Prophylactic Effect of Memantine in Docetaxel Induced Neuropathy in Patients With Breast Cancer

Abstract Purpose Peripheral neuropathy is a complication of taxane that in severe cases can limit the optimal treatment. The aim of this study was to evaluate the efficacy of memantine in prevention of docetaxel induced peripheral neuropathy in patients with breast cancer. Methods In this randomized clinical trial, 40 women between the ages of 18 and 64 years with non-metastatic breast cancer (stages I to III) were included (registry number: IRCT20160310026998N9 and registry date: 26 March 2019). All patients were treated with the AC-T regimen (with docetaxel). Patients in intervention group received memantine at a dose of 20 mg for 8 weeks at the beginning of the first cycle of docetaxel. Patients in control group did not take any medication for neuropathy prevention. To assess the neuropathy, DN4 and CTCAE questionnaires were used at baseline, one months, three months and six months after the intervention. Results The DN4 questionnaire score was remarkably less in memantine group in follow up one (p-value: 0.033) and three (p < 00.1). The CTCAE follow up score did not change during study. The Neuropathy duration and Neuropathy onset, were shown significant difference between the intervention and control groups, p = 0.050 and p = 0.001, respectively. From 40 patients, 8 (40%) in memantine group and 2 (10%) in control group, did not experience any kind of neuropathy. Conclusion Data showed that prophylactic administration of memantine 20 mg/day has been effective in prevention of severity and incidence of docetaxel induced neuropathy in patients with breast cancer.

Download Full-text

EFFECTIVENESS OF AN EDUCATIONAL PROGRAM ABOUT BREAST CANCER AND BREAST CANCER SELF-EXAMINATION ON PERCEPTION AND PRACTICE AMONG WOMEN IN ALJEERAIF WEST ADMINISTRATIVE UNIT (2)

10.36106/ijsr/4646294 ◽

2021 ◽

pp. 38-42

Author(s):

Amel Eltaib Elagib ◽

Ibrahim Ismail Mohammed ◽

SamiaYousif Idris ◽

Jaafar Abdelrahman Omar ◽

Somia Bilal Babiker ◽

...

Keyword(s):

Breast Cancer ◽

Educational Program ◽

Intervention Group ◽

T Test ◽

Control Group ◽

P Value ◽

Control Groups ◽

Administrative Unit ◽

Self Examination ◽

And Control

In Sudan, cancer incidence has been growing considerably in recent years and is likely to continue to grow creating a big burden on the health system resources. The aim of this study is to assess the baseline Perception and Practice about breast cancer and breast self-examination (BSE) and to nd out the effectiveness of an educational program about breast cancer and BSE on Perception and Practice among women in AlJeeraif West Administrative Unit. Community based intervention study with pre-post and control was carried out among 200 women who were recruited by means of multistage sampling. The sample size was divided equally into intervention and control groups. Baseline data was collected from both groups through direct interview, using structured close ended questionnaire. Educational program was implemented for the intervention group. Four months after the intervention, women in the study and control groups were exposed to the same questionnaire. Chi-square, paired t-test and independent t-test (difference of difference) were conducted in the course of the data analyses. There was statistically signicant difference in the intervention group pre-post program in all of the HBM components in the intervention group (p value0.000), while in the control group statistically signicant difference existed only in perceived barrier (p value.004) and perceived benet (p value.000) and over all perception (p value .016) with no signicant difference in other (HBM) components. In the intervention group practice and performance scores were highly signicant pre-post program (p value 0.000), where as in the control group only practice was signicant (p value 0.001). There were statistically signicant differences in the mean difference of performance, practice and perceptions between the intervention and control groups (p-value .000). The results of this study have conrmed the effectiveness of educational program based on the health belief model on improving perceptions and practice of breast cancer and breast self-examination.

Download Full-text

Peningkatan Kemampuan Perawat dalam Interpretasi EKG Normal dan Aritmia dengan Metode Angka “3”

Jurnal Keperawatan Silampari ◽

10.31539/jks.v4i2.1924 ◽

2021 ◽

Vol 4 (2) ◽

pp. 405-414

Author(s):

Ii Ismail ◽

Dewi Purnamawati ◽

Wati Jumaiyah ◽

Fitrian Rayasari

Keyword(s):

Intervention Group ◽

Average Score ◽

Control Group ◽

P Value ◽

Control Groups ◽

Treatment Variable ◽

Mean Values ◽

Linear Pattern ◽

Significant Difference ◽

And Control

This study aims to determine the effect of the number 3 method on nurses' ability to interpret normal ECG and arrhythmias. The research method used a quasi-experimental design with one group pre-test and a post-test with a control group. The results showed that there was a significant difference in the mean score of nurses in the interpretation of normal ECG and arrhythmias in both the intervention and control groups (p-value 0.007 and 0.002). The multiple linear regression test showed that the treatment variable contributed to the nurse's ability to interpret normal ECG and arrhythmias with a p-value of 0.002 with a negative linear pattern (Nurses' ability = 66.099 - 9.156 (treatment). In conclusion, there is a significant difference in the average score of nurses in interpretation. Normal ECG and arrhythmia in both the intervention and control groups. However, the intervention group with the number 3 method had a greater difference in mean values than the control group. Statistically, the more research treatments, the nurses' ability to interpret normal ECG and arrhythmias would decrease. Keywords: Arrhythmia, Normal EKG, Interpretation of ECG, Number Method 3

Download Full-text

Android-Based Education toward the Role of Postpartum Primipara Mothers in Fulfilling the Independent Perinium Care

Women, Midwives and Midwifery ◽

10.36749/wmm.1.2.55-67.2021 ◽

2021 ◽

Vol 1 (2) ◽

pp. 55-67

Author(s):

Werna Nontji ◽

Dwi Kartika Sari ◽

Sitti Maria Ulfa ◽

Syafruddin Syarif ◽

Inez Vravty Lestari ◽

...

Keyword(s):

Treatment Group ◽

Intervention Group ◽

Wilcoxon Test ◽

Control Group ◽

P Value ◽

Control Groups ◽

Post Test ◽

Android App ◽

And Control ◽

Perineal Care

Background: Educating mothers during their postpartum period could potentially help them to overcome some important phases after giving birth. The process of education is evaluated based on the mothers’ knowledge about their independent self-care. Independency is an activity that is started individually and is done based on self-capability. The independency in the postpartum care is not only important to decrease the mother’s mortality and morbidity rate, but it is also crucial to strengthen and improve the post-partum mother’s healthy behavior during the perineal care. Providing education using Android-based application called BUBI Care could be potential to facilitate a more dynamic transfer of knowledge to the postpartum mothers.Aims: To analyze the knowledge, skills, and independence of primipara postpartum mothers in independent perineal care before and after accessing BUBI Care app. Research Method: employing quasi experimental research with pre-test and post-test design with control group design. The sample for this research were 19 pregnant mothers TM III (pregnancy age of ? 38 weeks) on each group. The treatment group was educated using BUBI Care Android app that was conducted at one of Public Health Center. The control group was educated without BUBI Care that was conducted at a Midwife Practice Clinic. The research was conducted on September to October 2020. Study Result: According to the Wilcoxon test, there was a difference in the pre-test knowledge of the treatment and control groups with the similar median of 53 and p-value of 0.666, the treatment group showed their scores improved to 80 on the post-test while the control group stayed at 53 with the p-value of 0.000. It means that BUBI Care app education influences the post-test. On the other hand, the perineal care skill saw a difference between the intervention and control groups. The intervention group had a mean of 70.05 and 56.68 for the control group with the p-value of 0.002 which means that there was an influence from the BUBI Care app education. Additionally, Mann Whitney test showed that the intervention group had a mean score of 78.95, but the control group only had 49.26, the total difference between the two are 29.69 with the p-value of 0.000. It can be concluded that there is a significance in difference in the independency rate from the provision of BUBI Care Android app education.Conclusion: there is a significance effect on the intervention group in terms of Android based usage.

Download Full-text

Pengaruh Pemberian Tablet Fe Terhadap Hemoglobin Pada Taruni Politeknik Ilmu Pelayaran Semarang

Journal of Holistics and Health Science ◽

10.35473/jhhs.v2i2.47 ◽

2020 ◽

Vol 2 (2) ◽

pp. 52-67

Author(s):

Anggi Vina Hariyati ◽

Cahyaningrum ◽

Adil Zulkarnain

Keyword(s):

Intervention Group ◽

Sampling Technique ◽

Bivariate Analysis ◽

Control Group ◽

P Value ◽

Merchant Marine ◽

Purposive Sampling ◽

The Public ◽

Significant Difference ◽

And Control

Anemia is one of the public health problems that need more attention of the female because they experience menstruation and they are in the growth phase. From the data of Semarang City Health Office in 2011, it is shown the incidence of anemia in adolescents aged 10-19 years old are 68.24%. The prevention effort of the case is by measuring hemoglobin and prescribing blood supplement. The objective of the study is to find out the effect of Fe tablets on Hemoglobin in Semarang Merchant Marine Polytechnique students. The objective of the study is to find out the effect of Fe tablets on Hemoglobin in Semarang Merchant Marine Polytechnique students. This research used pre-experimental design with the two group pretest posttest. The population in this Study were all Merchant Marine Polytechnique Semarang at the 4th semester of female students amounting to 50 with the total respondents 34 respondents taken with purposive sampling technique. The data were collected by performing Hemoglobin examination. The results of the study show that the average Hemoglobin before being prescribed Fe on the intervention and control group was 11.29 g/dl. After being prescribed Fe to the intervention group, it is found the average increased to 13.69 g/dl, while in the control group it is found averaged 11.72 g/dl. Bivariate Analysis uses an independent t test, the value of t is 6.136 with a p-value of 0.000. It shows that the p-value is 0,000 <((0.05), this indicates that there is a significant difference in the decrease in Hemoglobin levels in the population after being prescribed blood supplement between the intervention and control groups in The Semarang Merchant Marine Politechnique Students. It is suggested that the female adolescents to consume more iron-containing foods or consume Fe supplements such as Fe, during menstruation. ABSTRAK Anemia merupakan salah satu masalah kesehatan masyarakat yang perlu khusus nya pada remaja putri yang perlu mendapatkan perhatian khusus karena remaja putri mengalami mestruasi tiap bulan dan dalam masa pertumbuhan . Hasil Data Dinas Kesehatan Kota Semarang tahun 2011. Kejadian anemia pada remaja usia 10-19 sebanyak 68,24%. Untuk menangani masalah tersebut pencegahan yang dilakukan yaitu dengan cara mengukur hemoglobin dan pemberian suplemen tablet tambah darah . Penelitian ini bertujuan untuk melihat Pengaruh Pemberian Tablet Fe Terhadap Hemoglobin Pada Taruni Politeknik Ilmu Pelayaran Semarang. Penelitian ini bertujuan untuk melihat Pengaruh Pemberian Tablet Fe Terhadap Hemoglobin Pada Taruni Politeknik Ilmu Pelayaran Semarang. Jenis penelitian ini menggunakan pre-eksperimen design dengan rancangan Two group pretest posttest. Populasi dalam penelitian iniadalah seluruh taruni politeknik ilmu pelayaran semarang semester 4 berjumlah 50 taruni dengan jumlah sempel 34 responden dengan tehnik pengambilan sempel purposive sampling. Pengambilan data dengan melakukan pemeriksaan Hemoglobin. Penelitian menunjukan bahwa rata-rata Hemoglobin sebelum diberikan pada taruni kelompok intervensi dan kontrol sama yaitu 11,29 g/dl. Dan setelah diberikan pada kelompok intervensi rata-rata meningkat menjadi 13,69 g/dl, sedangkan kelompok kontrol rata-rata sebesar 11,72 g/dl. Analisis bivariate Menggunakan uji t independen, didapatkan nilai t hitung 6,136 dengan p-value sebesar 0,000. Terlihat bahwa p-value 0,000 <a (0,05), ini menunjukkan bahwa ada perbedaan secara signifikan penurunan (selisih) kadar Hemoglobin b pada taruni sesudah diberikan tablet penambah darah antara kelompok intervensi dan kontrol pada taruni Politeknik Ilmu Pelayaran Semarang. Hendaknya bagi remaja putri lebih banyak mengomsumsi makanan yang mengandung zat besi atau mengomsumsi suplemen yang mengandung besi seperti Fe terutama saat mestruasi

Download Full-text

Evaluation of high-dose versus standard FAC chemotherapy for advanced breast cancer in protected environment units: a prospective randomized study.

Journal of Clinical Oncology ◽

10.1200/jco.1987.5.3.354 ◽

1987 ◽

Vol 5 (3) ◽

pp. 354-364 ◽

Cited By ~ 89

Author(s):

G N Hortobagyi ◽

G P Bodey ◽

A U Buzdar ◽

D Frye ◽

S S Legha ◽

...

Keyword(s):

Breast Cancer ◽

Response Rate ◽

Metastatic Breast ◽

Ambulatory Setting ◽

Survival Duration ◽

Control Group ◽

High Dose ◽

Control Groups ◽

Median Response ◽

And Control

Fifty-nine evaluable patients under 65 years of age with measurable metastatic breast cancer and without prior chemotherapy were randomly assigned to treatment with fluorouracil, Adriamycin (Adria Laboratories, Columbus, OH), and cyclophosphamide (FAC) at standard or high doses (100% to 260% higher than standard FAC) following a dose escalation schedule. Patients randomized to the high-dose FAC received the first three cycles of therapy within a protected environment. Subsequent cycles for this group were administered at standard doses of FAC in an ambulatory setting, the same as for the control group. After reaching 450 mg/m2 of Adriamycin, patients in both groups continued treatment with cyclophosphamide, methotrexate, and fluorouracil until there was disease progression. Analysis of pretreatment patient characteristics showed an even distribution for most known pretreatment factors, although the control group had slightly (but nonsignificantly) more favorable prognostic characteristics. Fourteen patients (24%) achieved a complete remission (CR) and 32 (54%) achieved a partial remission (PR), for an overall major response rate of 78%. There were no differences in overall, CR, or PR rates between the high-dose FAC and control groups. The median response durations were 11 and 10 months for the protected environment and control groups, respectively, and the median survival was 20 months for both groups. Hematologic, gastrointestinal (GI), and infection-related complications were significantly more frequent and severe in the group treated with high-dose chemotherapy. Stomatitis, diarrhea, and skin toxicity were dose-limiting. However, there were no treatment-related deaths. High-dose induction combination chemotherapy with the agents used in this study failed to increase the response rate or survival duration, and resulted in a substantial increase in toxicity.

Download Full-text

Piano-accompanied solfège reading experiences of preservice music teachers

Research Studies in Music Education ◽

10.1177/1321103x19871078 ◽

2020 ◽

pp. 1321103X1987107

Author(s):

Elif Guven

Keyword(s):

Music Teachers ◽

Control Group ◽

Reading Practices ◽

Control Groups ◽

Plot Analysis ◽

Experimental Implementation ◽

Significant Difference ◽

And Control ◽

Experimental Group

This study examines how piano-accompanied solfège reading practices of preservice music teachers ( N = 28) affect their performance on their musical hearing, reading, and writing (MHRW) classes. A pretest–posttest design with control groups was employed. The data were analyzed by 2 × 2 split-plot analysis of variance (ANOVA) and one-way ANOVA. Consequently, a significant difference was not found between the MHRW performance scores of the experimental and control groups. An analysis of mean performance scores revealed that the scores received by the control group were higher than those of the experimental group after the practice. Follow-up interviews that were held with 14 students after the experimental implementation revealed that students believed piano-accompanied courses were more useful, and they felt more comfortable with piano accompaniment. Although MHRW performance scores indicated that piano-accompanied solfège reading practices did not have a significant effect on preservice music teachers’ MHRW performances, it helped them participate in courses more enthusiastically.

Download Full-text

The effect of reflexology on quality of life in Iranian patients with breast cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.26_suppl.90 ◽

2016 ◽

Vol 34 (26_suppl) ◽

pp. 90-90

Author(s):

Shadan Pedramrazi

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Placebo Group ◽

Test Group ◽

Control Group ◽

Relaxation Techniques ◽

Control Groups ◽

Significant Difference ◽

And Control

90 Background: Breast cancer is one the most prevalent cancers among Iranian women. One of the complementary therapies is reflexology. The extant paper has been provided with the objective of determining the effect of reflexology on quality of life of patients with breast cancer undergoing chemotherapy in the breast disease center. Methods: This study is a randomized clinical trial which has been applied to 60 patients suffering from breast cancer under chemotherapy in breast diseases center, in 2012. The patients were selected randomly in three test, control and placebo groups. In test group, reflexology was implemented for 3 weeks and each session lasted half an hour. In placebo group, only relaxation techniques were implemented for 3 weeks, each session lasted 20-30 minutes. Control group received the routine therapies of breast cancer center. Results: Data were collected by standard questionnaires of EORTIC QLQ-C30.V.3 and EORTIC QLQ-BR23.V.3. The questionnaires were filled before intervention and two weeks after applying study. There was no significant difference in demographic characteristics or quality of life score of three groups, before intervention. Total score of quality of life was higher in interventional group compared to placebo group before and two weeks after intervention (p < 0.001) Results also indicated a significant difference in total score of quality of life between three test, placebo, and control groups after intervention (p < 0.001). A considerable improvement was noticed in the different aspects of quality of life in the test group compared to two other placebo and control groups. Conclusions: Reduction of pain, anxiety, nausea, and other symptoms related to cancer in patients suffering from cancer are assumed as the important cases of nursing cares focus, and precise nursing may diminish these symptoms considerably. Using reflexology in patients suffering from breast cancer may improve the quality of life as an effective method, and can be recommended for use in patients with breast cancer if it is supervised by health system personnel.

Download Full-text

Effect of Auricular Acupressure on Uremic Pruritus in Patients Receiving Hemodialysis Treatment: A Randomized Controlled Trial

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2015/593196 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 14

Author(s):

Cui-na Yan ◽

Wei-guo Yao ◽

Yi-jie Bao ◽

Xiao-jing Shi ◽

Hui Yu ◽

...

Keyword(s):

Intervention Group ◽

Maintenance Hemodialysis ◽

Control Group ◽

Common Symptom ◽

Uremic Pruritus ◽

Auricular Acupressure ◽

Significant Difference ◽

Vas Scores ◽

And Control

Background. Uremic pruritus (UP) is a common symptom in patients undergoing maintenance hemodialysis for end-stage renal disease (ESRD).Objective. To determine the clinical efficacy of auricular acupressure therapy on pruritus in hemodialysis patients and to explore possible underlying mechanisms.Methods. Patients receiving maintenance hemodialysis at a referral medical center were recruited and assigned to intervention (n=32) and control (n=30) groups. The intervention group underwent auricular acupressure treatment three times a week for six weeks. Auricular acupressure was not applied to patients in the control group. However, tape withoutVaccariaseeds was applied to the same six auricular acupoints as the intervention group. Pruritus scores were assessed using VAS scores, and enzyme-linked immunosorbent assays (ELISA) were used to measure levels of other possible contributory biochemical factors.Results. There was a significant difference in mean VAS scores between the postintervention and control groups during follow-up (3.844 ± 1.687 versus 5.567 ± 2.285,F=22.32,P<0.0001). Compared to the control group, serum histamine levels in the postintervention group at the six-week follow-up had decreased significantly (F=5.01,P=0.0290).Conclusion. Our findings suggest that auricular acupressure may be a useful treatment in the multidisciplinary management of UP in ESRD patients.

Download Full-text

The Effect of Cognitive- Behavioral Counseling on the Sexual Compatibility of New Married Couples: A Clinical Trial Study

10.21203/rs.3.rs-78870/v1 ◽

2020 ◽

Author(s):

Parvin Allahyari ◽

Mitra Kolivand ◽

Arash Namdari ◽

Khaled Rahmani

Keyword(s):

Intervention Group ◽

Married Couples ◽

Cognitive Behavioral ◽

Control Group ◽

Counseling Centers ◽

Control Groups ◽

Behavioral Counseling ◽

Sexual Compatibility ◽

Significant Difference ◽

And Control

Abstract Objective: sexual desire is an integral part of an identity and character of a human being, that affect how to behave with spouse. This study aimed to study the effect of cognitive-behavioral counseling (CBT) on sexual compatibility of new married couples in Sanandaj City in 2018. Method: This was a randomized clinical trial study and participants were 80 new married couples whose information was recorded at the premarital counseling centers that were randomly divided into intervention and control groups. Intervention group received 8 weekly 120-minute sessions of group consultation with cognitive-behavioral approach. Data were collected before the intervention, after 8 weeks of counseling, and two months after the last counseling session using the National Sexual Compatibility Scale. Data were analyzed using chi-square inferential statistics and independent t-test or nonparametric Mann-Whitney test. analysis of covariance was used to control of potential confounders. Results: The mean values of sexual compatibility in two intervention and control groups before counseling were 94.20±3.30 and 93.41±6.84 respectively. These scores reached to 100.11±2.96 in the intervention group and 98.83±3.66 in the control group immediately after the intervention. Also two months after the end of counseling, this rate was 101.98±4.03 in the intervention group and 98.83±3.66 in the control group. The intra-group comparison of sexual adjustment scores before and after counseling and two months after the intervention, showed a statistically significant difference (P <0.001). The trend of changes in the control group was not significant (P >0.05). There was a significant difference between two groups in level of scores two months after the intervention (P <0.001). Conclusion: CBT was effective in improving the level of sexual compatibility between new married couples. It is recommended to use this method of counseling, along with other services provided at pre-marriage counseling centers, to continue and improve the quality of sex and vitality of couples.

Download Full-text

THE EFFECT OF PRENATAL GENTLE YOGA AND HYPNOTHERAPY ON ANXIETY LEVEL AND SLEEP QUALITY IN THE THIRD TRIMESTER PREGNANT WOMAN AT PUSKESMAS SUMBER CIREBON REGENCY IN 2019

International Seminar of Gender Equity Maternal and Child Health ◽

10.34305/gemic.v1i1.311 ◽

2021 ◽

Vol 1 (1) ◽

pp. 32-38

Author(s):

Nurlaela Kurnia Rahayu ◽

Pepi Hapitria ◽

Rani Widiyanti

Keyword(s):

Sleep Quality ◽

Pregnant Women ◽

Intervention Group ◽

Anxiety Level ◽

Control Group ◽

P Value ◽

Third Trimester ◽

Control Groups ◽

The Third ◽

And Control

As the pregnancy gets older, the attention and thoughts of pregnant women begin to focus on something that is considered as a climax, so that the anxiety experienced will intensify just before the childbirth. Excessive anxiety and sleep disorders during pregnancy can cause mental disorders in pregnant women and inhibit fetal growth. To determine the effect of prenatal gentle yoga and hypnotherapy on anxiety level and sleep quality in the third trimester pregnant women. This is a quasi-experimental study with a pre-post test with a control group. The sample was 32 respondents consisting of 16 respondents as an intervention group and 16 respondents as a control group taken by purposive sampling. The analysis used was the Paired T-test. There is a difference in the average of anxiety level in the third trimester pregnant women in the intervention and control groups with a p value 0,000; there is a difference in the average of sleep quality in the third trimester pregnant women in the intervention and control groups with a p value 0,000; and there is no difference in the average of anxiety level and sleep quality in the third trimester pregnant women in the intervention and control groups with a p value 0,64. Prenatal Gentle Yoga and Hypnotherapy have an effect in reducing the anxiety level and improving the sleep quality in the third trimester pregnant women.

Download Full-text