  
S I Kirubaharane ◽  
S Palani ◽  
A Alexander ◽  
A Sreenivasan
Keyword(s):  
Otitis Media ◽  
Otoacoustic Emissions ◽  
Otoacoustic Emission ◽  
Chronic Suppurative Otitis Media ◽  
Distortion Product Otoacoustic Emissions ◽  
Control Group ◽  
Clinical Group ◽  
Distortion Product Otoacoustic Emission ◽  
Suppurative Otitis Media ◽  
Distortion Product

AbstractBackgroundDetection and valid measurements of distortion product otoacoustic emissions are not influenced by cochlear status alone, but also by middle-ear status. There is a need to understand the use of ultra-high frequency distortion product otoacoustic emissions in cases of abnormal distortion product otoacoustic emission findings for conventional frequencies related to the middle-ear condition.MethodThe present study investigated distortion product otoacoustic emission input–output functions in conventional and ultra-high frequencies in: 37 adults with chronic suppurative otitis media (clinical group) and 37 adults with normal hearing sensitivity (control group).ResultsThere were significant reductions in distortion product otoacoustic emission amplitude and mean signal-to-noise ratio in the clinical group compared to the control group, especially for conventional frequencies.ConclusionThere was a significant reduction in the rate of ears with measurable distortion product otoacoustic emissions in the clinical group, especially for conventional frequencies. The effect of chronic suppurative otitis media was more pronounced in the conventional frequency range compared to the smaller effect seen in the ultra-high frequency range.

scholarly journals Evaluation of The Bio-Stimulatory Effect of Platelet Rich Fibrin Augmented by Diode LASER Compared to Platelet Rich Fibrin Alone on Dental Implant Replacing Posterior Mandibular Teeth. Randomised Clinical Trial: Split Mouth Study

2019 ◽  
Vol 7 (5) ◽  
pp. 869-875
Author(s):  
Sherif Shafik Mohamed El Bahnasy ◽  
Mohamed Khalifa Zayet ◽  
Tarek Ibrahim El-Ghareeb ◽  
Hoda Abd Kader Saleh
Keyword(s):  
Bone Density ◽  
Dental Implant ◽  
Randomised Clinical Trial ◽  
Control Group ◽  
P Value ◽  
Platelet Rich Fibrin ◽  
Post Operative Pain ◽  
Significant Difference ◽  
And Control

BACKGROUND: Restoring masticatory function and replacing missing teeth with minimal pain and discomfort are the most important issues for the patient and clinician. Nowadays dental implants became the most popular line of treatment to replace missing teeth; offering a comfortable long lasting prosthesis. Osseo-integration reflects the long term success of a dental implant. Many bio-modulators are used aiming to improve the osseointegration and healing around dental implants such as Low-Level Laser treatment (LLLT) and Platelet Rich Fibrin (PRF). PRF has been proven to improve bone repair process around the dental implant. LLLT is considered a noninvasive, safe technique that stimulates osteogenesis and alleviates post-operative pain. AIM: Evaluation of the bio-stimulatory effect of LLLT on a dental implant with PRF compared to PRF alone clinically and radiographically. METHODS: A randomised clinical trial with the split-mouth design was conducted on nine patients with bilaterally missing lower posterior tooth. All patients received one dental implant on each side with PRF. LASER application was performed to one side twice weekly for one month starting on the day of insertion. Post-operative pain was assessed daily through the first week using numerical rating pain scale (NRS) as the primary outcome. Relative peri-implant bone density was measured using direct digital intraoral radiography immediately after insertion, one, four and nine months postoperatively. Implants stability were measured using radio frequency assessment immediately after insertion, four and nine months post-operative as secondary outcomes. RESULTS: The NRS for pain was significantly decreased by the end of the first-week postoperatively in the intervention and control group with a mean of (2.22 ± 1.56) (2.11 ± 1.83) respectively. However, there was no statistically significant difference between the test groups at P-Value (0.892). The relative bone density values were decreased by the end of the ninth month of follow-up in the intervention and control group with a mean of (134.42 ± 16.13) (128.77 ± 33.54) respectively. No statistically significant difference was observed between the two test groups at P-value (0.863). The radiofrequency values for implant stability showed no statically significant difference after nine months of follow up when compared to the initial stability values at the day of insertion in the intervention and control group. The mean radiofrequency values were (67.24 ± 1.79) and (66.9 ± 2.57) respectively, and no statistically significant difference was observed between the two test groups at P-value (0.793) CONCLUSION: There are no statistically significant differences in post-operative pain values, implant stability and bone density between the implant sites treated with PRF augmented by Diode laser compared to implant sites treated by PRF alone.

Interferon-gamma in suppurative otitis media: significance of otorrhoea type and disease outcome

2009 ◽  
Vol 123 (10) ◽  
pp. 1103-1107 ◽  
Author(s):  
A O Lasisi ◽  
O Olayemi ◽  
O G Arinola ◽  
S A Omilabu
Keyword(s):  
Standard Deviation ◽  
Otitis Media ◽  
Middle Ear ◽  
Interferon Γ ◽  
Chronic Suppurative Otitis Media ◽  
Enzyme Linked Immunosorbent Assay ◽  
Suppurative Otitis Media ◽  
The Mean ◽  
Prospective Longitudinal

AbstractBackground:Interferon-γ has been reported to have an immunoregulatory role in otitis media with effusion. However, such a role remains to be determined in acute suppurative otitis media.Aim:To determine the levels of interferon-γ in middle-ear secretion in children with acute suppurative otitis media, and to determine the significance of interferon-γ to the nature of otorrhoea and the outcome of otitis media.Settings and design:Prospective, longitudinal follow up of patients selected from community and tertiary health centres.Methods:We selected children with acute suppurative otitis media, diagnosed as otorrhoea of less than three months' duration. Middle-ear secretions were collected by pipetting and stored at −80°C. Interferon-γ was assayed using enzyme-linked immunosorbent assay. The patients were treated and followed up for nine to 12 months, to separate those with resolved acute suppurative otitis media from those with chronic suppurative otitis media.Result:The study initially included 358 cases of acute suppurative otitis media. Nine-month follow up was achieved in 304 patients (85 per cent). Of these patients, acute suppurative otitis media resolved in 187 (61 per cent), while chronic suppurative otitis media was evident in 117 (39 per cent). The children with completed follow up comprised 173 boys and 131 girls, aged between four months and nine years (mean age 6.6 years; standard deviation 1.32). These children had purulent otorrhoea in 171 cases (56 per cent) and mucoid otorrhoea in 133 cases (44 per cent). The children's middle-ear secretion interferon-γ concentrations ranged from 12 to 126 pg/ml. The mean middle-ear secretion interferon-γ concentration was 27.2 pg/ml (standard deviation 8.8) in patients whose acute suppurative otitis media resolved, and 73.1 pg/ml (standard deviation 9.5) in those progressing to chronic suppurative otitis media. In children with purulent otitis media, the mean middle-ear secretion interferon-γ concentration was 43.5 pg/ml (standard deviation 15.6); in those with mucoid otitis media, it was 74.3 pg/ml (standard deviation 19.1). Univariate analysis revealed significant differences in middle-ear secretion interferon-γ concentration, comparing resolved acute suppurative otitis media and chronic suppurative otitis media cases (p = 0.00), and comparing purulent and mucoid otitis media cases (p = 0.00). Pearson correlation testing revealed significant inverse correlation between interferon-γ concentration and middle-ear secretion immunoglobulin G concentration (p = 0.01), immunoglobulin E concentration (p = 0.03) and immunoglobulin A concentration (p = 0.00).Conclusion:A high concentration of interferon-γ in middle-ear secretions promotes chronicity of suppurative otitis media. Further research in this area may lead to the development of agents which assist the control of suppurative otitis media chronicity.

Sign in / Sign up

Export Citation Format

Share Document