Morphological and functional outcome of N- butyl cyanoacrylate tissue adhesive application in corneal perforations

Introduction: This study was conducted to characterize morphological and functional outcome of application of tissue adhesive (TA) in corneal perforations. Methods: This is a retrospective study in which data of corneal perforations which were managed by application of TA (N- butyl cyanoacrylate) from January 2015 to April 2018 were reviewed. The final outcome of TA in corneal perforation was considered as sealed or non-sealed over a period of three months. Criteria of success of TA application included resolution of infiltrates, corneal vascularisation and scarring. Morphological outcome was considered as corneal scarring, required therapeutic penetrating keratoplasty (TPK) and loss of anatomical integrity of globe as phthisis bulbi. Functional success was considered preservation of visual function with best corrected visual acuity (BCVA). Results: A total of sixty seven eyes of sixty seven patients were reviewed in the present study. The mean age of all the patients was 46.63 ±16.30 years (range: 5-81 years) with predominance of males 41(61.19%). Infective keratitis (IK) constituted major chunk of aetiology for corneal perforations 44(65.67%) with maximum 47(70.14%) of size of ≥1.5-3.0mm. 56(83.58%) cases sealed completely, rest 11(16.41%) cases failed to seal. Morphological outcome showed significant relationship with age, number of glue applications and complications with P value (0.05, 0.00, 0.00) respectively. The functional outcome showed significant relationship with age, frequency of applications, morphological outcome and complications (p value 0.02, 0.00, 0.00, 0.00) respectively. Conclusions: Infective keratitis is major cause of corneal perforations. Corneal perforations ≤3.0mm size shows healing and subsequent closure in 83.58%. Morphological and functional outcome shows significant relationship with age, number of glue applications and complications.

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Epidemiologic Study of the Main Risk Factors for one Year Ischemic Stroke and Surivial in Patients admitted to the neurology department of Ghayim Hospital in Mashhad, Iran, 2015

The Journal of Tolooebehdasht ◽

10.18502/tbj.v19i2.3394 ◽

2020 ◽

Author(s):

Hadi Fiouji ◽

Seyedeh Mahdieh Namayandeh ◽

Sara jam Barsang ◽

Marjan Erfani

Keyword(s):

Risk Factors ◽

Ischemic Stroke ◽

Significant Relationship ◽

Disease Risk ◽

Statistical Tests ◽

Epidemiologic Study ◽

Developed Countries ◽

P Value ◽

High Blood Glucose ◽

The Mean

Introduction: Stroke is the third most common cause of death in developed countries and is the most common neurological disabling disease. Today, several risk factors are known for stroke including lifestyle and risk factors such as hypertension and diabetes which differ in cultures and countries. The aim of this study was to determine the frequency of ischemic stroke in patients admitted to the brain department of Ghaem Hospital in 1395. Methods: In this observational cohort study, 201 cases of ischemic stroke who confirmed by neurologists as well as imaging techniques for diagnosis patients hospitalized to the neurology section of Ghaem Hospital, Mashhad, Iran During 1395. The Patients' information such as age, sex, and The place of living and also the type of stroke and its main risk factors, including history of stroke in the past, hypertension, diabetes mellitus, high blood sugar cigar and high blood lipids were extracted from their records and completed in the checklist. 1 year follow up performed by telephone calling. Data were analyzed and examined by SPSS 21 and statistical tests. Results: According to the analysis, except for the cigarette variable (P-value = 0.003) HDL and TG (P-value = 0.001), no significant relationship was found between the other risk factors of disease risk and sex. In this study, 201 patients with ischemic stroke were studied. The mean age of the participants in the study was 50.92 years. In this study, the prevalence of stroke in men were higher than that of women, 104 (51.7%) for males and 97 (48.3%) for women. In the study of the most important clinical risk factors for stroke, the results showed that the highest prevalence was hypertension in women with 68 (70.1%) and the least of them was smoking with 16 (16.5%). The mean annual death rate in this study was 15.9%, which did not have a significant relationship with sex groups. Conclusion: In this study, hypertension, having diabetes and high blood glucose levels were the most important risk factors for stroke in patients, these results are in accordance with the previous finding studies. Regarding the results, it seems that the control of blood pressure and diabetes is not effectively considered, which requires further investigation.

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SUPRACONDYLAR HUMERUS FRACTURES;

The Professional Medical Journal ◽

10.29309/tpmj/2019.26.04.3347 ◽

2019 ◽

Vol 26 (04) ◽

Author(s):

Fayyaz Ahmad Orfi ◽

Asrar Ahmad ◽

Irum Saleem ◽

Maheen Orfi

Keyword(s):

Functional Outcome ◽

Posterior Approach ◽

Operative Time ◽

Lateral Approach ◽

P Value ◽

Supracondylar Fractures ◽

Group A ◽

The Mean ◽

Group B ◽

Approach Group

Objectives: To compare lateral versus posterior approach in the management of supracondylar fractures of humerus in children in terms of functional outcome. Study Design: Retrospective Comparative study. Place and Duration of Study: This retrospective study was carried out over a period of seven years from Oct 2009 to Oct 2016, at Combined Military Hospitals Kharian, Malir and Nowshera. Patients and Methods: All the children having supracondylar fracture (Gartland Type-II and III) who underwent surgical intervention either by posterior or lateral approach were included in the study. In Group-A children operated by posterior approach were placed while in Group-B children were operated by posterior approach. They were followed up in OPD after 6 months. The final functional and cosmetic outcome was assessed by using Flynn’s criteria. Data was analysed by using SPSS version -20. A p-value of less than 0.05 was considered as statistically significant. Results: A total of 104 cases were operated during this study period. Fifty-four cases were done by posterior approach (Group-A), while 50 cases were operated by lateral approach (Group-B). In Group-A the mean age was 6.1 years while in Group-B, mean age was 6.6 years. In Group-A the male to female ratio was 72:28 while in Group-B it was 64:36. The mean weight in Group-A was 19.81Kgs (SD: ±4.53) while in Group-B it was 20.44 Kgs (SD:± 3.97). The mean operative time in Group-A was 36.30 minutes (SD: ±3.32) and in Group-B it was 23.58 minutes (SD: ±2.12). The functional outcome at six months follow-up was excellent in 35 (65%), good in 8 (15%), fair in 7 (13%) and poor in 4(7%) cases in Group-A while in Group-B it was excellent in 35 (70%), good in 10 (20%), fair in 4 (8%) and poor in only one case (2%). This difference was not significant at a p-value of 0.441. Conclusion: Though lateral approach required less operative time but there was no statistically significant difference from the posterior approach comparing the functional outcome in the management of paediatric supracondylar fractures of humerus.

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Role of Optical Coherence Tomography Angiography in Following-up Choroidal Neovascular Membranes during the Course of Aflibercept Therapy

Journal of Advances in Medicine and Medical Research ◽

10.9734/jammr/2021/v33i230811 ◽

2021 ◽

pp. 89-96

Author(s):

Ahmad R. Ziada ◽

Mostafa Abd El Latif Abo El Einen ◽

Hamdy Abd El Azim El Koumy ◽

El Said Ibraheem El Dessouky

Keyword(s):

Choroidal Neovascularization ◽

Optical Coherence Tomography Angiography ◽

University Hospital ◽

P Value ◽

Interventional Study ◽

Flow Area ◽

Corrected Visual Acuity ◽

The Mean ◽

Automated Software

Aims: To evaluate the mean area of choroidal neovascularization (CNV) and the flow area within the CNV and determine their value in monitoring the effect of aflibercept therapy. Study Design: prospective, interventional study. Place and Duration of Study: Tanta University Hospital in the period between March 2017 and March 2019. Methodology: OCT angiography images were obtained using the AngioVue (Optovue Inc., CA, USA). For quantitative analysis of the mean area of CNV and the flow area within the CNV, the CNV was manually delineated with the help of the manufacturer’s automated software, and the parameters of interest were automatically calculated and generated. Results: The study included forty eyes of 40 patients, 14 females and 26 males, the mean age of patients was 69 ± 5 years. The mean baseline best-corrected visual acuity (BCVA) was 51.29 ± 14.80 ETDRS letters, which significantly increased to 63.41 ± 5.03 at week 36; p-value < 0.05. The mean area of choroidal neovascularization decreased significantly from baseline (2.72 ± 4.29 mm2) to week 36 (1.53 ± 1.07 mm2); p-value < 0.05. The the flow area within the measured CNV decreased significantly from baseline (2.28 ± 2.08 mm2) to week 36 (0.91 ± 0.63 mm2); p-value < 0.05. Conclusion: The mean area of CNV and the flow area within the measured CNV are valuable biomarkers for following up CNV during treatment with aflibercept.

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Evaluation of Knowledge and Attitude of Kindergarten Teachers about Primary Tooth Trauma in Khorramabad City

Journal of Isfahan Dental School ◽

10.18502/ijds.v17i3.7530 ◽

2021 ◽

Author(s):

Zahra Golestannejad ◽

Rahman Nazeri ◽

Marzieh Ghaiour ◽

Mahdieh Mehrfar

Keyword(s):

Significant Relationship ◽

Work Experience ◽

Pearson Correlation ◽

Dental Trauma ◽

Knowledge Score ◽

Primary Tooth ◽

P Value ◽

Cross Sectional ◽

Level Of Knowledge ◽

The Mean

Introduction: Injury to both the primary and permanent dentitions is one of the most common dental problems. The prognosis of dental trauma depends on the basic measures taken immediately after trauma. This study was designed to assess the level of knowledge, the attitude of kindergarten coaches about primary teeth trauma in Khorramabad city. Materials & Methods: In this Cross-sectional study, 100 kindergarten coaches in Khorramabad participated in this study in 2019-2020. A valid and reliable confirmed questionnaire was used for data collection. Data were analyzed with Pearson correlation coefficients and independent t-test (p value < 0.05). Results: In this study, the mean score of coaches’ attitude was 68.5 and the mean score of knowledge was 34.9. In the present study, the factors of gender, age, level of education had no significant relationship with their knowledge score (p value > 0.05) and attitude, but between work experience with knowledge scores (p value = 0.02) and attitude (p value = 0.004) and so between the level of knowledge (p value = 0.004) and attitude (p value = 0.008) and passing the dental emergency training course, a direct relationship was observed. In this study, there was a significant relationship 64% of the coaches experienced dental trauma and their mean score of knowledge (p value = 0.04) and attitude (p value = 0.001) was significantly higher than other coaches. Conclusion: The assessed level of dental knowledge of the coaches participating in this study was poor, whereas their attitude about primary tooth trauma was good. The great suggestion is to hold educational programs in this regard to increase the level of knowledge of kindergarten coaches in the field of dental trauma.

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Knowledge, Attitude & Practice of Pediatricians regarding Oral Health and Early Childhood Caries

Journal of Isfahan Dental School ◽

10.18502/ijds.v17i1.5910 ◽

2021 ◽

Author(s):

Bita Ghasemi ◽

Romina Mazaheri ◽

Niloofar FalLah ◽

Naghmeh Feizi Najafi

Keyword(s):

Early Childhood ◽

Oral Health ◽

Significant Relationship ◽

Early Childhood Caries ◽

Knowledge Score ◽

P Value ◽

Attitude Score ◽

The Mean ◽

Knowledge And Practice ◽

Childhood Caries

Introduction: Educating pediatricians regarding oral health and early childhood caries can have a great effect on improving their knowledge, attitude & practice. The aim of this study was to determine the knowledge, attitude & practice of pediatricians regarding oral health and early childhood caries in city of Isfahan. Materials and Methods: In this descriptive-analytical study that is cross sectional, 80 pediatricians were selected randomly and a questionnaire that reliability and validity of it had been approved, was distributed between participants. Questions separately in terms of knowledge, attitude and practice regarding oral health and early childhood caries were designed. Finally, after collecting the questionnaires, Statistical analysis was performed using descriptive analysis (mean and standard deviation), Pearson correlation and Independent T-Test with the 0.05 level of significance. Results: The mean knowledge score was 58.4, the mean attitude score was 79.2 and the mean practice score was 55.5 (from 100). There was a direct significant relationship between pediatricians’ knowledge score with attitude (p value < 0.001) and practice (p value < 0.001), in addition there was a direct significant relationship (p value < 0.001) between pediatricians’ attitude score and practice score too. There was no significant relationship between knowledge with age (p value = 0.12) but there was a significant relationship between attitude (p value = 0.01) and practice (p value < 0.001) with age. There was also a significant relationship between with knowledge (p value = 0.03), attitude (p value = 0.01) & practice (p value < 0.001). Conclusion: The mean of pediatricians’ knowledge and practice score were average. Since there was a significant relationship between knowledge and practice score, so increase the pediatricians’ level of knowledge and improvement the attitude and practice of them in this context is important and developed training programs are necessary for them.

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Abstract W P133: Combined Malignant MCA Plus ACA or PCA Infarcts Do Not Have a Worse Outcome Than Isolated Malignant MCA Infarcts in Patients One Year Following Decompressive Hemicraniectomy

Stroke ◽

10.1161/str.46.suppl_1.wp133 ◽

2015 ◽

Vol 46 (suppl_1) ◽

Author(s):

Laith Maali ◽

Khader Abdelerahaman

Keyword(s):

Functional Outcome ◽

Functional Outcomes ◽

Statistical Significance ◽

Negative Influence ◽

P Value ◽

Decompressive Hemicraniectomy ◽

Malignant Mca Infarction ◽

The Mean ◽

Selection For ◽

One Year

Background: Malignant MCA infarction is a devastating disease associated with up to 80% mortality due to edema and herniation. Evidence from three European randomized trials show that decompressive hemicraniectomy (DHC) may improve functional outcomes in select patients. Adjacent cerebral territorial infarction often coincides with malignant MCA infarcts. This study compares the effects of isolated malignant MCA infarcts versus combined malignant MCA plus ipsilateral (ACA or PCA) infarcts on functional outcomes in patients surviving one or more years following DHC. We hypothesized that patients with no additional territorial involvement would have a better functional outcome. Methods: Retrospective analysis was performed on patients who underwent DHC for malignant MCA infarction from 03/2006 to 03/2012. Inclusion criteria include: Age 18-60, clinical and radiographical diagnosis of acute unilateral MCA stroke involving at least 50% of MCA territory, and DHC performed primarily to treat space occupying edema . Exclusion criteria include: Prestroke mRs of >2, life expectancy < 3 years, and death < 1 year after DHC. Patients were divided into two groups: (a) those with isolated MCA infarcts and (b) those with MCA combined with significant adjacent ipsilateral ACA or PCA involvement. Functional outcomes were calculated using the modified Rankin scale (mRs). The mean mRs was calculated for each group and the Wilcoxon-Mann-Whitney two tailed test was used to calculate statistical significance. Alpha level was set at p< 0.05. Results: A total of 26 patients met criteria. 20 patients had isolated MCA infarcts while 6 had combined MCA plus ACA or PCA infarcts. No statistical difference in functional outcome was observed between the isolated MCA group (x - =3.6) and the combined MCA group (x - =3.83) (p value=0.614). Conclusion: In this retrospective study, patients surviving one year after their DHC did not demonstrate a worse functional outcome due to additional cerebral territorial co-infarction. These findings argue against a major negative influence of combined infarctions on functional outcome compared to previous limited studies. Larger studies are needed to verify these results and to better assess criteria for ideal patient selection for DHC.

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Outcome of Trabeculectomy with Intraoperative Subtenon Injection of Mitomycin C

10.21203/rs.3.rs-269442/v1 ◽

2021 ◽

Author(s):

Pir Salim Mahar ◽

Asma Rahman

Keyword(s):

Visual Acuity ◽

Intraocular Pressure ◽

Medical Records ◽

P Value ◽

Operative Outcomes ◽

Corrected Visual Acuity ◽

Subtenon Injection ◽

The Mean ◽

Best Corrected Visual Acuity

Abstract Purpose: To evaluate the efficacy of trabeculectomy with intraoperative subtenon injection of Mitomycin C (MMC) in terms of control of Intraocular pressure post-operatively.Study design: Observational studyMethods: A total of 49 patient’s medical records who underwent trabeculectomy with intraoperative subtenon injection of MMC with diagnosis of Primary Open Angle Glaucoma (POAG) from January 2017 to December 2018 were evaluated to see the post-operative outcomes in terms of control of intraocular pressure (IOP) with 12 months follow-up. The medical records were retrieved using the hospital information system. Age, gender, pre-operative IOP, Best-Corrected Visual Acuity (BCVA), co-morbids, previous surgery, Central Corneal Thickness (CCT), fundus findings, number of glaucoma medications and postoperative complications were obtained by using a proforma.Results: Total 72 eyes of 49 patient records were evaluated to see post operative outcomes at three, six and twelve months follow up. The mean IOP preoperatively was 24.68±13.66 mm Hg with maximum anti-glaucoma treatment. After the surgery the mean IOP was 13.69±6.68 mmHg at 3 months follow-up, and 12.68±4.04 and 13.33±4.8 mmHg at 6 and 12 months respectively (P-value 0.001). Preoperatively mean CCT was 529.81±28.75 and at 12 months follow-up after surgery was 530.45±29.43 with P-value 0.245. Best Corrected Visual Acuity outcomes were seen at each follow-up and results were found to be statistically significant (P value ≤ 0.05).Conclusions: Twelve months follow-up of trabeculectomy show that intraoperative subtenon injection of MMC is effective in terms of control of IOP postoperatively with minimal complications in patients with POAG.

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A study on comparison of conventional suturing and tissue adhesive (2-octyl cyanoacrylate) for skin closure in inguinal hernia surgeries

International Surgery Journal ◽

10.18203/2349-2902.isj20185470 ◽

2018 ◽

Vol 6 (1) ◽

pp. 188

Author(s):

Shanthi Ponnandai Swaminathan ◽

Arun Victor Jebasingh ◽

Anbuselvi Annadurai ◽

Mannar Mannan

Keyword(s):

Inguinal Hernia ◽

Postoperative Pain ◽

Suture Material ◽

Tissue Adhesive ◽

P Value ◽

Skin Closure ◽

Wound Closure Techniques ◽

Tissue Glue ◽

Suture Group ◽

The Mean

Background: Wound closure techniques have evolved from suture material to advanced techniques that include skin staplers, skin glue and adhesive tapes. Based on efficacy of advanced suturing techniques patient may be benefited with better cosmesis, lesser postoperative pain, less wound infection and lesser hospital stay. The aim of the study was to compare the results of adhesive glue with suture material in skin closure in hernia surgeries.Methods: This study involves 100 patients undergoing open inguinal hernia surgery. In 50 of the patient’s skin closure was done with conventional suturing (3-0 ETHILON) and other 50 patients with tissue glue (2-octyl cyanoacrylate). Observation regarding postoperative pain, skin closure time and scar assessment were made, and their results were compared.Results: The mean time taken for skin closure in adhesive group was 2.72±1.32minutes and that of suture group was 4.88±1.533minutes. This difference was of great significance with p value of <0.001. The visual analogue scale shows mean value of 5.3±0.68 for suture group and for skin group it was 3.68±0.62. This value was of great significance with p value <0.001. Postoperative pain was comparatively less in tissue glue group. Postoperative scar was analysed with Vancouver scar scale at regular intervals. The mean score for suture group was 8.3±0.8 and for skin glue group it was 2.8±0.75. These differences of score was of great significance with p value <0.001.Conclusions: Adhesive glue is superior to conventional suturing in clean elective surgeries. It is a safe and an effective method of skin closure with less postoperative pain and better cosmesis of the scar.

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Revisiting the Natural History of Chronic Scaphoid Nonunions: A Retrospective Study of 20 Cases

Journal of Wrist Surgery ◽

10.1055/s-0040-1721435 ◽

2021 ◽

Author(s):

J. Terrence Jose Jerome

Keyword(s):

Retrospective Study ◽

Natural History ◽

Functional Outcome ◽

Grip Strength ◽

Scaphoid Nonunion ◽

Proximal Pole ◽

Degenerative Arthritis ◽

Level Of Evidence ◽

History Of ◽

The Mean

Abstract Background The natural history of scaphoid nonunion is the development of degenerative arthritis. A lot of information is still unclear about this progression. The purpose of this study is to analyze patients with scaphoid nonunions who had not received any kind of treatment and to assess the functional outcome. Materials and Methods This is a retrospective study that analyzed the patients with chronic scaphoid nonunions between 2009 and 2019. None of the patients received any treatment. The age at the time of injury, examination, pattern of fracture, types of scaphoid nonunion, symptoms, and duration of nonunion were noted. Diagnosis was confirmed by radiographs, computed tomography (CT) scan, and magnetic resonance imaging (MRI). Scapholunate and radiolunate angles were recorded. Pain score, modified mayo wrist score, grip strength, range of movement, and the functional outcome of these scaphoid nonunions were analyzed. A statistical correlation between the scaphoid nonunion presentations and the functional outcome was assessed. Results The mean age of the patients was 62 years (range: 35–82 years.). There were 17 male and 3 female patients. There were 9 waist and 11 proximal pole scaphoid nonunions. The mean duration of scaphoid nonunion was 34 years (range: 10–62 years). None of the patients had avascular necrosis (AVN) of the proximal scaphoid. The age at examination, gender, side of injury, fracture pattern (waist/proximal pole), fracture displacement ≤ 1 mm or > 1 mm, nonunion duration, and radiographic arthritic parameters had no significant impact on the functional outcome. Conclusions Untreated chronic scaphoid nonunion leads to the development of degenerative arthritis over a period of years, which is still unpredictable. Most of the patients become aware of the nonunion following a precedent injury or other reasons. Most of the patients have fair/good functional outcome despite reduced range of movements and grip strength. Many do not favor surgical intervention in the course of nonunion. Chronic nonunions open a lot of unanswered questions. Clinical relevance There have been numerous studies on the treatment aspects of scaphoid nonunion, with little knowledge about certain people with nonunion who did not have any kind of treatment. The demographics, clinical findings, and radiological parameters do confirm the progression of these nonunion to arthritis, but most of them had fair-to-good outcome throughout their life. It opens our thinking about the real need of treatment in such nonunions and raises numerous questions about the disease. Level of evidence This is a Level IV study.

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PENINGKATAN KUALITAS HIDUP MELALUI LOGOTERAPI PADA KLIEN YANG MENJALANI HEMODIALISIS

Jurnal Keperawatan ◽

10.32583/keperawatan.v11i1.425 ◽

2019 ◽

Vol 11 (1) ◽

pp. 9-18

Author(s):

Abdul Wakhid ◽

Ana Puji Astuti ◽

Maya Kurnia Dewi

Keyword(s):

Quality Of Life ◽

Renal Failure ◽

Test Group ◽

Sampling Technique ◽

T Test ◽

P Value ◽

Number Of Patients ◽

Post Test ◽

The Mean

Logoterapi merupakan terapi untuk menemukan makna positif dibalik sebuah kejadian yang tidak diharapkan. Logoterapi dilaksanakan secara individu maupun berkelompok dalam bentuk konseling dan berorientasi pada pencarian makna hidup individu. Tujuan logoterapi meningkatkan makna pengalaman hidup individu yang diarahkan kepada pengambilan keputusan yang bertanggung jawab. Penelitian ini dilakukan dengan menggunakan rancangan pre-experiment dengan metode pre and post test group, artinya pengumpulan data dilakukan terhadap responden untuk membandingkan kualitas hidup sebelum dan sesudah dilakukan intervensi. Teknik pengambilan sampel dilakukan dengan metode total sampling yaitu pengambilan seluruh sampel dengan tetap memperhatikan kriteria yang telah ditetapkan. Jumlah pasien yang menjalani hemodialisis di RSUD Ungaran sebanyak 21 orang dan di RSUD Ambarawa sebanyak 25 pasien. Analisis data dilakukan dengan menggunakan uji t test dependent. Hasil penelitian didapatkan bahwa dari 46 responden didapatkan rata-rata skor kualitas hidup pasien yang mejalani hemodialisis sebesar 60.22 dengan skor terrendah 55 dan skor tertinggi 69. Bahwa dari 46 responden didapatkan rata-rata skor kualitas hidup pasien yang mejalani hemodialisis sebesar 88.72 dengan skor terrendah 79 dan skor tertinggi 103. Hasil uji statistik dengan uji t test dependent diketahui ada pengaruh logoterapi terhadap kemampuan memaknai hidup pada klien yang menjalani hemodialisis di RSUD Kabupaten Semarang (p value: 0,0001). Saran perlunya peningkatan kemampuan perawat dalam memberikan layanan kesehatan termasuk pemberian atau pemanduan penemuan makna hidup bagi pasien hemodialysis, agar selain dengan hemodialysis, ada faktor internal dari pasien yang dapat dijadikan sebagai motivasi untuk sembuh dari penyakit. Kata Kunci: Logoterapi, kualitas hidup IMPROVE THE QUALITY OF LIFE OF PATIENTS WITH RENAL FAILURE WHO UNDERWENT HEMODIALYSIS ABSTRACT Logotherapy is a therapy to discover the positive meaning behind an unexpected event. Logotherapy is carried out individually or in groups in the form of counseling and oriented to the search for the meaning of individual life. This study aims to improve the quality of life of patients with renal failure who underwent hemodialysis. This research was conducted by using pre-experiment with pre-post test study. The sampling technique was done by the convenience sampling. The number of patients undergoing hemodialysis as many as 46 respondents. Data analysis was done by using test t test dependent. The result showed that from 46 respondents got the mean of quality of life of patients who had hemodialysis 60.22 with lowest score 55 and highest score 69. Whereas from 46 respondents got the mean score of life quality of patients who had hemodialysis 88.72 with score the lowest score 79 and the highest score 103. The result of statistical test with t test dependent is known there is influence of logoterapi to the ability of meaningful life on client who undergo hemodialysis at Semarang Regency hospitals (p value: 0.0001). Advice on the need to improve the nurse's ability to provide health services, including the provision or guidance of the discovery of the meaning of life for hemodialysis patients, in addition to hemodialysis, there are internal factors of the patient that can be used as a motivation to recover from illness. Keywords: Logotherapy, quality of life, kidney failure.

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