scholarly journals Oral cavity lesions: A study of 21 cases

1970 ◽  
Vol 1 (1) ◽  
pp. 49-51 ◽  
Author(s):  
S Pudasaini ◽  
R Baral
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Community Hospital ◽  
Buccal Cavity ◽  
Malignant Lesion ◽  
Common Site ◽  
Benign Lesions ◽  
Inflammatory Conditions ◽  
Neoplastic Lesions ◽  
Rational Management

Background: Development of lesions in the oral cavity is strongly linked with smoking and alcohol consumption. Non neoplastic lesions are mainly inflammatory conditions. It has been seen that the benign lesions are more common than malignant. Materials and methods: This was a retrospective study carried out in the Department of Histopathology of Helping Hands Community Hospital during a period of one and a half years from January 2009 to June 2010. The study included 21 cases of oral cavity lesions. Results: The most common site was lip with 9 cases (42.8%) followed by buccal cavity with 5 cases (23.8%). Out of the 21 cases of oral cavity lesions, 20 cases (95.2%) were benign and 1 case (4.8%) was malignant. The malignant lesion was a case of squamous cell carcinoma of soft palate. Conclusion: Any oral cavity lesion should have a tissue diagnosis for rational management of the case and to avoid mutilating surgery. Keywords: Oral cavity; Fibroma; Mucocele DOI: 10.3126/jpn.v1i1.4452 Journal of Pathology of Nepal (2011) Vol.1, 49-51

STUDY OF HISTOPATHOLOGICAL SPECTRUM OF ORAL LESIONS IN TERTIARY CARE HOSPITAL, CIMS (5 YEARS RETROSPECTIVE)

2021 ◽  
pp. 15-17
Author(s):  
Shahnaz Bano ◽  
Rashmi Gupta ◽  
Jyoti Porte ◽  
B. P. Singh
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Malignant Lesion ◽  
Psychological Trauma ◽  
Oral Lesion ◽  
Care Hospital ◽  
Common Site ◽  
Neoplastic Lesions

Background: Oral cavity is a common site for non-neoplastic and neoplastic lesions, most are asymptomatic, but lesion like squamous cell carcinoma leads to cosmetic disgurement and mental trauma to the patient. Early diagnosis of premalignant and malignant lesion improves the accuracy of diagnosis and early management. Aim: To study Histopathological Spectrum of Oral cavity Lesions on the basis of type, age, sex and site distribution. Material and methods: A retrospective study was carried out in a pathology department of Chhattisgarh Institute of Medical Sciences (CIMS), Bilaspur, (C.G.) for oral lesion during the time period of Jan 2016 to Dec 2020. Study includes total 275 cases, 650 blocks and 720 stained histopathology slides ( H and E stained). Data like age, sex, site of lesion was collected from histopathological register. Result: Total 275 cases of oral cavity lesions were studied in which were 188 (68.36%) male and 87 (31.64%) were female. Included age group from 6 years to 85 years, out of 275 cases 162 (58.91%) Malignant lesions, 64 (23.27%) non-neoplastic lesions, 31 (11.27%) Benign lesions, 18 (06.55%) premalignant lesions. Buccal mucosa was most common site for oral lesion followed by tongue and lips. Most common lesion was squamous cell carcinoma followed by pyogenic granuloma and inammatory lesions. Conclusion: In our study squamous cell carcinoma is most common malignant lesion of oral cavity . Clinical diagnosis is not enough for determination of the nature of lesion. Histopathological evaluation is important tool for diagnosis of the lesion in premalignant and early stages so we can prevent mental and psychological trauma to the patient

scholarly journals Expression OF p16INK4a Gene in Premalignant and Malignant Lesions of Oral Cavity

2021 ◽  
pp. 53-62
Author(s):  
R. Vijay David Raj ◽  
S. Marylilly
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Malignant Lesion ◽  
Malignant Neoplasm ◽  
Premalignant Lesions ◽  
Group I ◽  
Malignant Lesions

Squamous cell carcinoma is the summits malignant neoplasm of the oral cavity. Tobacco and alcohol is identified as risk factors, but squamous cell carcinoma can occur in patients with no known risk factors. Oral cancer is the sixth most common malignancy and is one of the major causes of cancer morbidity and mortality worldwide. Cancer is caused due to a series of alteration in genetic and epigenetic factors that occur in multiple steps and is influenced by the genetic predisposition of the individual and by exogenous environmental factors. These factors result in a series of molecular alteration, including inactivation of tumor suppressor genes expression of p16 has been proposed as a marker for malignant transformation. The p16 staining was correlated between the control and study groups and p 16 was shown to be increasing expressed in premalignant and less expressed in malignant category and was found to be statistically significant by Fischer’s exact test. This study concluded that p16 was increasingly expressed in premalignant lesions and less expressed in malignant lesion. In the present study 9 of the control cases were p16 negative and one case showed sporadic staining. The study group I showed 1 case of sporadic staining, 6 cases of focal staining and 8 cases of diffuse staining. The study II showed 14 cases of sporadic staining, 6 cases of focal staining and 5 cases of diffuse staining. Hence variations cannot be accurately assessed, but it plays a crucial role in assessing pre-malignant lesions progressing to malignancy. To confirm this, a larger sample study is required. As advances in research have leads to greater understanding of potentially malignant lesions in the oral cavity.

Clinico-pathological Spectrum of Oral Cavity Lesions at a Tertiary Care Center in Central Nepal: A Descriptive Cross-sectional Study

2021 ◽  
Vol 59 (234) ◽  
Author(s):  
Shankar Bastakoti ◽  
Gambhir Shrestha ◽  
Dej Kumar Gautam ◽  
Ishan Dhungana ◽  
Nandita Jha ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Malignant Lesion ◽  
Female Ratio ◽  
Central Nepal ◽  
Common Cancer ◽  
Malignant Lesions

Introduction: Head and neck cancer is the sixth most common cancer in the world. The disease burden is increasing at an alarming rate in developing Southeast Asian countries. This study aims to report the histopathological spectrum of oral cavity lesions at a tertiary cancer center in central Nepal. Methods: This study included all those cases of oral cavity lesions, of which diagnostic biopsy was done from January 2018 to December 2019. The data were retrieved from the Department of Pathology of BP Koirala Memorial Cancer Hospital. The study proposal was approved by the Institutional Review Committee at BPKMCH (Ref: 247/2020) on 28th June 2020. Results: A total of 851 cases of oral cavity lesions were included in this study. The mean age of the study population was 55.9 years, with male to female ratio of 3:1. Malignant lesions composed of 472 (55.5%) cases followed by premalignant lesion of 104 (12%). More than 453 (95%) malignant cases were squamous cell carcinoma, of which 342 (75%) were a well-differentiated type. The buccal cavity is the most common site of malignant lesion 212 (45%), followed by tongue 96 (20%) and lower gingivobuccal region 86 (18%). Conclusions: Malignant lesions are the most common histopathological fi ndings in the oral cavity lesion with squamous cell carcinoma type. Oral cancer is common cancer that can be prevented and cured if detected early.

CLINICOPATHOLOGICAL STUDY OF ORAL LESIONS IN A TERTIARY CARE HOSPITAL

2021 ◽  
pp. 17-20
Author(s):  
Sravani Ponnada ◽  
Lakshmi Latchupatula ◽  
Tadikonda Krishna Srivathsav ◽  
Bhagyalakshmi Atla
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oral Lesion ◽  
Oral Lesions ◽  
Care Hospital ◽  
Common Site ◽  
Female Ratio

Background: Oral cavity is a common site for various non-neoplastic and neoplastic lesions. Majority of lesions were neoplastic. Tobacco chewing, smoking and alcohol consumption were the common risk factors implicated in the etiology of malignant oral lesions. Squamous cell carcinoma was the most common lesion of the oral cavity. Aims&Objectives: To study the clinicopathological lesions of the oral cavity with respect to age, gender, location, clinical presentation, histopathological patterns and various risk factors. Materials And Methods: A retrospective study of 274 oral cavity lesions conducted for period of 2 years from January 2019 to December 2020 in the department of pathology, Andhra Medical College, Visakhapatnam, Andhra Pradesh. Results: In our study, the age range of the patients was from 3 years to 87 years. Majority of cases were seen in age group of 41- 50 years. Males were more commonly affected than females with a male to female ratio of 2.51:1. Majority of oral lesions were malignant. Squamous cell carcinoma was the most common oral lesion. Tongue was the most common site involved in oral lesions. Mucocele was the commonest non-neoplastic lesion and squamous papilloma was the most common benign lesion. Leucoplakia was the most common premalignant lesion and Squamous cell carcinoma was the commonest malignant lesion. Conclusion: Majority of oral lesions were malignant. Squamous cell carcinoma was the most common oral lesion. Early and accurate identication of potentially malignant oral lesions is important and essential for prevention of morbidity, mortality and for proper treatment of cases. Along with clinical examination and laboratory investigations, histopathological examination is still the gold standard to establish a denitive diagnosis and for conrmation of the nature and origin of oral lesions.

scholarly journals A Histopathological Study of Neoplastic Lesions of Conjunctiva

2018 ◽  
Vol 4 (1) ◽  
pp. 32-35
Author(s):  
Urvashi Gupta ◽  
Ruchi Shrestha ◽  
Ashok P Samdurkar ◽  
Anita Shahi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Malignant Melanoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Benign Lesion ◽  
Medical Science ◽  
Malignant Lesion ◽  
Histopathological Study ◽  
Squamous Papilloma ◽  
Neoplastic Lesions

BACKGROUND: Ocular malignant tumors are relatively rare compared to other eye lesions, require immediate diagnosis and management. But ignorant care due to unawareness of persons can result into debility, loss of vision, and occasionally life is jeopardized.1 The aim of the study is to determine the frequency of most common neoplastc lesions of conjunctiva with histopathologically confirmed diagnosis. MATERIAL AND METHODS: It was a retrospective cross-sectional study done in a period of two years (January 2011  December 2012) that included120 patients who presented  with conjunctival lesions to the pathology department of  Universal College of Medical Science, Bhairahawa, Nepal.  RESULTS: In this study out of 120 biopsies which were histopathologically diagnosed as conjunctival neoplasms were categorized into benign, dysplastic and malignant lesion and was common after second decade of life. Majority of cases (75 cases, 62.5%) were categorized as benign lesion with predominance of squamous papilloma (n=25) and nevus (n=21), followed by malignant lesion (27 cases, 22.5%) and dysplastic lesions (18 cases, 15%). Amongst malignancies, squamous cell carcinoma (SCC) was the most prevalent and a case of malignant melanoma was studied. Dysplastic lesion included conjunctival intraepithelial neoplasia (CIN) with and without squamous papilloma. CONCLUSION: Histopathology plays an important role in diagnosis of conjunctival lesions and rules out different categories of neoplastic lesions on routine basis. In this study Squamous cell carcinoma (SCC) 20.01% is the most common malignant tumor of conjunctiva. The next majority of cases diagnosed as the verrucuous carcinoma 1.66% and malignant melanoma 0.83% maximum case of malignant cases diagnosed in the age group of more than 50 years.  Journal of Universal College of Medical Sciences (2016) Vol.04 No.01 Issue 13, Page: 32-35

scholarly journals Profile of oral cavity neoplastic lesions: two year pilot study at tertiary care centre

2020 ◽  
Vol 6 (6) ◽  
pp. 1107
Author(s):  
Manish Munjal ◽  
Ramandeep Kaur ◽  
Porshia Rishi ◽  
Nitika Tuli ◽  
Harjinder Singh ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Survival Rate ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Histopathological Diagnosis ◽  
Female Ratio ◽  
Neoplastic Lesions

<p class="abstract"><strong>Background:</strong> In India 53,251 new head and neck cancer cases are diagnosed every year. Benign tumours are more frequently in the oral cavity than oropharynx.</p><p class="abstract"><strong>Methods:</strong> The prospective study was carried out in the Department of Otolaryngology and Head and Neck Surgery, Dayanand Medical College and Hospital, Ludhiana, over a period of two and half years, comprised of 66 cases of head and neck neoplasia. The demographic, gender profile, clinical presentation, histopathological diagnosis, therapeutic modality undertaken and post op complications of neoplastic lesions of the oral cavity were studied. follow up was done for 6 months. The therapeutic modalities included surgery, radiotherapy and chemotherapy as per the stage of the lesion.</p><p class="abstract"><strong>Results:</strong> Incidence of oral cancer is 13.6% among head and neck neoplasms over a period of 2 years (2011-2012). The overall male to female ratio was 1:1.25, among benign was 1:1 and among malignant was 1:1.3. Benign oral cavity tumors were managed surgically with wide excision. Out of 7, 4 (44%) malignant oral cavity tumor patient experienced difficulty in swallowing. Three (43%) out of 4 squamous cell carcinoma patients complained of difficulty in speaking, which is commonly seen in post-glossectomy patients. The survival rate for 6 months follows up, was 100%.</p><p class="abstract"><strong>Conclusions:</strong> Squamous cell carcinoma is the commonest oral cavity neoplasia. At post treatment follow up period of 6 months survival rate of benign neoplasia is better than malignant neoplasia.</p>

scholarly journals Precancerous Lesions of Oral Cavity

2010 ◽  
Vol 2 (1) ◽  
pp. 7-14
Author(s):  
Uday Pawar ◽  
Chris de Souza
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Precancerous Lesions ◽  
Precancerous Lesion ◽  
Malignant Lesion ◽  
Invasive Squamous Cell Carcinoma ◽  
Betel Nut ◽  
Papilloma Virus ◽  
Potentially Malignant ◽  
Malignant Condition

Abstract The term premalignant (precancerous) lesion has been replaced by the term potentially malignant lesion. Such lesions have as their cause, tobacco use, exposure to the human papilloma virus and the chewing of the betel nut. These substances contain carcinogens. The mucosa of the oral cavity is normally quite robust. Exposure to these substances can cause it to undergo change. These changes are usually initiated as a leukoplakic patch. While some leucoplakic patches recover and resolve, some progress into invasive squamous cell carcinoma. Oral submucus fibrosis is another such potentially malignant condition caused by the abuse of betel nut.

Spindle Cell Carcinoma of the Tongue: Fallacies in Its Diagnosis

2018 ◽  
Vol 3 (02) ◽  
Author(s):  
Amrit Kaur Kaler, Shweta C, Smitha Chandra B.C, Rajeev Naik
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Cell Population ◽  
Squamous Cell ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Biphasic Tumor ◽  
Carcinoma Of The Tongue ◽  
Ihc Markers

Spindle cell carcinoma is a rare aggressive biphasic tumor, composed of neoplastic proliferation of both epithelial (squamous) and spindle cell population. It constitutes about 1% of all oral cavity tumors 2a and is almost rare on the tongue; only few cases have been reported so far. This variant of squamous cell carcinoma, comprises major diagnostic problems due to its varied histomorphology and resemblance to sarcomatous lesion; hence diligent screening and IHC markers are mandatory for its diagnosis.

PD-L1 and survival in oral cavity squamous cell carcinoma

2020 ◽  
Vol 25 (4) ◽  
pp. 287-294
Author(s):  
S. I. Kutukova ◽  
N. P. Beliak ◽  
G. A. Raskin ◽  
M. S. Mukhina ◽  
Yu. V. Ivaskova ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Immune Cells ◽  
Negative Impact ◽  
Progression Free Survival ◽  
Negative Effect ◽  
Effect Of Pd

Relevance. Prognostic value of PD-L1 expression in oral cavity squamous cell carcinoma (OCSCC) and its effect on survival is still controversial. It should be to determine the prognostic role of PD-L1 expression on tumor and immune cells of OCSCC and assess their effect on overall survival (OS) and progression-free survival (PFS).Materials and methods. A prospective study included 145 patients, first diagnosed with OCSCC. PD-L1 expression on tumor and immune cells, infiltrating tumor and its microenvironment, was assessed in all tumor samples by IHC, CPS was calculated. Cut-off values were determined by ROC analysis for identification of PD-L1 expression effect on OS and PFS.Results. Most patients with oral mucosa squamous cell carcinoma showed positive expression of PD-L1 on tumor (77.2%) and immune cells (92.4%). The median PD-L1 expression on tumor cells was 13.5% [1.0-40.0], the median PD-L1 expression on immune cells was 5.0% [1.0-11.0], and the median CPS – 18.0 [3.0-7.8]. Univariate and multivariate analyses revealed a significant negative effect of PD-L1 expression on immune cells ≤ 7% on OS (HR 0.66; 95% CI 0.45-0.93; p = 0.0498); PD-L1 expression in tumor cells ≤ 15% (HR 0.65; 95% CI 0.43-0.98; p = 0.0416) and CPS ≤ 21 (HR 0.62; 95% CI 0.44-0.92; p = 0.0183) for PFS. PD-L1 expression in tumor cells ≤ 6% (HR 0.71; 95% CI 0.47-1.08; p = 0.1096) and CPS ≤ 7 (RR 0.67; 95% CI 0.44-1.01; p = 0.0575) had a confident tendency to negative impact on OS.Conclusion. Positive PD-L1 expression in tumor and immune cells as well as CPS are effective additional factors in the prognosis of the disease course, OS and PFS in patients with OCSCC.

The Length of Peri-Neural Spreading in Clinically Mandibular Invaded Oral Cavity Squamous Cell Carcinoma

2020 ◽  
pp. 459-464
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymphovascular Invasion ◽  
Perineural Invasion ◽  
Inferior Alveolar Nerve ◽  
Surgical Margin ◽  
Neural Invasion ◽  
Resected Margin

Background: The objective of surgical management of oral squamous cell carcinoma (OSCC) is adequate resection with a clear margin. However, there is still a debate as to the optimal length for a mandibular resected margin. Objective: To examine the length of peri-neural spreading in T4 mandibular invaded oral cavity squamous cell carcinoma. Materials and Methods: Twenty-eight T4 pathological OSCC specimens that involved mandible and serial slices were studied and the length of tumor spreading along the inferior alveolar nerve (IAN) was determined. Tumor characteristics, risk factors, and survival were analyzed. Results: The incidence of peri-neural invasion was 11.11%, and IAN invasion was found in 14.29% of the tumor-invaded mandibular marrow. The length of tumor spreading along IAN was 3 to 12 mm. Poor prognostic factors of T4 OSCC were it being located on the tongue (HR 14.16), was pathological N2-3 (HR 31.05), and had high-risk features such as peri-neural invasion, lymphovascular invasion, and extra-nodal extension. Conclusion: A mandibular resected margin of at least 18 mm is recommended as a clear surgical margin in cases of T4 mandibular invasion OSCC. Keywords: Oral cancer, Perineural invasion, Inferior alveolar nerve, Squamous cell carcinoma, Mandibulectomy

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